Tanovska, Nikolina

Preferred name

Tanovska, Nikolina

Official Name

Tanovska, Nikolina

Main Affiliation

nikolina.tanovska@medf.ukim.edu.mk

Now showing 1 - 10 of 12

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Risk factors associated with new-onset epilepsy in young adults: Population-based study
(Elsevier BV, 2021-10-19)
Babunovska, Marija
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Boskovski, Bojan
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Kuzmanovski, I
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Risk factors for childhood and late-onset epilepsy are thoroughly described in existing literature, while they are less defined and ambiguous for young adults. We aimed to evaluate the prevalence of various risk factors associated with new-onset epilepsy in adults aged 20-49 years. We included all incident cases in North Macedonia between 2015 and 2018.
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Myasthenia Gravis and Associated Diseases
(Scientific foundation SPIROSKI, 2018-03-05)
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Novotni, Gabriela
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Sazdova-Burneska, Slobodanka
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Kuzmanovski, I
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Boshkovski, Bojan
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease caused by the action of specific antibodies to the postsynaptic membrane of the neuromuscular junction, leading to impaired neuromuscular transmission. Patients with MG have an increased incidence of other autoimmune diseases. AIM: to determine the presence of other associated diseases in patients with MG.METHOD: A group of 127 patients with MG followed in 10 years period, in which the presence of other associated diseases has been analysed.RESULTS: The sex ratio is in favour of the female sex, the average age of the initial manifestation of the disease is less than 50 years, 65.4% of the patients with MG have another disease. 15.0% patients have associated another autoimmune disease. Thyroid disease is the most common associated with MG, rarely rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other autoimmune diseases. Other diseases include hypertension, heart disease, diabetes, respiratory diseases, dyslipidemia. 10.2% of the patients are diagnosed with extrathymic tumours of various origins. CONCLUSION: Associated diseases are common in patients with MG, drawing attention to the possible common basis for their coexistence, as well as their impact on the intensity and treatment of the disease.</jats:p>
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Correlation of CRP as inflammatory biomarker and clinical forms of MS.
(Лига против епилепсија на Република Македонија = League Against Epilepsy of the Republic of Macedonia, 2017)
Burneska Sazdova Slobodanka
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Aleksovski Vasko
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Boshkovski Bojan
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Kuzmanovski Igor
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What is in a name and what is in the brain? -clinicians’ dilemmas in the biomarker era
(Elsevier BV, 2025-05)
Novotni, Gabriela
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Karanfilska Plaseska, Dijana
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This viewpoint draws analogy from Shakespeare’s query, "What’s in a name?" and explores what defines neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD) and what clinicians understand by that name in relation to the underlying brain pathology and disease biology. The inspiration comes from the latest biological definitions of PD revealing significant similarities with the biological definition of AD.
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Overview of the Current Situation and Challenges about Neuromyelitis Optica Spectrum Disorders in the Republic of Macedonia
(Scientific foundation SPIROSKI, 2020-02-05)
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Boshkova-Petkovska, Tatjana
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Smokovski, Aleksandar
Abstract BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) are rare, progressive inflammatory disorders of the central nervous system characterized by severe, immune-mediated demyelination targeting optic nerves and spinal cord. Prior establishment of diagnostic criteria, patients were often misdiagnosed which led to delayed/inappropriate treatment and disability. Current practice involving immunotherapies is insufficient. Recent data are encouraging since the novel treatments allow effective prevention. AIM: The primary objective was to evaluate the current situation to identify challenges and develop intervention that might improve the current state as secondary objectives. METHODS: Standard questionnaire containing 22 questions was developed. Collected data were analyzed and descriptive report was created. RESULTS: Current estimated prevalence is approximately 20 NMOSD patients; trend is unknown due unavailability of patient registry. Six neurologists from one health-care institution are responsible for the whole management. Despite physicianâ€™s insufficient experience, ~80% of them are willing to switch patients into innovative treatments once available. Aquaporin-4-IgG testing is not routinely available resulting in ~30% testing rate. Approximately 80â€“90% of patients are on maintenance treatment with immunosuppressant, corticosteroids are used for acute relapse. Lack of novel innovative medications is evident. CONCLUSION: Current NMOSD management is challenging with significant unmet needs. Highest priorities that might provide improvement are: APQ4-IgG testing availability, establishment of patient registry, and availability of novel treatments.
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Giant mediastinal thymic cyst
(Macedonian Academy of Sciences and Arts, 2017)
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Goge Damjanovski
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Imran Ferati
The authors present a rare case of giant mediastinal cyst which arises from the thymus gland, and goes down in both pleural spaces, especially in the right chest cavity where a dominant part of the cyst was present. The cyst was full with 2.5 liters of transparent fluid, and compressed surrounding structures – heart and both lungs, especially the right one which was partially collapsed. The patient was a 52 years old woman, without any clinical symptoms. Accidentally, on the screened chest X-ray a shading in the distal third of the right chest was detected. The case was well documented with a CT of the chest, and an indication for surgical treatment was made. The surgery was done successfully in general anesthesia according to the small right anterior thoracotomy from which a giant part of the cyst was mobilized, which was in the right pleural cavity, but, also, the thymus with the origin of the cyst in the anterior and superior mediastinum was completely removed. In the end, a part of the cyst which was in the left pleural cavity was removed.
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Prevalence of various risk factors associated with new-onset epilepsy after the age of 50: a retrospective population-based study
(Wiley, 2022-02-01)
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Babunovska, Marija
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Boskovski, Bojan
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Kuzmanovski, I
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Population-based studies of epilepsy risk factors are rare. We aimed to evaluate the prevalence of various risk factors associated with new-onset epilepsy after the age of 50 years. We included all incident cases in North Macedonia between 2015 and 2018. Study participants were ascertained from the national healthcare platform. We performed a retrospective analysis of Electronic Health Records of 2,367 patients (1,017 females and 1,350 males) whose epileptic seizures started after the age of 50 years. Patients were stratified into 10-year age groups. The most common risk factor for new-onset epilepsy in our cohort was stroke, which was associated with new-onset epilepsy in 20% of patients aged 50-59 years and almost 50% of patients aged 70-79 years. The second most frequent risk factor was neoplasm in patients aged 50-69 years and dementia in patients older than 70 years. The other pre-existing conditions included: metabolic disorders, traumatic brain injury, and postencephalitic and inflammatory diseases. Chronic alcoholism was the most common metabolic risk factor associated with new-onset epilepsy and accounted for 84% of cases in this subgroup. Only metabolic disorders were significantly more frequent in males than in females (p<0.00001). We did not identify any epilepsy risk factor in 967 patients (41%). Systemic vascular risk factors were frequent in our cohort: 1,574 patients had hypertension (66%) and 449 patients had diabetes (19%), and 339 had both conditions (14%). We found that structural lesions were the most prevalent risk factor associated with new-onset epilepsy in middle-aged and elderly patients. Recognition of possibly modifiable factors associated with late-onset epilepsy could have a positive impact on reducing the risk of developing epilepsy.
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Paraneoplastic neurologic syndroms (case report)
(Лига против епилепсија на Република Македонија = League Against Epilepsy of the Republic of Macedonia, 2015)
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Novotni Gabriela
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Kuzmanovski Igor
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Burneska Sazdova Slobodanka
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Boshkovski Bojan
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Young onset subcortical dementia-a spectrum of HIV associated neurocognitive disorder
(Лига против епилепсија на Република Македонија = League Against Epilepsy of the Republic of Macedonia, 2017)
Novotni Gabriela
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Cvetkovska Emilija
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Kuzmanovski Igor
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Boshkovski Bojan
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Thymectomy for myasthenia gravis and anesthetic implications - a retrospective study
(League Against Epilepsy of the Republic of Macedonia = Лига против епилепсија на Република Македонија, 2017)
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Mojsova Maja

Tanovska, Nikolina

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