Mitrova Telenta, Julija
Preferred name
Mitrova Telenta, Julija
Official Name
Mitrova Telenta, Julija
Translated Name
Митрова Телента, Јулија
Alternative Name
Telenta Mitrova, Julija
Julija Mitrova Telenta
Митрова Телента, Јулија
Main Affiliation
Email
julija.mt@medf.ukim.edu.mk
8 results
Now showing 1 - 8 of 8
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Item type:Publication, DISRUPTION OF HAIR FOLLICLE IMMUNE PRIVILEGE IN ALOPECIA AREATA: ENIGMATIC MECHANISMS AND EMERGING CONCEPTS(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-12-12); ; ; ; Mircheska Arsovska, ElenaImmune privilege (IP) is a specialized immunological state that protects certain tissues, including the hair follicle (HF), from immune-mediated destruction. The maintenance of hair follicle immune privilege (HFIP) is crucial for uninterrupted hair growth and is mediated by several mechanisms. These include the downregulation of major histocompatibility complex (MHC) class I molecules, the secretion of immunosuppressive cytokines such as transforming growth factor-beta (TGF-β) and alpha-melanocyte-stimulating hormone (α-MSH), and the recruitment of regulatory immune cells that suppress pro-inflammatory responses. Additionally, the blood-hair follicle barrier limits immune cell infiltration, further preserving immune privilege. However, in alopecia areata (AA), HFIP collapses triggering an autoimmune attack against follicular structures. This breakdown is marked by increased antigen presentation, heightened expression of MHC class I and II molecules, and an influx of autoreactive cytotoxic CD8+ T cells. These T cells, particularly those expressing the NKG2D receptor, recognize stress-induced ligands on follicular keratinocytes and initiate a cytotoxic response. Interferon-gamma (IFN-γ) and interleukin-15 (IL-15) play central roles in amplifying inflammation by activating the JAK-STAT signaling pathway, further promoting immune cell infiltration and follicular destruction. Additional immune cells, including natural killer cells, dendritic cells, and macrophages, contribute to disease pathogenesis by enhancing antigen presentation and sustaining the inflammatory cascade. Given the central role of HFIP collapse in AA, therapeutic strategies aimed at restoring immune privilege represent a promising avenue for long-term disease management. Future research should focus on identifying key molecular regulators of HFIP and developing targeted interventions to re-establish immune tolerance within the hair follicle. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CHRONIC WOUNDS - MICROBIOLOGY AND BIOFILM FORMATION(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024); ; ; ; Ahtarova, BiljanaIntroduction: Chronic wounds are wounds that do not heal for more than 4 weeks. Among the most important causes of wound chronicity are wound infection, biofilm formation with microbial agents that are resistant to antimicrobial agents. Aim: To investigate microbial agents in chronic wounds, their potential to form biofilm. Material and methods: This was a prospective study involving 24 patients from the University Clinic for in Skopje. Microbiological swabs were taken from patients with chronic wounds on the lower extremities,and were analyzed at the Institute of Microbiology and Parasitology, Faculty of Medicine in Skopje. The biofilm formation potential in isolates was determined using the tissue culture plate (TCP) biofilm detection method. Results: In 17 patients, at least one microorganism was isolated from 23 wounds, a total of 36, and in 7 patients there was no positive isolate from 7 wounds. Eighteen wounds (60%) had an isolate with the potential to form a biofilm. The following microorganisms from the wound samples were recorded: 17 (47%) isolates of the genus Staphylococcus, 4 (11%) isolates each from the genera Proteusand Pseudomonas, 3 (8%) isolates each from Enterococcusand Escherichia, 2 (6%) isolates from Streptococcus, 1 (3%) each isolate from the genera Acinetobacter, Enterobacterand Candida albicans. Conclusion: In 60% of the isolates, a biofilm formation with different degrees was confirmed. A statistically significant association was found between the degree of wound healing and isolates with low potential for biofilm formation, as well as the type of isolate. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Toxic Epidermal Necrolysis: Case Report and Review(Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia, 2024-03-12); ; ; ; Stevens–Johnson syndrome and toxic epidermal necrolysis (TEN) are severe mucocutaneous adverse drug reactions primarily caused by drugs. Characterized by fever, prodromal symptoms, and extensive epidermal sloughing with mucous membrane involvement (>90%), they are collectively termed epidermal necrolysis and are considered a disease continuum.CASE PRESENTATION: A65-year-old man presented with widespread erythema and distinctive target-like lesions, accompanied by ruptured flaccid vesicles on the extremities. Following a 4-week carbamazepine treatment for a previous cerebrovascular insult, hematological analysis revealed abnormalities. Amultidisciplinary team, including a neurologist, endocrinologist, and ophthalmologist, prescribed a 3-day course of intravenous immunoglobulin at 0.5g/kg and an initial dose of 300mg prednisolone for 3days, supported by additional therapy. Discharged after 3weeks, the rash completely resolved within 2months. CONCLUSION: TEN, a severe mucocutaneous condition with a 30% mortality rate, often results from drug exposure. Swift identification of the causative drug is crucial for optimal outcomes. Treatment primarily includes discontinuing the offending drug and offering supportive care for mucocutaneous lesions. Amultidisciplinary approach is vital based on organ system involvement. The effectiveness of pharmacological treatments, such as intravenous immunoglobulin and corticosteroids, is continually under evaluation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BIOFILM IN CHRONIC DIABETIC FOOT ULCER-CASE REPORT(Macedonian Association of Anatomists and Morphologists, 2023); ; ; Dohceva Karajovanov, IvanaDiabetic foot ulcers(DFUs) as one of the most common complications in patients with diabetes mellitus are usually chronic wounds.The reason for its chronicity are infections and biofilm formation. We present a patient with diabetic foot neuropathic ulcer on the right foot. Microbiological swab showed isolates of bacteria and fungi, Candida albicans,Enterococcus and Acinetobacter which were tested for biofilm formation with microtiter plate assay. Biofilm mass was evaluated spectrophotometrically by measuring the absorbence of crystal violet. Enterococcus was with high potential of biofilm formation. Wound surface was measured every week for a period of one month and it was reduced for 23.93%. Ulcer was treated with peroral antibiotic and antifungal medications and standard wound care was performed. Microorganisms isolated from wound swabs showed mixed bacterial and fungal components. Current sudies show that relation in between this biofilm is still unclear. All of this is a key role in treating chronic wounds, making it a challenge for everyone not only in the field of making diagnosis , but also in the field of treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lindsay's Nails and Terry's Nails in End Stage Renal Disease - Case Series(Balkan Cities Association of Nephrology, Dialysis, Transplantation and Artificial Organs, 2021-02); ; ; ; Introduction. Nail changes occur as part of a single organ disease, multisystemic diseases or because of the intake of some medications. Chronic kidney disease (CKD) is associated with various nail abnormalities. Тo identify Lindsay’s nails and Terry’s nails in patients with end stage renal disease (ESRD) on maintenance he-modialysis (HD) and to determine the common anam-nestic, clinical and/or laboratory parameters that would help elucidate the etiopathogenesis of these nail pathology. Methods. Twenty patients with ESRD on hemodialysis were included into the study. Dermatological examina-tion took place during the dialysis session. Lindsay’s nails were identified when the distal part of the nail bed is red/rose-brown, clearly separated from the proxi-mal part of the nail bed, occupying 20-60% of the entire length of the nail bed. The proximal part of the nail bed is whitish, resembling grounded glass. When pressing the nail, the discoloration of the distal part of the nail bad does not fade completely. Terry’s nails were identified by a 0.5-3.0 mm wide distal band, pink-brown in color, with a proximal part of the nail bed that is white and occupies 80% of the entire nail bed. Data on demographic characteristics, history of the disease and the laboratory values were noted for each patient. Results. Out of 20 patients, all males, we diagnosed Half-and-Half nails, also called Lindsay’s nails, and Terry’s nails in 6(30%) patients [5 Half-and-Half nails (25%), and 1 with Terry’s nails (5%)]. All patients had sideropenic-free anemia, elevated urea and creatinine values and elevated parathyroid hormone (PTH) values (>190 pg/L, range 190.3-387.5 pg/L). Conclusion. After searching the relevant literature (MEDLINE, PubMed), we found this is the first study to link elevated PTH values and Half-and-Half nails (also called Lindsay’s nails), and Terry's nails in patients with ESRD on HD. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MICROBIOME AND MYCOBIOME IN CHRONIC WOUNDS(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023); ; Skin as the biggest organ with protective function in the human body, makes an equilibrium between microbial communities and immune system. Skin microbiome is defined as the genome of microorganisms found on the skin with which microorganisms have a complex relationship. Microbiota of healthy skin consists of resident and transient microorganisms. Two most common factors for delayed healing process in chronic wounds are infection and biofilm formation. Thus, it is important to analyze microbiome and mycobiome of chronic wounds. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SEZARY SYNDROM-CASE REPORT(SHMSHM - AAMD, 2021); Ahtarova, BiljanaSezary syndrome is a leukemic variant of primary CTCL (cutaneous T cell lymphoma) manifested with clinical triade consisting of erythroderma, peripheral lymphadenopathy and atypical mononuclear cells(Sezary cells).[8] We present a case of 45 years old female, with non-specific primary skin lesions which fastly progressed in erythrodermia. Skin biopsy, immunohistochemical investigations, biopsy from bone marrow and detectable Sezary cells>5% in periphery blood were inclusive for cutaneous limphoproliferative disease (Sezary syndrome). Lymph node punction showed atypical lymphocytes. RTG pulmo and ultrasound of abdomen without abnormalities. CHOP therapy was started. We present a case with Sezary syndrome, clinically classified T4N2M0 (stage IV A). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LONGSTANDING, REPETITIVELY MISDIAGNOSED KYRLE’S DISEASE IN A PATIENT WITH END-STAGE RENAL DISEASE: A CASE REPORT(University Ss. Cyril and Methodius in Skopje, 2023); ; ; Kyrle’s disease (KD) is a rare variant of acquired perforating dermatosis (APD), associated with systemic diseases in adults, particularly chronic kidney disease (CKD) and diabetes mellitus (DM). Hyperkeratotic papules of KD are clinically important as a sign of a systemic disorder that are often misdiagnosed, so clinicopathological correlation is needed to establish the diagnosis. We report a rare case with longstanding KD, associated with end-stage renal disease (ESRD) on hemodialysis for 25 years that was repetitively misdiagnosed as folliculitis, excoriations and prurigo nodularis. The KD skin changes started to develop during earlier stages of CKD, before the kidney disease was suspected, and continued to appear in flares with extensive lesions when the systemic disease in the background was not under control. Dermoscopy revealed a 3-zonal concentric pattern, characterized by bright whitish scales in the centre, a structureless whitish-grey area surrounding the central crusts, and a peripheral, rose/brown pigmentation. Histopathological examination revealed moderately acantathotic epidermal invagination filled with a keratotic plug admixed with cellular debris and neutrophils, and a modest parakeratosis. Our goal is to emphasize that the accurate and timely diagnosis is vital to be able to monitor patients for a life threating, systemic disease such as kidney failure, and attaining better management of the dermatological status which can become longstanding and hindering, as well as to outline the importance of the multidisciplinary approach to improve outcomes in patients affected by KD.