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    Impact of preoperative arterial and venous diameter on achievement of the adequate blood flow in arteriovenous fistula for hemodialysis
    (Wiley, 2020-06)
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    An arteriovenous fistula (AVF) remains the best choice of vascular access (VA) for hemodialysis (HD). The aim of the study was to determine the factors associated with the achievement of adequate blood flow (BF) of AVFs at the 4th week after creation. Created AVFs in 63 patients with chronic kidney disease (CKD) stage 4/5 and CKD stage 5 on hemodialysis (CKD5D) were analyzed in a prospective study. Doppler ultrasound (DUS) was used for measuring the diameter of the radial artery, the brachial artery and the cephalic vein before AVF creation. The BF of AVF was calculated by DUS at the 4th week after creation and adequate BF was defined as ≥ 600 mL/min. The average age of patients was 61.31 ± 12.9 years. An adequate BF of AVF at the 4th week after creation was achieved in 43.54% of patients. The BF of AVF measured in male patients was significantly higher compared to the BF of AVF obtained in females (576.03 mL/min vs 375.12 mL/min, P = 0.004). The diameter of the blood vessels with achieved adequate BF was significantly larger compared to the diameter of the blood vessels without adequate BF (radial artery: 2.45 mm vs 2.03 mm, P = 0.000; brachial artery: 4.78 mm vs 4.06 mm, P = 0.001 and cephalic vein: 3.12 mm vs 2.83 mm P =  0.018). The gender and the diameter of the blood vessels before AVF creation were significantly associated with achievement of adequate BF of AVF at the 4th week of creation.
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    Primary Failure of the Arteriovenous Fistula in Patients with Chronic Kidney Disease Stage 4/5
    (Scientific Foundation SPIROSKI, 2019-06-15)
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    Pavleska-Kuzmanovska, Svetlana
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    Gjorgievska, Julija
    An Arteriovenous fistula (AVF) is a creation of the natural blood vessels. It is a "gate of life" for the patients on hemodialysis.
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    The blood flow rate on the first day after arteriovenous fistula creation is a predictor of successful fistula maturation
    (Wiley, 2022-12-02)
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    Cibrev, Dragan
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    The determination of blood flow rate (BFR) is a useful tool for assessing the function of arteriovenous fistula (AVF).
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    Efficacy of Medium Cut-Off Dialyzer and Comparison with Standard High-Flux Hemodialysis
    (S. Karger AG, 2021-07)
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    Biljali, Sefedin
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    Background: A new medium cut-off (MCO) membranes has been designed to achieve better removal capacities for middle and large middle molecules in hemodialysis (HD) treatment. Aim: The aim of this study was to evaluate the removal efficacy of Theranova® in standard HD in comparison with standard high-flux HD. Methods: Four HD patients (M/F 1/4) were included in 12-week observational pilot study in HD with Theranova® 400 and Theranova® 500 dialyzers. Each patient was assessed 4 times, T0 with high-flux dialyzers, T1 at 1 month, T2 at second month, and T3 at third month, by measuring pre- and post-HD samples of urea, Cr, β2-microglobilin (β2M), myoglobin, albumin, free light chains kappa (FLC-k), and free light chains lambda (FLC-λ). Results: The data showed a higher average removal rate for all the uremic toxins with Theranova® dialyzers for β2M, myoglobin, FLC-k, and FLC-λ (62.7, 56.9, 63.5, and 54.6%, respectively) during the 3 months. Albumin retention was observed and did not change between T0 and T3 (p = 0.379). Conclusion: Compared to high-flux membranes, MCO membranes show greater permeability for middle molecules in midterm report.
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    FACTORS AFFECTING THE ATTAINMENT OF ADEQUATE BLOOD FLOW OF ARTERIOVENOUS FISTULA FOR HEMODIALYSIS
    (Oxford University Press, 2020-06-01)
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    Gjorgievska, Julija
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    Background and Aims: An arteriovenous fistula (AVF) remains the best choice of vascular access (VA) for hemodialysis (HD). The aim of our study was determination of factors associated with achieved adequate blood flow (BF) of AVF during 4-th week after creation. Method: Created AVF in 63 patients with chronic kidney disease (CKD) stage 4, 5 and 5-HD were analyzed in the prospective single center study, from January 2019 to October 2019. Preoperative mapping of blood vessels by Doppler ultrasound (DUS) on the forearm was performed in all patients. All patients were undergoing surgical creation of new forearm AVF (radio-cephalic) by one doctor. The DUS was used for measuring the diameter size of artery radialis, artery brachialis and vein cephalica before creation of AVF and again on 1-st day, 2-nd and 4-th week after AVF creation. In addition the BF of AVF was also measured by DUS on 1-st day, 2-nd and 4-th week after AVF creation. The adequate BF of AVF for hemodialysis treatment was defined as ≥ 600 ml/min. Patient gender and age, hemodialysis vintage, diameter size of artery radialis, artery brachialis and vein cephalica before creation of AVF were analyzed as factors that were affecting the achieved BF of AVF during 4-th week after creation. Results: The average age of patients was 61.31 ± 12.9 years. From all patients, 60.31% (38/63) were men. The adequate BF of AVF (≥600 ml/min) during 4-th week after creation was achieved in 43.54% (27/63) of created AVFs. The blood flow of AVF measured in male gender was significantly higher compared to the blood flow of AVF measured in female gender (576.03 ml/min vs 375.12 ml/min, p=0.004). The age of the patients and hemodialysis vintage were not significantly associated with achieved adequate BF of AVF during 4-th week after creation of AVF. The adequate BF of AVF was achieved in blood vessels with bigger diameter size. The diameter size of the blood vessels with achieved adequate BF was significantly higher compared to the diameter size of the blood vessels without adequate BF (artery radialis : 2.45 mm vs 2.03 mm, p=0.000; artery brachialis: 4.78 mm vs 4.06 mm, p=0.001 and vein cephalica: 3.12 mm vs 2.83 mm, p=0.018). Conclusion: The gender and the diameter size of artery radialis, artery brachialis and vein cephalica before creation of AVF were significantly associated with achieved adequate BF of AVF (≥600 ml/min) during 4-th week after creation of AVF.
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    Quality of Health Care and Mortality - Three Years of Experience
    (Macedonian Association of Anatomists and Morphologists, 2018)
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    Case report: First diagnosis of Fabry disease in North Macedonia in a patient presenting with kidney failure on hemodialysis
    (Frontiers Media SA, 2024)
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    Arsov, Todor
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    Fabry disease is a rare X-linked lysosomal storage disorder caused by α-galactosidase A (α-Gal A) deficiency. Reduced or absent enzyme activity causes progressive lysosomal accumulation of globotriaosylceramide (Lyso-Gb3) in various cells throughout the body to trigger inflammation and fibrosis.
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    SP588 PATHOHISTOLOGIC CHANGES IN ARTERIOVENOUS FISTULA IN PATIENTS WITH CHRONIC KIDNEY DISEASE
    (Oxford University Press (OUP), 2018-05-01)
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    Ivanovski, Ninoslav
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    USE OF ULTRASONOGRAPHY FOR CONFORMATION OF CENTRAL VENOUS CATHETER PLACEMENT FOR HEMODIALYSIS - SINGLE CENTER EXPERIENCE
    (Faculty of Medicine, Ss Cyril and Methodius University in Skopje, 2022)
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    Spasovska-Vasilova, Adrijana
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    Milenkova, Mimoza
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    Conformation for safe placement of central venous catheter for hemodialysis and exclusion of pneumothorax is done with chest x ray. However, this procedure is time consuming, so in order to shorten this time several attempts have been tried to use bedside ultrasound. To use bedside ultrasonography to confirm tip location of central venous catheter and rule out pneumothorax. The second aim was to compare these results with plain chest x ray. In 50 patients on hemodialysis central venous catheter were inserted in internal jugular vein or subclavian vein under ultrasound guidance. After insertion, a subxiphoid 4 chamber view was obtained looking to detect turbulence or microbubbles shortly after 10ml saline flush through catheter. Then, ultrasound of the patient's chest was performed to exclude pneumothorax. After the exam, a plain chest x raywas performed for the conformation of the findings. From 50 placed hemodialysis catheters, 47 were adequately placed. All catheters were identified with the use of ultrasound. The tip of the 3 misplaced catheters could not be detected with the use of ultrasound. No pneumothorax was observed. The average time for detection of correct catheter placement was much faster with the use of ultrasound compared with chest x ray (11,5min and 80 min, accordingly). The use of bedside ultrasound for conformation of central venous catheter placement and excluding pneumothorax is as accurate as with chest radiography, but it is can be done much faster.