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    Thyrotoxicosis Associated with Cholestatic Jaundice Treated with Therapeutic Plasma Exchange–Case Report
    (OMICS Publishing Group, 2017)
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    Chalovska, Viktorija
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    Avramoski, Vladimir
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    A case of ACTH producing oat cell carcinoma cause of ectopic Cushing's syndrome and life threatening hypokalaemia
    (Bioscientifica, 2013-04-01)
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    Jovanoska, Biljana
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    Rexhepi, Arben
    Introduction: Ectopic Cushing’s syndrome caused by ectopic ACTH secretion are under-diagnosed.Case report: A 50 years old male patient is hospitalized for severe hypokalaemia and diabetes.Last 6 months he had a history of chest pain, prolonged cough, general weakness, difficultiesclimbing stairs, confusion, loss of consciousness. Previously, he was hospitalized in psychiatrichospital for psychotic alterations, in cardiology for high blood pressure and cardiomyopathy (Ef40%). Type 2 diabetes is diagnosed before 3 months; treated with basal insulin. Initialinvestigations revealed Na 144 mmol/l (135–145), K+ 1.9 mmol/l (3.5–5.2), Urea 9 mmol/l, Cr(s)47 mmol/l, Glu(s) 9 mmol/l. DXA confirmed osteoporosis (T-score >−2.5). Basal cortisol 1300nmol/l, Daily rhythm of cortisol during 24 h was >1750 nmol/l. ACTH 641.2 pg/ml (7.2–63.6).On chest x ray it was suspicious tumoral mass, confirmed with chest CT. Tumor mass waspresent on upper mediastinum to the left until hilus, enlarged mediastinal lymph nodes,infiltration on the left lobe and pleural effusion in the same part. Gas analysis: partialymanifested respiratory insufficiency. Endoscopic bronchoscopy with ultrasound (EBUS) wasperformed for cyto/immunocytochemical analysis for ACTH. Citologycaly confirmed IVclassification group of malignancy – oat cell carcinoma and immunocytochemy for ACTH waspositive in 5–10% of neoplastic cells and positive for chromogranin in 30–40% and NSE in 50–60% of tumoral population. Patient was referred to Clinic of Pulmology and Institute ofOncology.Conclusion: Diagnosis of ectopic Cushing’s syndrome explain other co-morbidities such ashypokalaemia, diabetes, osteoporosis, psychosis. Appropriate diagnostic procedures withoutadditional tests (dexamethasone suppression test, MRI), accelerates the diagnosis of this life-threatening patient (18) (PDF) A case of ACTH producing oat cell carcinoma cause of ectopic Cushing's syndrome and life threatening hypokalaemia.
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    Impact of hormone replacement therapy on hyperandrogenicity and glucose homeostasis in postmenopausal women with diabetes
    (Medical Faculty, Ss Cyril and Methodius University in Skopje, 2016)
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    Temelkova Markovikj, Snezana
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    Maternal 75 g OGTT glucose levels as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus
    (Bioscientifica, 2013-04-01)
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    Velkovska-Nakova, Valentina
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    Jovanoska, Biljana
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    Objective: Our goal was to investigate which glucose measurement from the 75-g oral glucose tolerance test (OGTT) has more capability of predicting large for-gestational-age (LGA) newborns of mothers with gestational diabetes mellitus (GDM). Subjects and methods: The study group consisted of 118 consecutively pregnant women with singleton pregnancy, patients of Outpatients Department of the Endocrinology, Diabetes, and Metabolic Disorders Clinic. All were prospectively screened for GDM between 24th and 28th week of pregnancy and followed to delivery. Outcome measures included: patients' ages, pre-pregnancy BMI, BMI before delivery, FPG, 1 and 2 hour OGTT glucose values, haemoglobin A1c at third trimester, gestational week of delivery, mode of delivery and baby birth weight. Results: From 118 pregnancies, 78 (66.1%) women were with GDM, and 40 (33.9%) without GDM. There were statistically significant differences (30.7 versus 5.0%, p < 0.01) between LGA newborns from GDM and control group, respectively. Gestation week of delivery and fasting glucose levels were independent predictors for LGA (Beta = 0.58 and Beta = 0.37 respectively, p < 0.01). Areas under the receiver operator characteristic curve (AUC) were compared for the prediction of LGA (0.782 (0.685-0.861) for fasting, 0.719 (0.607-0.815) for 1-hour and 0.51 (0.392-0.626) for 2-hour OGTT plasma glucose levels). Conclusion: Fasting and 1-hour plasma glucose levels from OGTT may predict LGA babies in GDM pregnancies.
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    Comparing Time and Frequency Domain Heart Rate Variability for Deep Learning-Based Glucose Detection
    (Springer International Publishing, 2022-04-12)
    Shaqiri, Ervin
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    International Conference on ICT Innovations ICT Innovations 2021: ICT Innovations 2021. Digital Transformation pp 188–197Cite as Comparing Time and Frequency Domain Heart Rate Variability for Deep Learning-Based Glucose Detection Ervin Shaqiri, Marjan Gusev, Lidija Poposka, Marija Vavlukis & Irfan Ahmeti Conference paper First Online: 12 April 2022 165 Accesses Part of the Communications in Computer and Information Science book series (CCIS,volume 1521) Abstract Many researchers have been challenged by the usage of devices related to the Internet of Things in conjunction with machine learning to anticipate and diagnose health issues. Diabetes has always been a problem that society has struggled with. Due to the simplicity with which electrocardiograms can be captured and analysed, deep learning can be used to forecast a patient’s instantaneous glucose levels. Our solution is based on a unique method for calculating heart rate variability that involves segment identification, averaging, and concatenating the data to reveal better feature engineering results. Immediate plasma glucose levels are detected using short-term heart rate variability and applied a deep learning method based on Autokeras. In this paper. we address a research question to compare the predictive capability of time and frequency domain features for instantaneous glucose values. The neural architectural search for the time domain approach provided the best results for the 15-min electrocardiogram measurements. Similarly, the Frequency Domain approach showed better results on the same time frame. Regarding the time domain the best results are as follows: RMSE (0.368), MSE (0.193), R2 (0.513), and R2 loss (0.541). The best results for the Frequency Domain approach the best results are as follows: RMSE (0.301), MSE (0.346), R2 (0.45578), and R2 loss (0.482).
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    Malnutrition cause of Secondary Osteoporosis after surgical operation of Glucagonoma
    (Bioscientifica, 2013-04-01)
    Jovanoska, Biljana
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    Temelkova, Snezana Markovik
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    Dimitrovski, Cedomir
    Introduction: Glucagonoma is a rare condition with annual incidence 1 in 20 million, associated with diabetes mellitus, dermatitis, deep vein trombosis and depression. Case report: A 55-year-old woman patient was hospitalized at our department because of intense discomfort of the skin lesions that were pruritic and painful, erythematous area of skin with blisters that breach after a few days, red tongue, cracks on the mouth corners. She had a constant weight loss accompanied with bloody diarrhea. Her weight was 36 kg, height 150 cm and her BMI was 16. We made 75 g OGTT and it was normal. She was misdiagnosed like contact dermatitis magnum et pedum, stomatitis protetica, erythema exsudativum multiforme, colitis. On the examination she had cheilitis angularis, atrophic glossitis, stomatitis, normochromic normocytic anemia and the Hct was 0.27, SE 70/100. She had dermatological changes – erythematous patch, blisters centrally, erodes, crusts, heals with hyperpigmentation. We made a lab test and we got that her glucagonemia was increased twice than normal. The normal values are 200 ng/l and she had 400 ng/l. We made a CT scan where a round form of a tumor was noticed in the pancreas with dimensions 5 cm width and 8 cm length. After that, she underwent a surgical operation and the surgeon made a distal splenopancreatectomy to remove the tumor. The tumor immunohistochemistry was positive of glucagon, synaptophysin and chromogranin-A. After the operation, she suffered from malnutrition and she came again at our department to check herself for osteoporosis. We made a DXA scan and we saw that she had a generalized secondary osteoporosis caused due to malnutrition after operation (T score=−4.0 on the spin, T score=−3.8 on the right hip and T score=−3.6 on the left hip). Conclusion: Long-term misdiagnosed glucagonoma explain appearance of other co-morbidites such as osteoporosis and anemia.
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    Менопауза, липиден профил и кардиоваскуларни болести
    (MACEDONIAN ASSOCIATION OF ANATOMISTS AND MORPHOLOGISTS, 2008)
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    Pashoska, Milkica
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    Mishevska, Petranka
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    Metformin improves menstrual patterns, endocrine and metabolic profile in obese hyperinsulinemic women with a polycystic ovary syndrome
    (Macedonian Academy of Sciences and Arts, 2006-07)
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    Dimitrovski, Chedomir
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    Misevska, Sasha
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    Dimova, Zaneta