Markovikj Temelkova, Snezhana
Preferred name
Markovikj Temelkova, Snezhana
Official Name
Markovikj Temelkova, Snezhana
Main Affiliation
Email
snezana.marte@medf.ukim.edu.mk
15 results
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Item type:Publication, Renal lymphagiectasia - an unusual mimicker of renal hydronephrosis(Macedonian Association of Anatomists, 2021-12) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessment of mineralization of oral surgical defects in patients with diabetes mellitus according to Hba1C(Medical faculty, Ss Cyril and Methodius University in Skopje, 2018-11); ; ; Pisevska Cholakova, N - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HYPONATREMIA IN OLANZAPINE TREATED PATIENT(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University Skopje, R.N.Macedonia, 2021-06); ; Hyponatremia is sodium level imbalance, defined as levels below 135 mmol/l. Numerous factors may lie in its etiology and pathogenesis including psychotropic drug use, and in such cases hyponatremia is an adverse event. The syndrome of inappropriate secretion of antidiuretic hormone secretion (SIADH) has been reported with the use of antidepressants, antipsychotics and mood stabilizers. The exact pathophysiological mechanisms for this syndrome are still in the process of investigation. The findings so far indicate: increased secretion of ADH from hypothalamus as a result of dopamine-D2 receptor inhibition (suppression of the inhibitory effect of dopamine on ADH secretion), as well as the effect of 5-HT2 and 5-HT1C serotonin receptors which also leads to an increase in ADH levels and potentiation of its effect at the renal level. Having seen similar symptoms in SIADH and in psychiatric entities, it can cause hyponatremia to remain unrecognized in clinical practice, especially if mild and if it develops slowly. However, in some cases it may progress to severe hyponatremia which becomes an urgent condition. On the other hand, if recognized and treated in time, there is a satisfactory outcome. We report a case-report of 64-year-old woman who has been treated for a schizophrenia disorder for thirty years with good remission of symptoms by regular use of antipsychotics (orally and in depot form). The current deterioration occurred in the last five months, due to non-compliance to the treatment. During treatment hyponatremia was induced by the second generation of antipsychotic drug. In conclusion we recommend for clinicians not only to be cautious when prescribing psychotropic drugs, and to assess sodium laboratory values and clinical symptoms for all patients after initiation of antipsychotic drug as a routine clinical practice, but also to take into account differential diagnoses for presented symptoms - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RENAL LYMPHANGIECTASIA- AN UNUSUAL MIMICKER OF RENAL HYDRONEPHROSIS(Macedonian Association of Anatomists and Morphologists, 2021); ; Renal lymphangiectasia is a rare malformation of the renal lymphatics. It occurs in both children and adults and can be unilateral or bilateral with no gender predilection. It is a condition characterized by different degrees of dilatation of the lymphatic ducts. Because of the rarity, it can be easily misdiagnosed for other cystic masses, most commonly peripelvic cysts, renal cysts or hydronephrosis. Usually is asymptomatic and incidental finding, but in severe cases can lead to hypertension and renal failure. We report a case of unilateral renal lymphangiectasia in adult male patient with medical history of hydronephrosis and characteristic radiologic CT findings. From imaging methods, we conducted ultrasound (US), contrast enhanced computed tomography (CT) and CT angiography, because they have an important role as diagnostic procedures to recognize renal lymphangiectasia. Kidney cystic lesions revealed on ultrasound and confirmed on CT as hypodense intrarenal multiloculated findings, as well as fluid attenuation collections, not always go in favor of hydronephrosis. Knowledge of the radiological findings associated with renal lymphangiectasia can contribute to better differentiation from other conditions and with the right diagnosis, successful management and treatment can be provided for the patient. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia(Walter de Gruyter GmbH, 2022-03-01); ; <jats:title>Abstract</jats:title> <jats:p> <jats:bold>Background</jats:bold>: Evidence for disturbances in HPA activation and abnormal HPA regulatory mechanisms in schizophrenia is accumulating.</jats:p> <jats:p> <jats:bold>Aim</jats:bold>: To compare serum levels of cortisol, DHEA-S and their ratio between patients with schizophrenia and healthy controls and among patients before and after treatment with different types of antipsychotics.</jats:p> <jats:p> <jats:bold>Material and methods</jats:bold>: In this clinical prospective study, 60 patients with schizophrenia and 40 healthy age and sex matched control subjects were included. All patients experienced an acute exacerbation of the illness (PANSS: P1 and P3 ≥ 4). Clinical evaluation of patients was performed using the Positive and Negative Symptom Scale. A questionnaire for socio-demographic and clinical data collection was used. Serum levels of cortisol, DHEA-S and their ratio were measured at baseline in all participants and after 3 and 6 weeks, respectively, of the antipsychotic treatment with different types of antipsychotics in patients with schizophrenia.</jats:p> <jats:p> <jats:bold>Results</jats:bold>: Patients with schizophrenia had significantly higher serum cortisol and DHEA-S levels in comparison to the control group. There was no significant difference in serum levels of cortisol, DHEA-S and their ratio between patients treated with different types of antipsychotics (typical/atypical). Serum levels of the analyzed hormones significantly reduce during the 6-week period of examination in both subgroups treated with different types of antipsychotics.</jats:p> <jats:p> <jats:bold>Conclusion</jats:bold>: Elevated serum cortisol and DHEA-S in schizophrenic patients might be associated with their role in the pathophysiology of the disorder. There is no significant difference in serum levels of cortisol, DHEA-S and their ratio among the patients treated with different types of antipsychotics.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical use of trabecular bone score for diagnosis of osteoporosis: a review(Macedonian Association of Anatomists, 2019-12); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, - Some of the metrics are blocked by yourconsent settings
Item type:Publication, IMPACT OF HORMONE REPLACEMENT THERAPY ON HYPERANDROGENICITY AND GLUCOSE HOMEOSTASIS IN POSTMENOPAUSAL DIABETIC WOMEN(Bioscientifica on behalf of the Society for Endocrinology, 2016); ; ; ; Hyperandrogenicity in women is closely associated with insulin resistance and a risk factor for cardiovascular disease and noninsulin-dependent diabetes mellitus. It is known that hormone replacement therapy (HRT) decreases hyperandrogenicity and improves glucose homeostasis in postmenopausal diabetic women. To investigate the role of HRT on hyperandrogenicity and glucose homeostasis in postmenopausal diabetic women. A total of 40 type 2 diabetic postmenopausal women were prospectively enrolled and followed for 12 months. The examined group consisted of 20 women who were assigned to take HRT, while the rest were left without hormone therapy. HRT consisted of 17β- estradiol (E2) 1 mg and DRSP (drospirenone) 2 mg. Fasting blood glucose ( FPG), glycosylated hemoglobin (HbA1C), insulin, sex hormone binding globuline (SHBG) and total testosterone were measured, free androgen index (FAI) was calculated by formula and insulin sensitivity was determined by the homeostatic model assessment of insulin resistance ( HOMA-IR). All metabolic measurements were taken at baseline and after 12 months.HRT treatment, compared with control group, was followed by a marked increase of SHBG (from 29.0 ± 12.3 to 56.0 ± 8.54 nmol/l) and significant decrease of free testosterone (5.17 ± 1.2 to 1.92 ± 1.3), FPG (7.8 ± 0.86 to 6.9 ± 0.6 mmol/l), HbA1C(7.6 ± 0.54 to 7.2 ± 0.43 % and HOMA-IR (4.23 ± 1.7 to 3.18 ± 1.4 µU/ml-mmol/l).HRT in postmenopausal diabetic women ameliorated hyperandrogenicity, accompanied by marked improvements in glucose homeostasis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Index of the osteoporotic risk (IOR) in the evaluation of the postmenopausal osteoporosis(2018); ; ; Mladenovska, M - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RESULTS FROM POST - MARKETING OBSERVATIONAL STUDY FOR THE ASSESSMENT OF SAFETY OF INTRAVENOUS IBANDRONIC ACID IN POSTMENOPAUSAL WOMEN(SHMSHM - AAMD, 2020-12-23); ; ;