Kondov, Goran

Preferred name

Kondov, Goran

Official Name

Kondov, Goran

Translated Name

Кондов, Горан

Alternative Name

Goran Kondov

Горан Кондов

Kondov G

Кондов Г

G Kondov

Г Кондов

Main Affiliation

Now showing 1 - 10 of 59

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Early Complications after Lung Resections at Patients Treated For Lung Cancer with and Without Neoadjuvant Hemiotheraphy
(ID Design 2012, 2012-07)
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Trajanka Trajkovska
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Tretman na plevralen empiem
(Македонско лекарско друштво = Macedonian medical association, 2023-09-21)
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Cholanceski R
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Jakupi N
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Decoupling channel count from field of view and spatial resolution in single-sensor imaging systems for fluorescence image-guided surgery
(SPIE-Intl Soc Optical Eng, 2022-09-26)
Blair, Steven
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Garcia, Missael
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Zhu, Zhongmin
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Liang, Zuodong
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Lew, Benjamin
Near-infrared fluorescence image-guided surgery is often thought of as a spectral imaging problem where the channel count is the critical parameter, but it should also be thought of as a multiscale imaging problem where the field of view and spatial resolution are similarly important. Aim Conventional imaging systems based on division-of-focal-plane architectures suffer from a strict relationship between the channel count on one hand and the field of view and spatial resolution on the other, but bioinspired imaging systems that combine stacked photodiode image sensors and long-pass/short-pass filter arrays offer a weaker tradeoff. Approach In this paper, we explore how the relevant changes to the image sensor and associated image processing routines affect image fidelity during image-guided surgeries for tumor removal in an animal model of breast cancer and nodal mapping in women with breast cancer. Results We demonstrate that a transition from a conventional imaging system to a bioinspired one, along with optimization of the image processing routines, yields improvements in multiple measures of spectral and textural rendition relevant to surgical decision-making. Conclusions These results call for a critical examination of the devices and algorithms that underpin image-guided surgery to ensure that surgeons receive high-quality guidance and patients receive high-quality outcomes as these technologies enter clinical practice.
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PRIMARY HYPERPARATHYROIDISM INDUCED BY AN ECTOPIC ADENOMA, INITIALLY PRESENTED AS BROWN TUMOR OF THE TIBIA
(Department of Anaesthesia and reanimation, Faculty of Medicine, Ss Cyril and Methodious University Skopje, Macedonia, 2020-10)
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Samardziski, Milan
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The classic manifestation of unchecked, advanced hyperparathyroidism is the brown tumor, a non-neoplastic giant cell osteomedullary lesion. We report a case of, these days rarely seen manifestation of advanced hyperparathyroidism, brown tumor due to an ectopic mediastinal parathyroid adenoma. A 63-years-old woman presented with an expansile osteolytic lesion of the right tibia on the radiographic images. Because of the suspicion of primary or secondary bone tumor, bone scintigraphy was performed. The bone scan was indicative of metabolic bone disease. Furthermore, laboratory investigations were obtained that revealed hypercalcemia, hypophosphatemia, increased level of alkaline phosphatase, and parathyroid hormone. Subsequently, ultrasound of the neck was performed, but no enlarged parathyroid glands were detected, so the patient underwent dual-phase 99mTc-methoxy-isobu- tyl-isonitrile (MIBI) parathyroid scintigraphy using a hybrid SPECT/CT gamma camera. The MIBI scan showed ectopic hypermetabolic parathyroid tissue in the anterior mediastinum, as well as an additional appearance of focal radiotracer uptake in the sternal end of the right clav- icle, suggesting the presence of a brown tumor. After thorough clinical workup, the diagnosis was in favor of primary hyperparathyroidism and the patient underwent surgical resection of the ectopic parathyroid gland with gamma-probe guidance, later histopathologically confirmed it to be a parathyroid adenoma. Postoperatively her PTH level dropped and the electrolyte status normalized within 6 months. Osteolytic brown tumors can easily imitate bone malignancy and should be evaluated with caution. The use of intraoperative gamma-probe guidance could support the complete removal of the parathyroid adenoma tissue ensuring the surgical and therapeutic success for the patient.
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Convolutional neural network advances in demosaicing for fluorescent cancer imaging with color-near-infrared sensors.
(SPIE, 2024-07)
Jin Y
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Singhal S
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Nie S
Significance: Single-chip imaging devices featuring vertically stacked photodiodes and pixelated spectral filters are advancing multi-dye imaging methods for cancer surgeries, though this innovation comes with a compromise in spatial resolution. To mitigate this drawback, we developed a deep convolutional neural network (CNN) aimed at demosaicing the color and near-infrared (NIR) channels, with its performance validated on both pre-clinical and clinical datasets. Aim: We introduce an optimized deep CNN designed for demosaicing both color and NIR images obtained using a hexachromatic imaging sensor. Approach: A residual CNN was fine-tuned and trained on a dataset of color images and subsequently assessed on a series of dual-channel, color, and NIR images to demonstrate its enhanced performance compared with traditional bilinear interpolation. Results: Our optimized CNN for demosaicing color and NIR images achieves a reduction in the mean square error by 37% for color and 40% for NIR, respectively, and enhances the structural dissimilarity index by 37% across both imaging modalities in pre-clinical data. In clinical datasets, the network improves the mean square error by 35% in color images and 42% in NIR images while enhancing the structural dissimilarity index by 39% in both imaging modalities. Conclusions: We showcase enhancements in image resolution for both color and NIR modalities through the use of an optimized CNN tailored for a hexachromatic image sensor. With the ongoing advancements in graphics card computational power, our approach delivers significant improvements in resolution that are feasible for real-time execution in surgical environments. Keywords: bioinspired sensors; cancer surgery; convolutional neural network; demosaicing; image-guided surgery; near-infrared imaging.
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Myasthenia Gravis and Associated Diseases
(Scientific foundation SPIROSKI, 2018-03-05)
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Novotni, Gabriela
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Sazdova-Burneska, Slobodanka
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Kuzmanovski, I
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Boshkovski, Bojan
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease caused by the action of specific antibodies to the postsynaptic membrane of the neuromuscular junction, leading to impaired neuromuscular transmission. Patients with MG have an increased incidence of other autoimmune diseases. AIM: to determine the presence of other associated diseases in patients with MG.METHOD: A group of 127 patients with MG followed in 10 years period, in which the presence of other associated diseases has been analysed.RESULTS: The sex ratio is in favour of the female sex, the average age of the initial manifestation of the disease is less than 50 years, 65.4% of the patients with MG have another disease. 15.0% patients have associated another autoimmune disease. Thyroid disease is the most common associated with MG, rarely rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other autoimmune diseases. Other diseases include hypertension, heart disease, diabetes, respiratory diseases, dyslipidemia. 10.2% of the patients are diagnosed with extrathymic tumours of various origins. CONCLUSION: Associated diseases are common in patients with MG, drawing attention to the possible common basis for their coexistence, as well as their impact on the intensity and treatment of the disease.</jats:p>
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Do hypertensive patients chronically treated with Renin-Angiotensin system antagonist have risk of hypotension during induction in general anesthesia?
(MIT Univerzitet Skopje, 2021)
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Toleska, M.
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Impact of Size of the Tumour, Persistence of Estrogen Receptors, Progesterone Receptors, HER2Neu Receptors and Ki67 Values on Positivity of Axillary Lymph Nodes in Patients with Early Breast Cancer with Clinically Negative Axillary Examination
(2017-12-15)
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The study aimed to identify factors that influence the positivity of axillary lymph nodes in patients with early breast cancer and clinically negative axillary lymph nodes, who were subjected for modified radical mastectomy and axillary lymphadenectomy.
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Surgical Treatment of Traumatic Posterior Sternoclavicular Joint Dislocation: А Case Report
(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Walter de Gruyter GmbH, 2022-11-01)
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Mihajlova Ilie, Radmila Mila
Posterior sternoclavicular joint dislocation is a rare condition. In this paper, we present a 51-year-old male patient who was admitted to the emergency department in our hospital after he was hit by a mining railway wagon in the chest. A diagnosis of posterior sternoclavicular dislocation was confirmed after performing a CT scan. Following necessary preparations, the sternoclavicular joint was stabilized with two wire cerclage techniques during open reduction. During control at the postoperative 4th week, the range of motion at the shoulder was satisfactory, but the patient had mild pain at the joint level and was sent to physical therapy to improve the range of motion and to minimize the pain.
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Developments in surgical treatment of pleural empiema
(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University in Skopje, R.N.Macedonia, 2023-12)
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Cholanceski R
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Thoracic empyema is the accumulation of pus within the pleural cavity. The most frequent cause is direct contiguous spread of infection, the most frequent from lung infection. Current management of empyema is based on local empirical practice as there is no consensus on an optimal regimen. It is estimated that 40% (7-57%) of pneumonia, results with parapneumonic effusion, out of which 10% develop empyema of pleural space. Treatment covers antibiotics, pleural drainage, pleural drainage and use of fibrinolytics, VATS early debridement, VATS decortication, open decortication, open pleural window and thoracoplasty. The choice of adequate treatment is according to stage of empyema: I (exudative stage) - thoracic drainage, II (fibrinopurulent stage) - thoracic drainage with fibrinolytics and VATS debridement or VATS early decortication and for III (empyema in organization stage) - VATS or open decortication or later thoracoplasty. Early VATS debridement effectively manages simple parapneumonic effusions. VATS decortication has efficacy for managing early-stage empyema. In the past (2011-15) period 234 patients with empyema were treated, out of which 124 (52.99%) of empyema were treated with pleural drainage, 105 (44.87%) were treated with open decortication and 5 (2.14%) with thoracoplasty. In the last 6 months of 2023, 21 patients were treated, 19 (90.5%) male and 2 (9.5%) female. Unfortunately, in the last 6 months only 5 (23.8%) of the patients were treated only with pleural drainage, 4 (19%) patients were treated with VATS debridement or early decortication and 12 (57.14%) patients were treated with pleural drainage that finished with open decortication. This situation suggests that, unfortunately, empyema was detected in advanced stage that needed aggressive surgical treatment. Early detection of parapneumonic effusion and treatment in this stage will prevent development of empyema and need of aggressive treatment.

Kondov, Goran

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