Petlichkovski, Aleksandar

Preferred name
Petlichkovski, Aleksandar
Official Name
Petlichkovski, Aleksandar
Main Affiliation
Email
aleksandar.petlichkovski@medf.ukim.edu.mk

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    Genetics in Macedonia-Following the international trends
    (Wiley Online Library, 2018)
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    Genetics in Macedonia-Following the international trends.
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    Total IgE Distribution in Food Allergy Suspected Patients in Republic of Macedonia (2001-2011)
    (ID Design 2012/DOOEL Skopje, 2015-06-15)
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    IgE may be considered the hallmark of allergic disorders. It is easily detected in serum and can be measured as total IgE and as allergen-specific IgE. In fact, the serum IgE assay is used to diagnose an allergy.
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    Association between 22 cytokine gene polymorphisms and dilated cardiomyopathy in Macedonian patients
    (2009-11)
    Spiroska, Vera
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    Antov, Slobodan
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    Inflammation is an important component in the pathogenesis of many cardiovascular diseases and one of the commonest mechanisms in cardiomyopathy. There have been several studies on the cytokine polymorphism and dilated cardiomyopathy (DCM), but the results obtained were contradictory.
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    COMPARISON OF TWO METHODS FOR SARS-COV-2 ANTIBODY TESTING
    (University Ss. Cyril and Methodius in Skopje, 2022)
    Savevska, Tamara
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    Iljoska, Stefani
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    Distribution of CYP2C9 and VKORC1 Gene Polymorphisms in Healthy Macedonian Male Population
    (ID Design 2012/Scientific Foundation SPIROSKI, 2013-12-15)
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    Aleksandar Senev
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    <jats:p>Background: Distribution of CYP2C9 and VKORC1 gene polymorphisms may vary significantly among different ethnic groups, and eventually influence the variation in drug metabolism or even failure.Objective: The aim of this study was to evaluate the prevalence of CYP2C9 and VKORC1 alleles in the healthy population of Republic of Macedonia compared to the global geographic data reported from different ethnic populations. Also, to genotype CYP2C9 and VKORC1 genes and eventually to divide individuals in poor, extensive, or intermediate metabolizer.Material and Methods: Blood samples were collected after signing written consent, DNA was isolated from peripheral blood, and CYP2C9 and VKORC1 genes were typed (n=124). Genotyping was performed by commercially available kits (GeneID GmbH, Strassberg, Germany, AID Diagnostica), based on the method of polymerase chain reaction with a subsequent hybridization. The population genetics analysis package, PyPop ver. 0.6.0, was used for analysis of the data.Results: The frequency of alleles varies from 0.931 for CYP2C9*3 to 0.109 for CYP2C9*2 indicating common “wild type” allele in those genes. The frequency ranges spanned ~50% for each allele of VKORC1 gene, indicating no common “wild type” allele in this gene. Test of neutrality showed significant negative value for VKORC1 polymorphism that indicates balancing selection operating on the alleles at that locus. All polymorphisms of CYP2C9*2, CYP2C9*3 and VKORC1 showed a good fit with Hardy-Weinberg expectations.Conclusion: The results of polymorphic alleles of CYP2C9 and VKORC1 genes in Macedonian population can be used for the variation in drug metabolism studies as well for adapting dosage regimes for oral anticoagulant therapies.</jats:p>
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    Tumor necrosis factor gene polymorphisms in adult patients with autoimmune hemolytic anemia
    (Wiley, 2017-06)
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    Angelovic, R
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    Genadieva-Stavric, S
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    Cevreska, L
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    Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians
    (2009-07)
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    Trajchevska, Mirjana
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    Arsov, Todor
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    Strezova, Ana
    To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against tuberculosis (TB) in Macedonians.
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    What is in a name and what is in the brain? -clinicians’ dilemmas in the biomarker era
    (Elsevier BV, 2025-05)
    Novotni, Gabriela
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    Karanfilska Plaseska, Dijana
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    This viewpoint draws analogy from Shakespeare’s query, "What’s in a name?" and explores what defines neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD) and what clinicians understand by that name in relation to the underlying brain pathology and disease biology. The inspiration comes from the latest biological definitions of PD revealing significant similarities with the biological definition of AD.
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    Serum homocysteine levels and methylenetetrahydrofolatereductase genotypes in couples with idiopathic recurrent miscarriage
    (Balkan Clinical Laboratory Federation (BCLF), 2015-10)
    Irena Kostovska
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    Aleksandar Senev