Tosheska Trajkovska, Katerina

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Nephrin - marker for early detection of hypertensive nephropathy
(2017-09)
Irena Kostovska
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Protein za prijenos kolesteril estera (CETP) i veličina čestica LDL u bolesnika s koronarnom bolešću
(CROATIAN ATHEROSCLEROSIS SOCIETY, CROATIAN MEDICAL ASSOCIATION, 2019-05)
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Irena Kostovska
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Accreditation of medical laboratories in the Republic of Macedonia
(2015)
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Irena Kostovska
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EN ISO 15189 revision: EFLM Committee Accreditation and ISO/CEN standards (C: A/ISO) analysis and general remarks on the changes
(Walter de Gruyter GmbH, 2025-01-06)
Linko, Solveig
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Boursier, Guilaine
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Bernabeu-Andreu, Francisco A.
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Dzneladze, Nana
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Vanstapel, Florent
The EN ISO 15189:2022 standard, titled “Medical laboratories – Requirements for quality and competence,” is a significant update to the regulations for medical laboratories. The revised standard was published on December 6, 2022, replacing both EN ISO 15189:2012 and EN ISO 22870:2016. Key objectives of the revision include: 1. Alignment with ISO/IEC 17025:2017, 2. Removal of unintended prescription, 3. Focus on patient interest and safety, 4. Minimization of new requirements, and 5. Improved clarity of text. Dedicating to harmonizing accreditation processes across Europe the EFLM Committee on Accreditation and ISO/CEN standards (C: A/ISO) has produced this guidance document to assist the laboratory medicine community in understanding and implementing the criteria of the EN ISO 15189 revision. Two main objectives of the guidance in educating both laboratories and accreditation bodies with their assessors as well as other stakeholders in laboratory medicine were agreed on. Firstly, to clarify the relevant changes covering all paragraphs of the standard and secondly to make an impact analysis on previous C: A/ISO guidance documents.
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Bioluminescence determination of enzyme activity of firefly luciferase in the presence of pesticides
(Wiley, 2005)
Snezana Trajkovska
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Jean Jacques Aaron
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Filip Spirovski
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Firefly luciferase (EC 1.13.12.5) (FL) is the key enzyme in the firefly bioluminescence method (FB), which is widely used to determine the viability of living cells. The FB method can also be applied to monitoring the influence of different pollutants, such as pesticides. Firefly luciferase is a hydrophobic enzyme and its activity depends on the type of solvent, pH and substances present in the reaction mixture. The influence of three aromatic pesticides, including fenoxaprop-p-ethyl (I), diclofop-methyl (II) and metsulfuron methyl (III), on the enzyme activity was indirectly evaluated through the measurement of emitted light in the bioluminescence reaction, expressed in relative luminescence units (RLU). The reaction mixture used in the bioluminescence measurements consisted of: Tris buffer (pH 7.75), adenosine triphosphate (ATP) and ATP monitoring reagent, where FL is present. Ethanol-water solutions of each pesticide were then added at concentrations of 2.4 x 10(-4)-2.4 x 10(-8) mol/L. The FL activity inhibition factors (FL In%) were determined. The FL activity was maximally inhibited in the presence of all pesticides under study at a concentration of 2.4 x 10(-4) mol/L and was lowered by about 15-26% for pesticide I at concentrations of 2.4 x 10(-5)-2.4 x 10(-8) mol/L, whereas pesticides II and III, applied in the same concentration range, showed smaller FL inhibition values (5.3-20%). The pesticide degradation products (obtained after a 1 month period), measured in the same experimental conditions, in most cases exhibited a much less inhibitory effect on the enzyme activity than the corresponding initial pesticide.
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Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease
(Academy of Medical Sciences of Bosnia and Herzegovina, 2012)
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Zafirovska, Planinka
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Jaglikovski, Branko
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Chronic infections in CHD are due to one or both of the organisms Chlamydia pneumoniae and Helicobacter pylori.
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Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria
(S. Karger AG, 2018)
Shpetim Salihu
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Febrile proteinuria is functional proteinuria and is seen as a transitory phenomenon during acute febrile illness, mainly viral infections. It is a benign phenomenon and clears promptly with resolution of the infection.
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Comparative analysis of orthodontically indicated labial frenectomy with conventional surgery and diode laser
(Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2018)
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Milevski M
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Dzipunova B
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Radojkova -Nikolovska V
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Uloga podokaliksina u ranom otkrivanju hipertenzivne nefropatije
(2019)
Irena Kostovska
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Unusual cause of death in a patient with Covid-19
(Springer, 2021-09)
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Dzengis, Jasar

Tosheska Trajkovska, Katerina

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