Hadji-nikolova, Natasha

Preferred name

Official Name

Hadji-nikolova, Natasha

Translated Name

Хаџи-Николова, Наташа

Alternative Name

Natasha Hadji-Nikolova

Natasha Hadji Nikolova

Natasha Hadzi Nikolova

Hadji Nikolova, Natasha

Hadzi Nikolova, N

Alchinova, Natasha

Alchinova, N

Hadji-Nikolova, N

Наташа Хаџи Николова Алчинова

Hadji Nikolova Alchinova, Natasha

Hadji Nikolova Alchinova, N

Main Affiliation

natasha.hadji.nikolova@medf.ukim.edu.mk

Now showing 1 - 6 of 6

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Assessment of late gadolinium enhancement in cardiac MRI
(Macedonian Association of Anatomists, 2021)
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Aliji, Vjolca
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Ilievski, Mitko
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Stojkoski, Aleksandar
The aim of this study was to evaluate MRI characte ristic s of ischemic and non - is chemic cardiomyopathies with late dadolinium enhancement analysis that can provide differentiation between these two cardiomyopathies. Eligible 96 patients, age range from 26 to 71 years, who showed different and overlapping c linical symptoms, ECG andtransthoracic echocardiography findings that needed further evaluation were included in our study for further evaluation with cardiac MRI. Of the evaluated patients, 47 were females and 49 were males. The examinations were performe d with MRI Scanner 1,5T Siemens Avanto by using 3 channeledSiemens ECG electrodes with retrospective triggering. With the help of PSIR sequence for late gadolinium enhancement evaluation we differentiated ischemic cardiomyopathy from non - ischemic cardiomyo pathy, which is crucial for management of patients with cardiac dysfunction. Of the examined 96 patients, 42 patients were diagnosed with ischemic cardiomyopathy, 51 with non - ischemic cardiomyopathy, and 3 patients had non - conclusive diagnosis. It was foun d that late gadolinium images in the setting of cardiac MRI were capable of detecting myocardial scars and fibrosis. Moreover, they helped in differentiation between ischemic and non - ischemic cardiomyopathieson the basis of myocardial scar enhancement patt ern.
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Correlation between CMR and chest CT in assessment of constrictive pericarditis.
(2023-10-11)
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Ilievski, Mitko
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Description of Clinical Presentation A 35-year-old adult presented to the cardiology department with shortness of breath, coughing, and fatigue. He had a history of recurrent colds with high fever, but their recent cold led to worsening symptoms. Tests revealed atrial fibrillation with a heart rate of 150 bpm, enlarged atria, and reduced systolic function. Laboratory results showed thrombocytopenia, elevated GGT, and high bilirubin, with no elevated Troponin levels. CMR showed systemic volume overload, with passive liver congestion and left pleural effusion, no pericardial effusion, but thickening with dimensions of 4,6mm. SSFP sequences showed left and right ventricle hypokinesia with impaired diastolic filling, severe diastolic septal bounce and abnormal contour of left lateral wall which was akinetic. The T2-STIR sequence showed hypersignal intensity in the basal anterolateral and inferolateral segments, distributed within the subepicardial and mid-wall regions. Additionally, focal pericardial involvement was observed in these segments, along with two central hypo signal lesions that showed identical signal characteristics across all sequences. On delayed enhancement PSIR sequences, there was increased signal intensity in the specific areas on the T2-STIR sequence, suggesting gadolinium accumulation and in the mid and apical inferior and inferolateral segments with subepicardial distribution. There was pericardial enhancement dominantly at the basal ventricular segments, along with focal pericardial enhancement at the left apex also featuring a central hypo signal lesion. The patient underwent a native chest CT examination, revealing circumferential thickening of the pericardium with linear diffuse calcifications. This finding was correlated with the MRI results, indicating a state of subacute to chronic inflammatory/fibrotic constrictive pericarditis with constriction throughout the entire heart with concomitant myocarditis changes dominantly at the left lateral wall. Diagnostic Techniques and Their Most Important Findings Cardiac MRI is a valuable tool for diagnosis of pericardial constriction where the ventricles may appear compressed or have a "square root sign" appearance, reflecting impaired ventricular filling during diastole. T1 and T2 mapping, can provide insights into the tissue characteristics of the pericardium and myocardium. These techniques can help differentiate between pericardial and myocardial involvement and assess the degree of fibrosis. Cardiac MRI can assess respirophasic variation in ventricular filling, which is a hallmark feature of pericardial constriction. During inspiration, there may be an exaggerated increase in ventricular filling due to reduced compliance of the constricted pericardium. Learning Points from this Case Pericardial constriction, characterized by impaired diastolic filling due to thickened, fibrotic, and/or calcified pericardium, can be a diagnostic challenge, often requiring the use of multiple imaging modalities which within this case with the correlation between TTE, CMR and CT scan a noninvasive diagnosis can be made.
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Preoperative localization of occult breast lesions and microcalcifications in breast
(Balkan Society of Radiology, 2019-10-17)
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Jakimovska, Maja
Introduction: Early detection of occult breast lesion and microcalcifications can reduce mortality of breast carcinoma. The preoperative wire localization of mammographic identified occult breast lesions and microcalcifications is a relatively simple and safe procedure. The wire has been removed at surgery. Purpose: To present a value of preoperative localization in successful removal of occult breast lesions and microcalcifications. Materials and methods: A review of locating procedures done for 35 patients during 2017 – May 2019 period. In our institution both symptomatic and asymptomatic patients undergo mammography. The preoperative wire localization was performed only for mammographic identified occult breast lesions and microcalcifications. We used a perforated mammography compression plate and hook wires. The goal of preoperative wire localization is to place the tip of the needle as close to lesion. Local anesthesia is used in the skin and subcutaneous tissue. Our routine mammograms include a craniocaudal view and oblique view. The patient is always seated for the procedure. The specimen was radiographed in all cases. Results: The study included 35 patients, mean age 52 years. All localizations were performed by radiologists. Surgery was performed by two different surgeons. Reasons for wire localizations were masses (13), calcifications (18) and masses with calcifications (4). Primary malignancy detected in 20 patients, CIS in 5 patients. We were not aware of any infections or other complications that resulted from this procedure in our series. The localization procedure takes approximately 45 minutes. Conclusion: Preoperative wire localization of breast lesions is an integral component of the early detection of breast carcinoma.
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MRI SIGNS IN METHOTREXATE-RELATED LEUKOENCEPHALOPATHY IN CHILDREN WITH BURKITT LYMPHOMA-ABDOMINAL MANIFESTATION
(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2024-01)
Mihajlovska Michevska, Tamara
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Gjorgjioska, Stefani
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Jukikj, Edis
Burkitt lymphoma, classified as a subtype of non-Hodgkin lymphoma, primarily targets children. It frequently presents with extranodal involvement, often manifesting as an abdominal or pelvic mass upon initial presentation. Treatment regimen commonly incorporates chemotherapy, wherein the prognosis, particularly in pediatric cases, is notably favorable, with survival rates exceeding 90%. However, the utilization of methotrexate, a chemotherapy agent employed in hematological malignancies and other neoplasms, warrants careful consideration due to its propensity for neurotoxicity. Methotrexate-induced neurotoxicity may be presented across a spectrum of acute and chronic leukoencephalopathies. One significant manifestation is toxic encephalopathy, characterized by its predominant affliction of subcortical white matter. Additionally, notable findings include confluent hyperintensities observable on T2 and FLAIR imaging, particularly evident in the centrum semiovale region. Magnetic resonance imaging (MRI) stands as the preferred diagnostic modality. This non-invasive and sophisticated imaging technique holds immense clinical and research utility. Leveraging MRI enables early detection of neurological conditions, facilitates ongoing monitoring of treatment outcomes, and supports timely interventions, thereby offering significant benefits in patient’s care. We report the case of a 4-years-old patient diagnosed with Burkitt lymphoma, who underwent an MRI scan following symptoms of blindness and convulsions. Initial CT scans showed no discernible pathology. Subsequent MRI findings revealed signal abnormalities, typical of methotrexate-related leukoencephalopathy. Notably, convulsions ensued shortly after initiating methotrexate treatment. These MRI findings are characteristic of toxic encephalopathy, highlighting the importance of vigilant monitoring in patients undergoing methotrexate therapy.
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Endovascular Thrombectomy in a 72-Year-Old Stroke Patient: A Case Study
(Macedonian Association of Radiologists, 2023-11)
Stamenkovski, Nikola
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Daskalov, Dejan
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RUPTURED HEPATIC ARTERY ANEURYSM SUCCESSFULLY TREATED WITH DUAL-LAYER STENT ENDOVASCULAR TREATMENT: CASE REPORT AND LITERATURE REVIEW
(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024)
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Spontaneous rupture of a hepatic artery aneurysm into the peritoneal cavity is a serious life-threatening complication related to hemodynamic instability and high mortality rate. We present a case of a hepatic artery aneurysm complicated with intraperitoneal bleeding and successfully treated with endovascular stent insertion. A 78-year-old male patient was admitted to a tertiary care center due to an abdominal pain and a large amount of free fluid in the peritoneal cavity. The diagnostic paracentesis confirmed hemoperitoneum. The CT scan revealed an aneurysm of the common hepatic artery that was successfully treated with an insertion of a dual-layered carotid stent. Endovascular stent insertion of a ruptured aneurysm of the common hepatic artery is an effective therapeutic procedure that can provide a definitive curative treatment in some patients.

Hadji-nikolova, Natasha

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