Celeska, Irena
Preferred name
Celeska, Irena
Official Name
Celeska, Irena
Main Affiliation
Email
iceleska@fvm.ukim.edu.mk
14 results
Now showing 1 - 10 of 14
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Item type:Publication, LABORATORY TESTS IN MONITORING HEALTH STATUS IN SHEEP FLOCKS(Serbian veterinary society, 2017-09); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of Health Related Quality of Life in Dogs Treated with Chemotherapy for Lymphoma(Acta Veterinaria, 2023-06); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, First Case of Strongyloides stercoralis Infection in a Dog in the Republic of Macedonia(Walter de Gruyter GmbH, 2018-03-01); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Modification of the Standard 7-Day Ovsynch Protocol to Increase the Luteolytic and Synchronization Risks in Dairy Cows(Walter de Gruyter GmbH, 2020-10-01); ; ; ; Angjelovski, Branko<jats:title>Abstract</jats:title> <jats:p>We hypothesized that a single dose of PGF<jats:sub>2α</jats:sub> belatedly injected on day 8 after GnRH-1 in cows receiving a 7-day Ovsynch-56 protocol (GnRH – 7 days – PGF<jats:sub>2α</jats:sub> – 56h – GnRH – 16h – timed AI) will increase the proportion of cows with complete luteolysis. At day 35±3 postpartum, 70 lactating Holstein cows from one herd were scored for body condition and pre-synchronized with PGF<jats:sub>2α</jats:sub> and GnRH (3 days apart) and 7 days later submitted to an Ovsynch-56 protocol for first AI after random assignment to two treatments: (1) OV-7 (n=35) with an injection of PGF<jats:sub>2α</jats:sub> either on day 7; or (2) OV-8 (n=35) on day 8 after G1, respectively. Blood was collected before the first PGF<jats:sub>2α</jats:sub>, at day 7 and day 8 in OV-7 and OV-8, respectively, at AI and at 7 days after AI to assess progesterone concentration. Ten cows were classified as acyclic and were excluded from the analysis resulting in 60 cows (OV-8, n=27; OV-7, n=33). In total, more (P=0.01) OV-8 cows and more (P=0.04) primiparous OV-8 cows had complete luteolysis compared with their OV-7 herd mates. In addition, more (P=0.008) OV-8 cows with BCS<2.75 had complete luteolysis compared with their OV-7 herd mates, whereas no difference was observed between treatments among cows with BCS ≥2.75. In conclusion, delaying the application of PGF<jats:sub>2α</jats:sub> by 1 day reduced the percentage of primiparous cows and cows with poorer BCS having incomplete luteal regression at the time of AI.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular Detection of <i>Ehrlichia canis</i> in the Pet-Dog Population in R. N. Macedonia(Walter de Gruyter GmbH, 2021-06-01); ; Djadjovski, Igor<jats:title>Abstract</jats:title> <jats:p>Canine monocytic ehrlichiosis (CME) is a widespread, tick-borne, canine disease, caused by an obligate intracellular bacterium, <jats:italic>Ehrlichia canis</jats:italic>. The main vector, a brown-dog tick, <jats:italic>Rhipicephalus sanguineus</jats:italic>, is widely distributed, especially in areas with tropic, subtropic, or Mediterranean climates (Central and South America, Eastern and Western Asia, Africa, Australia and Southern Europe). The study performed in 2012, by Stefanovska et al., determined a seroprevalence of 18.7% of <jats:italic>E. canis</jats:italic> among the Macedonian dog population. Up to date, the presence of <jats:italic>E. canis</jats:italic>, using molecular diagnostic methods, has not been investigated in Macedonia. Therefore, this study aimed to confirm the presence of <jats:italic>E. canis</jats:italic>, in the pet-dog population on the territory of the city of Skopje, North Macedonia, using a highly sensitive multiplex Real-Time PCR method (qPCR). Whole blood samples from 80 dogs of different breeds and ages, with clinical symptoms of CME and positive serology result for the presence of antibodies against <jats:italic>E.canis</jats:italic>, were collected for analyses. Out of 80 dogs, 36 (45%) were found as positive. The present work reports the first molecular detection of <jats:italic>E. canis</jats:italic> in pet dogs on the territory of the city of Skopje, Macedonia.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, GLYCEMIA AS A RELIABLE INDICATOR FOR DIABETES MELLITUS IN DOGS AND CATS(University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina, 2021-11-12); ; Atanaskova Petrov, ElenaDiabetes mellitus (DM) is a common endocrinopathy in pet animals with variable pathophysiological metabolic pathways in dogs. Consequently, various hematological and biochemical parameters tend to have high variability. Therefore, the aim of this study was to assess the most reliable and practical hematological and/or biochemical parameter for monitoring DM during the insulin treatment in dogs and cats. This research included 11 pet animals (8 dogs and 3 cats) with high resolution of DM clinical symptoms. Red blood cell (RBC) and white blood cell count (WBC) were measured on whole blood samples by using hematological analyzer. Alanine aminotransferase (ALT), alkaline phosphatase (ALKP), glucose, urea, and creatinine were obtained from plasma samples analyzed with automatic colorimetric analyzer. The variability of the parameters was assessed by the coefficient of variation (CV, %). Parameters with CV >34% were considered with non-normal distribution. RBC and glucose had CV of 24% and 25%, respectively. The other parameters had CV ranging between 39% and 162%. Polyuria and polydipsia were present in 7 dogs and 1 cat. Polyphagia was present in 4 dogs and 1 cat. Intermittent polyphagia was found in 3 dogs. The clinical manifestations had variable underlying conditions which resulted in variable concomitant organopathies. In conclusion, the blood glucose indicated normal distribution and can be used as a reliable indicator for monitoring DM in diabetic dogs and cats. By using telemetric blood glucose monitoring devices, the veterinary doctors will have continuous and reliable data for the status and the effectiveness of the therapy for their patients. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hypothyroidism in dogs as a baseline of different clinical signs and laboratory results(University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina, 2020-10-03); Atanaskova Petrov, ElenaIntroduction: Hypothyroidism is the most common endocrinopathy in dogs. It is clinical condition with decrease serum level concentration of thyroid hormones, resulting with different clinical signs. As a common subclinical and clinical condition, hypothyroidism can be congenital and acquired, as well as primary, secondary and tertiary (the last mentioned is very rare). This clinical condition is sometimes hard for diagnosis, but it is very easy for treatment. Aims: The main purpose of this clinical study is interpretation of serum concentration of fT4 in correlation with other laboratory findings (hematology and biochemistry) and clinical manifestation. For that purposes 5 clinical cases will be describe with history data, clinical manifestation and laboratory findings such as clinical condition after treatment protocol. Material and methods: Clinical research was performed in 5 clinical cases admitted in the University clinic. According anamnestic data from the owners, dogs presented different clinical signs, reported at the personal files of the patients. Hematology was performed immediately after sampling on veterinary hematology analyzer Exigo (Sweden), as well as biochemistry status: enzyme serum concentration (ALT, AST, ALKP), degradation profile (urea and creatinine), protein status (albumin, total protein), lipid parameters (cholesterol, triglycerides), according manufacture instruction (Human, Germany) with colorimetric procedure on automatized analyzer Chem Well 2910 (USA). Cytology (Diff Quick staining) was performed only in cases with dermatological lesions. ELISA laboratory method was used for measurement serum concentration of free thyroxin (fT4), on BDLS ELISA reader. Results and Discussion: First case was 6 year female mix breed neutered dog, with progressive skin lesion with hyperpigmentation and episodes of epileptiphormic seizures. Hematology presented mild normocytic, normochromic anemia (5.09 1012/L), and biochemistry results presented only mild increase of ALT (69 U/L) and mild hyperlipidemia (cholesterol 6.89 mmol/l and triglycerides 2.05 mmol/l). Anticonvulsive therapy protocol (phenobarbital 1mg/kg) was not responsive, epileptiformic seizures continue with the same frequency. Cytology finding show non-pruritic non-inflammatory alopecia, with low cellularity of superficial cornified epithelial cells. Serum level concentration fT4 presentedsevere hypothyroidism of 0.29 ng/dl. Initial treatment with levothyroxine started with 10 μcg/kg BID and after one month the treatment dose was increased of 22 μcg/kg BID. Clinical signs of epileptiformic seizures disappeared and laboratory findings corrected within reference ranges. Skin lesions recurrence in irregular intervals. After 5 years of treatment the patient developed hepatic fibrosis. Second case was 5 year male Samoyed, with no specific clinical signs only with polyphagia and increased body condition score. Laboratory finding presented only moderate elevation of degradation profile (urea 18.24 mmol/l and creatinine 174.54 μmol/l). Renal supportive and protective protocol combined with intravenous fluid crystalloid therapy did not give satisfactory results. Serum concentration of fT4 (0.51 ng/dl) show moderate decrease level. Initial treatment with levothyroxine 15 μcg/kg BID give satisfactory results with correction of degradation profile, regular appetite and normal body condition score. Third case was 10 year female Maltese, with history of chronic caught, collapse trachea, intolerance of physical exercise and congestive heart failure with mitral dysplasia. Cardiotonic (0.25 mg/kg pimobendan BID) and diuretic (2 mg/kg furosemide and spironolactone 1 mg/kg SID) treatment was not completely effective protocol, didn’t give satisfactory results. There were intermittent remission of subcutaneous myxedema. Serum concentration of fT4 (0.34 ng/dl) presented marked hypothyroidism. There is no evident dermatology lesions or alterations in laboratory results. Initial treatment of levotiroxine in dose of 22 μcg/kg BID give satisfactory results. Fourth case is a 4 year male cocker spaniel presented marked dermatology clinical signs with symmetric bilateral alopecia, “rat tail” and superficial exfoliate dermatitis. Cytology findings present low cellularity of epithelial cells, intact inflammatory cells predominant neutrophils, less small lymphocytes and telogen defluxion of hair. Dermatology cosmetically products, topically used, was not effective treatment. Biochemistry lipid parameters (hypercholesterolemia 7.15 mmol/l and hypertriglyceridemia 2.84 mmol/l) were indicators for measurement of fT4. Moderate serum concentration of 0.54 ng/dl indicate hypothyroidism. Treatment protocol of levothyroxine 15 μcg/kg BID together with dermal supportive supplements give better condition of the skin and normal values of the lipid parameters. Fifth case: 5 year male Labrador retriever, with bradycardia, myxedema, seborrhea sicca, obtain laboratory results have shown increase serum level of ALT (105.3 U/L). Unclear clinical symptoms and elevated ALT were suspected indicators for hypothyroidism. Serum concentration of fT4 of 0.61 ng/dl confirm diagnosis. Treatment with levothyroxine 20 μcg/kg BID improve better condition of the patient. Conclusion: Decreased serum concentration of fT4 can be used as baseline of many different clinical conditions, non-responsive of regular conventional protocols. Clinical and subclinical hypothyroidism correlated with the degree of clinical manifestation and altered laboratory results. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical Signs and Behavior in Dogs with Hypothyroidism(Macedonian Veterinary Review, 2023-06); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Simulations of photon versus particle therapy for treating cancer in canines using matrad: case study of a beagle with pituitary macroadenoma(Faculty of Veterinary Medicine, University of Belgrade, Serbia, 2025); ; In this study, we propose that dogs diagnosed with tumors exhibiting a similar pathology to those in humans could play a crucial role in trials for novel radiation therapy modalities, such as particle therapy (beyond protons and carbon ions) or FLASH therapy. A multidisciplinary team including a veterinary oncology scientist, a human radiation oncologist, and medical physicists, conducted a simulation of a comparative treatment planning using matRad software to compare the benefits of three treatment modalities: (1) X-rays, (2) protons, and (3) carbon ions. Diagnostic results from a Beagle dog with a pituitary macroadenoma were utilized for this study. The dog was euthanized due to severe deterioration in basic physiological functions, including eating, swallowing, breathing, head tilt, and movement, over a period of several days. The dog’s owner, who is closely related to one of the coauthors, provided oral consent for the use of all available clinical data from the deceased dog. These results were used as a hypothetical case to simulate and compare the effectiveness of three radiation treatment modalities. This pioneering approach opens an avenue to the potential of involving living companion animals already diagnosed with cancer in treatment research, advancing both veterinary and human oncology. The results suggested that if treated with radiation, the dog would have benefited most from particle therapy, which delivers a maximum dose to the tumor while considerably minimizing exposure of the surrounding critical organs – an advantage not achieved with conventional X-rays. This collaboration emphasizes the importance of integrating veterinary and human radiation oncology. This work paves the way for developing initial protocols to treat pets with cancer, serving as a preclinical foundation before clinical studies are conducted on humans. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical Signs and Diagnostic Procedures for Detection of Bovine Viral Diarrhea(Days of Veterinary Medicine, 2014-09); ;