Atanasova Boshku, Aleksandra

Preferred name
Atanasova Boshku, Aleksandra
Official Name
Atanasova Boshku, Aleksandra
Main Affiliation
Email
atanasovaboshku@medf.ukim.edu.mk

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Now showing 1 - 10 of 17
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    Postpartum decline in sflt-1/plgf ratio confirms placental source of angiogenic imbalance and endothelial dysfunction in preeclampsia
    (Elsevier BV, 2024-02)
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    Todorovska, Irena
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    Paneva, I.
    Preeclampsia (PE) is a multisystem disorder in pregnancy with a specific collection of signs and symptoms as a result of serious dysfunction of multiple organs. Abnormal placentation in the first trimester, most likely triggers the disbalance of the placental anti-angiogenic factor soluble fms-like tyrosine kinase-1(sFlt-1) and pro-angiogenic placental growth factor (PlGF), which result in systemic endothelial dysfunction (injury) to progressive end-organ damage. According the PROGNOSIS study, the cut-off value of the sFlt-1/PlGF ratio over 85 confirms the suspected PE and proved to be useful in preeclampsia diagnosis. A severely elevated sFlt-1/PlGF ratio is associated closely with the need to deliver within 48hours.
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    IODINE SUPPLEMENTATION AND THYROID STATUS IN HEALTHY PREGNANT WOMEN IN IODINE-REPLETE REGION
    (2019)
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    Background: Optimal iodine intake is essential for proper function of the thyroid in pregnancy, affecting thus the foetal development. Recent data worldwide have revealed insufficient iodine intake in pregnant women in certain countries with confirmed iodine sufficiency and raise the issue of iodine supplementation in this population. The objective of the study was to determine the effects of the iodine supplementation in pregnant women (PW) on their thyroid status and compare the findings with the data of pregnant women without iodine supplementation, all living under iodine sufficiency of general population. Material and Methods: The case control study was performed on total 543 PW (aged 15 – 40 years), 267 of which were taking iodine supplements. Iodine status was assessed as median urinary concentration and thyroid function tests (TFTs) were performed by chemiluminescent immunoassays. Data analysis was performed by descriptive and nonparametric statistics. Results: The overall median urinary iodine concentration (UIC) in PW was 167,5 μg/L. The median value of the group with iodine supplementation was higher compared to non-supplementation group (180,5 μg/L vs 160,2 μg/L), but the difference was not statistically significant. The median value was higher for thyroid stimulating hormone (TSH) in the group of PW with iodine supplementation (1,8 mIU/L vs. 1,6 mIU/L), while for thyroglobulin (Tg) in the group without iodine supplementation (11,4 μg/L vs. 10,5 μg/L). The difference in free thyroxine (FT4) results between the two groups was not statistically significant. Conclusions: Living in a long-term iodine sufficient region, PW on iodine supplementation with 150 μg/day remained euthyroid, without evidence of increased incidence of iodine-induced thyroid disorders.
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    Kinetics of Antibody Response to Repeated Vaccination with Sputnik V: A Pilot Study with a Series of Five Cases
    (2022-08)
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    Aleksovski, Vasko
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    Widespread vaccination is considered as one of the best methods in combating any pandemic including COVID-19. Gam-COVID-Vac also known as Sputnik V, is one of the first vaccines that was registered in 74 countries and received an emergency approval for immunization. Monitoring anti-SARS-CoV-2 antibodies over time is essential for evaluation of post-vaccination humoral immune response.To date, there are only a limited number of clinical studies regarding the analysis of immune response after Sputnik V administration. It is of crucial importance to report independently on safety and efficiency of this vaccine with the aim to speed up the process of its final approval by the WHO.
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    METABOLIC VARIATIONS AMONG WOMEN WITH POLYCISTIC OVARY SYNDROME ACCORDING TO BODY MASS INDEX
    (Македонско лекарско друштво = Macedonian medical association, 2025-12)
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    Naumova, Rosa
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    Introduction. There is a two-way relationship between obesity and polycystic ovary syndrome (PCOS). Although most individuals with PCOS are overweight or obese, a notable number maintain a normal body mass index (BMI). The conventional diagnostic approach to PCOS, based on phenotypic characteristics, categorises patients according to ovulatory function and androgen levels. This study aimed to compare clinical, metabolic, and endocrine parameters in lean and obese women diagnosed with PCOS. Methods. This cross-sectional study enrolled a total of 89 women, aged between 18 and 40 years, diagnosed with PCOS based on the Rotterdam criteria. Participants were stratified into groups according to their BMI. Anthropometric measurements and venous blood samples were obtained for the evaluation of glucose metabolism, lipid profile, and selected endocrine parameters. Calculated indices included BMI, waist-to-height ratio (WHR), and the homeostasis model assessment of insulin resistance (HOMA-IR). Results. Among the 89 women with PCOS included in the study, 39.3% were classified as lean, while 60.7% were categorised as obese. Regardless of phenotypic variation, obese PCOS patients exhibited significantly elevated BMI and WHR, alongside increased levels of luteinizing hormone (LH), LH/FSH ratio, and free androgen index (FAI), higher insulin concentrations, insulin resistance, and dyslipidemia. Conversely, lean women with PCOS maintained normal insulin levels, lacked clinically relevant insulin resistance, and presented with normal lipid profiles. Conclusion. The results indicated significant differences in metabolic profiles between lean and obese patients with PCOS, regardless of phenotypic classification. Metabolic abnormalities were particularly pronounced in women with increased body weight, emphasising the need for focused care and implementation of preventive measures aimed at reducing the risk of long-term health complications. These findings highlight the importance of early metabolic screening in all PCOS patients, along with a personalised approach to management based on individual characteristics.
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    W223 Angiogenic profile according sFlt-1/PlGF ratio before and after delivery in patient with preeclampsia
    (Elsevier BV, 2022-05)
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    Todorovska, I
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    Simeonova Krstevska, S
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    VITAMIN D STATUS AMONG PREGNANT WOMEN OF NORTH MACEDONIA:ASSESSING DEFICIENCY RATES AND ASSOCIATED RISKS FACTORS
    (Walter de Gruyter, 2025-04-16)
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    Aleksovski, Vasko
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    Gjorgievska Nikolovska, Elena
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    Objective. Vitamin D is an essential vitamin that plays a key role in maintaining overall health. During pregnancy, the demand for vitamin D increases to support the growing needs of the fetus. Vitamin D deficiency is highly prevalent in pregnant women worldwide. The aim of our study was to evaluate the vitamin D deficiency rate among pregnant women in the Republic of North Macedonia, along with influencing factors. Materials and Methods: We conducted a prospective study of randomly selected pregnant women with different body mass index and in two different seasons among vitamin supplementation users and non-users. Results: A total of 309 pregnant women aged > 18 years were recruited from August 2022 to January 2023, with an average vitamin D concentration of 38.9 (36.6-40.2) nmol/l. During the winter period, 80.8 % of pregnant women had vitamin D deficiency. Conclusion: Despite the fact that more than 77.3 % of pregnant women consume multivitamins containing vitamin D, vitamin D deficiency is highly prevalent among pregnant women especially among obese pregnant woman and during the winter months.
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    Association of vascular and inflammatory markers with metabolic disorders in women with polycystic ovary syndrome
    (National Library of Serbia, 2019)
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    <jats:p>Background/Aim. The prevalence of metabolic disorders, obesity and insulin resistance in women with polycystic ovary syndrome (PCOS) occur early in life and places this group at risk of cardiovascular disease. Hyperhomocysteinemia and increased C-reactive protein (CRP) activity have an effect on promoting atherosclerosis. This study was designed to evaluate whether high sensitivity (hs-CRP) and homocysteine (Hcy) are elevated in PCOS and to elucidate their possible relation to obesity, insulin resistance, or metabolic changes usually present in women suffering from PCOS. Methods. Serum concentration of hs-CRP and plasma levels of Hcy were evaluated in 73 PCOS women and 43 healthy women, together with clinical, anthropometric and hormonal parameters. Results. The mean of body mass index (BMI), waist circumference (WC), waist to hip ratio and mean concentration of luteinizing hormone (LH), testosterone, androstenedione, free androgen index, fasting insulin, homeostatic model assessment of insulin resistance (HOMA- IR), hs-CRP and Hcy were significantly higher in PCOS women compared to age-matched healthy women. There was a positive correlation between hs-CRP and BMI, WC, insulin, triglycerides (p < 0.001) and significant negative correlation with LH, sex hormone binding protein (SHGB), HOMA-IR, high density lipoprotein cholesterol (HDL-C) (p < 0.001). The Hcy concentration had a significant negative correlation with HDL-C level (p < 0.05). The present study demonstrated increased mean concentration of Hcy in hs-CRP women with PCOS. Conclusion. Our results support the use of these biomarkers in the evaluation of potential risk for cardiovascular diseases and early prognosis and treatment implications.</jats:p>