Dzikova, Elena
Preferred name
Dzikova, Elena
Official Name
Dzikova, Elena
Main Affiliation
Email
elena.dzikova@medf.ukim.edu.mk
23 results
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Item type:Publication, Non-invasive Prenatal Determination of Fetal Maturity(Македонско лекарско друштво / Walter de Gruyter GmbH, 2016-12-01); ; Stojceva-Taneva, OliveraThe prenatal prediction of fetal maturity is very important, since neonatal respiratory distress syndrome (RDS) is one of the biggest causes of neonatal mortality. Our aim was to investigate a new non-invasive method for prediction of fetal maturity and to determine in which group according to gestational age of the fetus, the treatment works the best and in which cases it is necessary to be repeated. Methods. We examined 60 patients (30 with impending preterm delivery, divided in 3 groups: 28-30, 30-32, and 32-34 gestational weeks and 30 controls), at the University Clinic for Gynecology and Obstetrics, Medical Faculty, University “Ss. Cyril and Methodius”, Skopje, R. Macedonia. Fetal maturity was examined using ultrasound histogram from fetal lungs and liver, correlated with gestational age and postpartum RDS. Where possible, we performed amniocentesis for lamellar body count (LBC) to correlate our results with the current invasive method for prediction of fetal maturity. Results. Pre-therapy investigation showed a strong fetal immaturity in 28-32 weeks of gestation and less evident fetal immaturity in 32-34 weeks of gestation. Seventy-two hours post-treatment, fetal maturation was low in the first group, higher in the second and the highest in the third group. Amniocentesis for LBC showed correlation with the ultrasound results. Postpartum results were correlated with pre-delivery ultrasound and showed significance of p <0.05. Conclusion. The results obtained in our study were with high significance, and they were in correlation with other similar studies. However, more extensive investigations should be made to replace the current invasive technique. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MATERNAL OBESITY, АGE AND MATERNAL THYROID STATUS - AN INTRIGUING CONNECTION TO THE NEONATAL OUTCOME(Македонско лекарско друштво /Macedonian Medical Association, 2020); ; Introduction. Thyroid dysfunction is the second most common endocrine disorder affecting women of reproductive age. Higher body mass index (BMI>30 kg/m2) is linked with many endocrine abnormalities, including thyroid dysfunction. Gestational age at birth (GAB) and birth weight (BW) are important predictors of neonatal mortality and morbidity. The objective of this prospective study was to determine the adverse neonatal outcomes of women [small for gestational age (SGA), intrauterine growth restriction (IUGR) and others] complicated with impaired thyroid function and obesity, when compared with those with normal function. Methods. Dried blood spot and urine samples were analyzed for thyroid and iodine status in 358 pregnant women in any gestational week, without known thyroid disorders. They gave birth at the University Clinic of Gynecology and Obstetrics-Skopje. The blood samples were analyzed with time-resolved fluoroimmunoassay in Zurich, and UIC was analyzed by mass spectrometry in Helsinki. Results. We found a significant positive correlation between total thyroxine (TT4) and GAB (p=0.045) and UIE and mother age (p=0.007), but a significant negative correlation between GAB and UIE (p=0.051), GAB and mother’s age (p=0.01), GAB and BMI (p=0.02). There was an inverse correlation between BW and maternal age (βst=-0.0641, P=0.010) and between BW and maternal TT4 (βst=-3.3640, P=0.0016). We found a positive correlation between BW and maternal BMI (βst = 21.847, P = 0.006). Conclusion. Overweight, obese and older women are at increased risk of thyroid dysfunction during pregnancy considered as high-risk pregnancies for adverse neonatal outcomes. We can use maternal TT4, BMI and age for predicting the BW. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HYDROSALPINX AND DISTRIBUTION OF PREGNANCIES AMONG LAPAROSCOPICALLY TREATED PАTIENTS(Македонско лекарско друштво = Macedonian Medical Association, 2020); ; Introduction. Hydrosalpinx is a common medical condition encountered among female population with infertility issues. One or both fallopian tubes can be filled with a substantial amount of fluid, making them dilated and dysfunctional, usually as a result of an injury or infection. Damages of different degrees can be seen on the mucosal lining, which compromise the processes of normal fertilization and zygote passage. Methods. We retrospectively analyzed clinical records from a period of five years (2013-2017), selecting pa- tients diagnosed as having unilateral or bilateral hydrosalpinx. Clinical files were divided by years and according to the treatment protocol used. Our scope of interest was focused on patients who were treated surgically, with different types of laparoscopic interventions. A total of 74 patients met our criteria for selection. Results. Two groups were related to conservative la- paroscopic approaches and one to complete radical surgical treatment, unilateral or bilateral salpingectomy. Patients in the first group, 9(16.36%), were treated with a laparoscopically-guided creation of salpingostomy. The second group comprised patients treated only with bi- lateral chromopertubation and consisted of 17 (30.91%) patients. The third, and the most numerous group com- prised 29(52.7%) patients treated with salpingectomy. Bilateral salpingectomy was performed in 9(31.03%) and unilateral in 20(68.97%) patients, showing that majority of patients were treated with unilateral salpingectomy, after intraoperative evaluation of tubal patency of the contralateral uterine tube. A total number of 30 patients (54.5%) had successful pregnancies, which ended up with a desired outcome, healthy live birth. Procedures for artificial reproduction and successful pregnancies achieved with IVF were recorded in 11(36.67%) patients and in the remaining 19(63.33%) patients pregnancies were achieved via spontaneous conception. Conclusion. Hydrosalpinx management is mainly influenced by the local tubal changes evaluated laparoscopically and can be surgically treated, either conservative or radical. Conservative approaches lead to fair chances of spontaneous conception and successful pregnancies. An integrated management of hydrosalpinx with bilateral salpingectomy and postsurgical usage of artificial reproduction techniques also leads to a substantial cumulative pregnancy rate. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ISOLATED MATERNAL HYPOTHYROXINEMIA AND ITS PERINATAL OUTCOME IN NORTH MACEDONIA(Sestre Milosrdnice University Hospital Center (KBC Sestre milosrdnice), 2021-06); ; Isolated maternal hypothyroxinemia (IMH) is defined as the presence of low maternal total thyroxine (TT4) level in conjunction with normal maternal thyroid-stimulating hormone (TSH) level. The aim was to investigate whether IMH is associated with adverse pregnancy outcome in North Macedonia. Dried blood spot samples were obtained from 359 pregnant women meeting the inclusion criteria and analyzed for TT4 and TSH. Postpartum data were entered from their medical histories. Out of 359 women, 131 (37.42%) belonged to IMH group. There were statistically significant differences in birth weight (p=0.043), intrauterine growth restriction (IUGR) (p=0.028), Apgar score at 1 min <7 (p=0.018) and cesarean section for dystocia/disproportion (p=0.024) between the IMH and normal thyroid function (NTF) groups. In regression analysis, TSH was a significant variable predicting Apgar score (βst=0.05597, p=0.047), body mass index predicting birth weight (βst=0.02338, p=0.045) and TT4 predicting small for gestational age/IUGR (βst=-0.089834, p=0.029) in IMH group. TT4 was a strong predictor of birth weight (βst=-0.004778, p=0.003) and premature delivery (βst=0.028112, p=0.004) in NTF group. The impact of IMH in pregnancy remains controversial. IMH was associated with an increased maternal BMI and higher birth weight of neonates. Overweight could be a potential risk factor for thyroid dysfunction in pregnant women, and specifically IMH. The worst fetal outcome was seen in IMH mothers examined in second trimester. We found TSH, TT4 and BMI to be strong predictors of perinatal outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Thyroid Function of Pregnant Women and Perinatal Outcomes in North Macedonia(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2021-10) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Determination of Fetal Maturity Using Signal Transformations of Fetal Thalamus Estimating Fetal Maturity by Ultrasound(Walter de Gruyter GmbH / Macedonian Medical Association, 2017-01-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Reproductive outcome, duration of pregnancy and mode of delivery after hysteroscopic metroplasty in patients with infertility(Association of Medical Doctors, 2016); ; ; Introduction: Reproductive outcome can be negatively affected in patients with congenital uterine anomalies (CUA), increasing the number of un- successful pregnancies and obstetric complications. Standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anomalies is hysteroscopic metroplasty (HM). The aim of the study was to analyze the reproduc- tive outcome, duration of pregnancy and mode of deli- very in group of patients with infertility after hystero- scopic metroplasty. Material and methods: We analyzed 48 patients with previous history of fetal loss (abortion) to whom hysteroscopy was done in the period of 01. 11. 2009 to 01. 05. 2013 year at the University Clinic of Obstetrics and Gynecology in Skopje. In patients who were diag- nosed having CUA hysteroscopic metroplasty was do- ne. Patients and their reproductive outcome were follo- wed for a period of at least 2 years after the interven- tion. Reproductive outcome was followed considering pregnancy rate, fetal loss (abortion) up to 22 gestatio- nal week, rates of preterm and term deliveries, live births and mode of delivery. Statistical analysis was performed using computer software and value for the confidence interval (± 95% CI) was considered to be statistically significant with level of p < 0.05. Results: After hysteroscopic metroplasty, there was a significant decrease of the abortion rate to 13.9%, and significant increase in pregnancy rates of 86.1%. Overall pregnancy rate was 75%, and term delivery was noted in 93,6% of the patients, with spontaneus deliveri- es in 58,6%. There were no complications during the hysteroscopic metroplasty, nor during the deliveries. Conclusion: Hysteroscopic metroplasty has a sig- nificant effect on the reproductive outcome, resulting in a large number of live births and no significant com- plication during consecutive pregnancy and delivery. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EFFECT OF ADIPOSITY AND FAT DISTRIBUTION ON ENDOMETRIAL CANCER RISK IN POSTMENOPAUSAL PATIENTS(University Ss. Cyril and Methodius in Skopje, 2023); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Periureteralna endometrioza - prikaz slučaja(Serbian Medical Society, 2022); ; ; Cilj rada bio je da se prikaže redak slučaj periureteralne endometrioze kod odrasle pacijentkinje, i da se naglase značaj sumnje na endometriozu urinarnog trakta i važna uloga skenera male karlice u postavljanju tačne dijagnoze ove retke bolesti. Autori prikazuju redak slučaj periureteralne endometrioze sa simptomima koji prvenstveno potiču od endometrioze jajnika. Dijagnoza periureteralne endometrioze utvrđena je na osnovu skenera male karlice i abdomena. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EP1071 Genotype distribution of HPV in patients with histologically proven findings for cervical intraepithelial neoplasia or invasive cervical cancer in Macedonia(BMJ Publishing Group Ltd, 2019-11); ; ; Introduction/Background The aim of this study was to provide basic data on genotype distribution of HPV in patients from Macedonia with histologically proven findings for squamous intraepithelial lesions or invasive cervical cancer, in order to better plan the vaccination program and screening for cervical cancer and to plan and with hope to introduce a National cervical cancer screening programme with HPV genotyping as a primary screening test. Methodology We analyzed the histological findings positive for cervical intraepithelial neoplasia or invasive cervical cancer and genotype HPV distribution results in 564 patients treated at the University Clinic for Gynecology and Obstetrics in Skopje, Macedonia, during 2017. Results 78% of the total of 564 subjects appeared to be positive for HPV. The genotype distribution of HPV in cervical squamous intraepithelial lesions or invasive squamous cell cancer and adenocarcinoma of the uterine cervix was 69.2%, 87.2%, 97.6% and 71.4%, respectively. The distribution of HR HPV types was for 21% higher in HSIL lesions than in LSIL. The most frequent isolated HPV types were: 16, 18, 35, 31, 33, 58, 6, 11 and 40. The most common genotype was HPV 16 with the highest rate in HSIL (48.4%), a little bit lower in invasive squamous cancer (30.1%) and the lowest in LSIL (19.6%). On the other hand, the prevalence of HPV 18 was the highest in patients with invasive adenocarcinoma of the uterine cervix, 30.1%. Conclusion In Macedonia, the most predominant genotypes of HPV in squamous intraepithelial lesions and invasive cervical cancers are the human papillomavirus types 16, 18, 35, 31, 33, 58, 6, 11 and 40 which is very important to know in order to plan the vaccination program and to create an expedient National cancer screening programme that will be more effective strategy against invasive cervical cancer.
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