Now showing 1 - 10 of 33
  • Some of the metrics are blocked by your 
    Item type:Publication,
    BODY MASS INDEX AS A DETERMINANT OF OUTCOME OF TREATMENT WITH NON-INVASIVE VENTILATION IN PATIENTS WITH RESPIRATORY FAILURE DUE TO ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    (Macedonian Association of Anatomists and Morphologists, 2015-12)
    ;
    ;
    Goseva Z
    ;
    ;
    Arbutina S
    Introduction: In the last two decades noninvasive ventilation (NIV) has become an integral part of the protocol for the treatment of patients with acute respiratory failure. Aim of the study: To assess the relationship between body mass index (BMI) and outcome of treatment with NIV in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Material and methods: A total of 52 patients, over the age of 40, hospitalized because of acute exacerbation of COPD and treated with NIV were prospectively recruited. The patients were divided into two groups: 1) successful NIV treatment group; 2) failed NIV treatment group. Results: There was no significant difference in distribution between the two patients groups in terms of sex and age. Compared to group 1, in the group 2, difference was observed in the values of GCS that were lower, and the PaCO2 and APACHE II scores were higher, but the difference between the two groups was not significant (p> 0.05). Significant difference was observed between the values of pH (p <0.05) and BMI (p <0.01). The majority of patients with NIV treatment failure were with BMI <22kg / m2. Conclusion: The degree of acidosis and BMI are factors of statistical significance for the outcome of NIV treatment. Further studies are needed to clarify the reasons for the association between NIV and low BMI.
  • Some of the metrics are blocked by your 
    Item type:Publication,
    LEUKOTRIENE RECEPTOR ANTAGONISTS IN MANAGING SEVERE UNCONTROLLED ASTHMA
    (European Medical Group, 2017-08-03)
    ;
    ;
    ;
    Goseva, Zlatica
    ;
    Gjorchev, Angelko
  • Some of the metrics are blocked by your 
    Item type:Publication,
    IL-33 in patients with severe uncontrolled allergic asthma
    (European Respiratory Society, 2017-09)
    ;
    ;
    ;
    Goseva, Zlatica
    ;
    Angelko, Gjorcev
  • Some of the metrics are blocked by your 
    Item type:Publication,
    The Prevalence of Diabetes Mellitus in COPD Patients with Severe and Very Severe Stage of the Disease
    (ID-Design/Scientific foundation SPIROSKI, 2016-05-22)
    ;
    ;
    ;
    Sasha Anastasova
    ;
    Irena Angelovska
    AIM: The aim of the study was to investigate the prevalence of diabetes mellitus in privies diagnosed chronic obstructive pulmonary disease (COPD) patients with severe and very severe disease, which ware stable. METHODS: We investigated 100 subjects, all of them smokers, with smoking status >10 years. They were stratified in two groups. It was clinical, randomized, cross sectional study. Besides demographic parameters, functional parameters, BMI, cholesterol, LDL and HDL, and the level of blood sugar was measured. RESULTS: The prevalence of diabetes mellitus in our survey in total number of COPD patients with severe and very severe stage was 21%. In the very severe group were recorded significantly higher average values of glycaemia compared with severe group (7.67 ± 3.7 vs. 5.62 ± 0.9, p = 0.018). In the group with severe COPD, it was not confirmed any factor with significant predictive effect on the values of glycaemia. As independent significant factors that affect blood glucose in a group of very severe COPD were confirmed cholesterol (p <0.0001) and HDL (p = 0.018). CONCLUSION: These results suggest that the presence of the COPD in patients itself is a factor that results in the clinical presentation of diabetes mellitus Type 2.
  • Some of the metrics are blocked by your 
    Item type:Publication,
    The rationality of the use of NIV in elderly patients with acute COPD exacerbation
    (European Respiratory Society, 2018-09-15)
    ;
    ;
    ;
    ;
    Jovanoski, Smilko
  • Some of the metrics are blocked by your 
    Item type:Publication,
    Predictive Factors for the Effect of Treatment by Noninvasive Ventilation in Patients with Respiratory Failure as a Result of Acute Exacerbation of the Chronic Obstructive PulmonaryDisease
    (ID Design 2012/Scientific Foundation SPIROSKI, 2015-11-11)
    ;
    ;
    Goseva Z.
    ;
    ;
    Jovanovska Janeva E.
    BACKGROUND: Noninvasive mechanical ventilation (NIV) applies ventilator support through the patient’s upper airway using a mask. AIM: The aim of the study is to define factors that will point out an increased risk of NIV failure in patients with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). PATIENTS AND METHODS: Patients over the age of 40, treated with NIV, were prospectively recruited. After data processing, the patients were divided into two groups: 1) successful NIV treat-ment group; 2) failed NIV treatment group.RESULTS: On admission arterial pH and Glasgow coma scale (GCS) levels were lower (pH: p<0.05, GCS: p<0.05), and Acute Physiology and Chronic Health Evaluation II (APACHE) score and PaCO2were higher (p<0.05) in the NIV failure group. Arterial pH was lower (p<0.05) and PaCO2and respiratory rate were higher (p<0.05) after 1h, and arterial pH was lower (p<0.05) and PaCO2(p<0.05), respiratory and heart rate were higher (p<0.05) after 4h in the NIV failure group.CONCLUSION: Measurement and monitoring of certain parameters may be of value in terms of predicting the effectiveness of NIV treatment.IntroductionChronic Obstructive Pulmonary disease (COPD) is one of the commonest diseases in the world. It is an increasing international health problem with a projected third leading cause of mortality within the adult population[1]. Chronic obstructive pulmo-nary disease is a respiratory disorder largely caused by smoking, and is characterized by progressive, par-tially reversible airway obstruction and lung hyperinfla-tion, systemic manifestations, and increasing fre-quency and severity of exacerbations. An acute exac-erbation is defined as a sustained worsening of dysp-nea, cough or sputum production leading to an in-crease in the use of maintenance medications and/or supplementation with additional medications[2]. The management of the acute exacerbations of COPD accounts for a large proportion of the health care costs because of the need for prolonged hospitaliza-tions and increased rate of mortality[3]. An important event in the course of the disease is the shortening of the inspiratory time, leading to a decrease of the Total Lung Capacity (TLC) and increase of the respiratory rate. The management which aims to increase the TLC with subsequent increase in the alveolar ventila-tion, as well as the decrease of the respiratory rate, is expected to reverse the impaired respiratory physiolo-gy[4].
  • Some of the metrics are blocked by your 
    Item type:Publication,
    Correlation between plasma levels of IL-33 and Vitamin D in patients with severe uncontrolled allergic asthma
    (European Respiratory Journal, 2017-09)
    ;
    ;
    ;
    Gjorchev, Angelko
    ;
    Goseva, Zlatica
  • Some of the metrics are blocked by your 
    Item type:Publication,
    Key Issues in the Management of Multi-Drug Resistant Tuberculosis: A Case Report
    (ID-Design/Scientific foundation SPIROSKI, 2018-07-20)
    ;
    ;
    ;
    Global tuberculosis (TB) epidemic is being driven to an increasing extent by the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis complex (MTBC). We present a case of primary multidrug-resistant tuberculosis (MDR-TB), highlighting Macedonian MDR-TB management issues.
  • Some of the metrics are blocked by your 
    Item type:Publication,
    Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Aetiology
    (ID Design 2012/Scientific Foundation SPIROSKI, 2016-03-15)
    Goseva, Zlatica
    ;
    ;
    Gjorcev, Angelko
    ;
    Jovanovska Janeva, Elena
    ;
    BACKGROUND: The proportion of T and B lymphocytes in pleural fluids and blood may point to the presence of local immunological phenomena in pleural disorders.AIM: Aim of study was to evaluate the lymphocyte phenotype and the ratio between helper (CD4+) and cytotoxic/suppressor (CD8+) lymphocytes in malignant and non-malignant effusions.MATERIAL AND METHODS: We studied 48 patients with pleural effusions. First group had 18 patients with tuberculosis pleural effusions; second group had 20 patients with malignant pleural fluids, third group had 10 patients with transudates and 30 healthy controls. We investigated the distribution of T and B lymphocytes, T cells with helper/inducer CD4 or suppresser/cytotoxic CD8 phenotypes and the CD16 subset.RESULTS: Results showed decreases levels ofCD3, CD4, and CD16 T cells in blood of patients versus healthy controls. There were increases in the percentage of the CD3 and CD4 T cells in the pleural fluid compared with values in the blood with statistical significance in tuberculous pleurisy. The values of CD8 were similar in the pleural fluid and in blood. Levels of CD16 were non-significantly higher in pleural fluid in all groups.CONCLUSION: This study confirms the hypothesis that pleural cavity is compartment with immunological reactivity and results could be used in differential diagnosis together with other examinations.IntroductionLymphocytes are the primary effectors of cellular and humoral immunocompetence in humans. Lymphocytic pleural effusions are characterized by divergent cellular responses depending on the etiology of disease[1]. The accumulation of fluid in the pleural space indicates the presence of systemic or local disease. Pleural exudates involve the migration of immune cells to the pleural cavity[2]. Lymphocytes dominance occurs in the most chronic pleural effusions[3, 4]. The proportion of T and B lymphocytes in pleural fluids relative to that in peripheral blood may point to the presence of local immunological phenomena in various pulmonary and pleural disorders. Tuberculosis and malignant disease are among most frequent causes of pleural effusions. In both causes, the pleural fluid is generally lymphocytic, with predominance of T lymphocytes, particularly CD4+ positive T cells[2, 5, 6]. Malignant effusions are a relatively easily accessible source of tumor-associated T cells andthis represent a suitable model for the study of interactions between tumor cells and the host immune system[7]. Considering the compartmentalization of the pleural space, the association between the local and systemic cellular responses should be analyzed.
  • Some of the metrics are blocked by your 
    Item type:Publication,
    The Prevalence of Diabetes Mellitus in COPD Patients with Severe and Very Severe Stage of Disease
    (Scientific Foundation SPIROSKI, Skopje, 2016-05-22)
    ;
    ;
    ;
    ;