Spasovska, Aneta
Preferred name
Spasovska, Aneta
Official Name
Spasovska, Aneta
Alternative Name
Spasovska Trajanovska Aneta
Aneta Spasovska Trajanovska
Спасовска Трајановска А
А.Spasovska Trajanovska
Спасовска Трајановска Анета
А.Спасовска Трајановска
Анета Спасовска Трајановска
Спасовска Трајановска А
Spasovska Trajanovska, Aneta
Aneta Trajanovska
Trajanovska Aneta
Main Affiliation
Email
aneta.spasovska@medf.ukim.edu.mk
18 results
Now showing 1 - 10 of 18
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Item type:Publication, Anxiety in acute myocardial infarction survivors(SHMSHM / AAMD, 2020); ; Sevime Sallahi PasholliIntroduction :Data obtained in some studies indicate that somatic disorders, in a certain percentage, are associated with a mental health problems, whether in a form of two co-existent diseases, whether psychological problems are only associated symptoms and/or response to somatic disease. Anxiety is psychological symptoms frequently encountered in patients suffering from acute myocardial infarct (AMI). The AIM of our study was to determine the percentage of anxiety in two investigated groups of patients with myocardial infarction and to determinate the correlation between socio-demographic characteristic and level of anxiety in survivors of AMI. Material and methods: The study was designed as observation cross-section including 80 patients treated at the university Clinic of Cardiology Skopje , observed as 2 groups : group 1 was presented with patients during hospitalization for AMI, and 2 group were patients survivors after 6 months of the acute coronary event. Anxiety status was assessed using HAMA scale. Results : The two groups of patients did not show significant difference according distribution of gender , smoking , physical activity, stress , age, mean HAMA , BMI , age of education and marital status . In the first group 21 (51,2%) of patients have anxiety symptoms while in second group 25 (64,1%). In our study acute MI was more prevalent in a men but women had a higher risk of anxiety disorders 27,3% v.s (22,7%). In examination groups the anxiety (HAMA score) was positive correlate with socio-demographic and clinical parameters where only we got negative correlate between anxiety with marital status and BMI in the first group and negative correlation with married status, smoking status, physical activity, stress and BMI in the second group . .Conclusion: The results in our study showed indicative representation of anxiety in patients survivors of AMI. So screening for anxiety in all AMI patients is also important because this patients should be treated differently than those who are not anxiety. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation between methadone dosage, cortisol plasma level and depression in methadone maintained patients(AU-CNS, 2015-12); ; Background. Opioids can affect neuroendocrine functions, with the consequence that various endocrine abnormalities, including the increased level of cortisol that can result from depression, may be acceptable in patients who use opioids. Aim of this study is to examine the correlation between methadone dosage, cortisol plasma level and depression in methadone-maintained patients. Methods. This is an analytical, cross-sectional study that included 45 patients, who were divided into two groups. The first group consisted of 10 patients (4 females and 6 males), whose doses ranged between 10 and 55 mg. The second group consisted of 35 patients (5 females and 30 males), whose doses ranged between 65 and 120 mg. To discover demographic characteristics we used medical records, to determine cortisol plasma level we relied on the Chemiluminescence Immunoassay (CLIA) method, and to determine depression we made use of the Beck depression inventory (BDI). The results were statistically analysed using a combination of descriptive methods – the t-test for independent samples, the χ² test, the Mann-Whitney U test and the Pearson coefficient of linear correlation. Results. Theresults obtained show statistically significant differences between the two groups in terms of their BDI scores, with higher scores indicating patients who were taking higher doses. There is a statistically significant correlation between cortisol plasma level and depression, but not between methadone maintenance dose and cortisol plasma level, even if a high proportion of patients in the group taking higher doses showed a higher cortisol plasma level. Conclusions. In methadonemaintained patients the methadone dose is not statistically correlated with cortisol plasma level, but some other factors in the group taking higher methadone doses tend to determine higher BDI scores. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Depression in Survivors of Acute Myocardial Infarction(Academy of Medical Sciences of Bosnia and Herzegovina, 2019); ; Introduction: There was growing evidence of increased cardiovascular risk in patients with depressive disorders. Aim: To determinate the percentage of depression of the three investigated groups of patients with myocardial infarction and to determinate the correlation between sociodemographic characteristic and level of depression in survivors of AMI. Methods: The study was designed as observation cross-section including 120 patients treated at the University Clinic of Cardiology Skopje during 2018-2019 year, observed as 3 groups: group 1 was presented with patients during hospitalization for AMI, group 2 were patients survivors after 3 months of the acute coronary event and group 3 patients survivors after 12 months of the acute coronary event, Depression status was assessed using BDI. Results: the three groups presented almost equal representation of depression according BDI (X²=1,182, df=2, p=0,913) presented with 34,1 %, 30,8% and 30% respectively. The three groups of patients did not show significant difference according distribution of gender smoking , physical activity, stress, diabetes mellitus, age, mean BDI, BMI, Systolic BP, age of education and marital status . Only group 3 presented significantly higher diastole BP comparing in group 1 and group 2 (F=9,532, df=2,p< 0,001). The depression (BDI score) in examination groups was associated with sociodemographic and clinical parameters where female gender, higher education level, decreased BMI, smoking, decreased physical activity, younger age and single status are independent predictors of depression in patients who survived acute myocardial infarction. Conclusion: The results obtained in our study showed indicative representation of depression in patients survivors of AMI and significant association with sociodemographic and clinical parameters as predictors of depressive disorder. Regular screening for depression in patients survivors of AMI may improve the therapy decision, prognosis and the quality of patients' life. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation between duration of treatment and cortisol plasma level in methadone maintained patients(AU-CNS, 2016-12); Background. The various endocrine abnormalities reported in heroin addicts and patients in methadone maintenance treatment include: increased thyroxin, triiodothyronine and prolactin levels, and abnormalities in sexual hormone, ACTH and cortisol secretion. The pathophysiological mechanism that has been postulated does explain these findings, including the direct action of heroin or methadone along the hypothalamic-pituitary-adrenal axis. Aim. The aim of this study is to determine the correlation between duration of methadone treatment and cortisol plasma levels in patients treated with methadone maintenance therapy. Methods. The study was carried out at the Centre for Prevention and Treatment of Drug Abuse and Addiction, a part of the Skopje Psychiatric Hospital. The hormonal analysis was carried out at the Department of Clinical Biochemistry, Skopje University Hospital. It is an analytical, cross-sectional study that included 50 male patients in methadone maintenance treatment, divided into two groups. The first group consisted of 34 male patients who had been maintained on methadone treatment for over 2 years. The second group consisted of 16 male patients who had been maintained on methadone treatment for 2 years or less. To discover demographic characteristics we used medical records, and to determine cortisol plasma level we relied on the Chemiluminescence Immunoassay method. The results were analysed statistically by using a t-test for independents samples, χ² test, and Pearson coefficient of linear correlation. Results. The results show that patients treated with methadone for 2 years or less have significantly higher plasma cortisol levels than patients treated with methadone for over 2 years. Conclusions. Longer duration of methadone maintenance treatment tends to normalize the cortisol plasma level. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANXIETY SYMPTOMS AMONG PATIENTS WITH HYPOTHYROIDISM(Scientific Institute of Management and Knowledge, 2021); Janichevikj Ivanovska, Danijela - Some of the metrics are blocked by yourconsent settings
Item type:Publication, TREATMENT OF METHADONE PATIENTS WITH NEUROLEPTIC THERAPY AND HYPERPORLACTINEMIA(Scientific Institute of Management and Knowledge, 2024); Janichevikj Ivanovska, DanijelaAccording to certain findings, heroin addiction represents a significant medical as well as social problem. It is known that with opioid substitution treatment this disease can be overcome or alleviated. However, the application of this treatment does not always give the expected results, so it is necessary to apply additional neuroleptic therapy until the patients are fully stabilized. But the joint application of substitution and neuroleptic therapy can lead to a series of side effects, one of which is the appearance of hyperpolactinemia.The aim of this study is to observe the prevalence of symptoms of hyperprolactinemia in patients with poor response to methadone treatment, treated with neuroleptic therapy.Material and methods: The cross-sectional study evaluated 20 male patients with a mean age of ±24.13 years treated at the Skopje Psychiatric Hospital with high doses of Sol methadone 80-120 mg/day. All patients had abad agreement on the methadone treatment, so additional therapy was included, tab. Risperidone with an average dose of 2 mg/day. Participants signed an informed consent to participate.Patients were assessed using a semi-structured questionnaire specifically designed for the study. Data consisted of age, sex, and symptoms of hyperprolactinemia: amenorrhea, loss of libido, erectile dysfunction, and gynecomastia. The results of this study were analyzed using descriptive methods, t-test and Pearson's correlation coefficient. The p value of statistical significance was set at p<0.05.Results: The results obtained in our study showed that a certain percentage of methadone patients who were on Risperidone therapy had symptoms of hyperprolactinemia, but the results were without statistical significance p>0.05.Conclusion: although in our study we obtained a small percentage of patients with symptoms of hyperprolactinemia, care must be taken in patients on methadone treatment who are also treated with neuroleptic therapy due to their synergistic effect, we should always keep in mind the possibility of developing hyperprolactinemia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Effect of Buprenorphine therapy on depressive symptomatology in heroin addicts(Scientific Institute of Management and Knowledge, 2025-04-16); Danijela Janichevikj, IvanovskaAbstract: According to the World Health Organization, heroin addiction is one of the most widespread diseases, right behind cardiovascular and malignant diseases. Heroin addicts have a large number of comorbid somatic and psychological disorders, among which depressive states occupy a significant place. It is known that on the territory of North Macedonia, two substitutes are used in the treatment of heroin addiction: methadone, which is an opioid agonist, and buprenorphine, which is an opioid agonist and antagonist. Of particular importance is the effect of buprenorphine on kappa receptors, which have a major impact on mood and sexual functioning. So the goal of this research is to see the effectiveness of buprenorphine therapy on depression in heroin addicts. Materials and methods: In this prospective study, which was conducted at the Day Hospital for Addictions at the Psychiatric Hospital Skopje, 20 heroin addicts undergoing treatment with buprenorphine therapy were evaluated before treatment after three months and after six months of treatment. The study used a questionnaire to collect sociodemographic data (gender, age, education, marital status, employment) specifically designed for the study. Depression scores were determined using the Hamilton Depression Rating Scale. Data were analyzed by descriptive method and by Student's t test. Statistical significance was considered p< 0.05. According to the data obtained, after three months of treatment with buprenorphine we had a decrease the score of depression but without statistical significance p= 0,43, while after six month of treatment we had a decrease with statistical significance p=0,034. However, in 5% of the respondents the score of depression was still high. Conclusion The results obtained in our study indicated that buprenorphine therapy affects the reduction of depressive symptomatology in heroin addicts. So, when we have a high depression score in patients, antidepressants should not be used immediately, but buprenorphine should be allowed to take effect first. If there is no improvement, then move on to the second step, including antidepressant therapy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2023-12); ; ; Initial studies on impaired glucose-insulin homeostasis in heroin dependents have not defined the impact of concomitant hepatitis C infection (HCV), which has been strongly associated with the development of insulin resistanceand metabolic syndrome (MS). The aim of our study was to evaluate the association of heroin dependence with glucose-insulin homeostasis and MS in heroin dependents with HCV seronegativity. Materials and methods: The study was prospective and cross-sectional, including 160 heroin dependents compared to a control group of 60 participants.MS was diagnosed using International Diabetes Federation criteria. The homeostatic model assessment for insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-%B) were used for assessing insulin resistance and β-cell function of pancreas. Results: MS was detected in 9.32% of heroin addicts. Heroin dependents with MS compared to dependents without MS were older, had higher BMI, waist circumference and significantly higher systolic and diastolic blood pressure, increased triglycerides (F=8.233, df=2, p<0.001), apoB (F=8.154, df=2, p=0.001), and reduced HDL-C (F=25.926, df=2, p<0.001) and apoA-I (F=16.406, df=2, p<0.001), significantly increased inuslinemia (F=4.928, df=2, p<0.05), insulin resistance-HOMA-IR (F=4,928, df=2, p<0,05) and insignificantly increased pancreatic β-cell function (194.66 ±224.05) (F=2.461, df=2, p>0.05). Conclusions: Insulin resistance and МS, independent of HCV, was also registered in heroin dependence. Timely recognition will enable more successful treatment of comorbidities and illicit drug dependence. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, IMPACT OF BUPRENORPHINE THERAPY ON THE NORMALIZATION OF SEXUAL FUNCTION AND STATES OF ANXIETY(Institute of Management & Knowledge, 2025-05); Abstract: According to certain, studies, chronic opioid use has a major impact on the function of the hypothalamicpituitary-adrenal axis. Hypogonadism occurs in more than half of male opioid users and elevated cortisol levels in approximately one-fifth of addicts. Buprenorphine as a kappa opioid antagonist reduced release of adrenocorticotropic hormone and in these way was reducing anxiety and depression in heroin addicts. The AIM of our research was to determinate the impact of buprenorphine therapy on sexual function and anxiety. Materials and methods: The cross-sectional study included 19 male and 1 female patients on buprenorphine therapy aged between 25-51years with a diagnosis of F11.22. The patients were evaluated in the Day hospital for treatment of drug abuse, department of Psychiatric Hospital Skopje. Sociodemographic characteristics (age, marital status, years of education, employment) of patients were determined using a questionnaire specially designed for the study. The anxiety state of the patients was determined using the Hamilton Anxiety Rating Scale consisting of 14 items. Sexual dysfunction was determinate by Scale for Quality of Sexual Function (QSF) as an outcome measure for both genders. The results were analyzed statistically using descriptive methods, the t-test for independent samples. The correlation between the observed variables was tested using Spearman’s rank correlation coefficient (rho). A significance level of 0.05 was used to determine statistically significant differences and associations. Statistical analysis was performed using SPSS for Windows, version 25. The results show inverse correlation between duration of buprenorphine treatment with the score of anxiety r=-0,411; p=0,072 and with sexual dysfunction r=-0,192; p=0,418. Also in our study we got inverse correlation between the buprenorphine doses with the score of anxiety r=-0,136; p=0567 and with sexual dysfunction r=-0,528; p=0,017. But in both cases we got results without statistically significances. Conclusion: Longer buprenorphine treatment with adequate doses give lower scores of sexual dysfunction and anxiety - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DEPRESSION AND DIABETES(Institute of Knowledge Management, 2020);