Balkanov, Trajan
Preferred name
Balkanov, Trajan
Official Name
Balkanov, Trajan
Main Affiliation
Email
trajan.balkanov@medf.ukim.edu.mk
26 results
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Item type:Publication, P1102EVALUATION THE EFFICACY OF MEDIUM CUT- OFF MEMBRANE DIALYZERS AND COMPARISON WITH HIGH FLUX DIALYZERS IN CONVENTIONAL HEMODIALYSIS(Oxford University Press (OUP), 2020-06-01); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Efficacy of Medium Cut-Off Dialyzer and Comparison with Standard High-Flux Hemodialysis(S. Karger AG, 2021-07); ; ; Background: A new medium cut-off (MCO) membranes has been designed to achieve better removal capacities for middle and large middle molecules in hemodialysis (HD) treatment. Aim: The aim of this study was to evaluate the removal efficacy of Theranova® in standard HD in comparison with standard high-flux HD. Methods: Four HD patients (M/F 1/4) were included in 12-week observational pilot study in HD with Theranova® 400 and Theranova® 500 dialyzers. Each patient was assessed 4 times, T0 with high-flux dialyzers, T1 at 1 month, T2 at second month, and T3 at third month, by measuring pre- and post-HD samples of urea, Cr, β2-microglobilin (β2M), myoglobin, albumin, free light chains kappa (FLC-k), and free light chains lambda (FLC-λ). Results: The data showed a higher average removal rate for all the uremic toxins with Theranova® dialyzers for β2M, myoglobin, FLC-k, and FLC-λ (62.7, 56.9, 63.5, and 54.6%, respectively) during the 3 months. Albumin retention was observed and did not change between T0 and T3 (p = 0.379). Conclusion: Compared to high-flux membranes, MCO membranes show greater permeability for middle molecules in midterm report. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Antibiotic Consumption in Hospitalized Children at the University Clinic for Pediatric Diseases – Skopje(Scientific Foundation SPIROSKI, 2020-06-10); ; ; <jats:p>BACKGROUND: The misuse and overuse of antibiotics contribute to the development of antimicrobial residence. Official data in EU/ EEA in 2017 in the hospital sector suggested that the consumption is lowest in the Netherlands, with 1 DDD per 1,000 inhabitants/day in comparison with Finland, with 2.8 DDD/TID. AIM: The aim of this study was to analyze data on the scope and structure of the antibiotic prescription in pediatric patients at University Children’s Hospital for period of 3 months in 2018 and 2019. MATERIALS AND METHODS: The data for antibiotic consumption were obtained from a hospital pharmacy, which are ordinated to hospitalized patients. RESULTS: The total amount of utilized antibacterial drugs with ATC code J01 for first quarter in 2018 is 33.65 DDD/100BD in comparison to the first quarter of 2019 when it declined to 32.09 DDD/100BD. The most consummated antibiotics in the first trimester of both years were the group of cephalosporins, especially the 3rd- and 4th-generation parenteral cephalosporins with from 16.96 to 19.25 DDD/100BD in the evaluated period. Decrease of penicillin’s, carbapenems, macrolides and quinolones were confirmed in the analyzed period. The most commonly used drugs remain ceftriaxone – 13.49 DDD/100BD in 2018 and increased to 14.41 DDD/100BD in 2019, followed by amikacin 3.21 DDD/100BD in 2018 and increased to 3.50 DDD/100BD in 2019 but azithromycin consumption significantly declined from 1.97 DDD/100BD to 0.81 DDD/100BD administered orally. The third most commonly utilized antibiotic in first quarter of 2019 become meropenem, antimicrobial drug from the group of carbapenems with 2.71 DDD/100BD. CONCLUSION: The benefits of monitoring the antibiotic prescribed pattern are critical due to the fact that they provide adequate data on consumption of antibiotics and adherence to guidelines.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison of Oxidative Stress Levels in Healthy Children and Children with Allergic Rhinitis(Walter de Gruyter GmbH, 2023-03-01); ; ; ; Background/aim: Allergic rhinitis (AR) is characterized by chronic inflammation of the nasal mucosa. Under the influence of exogenous factors - allergens, reactive oxygen species (ROS) are released during cellular metabolism. They induce a series of pathological changes in the mucosa. Oxidative stress is а result of an imbalance between the production of ROS and the ability to neutralize them. The aim of this study is to compare the levels of oxidative stress between healthy children and children with allergic rhinitis. Material and methods: A total number of 60 children were included (30 healthy children and 30 children with AR). The oxidative stress index was determined by using the FRAS 5 (Free Radical Analytical System) Bravo system. Demographic characteristics, medical history, children's living conditions and eating habits were obtained from the questionnaire. Anthropometric measurements and the absolute number of eosinophils in the peripheral smear were performed on each child. Results: This study showed high oxidative stress index and a significantly higher value of the absolute number of eosinophils in the peripheral smear in children with AR in comparison to healthy children (p<0.05). The group of children with AR had more atopic characteristics and was more exposed to passive smoking than healthy children. Conclusion: Compared to healthy children, children with AR have a high index of oxidative stress, despite of the very high mean value of the concentration of water-soluble antioxidants in serum (PAT test) in the group of children with AR. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Determination of Terpenoid Profile in Dry Cannabis Flowers and Extracts Obtained from Different Cannabis Varietes(Sciencedomain International, 2021-12-08) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute fulminant hepatatis in kidney transplant recipient after repeated sevoflurane anesthesia--a case report and literature review(Bentham Science Publishers Ltd., 2013-04); ; ; Dohchev, SasoA liver dysfunction induced by halogenated volatile anaesthetics is considered as a significant diagnostic problem. The aim of our report was to describe the first case of lethal hepatic failure in a female patient undergoing kidney transplantation (KTx) from a living donor after repeated sevoflurane anaesthesia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Does Cannabis Extract Obtained From Cannabis Flowers With Maximum Allowed Residual Level of Aflatoxins and Ochratoxin a Have an Impact on Human Safety and Health?(2021) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hairy Cell Leukemia Treatment: The Past and the Present–Where We Are Now?(Elsevier BV, 2019-09); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute Graft Versus Host Disease in Hematopoietic Stem Cell Alotransplant Recipients(ScopeMed, 2011); ; ; ; The transplantation of hematopoietic stem cells (HSCT) is a therapeutic intervention where the hematopoietic stem cells and the cells originating from them are being removed and replaced by the normal stem cells of donor or the patient him/her-self. HSCT today represent standardized biological manipulation for treating malignant, genetic and autoimmune diseases. The application of allogeneic hematopoietic stem cell transplantation (HSCT) is limited by life-threatening complications such as severe or acute graft-versus-host disease (GVHD). Despite intensive prophylaxis with immunosuppressive agents, the incidence of GVHD occurs in 9-50% of patients undergoing transplant with an identical HLA sibling matched donor and 75% of patients undergoing unrelated HLA donors. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Utility of exhaled nitric oxide in pediatric practice-review of literature.(Macedonian Association of Anatomists and Morphologists, 2019); ; ; ; Popova, GoricaThe field of interest for measurement of exhaled nitric oxide (NO) and nasal NO is significantly evolving over the last 25 years, with over 1000 publications published in that area. Inflammation of the airways is a central process in asthma and other lung disorders, but the monitoring of the inflammation has not been included in the current recommendations. The exhaled air contains volatile media such as nitric monoxide, carbon monoxide, ethane, pentane and non-volatile substances in the liquid phase in the exhalation, as a condensate (hydrogen peroxide). It is increasingly confirmed that the measurement of exhaled mediators in general, and especially NO, is a new way to monitor certain aspects of asthma, COPD and interstitial lung disease, which cannot be estimated with other methods, like lung function. In asthma, exhaled NO is recommended to be used as a marker for diagnosis, for monitoring the response of anti-inflammatory drugs, confirming the safety of therapy and predicting asthma exacerbation. Measurements of FeNO are easily performed, they are reproducible and technically less expensive than the analysis of induced sputum. In symptomatic patients, high FeNO levels (> 50 ppb), refer to significant eosinophilia in the airways, which will most likely respond to treatment with ICS. The current data provides support for the diagnostic use of FeNO in children with symptoms of asthma. For patients with chronic and/or severe asthma, FeNO levels are useful for determining whether eosinophilic inflammation of the airways is active or not. Both high (> 50ppb) and low (<25 ppb) levels of FeNO can be used to for predicting the outcome in patients with a definitive history of asthma who are currently in remission and who have stopped treatment with ICS.
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