Bozhinovska, Nikolina
Preferred name
Bozhinovska, Nikolina
Official Name
Bozhinovska, Nikolina
Translated Name
Nikolina Bozhinovska, Nikolina Bozinovska, Nikolina Bozinoska, Николина Божиновска, Николина Божиноска
Alternative Name
Nikolina Bozhinovska, Nikolina Bozinovska, Nikolina Bozinoska, Николина Божиновска, Николина Божиноска
Email
n.bozinovska@hotmail.com
Researcher ID
0000-0003-1844-6839
7 results
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Item type:Publication, Nuclear medicine hybrid imaging (SPECT/CT) in distinguishing the presence of a hepatic hemangioma: Single center study(Centre for Evaluation in Education and Science (CEON/CEES), 2023); ; ; <jats:p>Objective. Hepatic hemangioma (HH) is the most common benign liver tumor, and the second most frequent tumor in the liver after hepatic metastasis. The SPECT/CT hybrid technique will be beneficial for the investigation of this type of HH since it can precisely identify the hepatic lesions. The aim of this study was to reevaluate the sensitivity and specificity of the nuclear medicine method for confirmation or exclusion of benign hemangioma of the liver based on a series of cases at our department and briefly review the literature. Methods. We retrospectively analyzed 107 patients, 62 females (57.94%) and 45 males (42.05%) with mean age 50.05±11.92 years, referred to the Nuclear Medicine Department for 99mTc-RBC scintigraphy of the liver to conclude or exclude the presence of HH, in the period 2019 to 2020. Results. Hepatic scintigraphy located the hemangiomas mostly in the right hepatic lobe. The size of the lesion varied from to 6-140 mm (46.04 ± 27.1); 13 hemangiomas were described as giant. SPECT-CT confirmed HH in 1 patient that was negative on ultrasound, besides 30/87 (34.48%) patients who were described as positive on US and turned out to be negative on the scintigraphic method. In 53 (60.92%) patients, positive matching of the US images and hybrid SPECT/CT imaging for HH was found. Most of the patients had benign referral diagnosis, while 12 of them had confirmed malignant diagnosis in whom eight (n=8, 66.67%) were confirmed free of hepatic metastasis and SPECT-CT detected HH, while in 4 patients who were described as positive for HH on the CT scan, the scintigraphic method excluded HH and further evaluation of the hepatic lesion was needed. Conclusion. Hepatic hemangiomas require a careful diagnosis to differentiate from other focal hepatic lesions, cooccurring diagnoses are also possible. Differentiating between HH and hepatic metastatic disease is a typical clinical difficulty when the problem is present in staging or monitoring patients with oncological disease.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SUBACUTE THYROIDITIS AND ITS CLINICAL CHARACTERISTICS — A RETROSPECTIVE SINGLE CENTER CLINICAL STUDY(2022-07); ; ; INTRODUCTION. Typical clinical features of subacute thyroiditis (SAT) are commonly assessed such as – neck pain and high body temperature, as well as thyroid function abnormalities, elevated inflammatory markers, and strongly suggestive hypoechoic ultrasonography characteristics. Non-steroid anti-inflammatory agents and corticosteroids are used. AIM. To examine the clinical characteristics in patients with SAT, by determining the level of thyroid hormones, the size and structure of the thyroid gland as well as ultrasound and scintigraphy findings. MATERIALS AND METHODS. We performed retrospective analysis in 122 cases of SAT (both genders, mean age 45.05±12,18 years), in the period 2015-2020. We evaluated monthly frequency of the SAT occurrence, the clinical status of the patients including symptoms, body temperature, laboratory results of FT4 and TSH, CRP and ESR level, ultrasonography and scintigraphy findings. RESULTS. Most of the patients complained of neck pain, high body temperature was detected in 66/100 (66%) pts. CRP and ESR Patients were usually diagnosed in hyperthyroid phase of the disease. Enlarged thyroid gland was mostly seen on US, while 52 had normal thyroid gland, with predominantly hypoechoic non-chomogenous structure. Scintigraphy noted “empty” scan (without presentation of functional thyroid tissue) in 72/98 (73,47%) and hypofixation mainly in both lobes in 26/98 (26,53%) pts. CONCLUSION. The awareness of physicians needs to be increased in patients with neck pain for proper diagnosis of SAT, that is often is often misdiagnosed or delayed, leading to erroneous antibiotic overuse. Generally, nonsteroidal anti-inflammatory drugs are effective in reducing thyroid pain in patients with mild cases. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BIODISTRIBUTION STUDY OF 188Re-HEDP AS A RADIOPHARMACEUTICAL FOR BONE PAIN PALLIATION(Macedonian Association of Anatomists and Morphologists, 2023-12); ; Chochevska, MajaBone seeking radiopharmaceuticals like Rhenium-188 hydroxy ethylidene diphosphonate (188Re-HEDP) are used for palliative treatment of bone metastases, and as target radionuclide therapy in patients with inoperable osteosarcoma in addition to the external radiation therapy. In this study was evaluated the preparation, quality control and biodistribution of 188Re-HEDP in mice to be determined the in vivo affinity to the target bone tissue and to the other non-target tissues and organs. 188Re-HEDP was prepared with radiochemical purity of 98.87%. Its biodistribution data showed high uptake and durability in the skeletal tissues without significant uptake in other tissues and organs. It means that 188Re-HEDP kit formulation and the prescribed conditions in our study allows obtaining a radiopharmaceutical with promising therapeutic efficiency in palliative treatment of primary bone tumors as well as secondary osseous metastatic lesions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Corrélation entre les scores de risques d’ulcération du pied chez les diabétiques et la maladie rénale chronique(John Libbey Eurotext, 2017-09); ; ; Introduction Le pied diabétique est une lésion dans le pied ou membres inférieurs, qui est causée par une angiopathie diabétique et de l’infection neurologique. C’est une des complications les plus graves du diabète. Patients et méthodes Le but d’étude se d’évaluer la corrélation entre les scores de risque d’ulcération du pied chez les malades atteints de diabète de type 2 et le degré de maladie rénale chronique (MRC). De comparer ces risques et leur impact sur les facteurs métaboliques ainsi que les facteurs qui influencent le temps d’identification de risque d’ulcération du pied et le degré de MRC. Résultats Il s’agit d’une étude transversale, dans lequel, pendant la visite 1 (V1), le nombre total de patients atteints de DM2 et MRC ont été examinés ainsi que 6 mois plus tard durant la visite 3 (V3). Les malades ont été examinés et testés pour le pied diabétique et classifié selon le groupe de travail international (IWGDF) dans trois groups : risque moyenne, haut risque et très haut risque. De plus les malades ont été examinés et classifiés pour le degré de MRC selon la formule de Cockroft–Gault et MDRD. Le nombre total des malades qui ont entré dans l’étude est 107, et parmi 50,5 % étaient des hommes et 49,5 % étaient des femmes. L’âge moyen des malades était 59,12 ans, et moyen niveau d’HbA1c était 9,5 % et six mois plus tard le niveau d’HbA1c était 8,8 % (p < 0,004). L’IMC était 28 kg/m2. Le score de risque à V1 et V3 a une signification statistique (p < 0,004) à savoir V3 montre score plus élevé de risque. L’analyse de corrélation montre que les groupes ayant un risque plus élevé de points d’ulcération (2 et 3) ont également un degré de néphropathies supérieur (3 et 4) pendant V1 et aussi pendant V3 (p < 0,001). Discussion Chez les malades d’âge moyen atteints de DM2 et MRC, la durée de DM2, HbA1c et la pression artérielle élevée ont un rôle important dans l’évaluation du risque d’ulcération du pied et la progression de la MRC. Conclusion Les patients présentant un risque élevé pour les scores d’ulcération, se rapportent à un degré de néphropathies supérieur. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SPECT/CT - solving the dilemma of hepatic hemangioma(2019); ; ; ; Hemangiomas, or hemangioma-like appearing lesions, are frequently detected in liver often as an incidental finding on computed tomography (CT) scans. Once detected, they can be a clinical dilemma as they need to be characterized. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Preoperative detection of sentinel lymph node in patients with endometrial cancer - comparison of planar lymphoscintigraphy, spect and SPECT/CT(2022); ; ; Sentinel lymph node (SLN) mapping allows minimal invasive assessment of lymph node status in patients with early-stage endometrial cancer (EC). Intraoperative detection of SLNs is based on the results obtained from preoperative nuclear medical images. The purpose of this study was to compare the data obtained from planar lymphoscintigraphy (PL), single-photon emission computed tomography (SPECT), and SPECT with computed tomography (SPECT/CT) for preoperative SLN detection in patients with EC. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Bone scan indications in patients under 30 years of age(2020); ; ; ; Aim Bone scintigraphy can be a useful tool in evaluating bone disorders in young adults. Although it has a low specificity, combining planar dual phase bone scan (DPBS) and hybrid imaging (SPECT/CT), can help in detecting metabolic activity of bone lesions (BL) of various etiology. Materials & Methods Bone scan indications in young patients under 30 years were retrospectively evaluated in a two-year period at our Nuclear Medicine Department. The DPBS and afterwards SPECT/CT procedure on the region of interest was performed 3 hours after i.v application of 99mTc-MDP in dose calculated by age. Results We evaluated 65 patients (27 males, 38 females), average - 15.32±7.25y. The most frequent indication was metabolic activity of primary BL of non-malignant etiology (38/65, 58.46%), followed by primary malignant BL (12/65 patients, 18.46%). In 10 (15.38%) patients the indication was to detect bone mets due to non-bone malignancies (Malignant Melanoma, Neuroblastoma, Nephroblastoma, Medulloblastoma, Hodgkin Lymphoma, Histiocytosis). The non-malignant etiology was predominantly due to primary benign bone tumors (22/38, 57.89%) including Osteoid osteoma - 8, Fibroma Non-Ossificans - 4, Enchondroma - 1, Osteochondroma - 1, followed by Aneurysmal Bone Cyst-7, Exostosis-1. Other rare indications were trauma, sacroiliitis, rheumatologic diseases and fibrous dysplasia. In suspected malignant bone tumors histopathology revealed Osteosarcoma in 4 patients, Chondrosarcoma - 2, Ewing sarcoma - 1, Histiocytosis - 3, Malignant Lymphoma - 1, NET - 1. More than 2/3 of the patients complained of bone pain and in 23% the pain was associated with an injury. In 50/55 patients, BL presented in the appendicular skeleton, mainly in the inferior extremities. DPBS was performed in all except 9 patients (with malignancy of non-bone etiology), where indication was detecting distant mets. From 56 patients, DPBS was positive in 36.92%, while negative in the pool phase and positive only on the late phase in 27.69%. Positive both planar and SPECT/CT were detected in more than half of the patients (52.31%), while 4 patients had negative planar and positive SPECT/CT (ABC-1, Ewing - 1, Sacroiliitis - 1, Nephroblastoma - 1). Conclusion Bone scintigraphy is still a valuable nuclear method complementary to other diagnostic modalities. In young adults the main clinical indication is evaluation of primary BL of non-malignant etiology. Because of its high sensitivity, it can detect metabolic activity of BL and their turnover (osteoblastic reactions) of various etiologies (benign, malignant, traumatic, inflammatory, rheumatic) and assists in further management of the patient.