Popovski, Emil

Preferred name

Popovski, Emil

Official Name

Popovski, Emil

Main Affiliation

emilp@pmf.ukim.mk

Now showing 1 - 10 of 15

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[(3-Chlorobenzamido)methyl]triethylammonium Chloride
(MDPI AG, 2015-04-01)
Breznica-Selmani, Pranvera
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Mikhova, Bozhana
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Draeger, Gerald
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Lactobacillus casei Encapsulated in Soy Protein Isolate and Alginate Microparticles Prepared by Spray Drying
(Faculty of Food Technology and Biotechnology - University of Zagreb, 2017-06)
Hadzieva, Jasmina
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Crcarevska, Maja Simonoska
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Dodov, Marija Glavaš
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Dimchevska, Simona
This article presents a novel formulation for preparation of Lactobacillus casei 01 encapsulated in soy protein isolate and alginate microparticles using spray drying method. A response surface methodology was used to optimise the formulation and the central composite face-centered design was applied to study the effects of critical material attributes and process parameters on viability of the probiotic after microencapsulation and in simulated gastrointestinal conditions. Spherical microparticles were produced in high yield (64%), narrow size distribution (d50=9.7 µm, span=0.47) and favourable mucoadhesive properties, with viability of the probiotic of 11.67, 10.05, 9.47 and 9.20 log CFU/g after microencapsulation, 3 h in simulated gastric and intestinal conditions and four-month cold storage, respectively. Fourier-transform infrared spectroscopy confirmed the probiotic stability after microencapsulation, while differential scanning calorimetry and thermogravimetry pointed to high thermal stability of the soy protein isolate-alginate microparticles with encapsulated probiotic. These favourable properties of the probiotic microparticles make them suitable for incorporation into functional food or pharmaceutical products.
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1,1,2,2-Tetrakis[(benzoylamino)methyl]hydrazine
(MDPI AG, 2011-03-23)
Tanatarec, Jasmina
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Mikhova, Bozhana
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Synergy of novel coumarin derivatives and tamoxifen in blocking growth and inducing apoptosis of breast cancer cells
(Macedonian Pharmaceutical Association, 2014)
Ballazhi, Lulzime
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Imeri, Faik
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Jashari, Ahmed
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<jats:p>Possible synergistic effect of tamoxifen (2 μM) and hydrazinyldiene-chroman-2,4-diones (10-100 μM) was examined with an aim to create more effective treatment for ER+ breast cancer. Anti-breast cancer effect has been evaluated on the proliferation of MCF-7 breast adenocarcinoma cells using MTT and alamarBlue assays. Cell viability was evaluated after 48h-treatment and the ICs50 of the coumarin derivatives were determined. The apoptotic effect was evaluated by detection of PARP cleavage and reduced activity of the survival kinase Akt. The results demonstrated dose-dependent activity, with a percent of growth inhibition after combination treatment being significantly higher (53% to 79%, 10 μM and 100 μM, respectively) than the one in the cell lines treated with tamoxifen (29% to 37%) and the synthesized coumarin derivatives alone (11% to 68%, 10 μM and 100 μM, respectively). The ICs50 of the synthesized compounds significantly decreased in synergy with tamoxifen (33% to 51%). Coumarin derivative having thiazole moiety with additional methyl groups attached to the carbons at positions 5 and 4 in the thiazole ring showed to be the most potent, with IC50 20 µM when administered alone and 10 µM in synergy with tamoxifen. The levels of phospho-Thr308 Akt were down-regulated by the combination treatment, pointing to tyrosine kinase phosphorylation inhibition. In conclusion, the novel coumarin derivatives enhance the activity of tamoxifen and this combination may be suitable for prevention of ER+ breast cancer or development of related compounds. Further studies are needed to elucidate precisely the type of receptor involved in the activity and the mechanism of action.</jats:p>
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Methyl 4-[(Benzoylamino)methoxy]benzoate
(MDPI AG, 2010-12-24)
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Panovska, Ana Poceva
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From optimization of synbiotic microparticles prepared by spray-drying to development of new functional carrot juice
(National Library of Serbia, 2014)
Petreska-Ivanovska, Tanja
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Petrushevska-Tozi, Lidija
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Hadjieva, Jasmina
<jats:p>Lactobacillus casei loaded chitosan-Ca-alginate microparticles enriched with the prebiotic fructooligosaccharide were prepared using spray-drying method associated with the polymers complexation and cross-linking with calcium. The concentrations of the formulation factors of alginate, chitosan and CaCl2 were optimized using 23 full factorial design. Experiments showed that microparticles with favorable physicochemical properties and high probiotic viability during preparation and storage could be obtained when 40 mg/g sodium alginate, 5 mg/g chitosan and 50 mg/g CaCl2 is used. Stability of L. casei during microencapsulation was identified by FTIR spectroscopy. The viability of the probiotic in the optimal formulation of synbiotic microparticles remained above the therapeutic minimum during incubation of 24 hours in simulated gastrointestinal conditions (7.67?0.4 log cfu/g) as well as after 3 months of cold storage (8.1?0.6 log cfu/g). High viability of L. casei was maintained during 6 weeks of cold storage when carrot juice was enriched with encapsulated cells. The effective preservation of L. casei into synbiotic microparticles provided production of new non-dairy functional food as an alternative of the population who is at risk of lactose intolerance.</jats:p>
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(Benzoylamino)methyl 4-Acetyloxybenzoate
(MDPI AG, 2011-01-26)
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Effect of prebiotic content on functional and physicochemical properties of Lactobacillus casei loaded chitosan-Ca-alginate microparticles
(Macedonian Pharmaceutical Association, 2012-10)
Petreska Ivanovska, Tanja
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<jats:p>This study aims to evaluate the influence of different concentrations of fructooligosaccharide (FOS) as prebiotic on functional and physicochemical properties of Lactobacillus casei loaded chitosan-Ca-alginate microparticles prepared by spray-drying method, after preparation and 6-month storage at 4 °C. Prebiotic compound positively influenced the viability of L. casei during preparation of the microparticles and in storage conditions, while no significant difference of the probiotic viability was observed when different concentrations of FOS in a range of 1.5 - 5% w/w were applied. Having in regard that non-significant improvement in the functional and physicochemical properties of the microparticles with increased content of the FOS was observed, the concentration of 1.5% w/w was recommended as an optimal for preparation of synbiotic loaded microparticles.</jats:p>
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Optimization of the formulation for preparing Lactobacillus casei loaded whey protein-Ca-alginate microparticles using full-factorial design
(Informa UK Limited, 2014)
Smilkov, Katarina
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Petreska Ivanovska, Tanja
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Petrushevska Tozi, Lidija
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Hadjieva, Jasmina
This article presents specific approach for microencapsulation of Lactobacillus casei using emulsion method followed by additional coating with whey protein.
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(Benzoylamino)methyl 4-[(Benzoylamino)methoxy]benzoate
(MDPI AG, 2010-12-24)
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Panovska, Ana Poceva

Popovski, Emil

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