Kadifkova panovska, Tatjana
Preferred name
Kadifkova panovska, Tatjana
Official Name
Kadifkova panovska, Tatjana
Main Affiliation
Email
taka@ff.ukim.edu.mk
9 results
Now showing 1 - 9 of 9
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Item type:Publication, Toxicity screening of weight loss tea products by Brine Shrimp Lethality Assay(Macedonian Pharmaceutical Association, 2023-09); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The importance of AKR1D1 enzyme in drug metabolism(Macedonian Pharmaceutical Association, 2022-12-31); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of weight loss supplements toxicity in rifampicin pretreated HepG2 cells(Macedonian Pharmaceutical Association, 2023-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Analysis of ergosterol as a potential contaminant in two herbal raw materials(Macedonian Pharmaceutical Association, 2020-10-29); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Safety issues of herbal weight loss dietary supplements: Hepatotoxicity and adulteration(Centre for Evaluation in Education and Science (CEON/CEES), 2024); ; ; <jats:p>Herbal weight loss supplements are widely used in the management of obesity, but consistent data to support long-term weight loss efficacy and safety are missing. Besides, legal framework for food supplements is less restrictive than regulation of medications. The objective of this review is to give weight to the fact that many weight loss supplements contain herbal compounds with unknown mechanism of action, increasing the risk for adverse effects, even toxicity, especially in co-administration with prescribed drugs. Hepatotoxicity ranging from elevated transaminases and autoimmune-like hepatitis to acute liver failure appears to be underrecognized, but is not uncommonly encountered. Another and even more serious concern is adulteration of weight loss supplements by illegal addition of unauthorized substances or medications to provide quick effects and to increase sales. Here are some significant data regarding the possible hepatotoxicity of frequently used herbal extracts, as well as the health risks related to some common adulterants. Towards safer use of supplements, a comprehensive and critical discussion of current regulatory principles is essential to address the existing gap between the increased use of food supplements and the lack of knowledge about their benefits, providing better protection for consumers.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of Tanacetum vulgare L. and Juniperus communis L. biocompatibility limitations in eukaryotic cells(Macedonian Pharmaceutical Association, 2022-12-31) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Toxicity of food supplements as an adjuvant for COVID-19 treatment or prevention(Galaxy Science, 2022-01-31); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cytotoxic screening of selected Cannabis cultivars using brine shrimp lethality assay(Macedonian Pharmaceutical Association, 2022-12-31) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pattern of benzodiazepine use among death cases in Republic of North Macedonia(Macedonian Pharmaceutical Association, 2021); ; ; The aim of this study was to determine the pattern of benzodiazepine related deaths in Republic of North Macedonia. Retrospective survey of post-mortem toxicology data from eight-year period, obtained from Laboratory of Forensic Toxicology was performed, including cases with known gender, age, cause and manner of death and complete toxicology report. Post-mortem toxicology analyses were conducted with Fluorescence Polarization/Enzymatic Immunoassay and Biochip Array Technology method for screening of urine and blood respectively, and confirmation by GC-MS after solid phase extraction. Total of 1169 cases were investigated. Benzodiazepines were detected in 30.05% of the cases, with statistically significant difference between cases of natural and of violent cause of death, as well as between genders, but without statistically significant difference due to the age between both genders. Study revealed women were more likely to use benzodiazepines with the median age to be 52.88 and 49.87 for males and females, respectively. According to post-mortem toxicology data benzodiazepines are the most used drugs in our country. Of them, diazepam was found to be the most often used one. Data analyses have shown that benzodiazepines were often combined with alcohol, psychoactive medicines and drugs of abuse. In 46.6% of all cases with positive findings for benzodiazepines, use of drugs of abuse was detected, mostly heroine and methadone. Important note should be given to the simultaneous use of benzodiazepines with heroine and methadone, which have resulted in increased number of fatal intoxications. Further studies are needed to determine the reason for popular use of benzodiazepines among drug addicts.