Jovanova, Silvana
Preferred name
Jovanova, Silvana
Official Name
Jovanova, Silvana
Main Affiliation
Email
silvana.jovanova@medf.ukim.edu.mk
17 results
Now showing 1 - 10 of 17
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Tachycardia – induced cardiomyopathy (TIC): a reversible state(Hrvatsko kardiološko društvo, 2012-10); ;Arnaudova-Dezhulovikj, F; ; Tachycardia-induced cardiomyopathy (TIC) is defined as a condition characterized by atrial or ventricular myocardial dysfunction as a result of prolonged and increased atrial or ventricular rates. There is no underlying structural heart disease, and the condition is reversible upon control of the arrhythmia. The prevalence of the disease can’t be truly estimated as it is mainly described in case reports. During 2011 we established the diagnosis of tachycardia induced cardiomyopathy in 4 patients. All of them were male, at the age of 40–55, with no previous cardiovascular disease. At the time of presentation two patients had atrial fibrillation, and the other two of them atrial flutter, with fast ventricular rate (130–160 bpm. All of them presented with symptoms and signs of congestive heart failure. The duration of the arrhythmias was approximately 4–8 weeks before hospitalization. On admission, echocardiographic parameters were consistent with dilated cardiomyopathy with moderately to severe reduced ejection fraction (25–40%). In all cases there was no structural heart disease, no signs of inflammation or metabolic disturbances. Coronary angiography showed normal coronary arteries. In all cases there was resolution of the ventricular dysfunction following appropriate treatment of the arrhythmias and achieving and maintaining sinus rhythm. During the follow-up period of 12–18 months the patients are in NYHA I functional class, with echocardiographic dimensions and volumes within normal ranges, on beta blockers, ACE inhibitors, ASA or OAT. Two of them had few episodes of AF of short duration. The recognition of tachycardia-induced cardiomyopathy is important as appropriate treatment (rhythm and/or rate control) has a good outcome. It needs to be taken into consideration in the differential diagnosis of idiopathic dilated cardiomyopathy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Plasma levels of ApoB, ApoA1, and Apo B/A1 ratio are associated with coronary artery disease(Turkish Biochemical Society, 2019-10); ; ; ; Irena Kostovska - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Low density lipoprotein size in relation to carotid intima-media thickness in coronary artery disease(Slovak Academy Press s.r.o., 2012); ; ; ;Krstevska MAWith increasing interest in the role of non-traditional lipid risk factors in coronary artery disease, we undertook this study to relate LDL subclass size and carotid intima-media thickness of the common carotid artery in coronary artery disease patients. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cholesteryl ester transfer protein, low density lipoprotein particle size and intima media thickness in patients with coronary heart disease(Association of Basic Medical Sciences of FBIH, 2011-08); ; ; ;Branko JaglikovskiCholesteryl ester transfer protein (CETP) plays a key role in reverse cholesterol transport and high density lipoprotein (HDL) metabolism. Predominance of small, dense LDL particles is associated with an increased risk of atherosclerosis and coronary heart disease (CHD).The aim of the study was to determine the potential relationship between the CETP concentration and low density lipoprotein (LDL) particle size and their association with intima media thickness (IMT) in patients with CHD. Lipid parameters, CETP concentration and LDL particle size were determined in 100 healthy subjects (control group) and in 100 patients with CHD, aged 43 to 77 years. Plasma CETP concentrations were measured by an enzyme-linked immuno-sorbent assay with two different monoclonal antibodies. LDL subclasses were separated by nondenaturing polyacrilamide 3-31% gradient gel electrophoresis. CETP concentration was higher in patients compared to controls (2.02 ± 0.75 mg/ml vs. 1.74 ± 0.63 mg/ml, p<0.01). Mean LDL particle size (nm) was significantly smaller in patients than in controls (24.5 ± 1.1 vs. 26.1 ± 0.9; p<0.001). There was no relation between LDL particle size and CETP concentration (r=-0.1807, p=0.072). Age, diastolic blood pressure, CETP concentration and LDL particle size were independent factors for determing IMT by multiple linear regression analysis. They accounted for 35.2 % of the observed variability in IMT. CETP is not an independent contributor of LDL particle size. CETP might play a role in determining lipoprotein distributions, but did not seem to be the sole factor in the formation of small LDL particles. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, In-hospital outcome of patients with peripartum cardiomyopathy – a single center study(Medical Publishing, d.o.o., 2014-10-29); ;Arnaudova-Dezulovic, Frosina; ; Palasheva, LidijaPeripartum cardiomyopathy (PPCMP) is a disorder of unknown cause in which initial left ventricular systolic dysfunction and symptoms of heart failure (HF) occur between the last month of pregnancy and the first 5 months postpartum. The causes and pathogenesis are poorly understood and PPCMP remains a diagnosis of exclusion. Clinical presentation includes usual signs and symptoms of heart failure, and unusual presentations relating to thromboembolism. Effective HF treatment reduces mortality rates and increases the number of women who fully recover left ventricular (LV) systolic function. PPCMP is common in some countries and rare in others. During 6 years period (2008-2014) 22 patents (pts) were admitted to our hospital with diagnosis of PPCMP. 16(73%) pts were admitted to our hospital immediately post-partum, because of acute HF which needed immediate and aggressive HF treatment. Six (27%) pts presented congestive HF symptoms during the first three months after delivery. At the admission all the pts had documented LV systolic dysfunction with echocardiography (EF <45%). Five of them (23%) had severely impaired LV systolic function (EF=25-30%), seven (32%) pts had EF of 30-40%, and 10 (45%) pts had mild LV systolic dysfunction. During the hospitalization, clinical and functional improvement and stabilization was achieved in all patients. Complete recovery of LV systolic function was observed in 12 (55%) pts with PPCMP. In 10 pts (45%) there was persistence of LV systolic dysfunction determined with echocardiography. Peripartum cardiomyopathy is rare, but a serious disease associated with significant cardiac functional deterioration. Early diagnosis and appropriate medical treatment allows good functional recovery in majority of these patients and favorable prognosis. Reliable population-based information about incidence and prevalence of PPCMP is essential to the development of health policies for prevention and control of this condition. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HEART DAMAGE IN PREGNANCIES COMPLICATED WITH PREECLAMPSIA: CASE REPORT(Macedonian Medical Association/ Walter de Gruyter GmbH, 2016); ; ; ; Introduction. Heart function in pregnancy is a subject of many debates and studies. A large number of epidemiologic studies have found association between preeclampsia and cardiovascular morbidity/mortality. About 5-8% of deliveries are complicated with preeclampsia. Until recently, heart damage associated with preeclampsia has not been studied. A number of heart difficulties only appear long after the reproduction period has en-ded. Preeclampsia increases the risk for B stage (asymptomatic) of heart failure. Case report. A 37-year-old pregnant patient, G2P1 27 weeks of gestation, paid her first visit to the Gynecology Outpatient Clinic. She complained on heavy breathing, difficulty with movement and hypertension. She was referred for further evaluation to the Cardiology Outpatient Clinic with a suspicion of gestational hypertension and heart abnormalities. The pregnancy was evaluated several times at the Out-patient Clinics of Gynecology and Cardiology with the diagnosis of gestational hypertension. Echocardiography showed abnormal heart remodeling. In the 36 g.w laboratory findings showed urine dip stick ++,ТА160/110. The diagnosis was changed to preeclampsia. The patient was delivered with a re-caesarean section because of previous S.C and preeclampsia. Postpartum echocardio-graphy confirmed left chamber hypertrophy with per-sistent hypertension. Results. Clinical cardiovascular complications in preec-lampsia continue long after the pregnancy has ended. Studies show that pregnancies with both early and late preeclampsia have an increased risk for asymptomatic left chamber dysfunction/hypertrophy and essential hypertension in the next 2 years after delivery. If the damages are caught early prevention can be started sooner rather than later before patients become symptomatic (C stage of heart failure). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Usefulness of echocariography in detecting hart abnormalities in pregnancies with Preeclampsia/Gestational Hypertension(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2017); ; ;Miceva, Irena; Introduction. Preeclampsia is a disorder in pregnancy which includes high blood pressure and proteinuria. It is recognized in 5-8% of all pregnancies. In the last several years an association between heart abnormalities and preeclampsia has been observed. Echocardiography as an imaging method is increasingly being used in obstetrics in the management of hemodynamic changes which occur in normal but also in pregnancies with preeclapsia. The aim of the study was to determine the usefulness of echocardiography in the control of pregnancies complicated with preeclampsia/gestational hypertension. Materials and methods. A total number of 38 patients were analyzed in our study. It was realized at the University Clinic for Gynecology and Obstetrics and University Clinic for Cardiology. Pregnant women were recruited from the Outpatient clinic at the University Clinic for Gynecology and Obstetrics. After signing an informed consent for participation in the study pregnant women were divided in two groups ( normotensive and pregnancies with gestational hypertension/preeclampsia). Echocardiographic examination was done at patients entry in the study. Results and discussion. In more than 38% of the cases in the examined group with hypertension an abnormal heart remodeling was seen with asymptomatic left ventricular dysfunction/hypertrophy. In the normotensive control group the heart function was normal in all evaluated cases - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dilated cardiomyopathy in acromegaly - Case report(2014-10); ; ;Todorova, BiljanaIntroduction: Patients diagnosed with acromegaly develop many cardiovascular complications such as hypertension, arrhythmia, systolic and diastolic dysfunction, valvular dysfunction and heart failure. Dilated cardiomyopathy (DCM) with systolic and diastolic dysfunction is relatively rare but is associated with high mortality to 60%. In MCC the heart muscle gradually dilate and the dysfunction that develops is irreversible. It is therefore necessary early diagnosis and treatment of acromegaly by removal of the tumor and drug treatment with drugs that prevent the heart failure. Material and methods: We present a case of acromegaly diagnosed at the patient at the age of 27 with pituitary macroadenom, hipopituitarizam, diabetes,insipiden diabetes and atrophy of the optic nerve. The patient was subjected to endoscopic surgery but the disease remained active and she was treated with radiotherapy. Our patient has ignored the underlying disease and didn’t call in to the review and controls. The patient was hospitalized with difficult situation of heart failure with anasarca, hypertension, fatigue and severe left ventricular dysfunction with global hypocinesia in the Clinic for Cardiology. She was treated with diuretics, cardiotonics, vasodilators and hormone replacement therapy. Conclusion: Early diagnosis and prompt treatment of acromegaly can prevent irreversible cardiomyopathy. The problem is greater, if it is associated with other morbidities such as hypertension and diabetes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute Myocarditis after Pfizer-BioNTech COVID-19 m-RNA Vaccination(Scientific Foundation SPIROSKI, 2022-11-30) ;Elena Grueva-Nastevska; ;Planinka Zafirovska ;Elma KandicBACKGROUND: Prosthetic mechanical valve endocarditis (PVE) can be manifested as early PVE (acquired perioperatively) and late PVE (resulting from infections unrelated to the valve operation). Causes of both are similar but are late PVE are more prone to less virulent microbes. PVE resulting with paravalvular abscess is confirmed through echocardiography (transthoracic or transesophageal), it results with a high mortality rate especially if it is not early recognized. CASE PRESENTATION: We are presenting a patient with heart failure symptoms caused by PVE after Pfizer-BioNTech coronavirus disease-2019 (COVID-19) m-RNA vaccination. CONCLUSION: The exact mechanism of myocarditis in young men who received the second dose of mRNA COVID-19 vaccine is not yet known. However, this is a rare complication and most people generally recover quickly requiring only supportive treatment. In contrast, the risk of developing myocarditis from the viral infection is much higher.
