Damjanovska krstikj, LJubinka
Preferred name
Damjanovska krstikj, LJubinka
Official Name
Damjanovska krstikj, LJubinka
Main Affiliation
Email
ljubinka.damjanovska.krstikj@medf.ukim.edu.mk
20 results
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Item type:Publication, A Comparison of Two Radiography Scoring Methods Used by Rheumatologists and Radiologists in Patients with Established Rheumatoid Arthritis(Synergy Publishers, 2015-04-29); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Porphyromonas Gingivalis - A Periodontal Pathogen with Potential Role in Rheumatoid Arthritis and its Association with Anti-CCP and Anti-MCV Antibodies Positivity(Synergy Publishers, 2022-02-23); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Late onset of SLE in males: A misdiagnosed disease(Macedonian Association of Anatomists and Morphologists, 2022); ; Systemic lupus erythematosus (SLE) is an autoimmune disease characterisedby the production of antibodies to components of the cell nucleus in association with a diverse array of clinical manifestations. When the immune system attacks its own tissues, it causes widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy.Late-onset SLE represents a specific subgroup of SLE and is often initially missed leading to a significant delay in diagnosis. Elderly patients frequently present to hospital with nonspecific symptoms such as fatigue, recurrent fever of an unknown cause, weight loss, serositis (pleural and/or pericardial effusions), and acute kidney injury.We are describing a case of late onset SLE in a male patient that has been previously only syptomaticaly treated for the complications of the disease itself, whilst it took a longer period for physicians to thinkof SLE and make further investigations about it, because of the age and sex of the patient. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANTISYNTHETASE SYNDROME: A RARE AND CHALLENGING DIAGNOSIS – CASE REPORT AND LITERATURE REVIEW(Central Medical Library - Bulgaria, 2022-10); ; ; Antisynthetase syndrome (ASS) is rare idiopathic inflammatory myopathy (IIM) characterized principally by myositis, generally symmetrical arthritis and interstitial lung disease (ILD) in association with serum autoantibodies to aminoacyl-transfer RNA synthetases. More variable features include arthralgia, Raynaud phenomenon, heliotrophic rash, distal esophageal dysmotility and mechanic's hands. In this case report we describe a 46-years old woman who initially presented with arthritis and subtle myositis which delayed the recognition of ASS and contributed for considering the condition as seronegative rheumatoid arthritis for several years. During the next few years, the patient was progressively worsening, with a disability to stand up from a sitting position, gradual onset of exertional dyspnea, difficult-to-control dry cough and thick, hyperkeratotic skin of both hands (mechanic’s hands). This constellation of symptoms was highly suspicious for ASS and additional serological and radiological examinations were done which confirmed the diagnosis. The need for further detailed investigation when an interstitial lung disease overlaps with a known rheumatoid condition is obligatory, as shown in this case. A multidisciplinary evaluation is highly recommended to evaluate the clinical, serological and radiological findings in each patient suspected for ASS in order to establish early diagnosis and timely management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus, a diagnostic and a management challenge(Bulgarian Rheumatology Society, 2023-08-31); Thrombotic thrombocytopenic purpura (TTP) is a rare, potentially fatal blood disorder that can be challenging for clinicians to identify in the setting of autoimmune diseases such as systemic lupus erythematosus (SLE). SLE can present with thrombotic microangiopathy (TMA) and differentiation between the two diseases can be quite difficult. In this case report we present a 62-year-old female with a history of SLE who was hospitalized with thrombocytopenia, dysarthria, dizziness, paresthesia and altered mental status. The laboratory results revealed direct Coombs negative hemolytic anemia, severe thrombocytopenia, significant elevation of lactate dehydrogenase, leukocytosis and presence of few schistocytes in the peripheral film. In addition, we also present evidence for circulating anti-ADAMTS13 antibody/ADAMTS13 antigen. Based on clinical, hematological, and biochemical findings, we concluded that it was a case of TTP-like microangiopathy associated with SLE and indicated treatment with methylprednisolone pulses and plasmapheresis. Later on, she developed psychosis and made plasmapheresis difficult to perform. We continued corticosteroids (dose 1mg/kg), RhoGAM, Chloroquine and Azathioprine, obtaining a satisfactory response after one week of treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Дијагностичка вредност на анти-цикличните цитрулирани пептидни антитела кај пациенти со ревматоиден артритис(Македонско лекарско друштво = Macedonian Medical Association, 2007); ; Н. МаринаThe aim of the study was to determine the diagnostic value, specificity and sensitivity of anti-CCP antibodies (ACPA) as a new test for rheumatoid arthritis, in comparison with IgM RF. A cross-sectional study was carried out to analyze the prevalence of ACPA and IgM RF in the sera of 160 randomly selected patients from the Clinic of Rheumatology: 60 with RA, 50 with connective tissue diseases and other rheumatic diseases (non-RA) and 50 healthy controls (HC). All of the RA patients fulfilled the revised ACR classification criteria. Commercial anti-CCP ELISA kits and IgM RF Latex test were used. As expected, ACPA showed comparable sensitivity (66,8% vs. 68,3%) and higher specificity (98% vs. 87%) than IgM R, at optimal cut off values. The ROC curve was generated for both tests. AUC was greater for ACPA than for igM RF (0,92 vs 0,82). The presence of either ACPA or IgM RF increased the testing sensitivity to 76,6%. There was a positive significant correlation between ACPA and IgM RF, r=0,459, p<0,001. ACPA antibodies are very useful serological markers for the diagnosis of RA, with comparable sensitivity and higher specificity than IgM RF. For early and precise diagnosis of RA, the concomitant use of both tests is necessary . - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Satisfaction Level of Rheumatoid Arthritis Patients Enrolled in the Treatment with Subcutaneous Tocilizumab. Journal of Autoimmune Diseases and Rheumatology(Karachi: Synergy Publishers, 2020); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Overlap syndrome in refractory case(Macedonian Association of Anatomists, 2022); ; This is a report of the case of a 23 years-old girl with refractory dermatomyositis, complications in her treatment and the unfortunate fatal end. Dermatomyositis can be a notoriously difficult disease to treat, and remission is often elusive or short-lived despite aggressive therapy. In the years after the diagnosis, many aggressive modalities of treatment were tried, including rituximab. The patient had frequent exacerbations of the myositis, needed aggressive therapy and developed many side effects associated with the treatment. Most common of these were infections. After suffering severe stress, she developed fever, was diagnosed with sepsis and despite exhaustive treatment at the intensive care unit she passed away. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Rheumatoid arthritis and the proinflammatory cytokine IL-17(Pensoft Publishers, 2023-02-28); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Rituximab in treatment of a patient with granulomatosis with polyangitis - a case report(Македонско лекарско друштво = Macedonian medical association, 2023-01);