Spasovski, Dejan
Preferred name
Spasovski, Dejan
Official Name
Spasovski, Dejan
Main Affiliation
99 results
Now showing 1 - 10 of 99
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, - Some of the metrics are blocked by yourconsent settings
Item type:Publication, IMPACT OF INITIAL RENAL INVOLVEMENT AND BENCE JONES PROTEINS IN THE URINE ON OVERALL SURVIVAL OF PATIENTS WITH MULTIPLE MYELOMA(Macedonian Association of Anatomists, 2022); ; ; ; Ridova, Nevenka - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The evaluation of some markers of proximal renal tubules damage in patient with psoriatic arthritis(Macedonian Medical Association, 2018); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE RELEVANCE OF PREDICTING RHEUMATOID ARTHRITISSEVERITY: FACILITATING EARLY TREATMENT IN POOR PROGNOSISAND PROGNOSTIC LABORATORY MARKERS OF JOINT DAMAGE(Macedonian Association of Anatomists, 2021-07-26); ; ; ; Simultaneous testing especially of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF), which are reversible measures of inflammation, together with clinical variables of inflammatory synovitis are recommended for evaluation of disease activity. In this study 35 patients (pts) with early RA were included, while 35 pts were in the healthy control group. Pts were treated with Methotrexate at an average dose of 10 mg once weekly. RA was evaluated following the dynamics of changes of the mean values of ESR, CRP and RF. Statistical analysis showed statistically significant differences among mean values of ESR in the four time intervals (p= 0.00002). Regarding CRP, there were statistically significant differences among mean values in all four time intervals (p= 0.0428)(standard deviations were with great variations). There were no statistically significant differences of RF in the four time intervals (p= 0.573). We found high values of CRP and RF in most of the patients. In spite of the therapy with Methotrexate, disease progression continues especially in patients with elevated values of ESR, CRP and RF, which are shown as predictors for aggressive course of disease. This enables selection of high risk groups of patients for aggressive course of disease and points to the need of early and aggressive treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HOW WE TREATED ACUTE PROMYELOCYTIC LEUKEMIA: WHERE WE ARE NOW?(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Haploidentical Stem Cell Transplantation in Patients with Myelodysplastic Syndrome: Case Report First Experience(Scientific Foundation SPIROSKI, 2021-11-23); ; ; ; Popova-Labachevska, Marija<jats:p> BACKGROUND: Allogeneic stem cell transplantation (ASCT) is a potentially curative therapeutic approach in patients with intermediate and high-risk myelodysplastic syndrome (MDS). If a family sibling or unrelated donor is not available mismatched donors are viable option for young patients with no comorbidities. The aim of this case presentation was to evaluate our first experience with haploidentical transplantation for this indication. CASE PRESENTATION: We present a case of 50 years male patient with myelodysplastic syndrome (MDS) diagnosed at University Clinic for hematology, Skopje, North Macedonia. Patient was scored in IPSS -R as high risk patient. He was referred for HLA DNA typing of family siblings and since he didn’t have identical sibling and unrelated donor, he was referred to continue treatment with haploidentical stem cell transplantation. He received Flu Bu conditioning and PTCY, cyclosporine and MMF for GVHD prophylaxis. Peripheral blood stem cells (PBSC) from his mismatched brother were infused in the amount of CD34=5.8x106/kg. He experienced prolonged engraftment, severe infective bacterial infections and CMV reactivation with clinical manifestation of CMV colitis. He was successfully treated with antiviral drug and completely resolved. His bone marrow analysis showed complete remission and chimerism evaluation revealed high donor engraftment. Patient is now +34 months post transplant in complete remission. CONCLUSION: The use of a mismatched donor increases the risk of NRM, but there is also evidence to suggest that an haploidentical donor is a valid choice, as general outcome appears to be at least similar to MUD.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Novel immune modulating therapy: Tocilizumab in patients with rheumatoid arthritis refractory to basic therapy(2010-09-22) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Trunk/Legs Dual Energy X-Ray Absorptiometric Index Of Abdominal Obesity In Diagnosing Visceral Obesity In Cushing’s And Obese Women(2020); ; ; Maja DimitrovskaObjectives: Obesity and especially central body fat distribution (BFD) are known risk factors for cardiovascular and metabolic diseases. Android obesity in Cushing’s syndrome (CS) and in non CS abdominally obese women with the metabolic syndrome, which is predominantly visceral, intra-abdominal, is more predictive of adipose-related comorbidities than gynecoid obesity, which has a relatively peripheral (gluteal) distribution. Determination of dual-energy x-ray absorptiometric (DXA) indexes cut-off point values of abdominal obesity is very important to discover obese women with abdominal obesity. The aim of this study was to determine cut-off point values of DXA indexes of central, abdominal obesity determined as a ratio of trunk to legs tissue and fat mass and their percentages that best differentiate CS and O and confirm central, abdominal obesity. Material and Methods: DXA assessment of body composition and BFD was performed in two groups of women, each consisting of 21 subjects: 1st group of CS with clinically confirmed CS with Body Mass Index (BMI) (30.03±6.49 kg/m2 ) and age of 42.98±13.27 years and 2nd group of obese women (O), matched with CS according to their BMI (29.91±6.12 kg/m2 ) and age (41.04±12.85 years). Trunk/Legs tissue mass ratio (Tr/L-T), trunk/legs fat mass ratio (Tr/L-F), trunk/legs tissue % fat mass ratio (Tr/L-T%f) and trunk/legs fat mass % ratio (Tr/L-F%) were determined as indexes of central, ab - dominal obesity and their cut-off point values that best differentiate CS women from O were also determined. Sensitivity (S), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV) and DG (diagnostic accuracy) of these idexes were determined. Results: Tr/L-T values in CS were 2.05±0.44, significantly higher compared to 1.42±0.28 in O, and Tr/L-F values in CS 2.33±0.55 were also significantly higher compared to O (1.39±0.66) (p<0.0001). Tr/L-T%f values in CS were 1.15±0.14, significantly higher compared to 0.94±0.22 in O, as well as Tr/L-F% values of 1.18±0.12 in CS were significantly higher compared to O (0.94±0.68) (p<0.0001). Tr/L-T cut-off point value of 1.6 best differentiated CS from O for DG of 88.89% and Tr/L-F cut-off point value of 1.8 best differentiated CS from O for DG of 88.89%. Tr/L-T%f value of 1.0 differentiated CS from O for DG of 72.22% and Tr/L-F % value of 1.1 differentiated CS and O for DG of 77.78%. Tr/L-T and Tr/L-F differentiated CS and O with higher diagnostic accuracy. Tr/L-T with higher sensitivity of 94.44% and NPV value of 93.75% differentiated CS from O compared to the Tr/L-F correspondent values 83.33% and 85%. Conclusion: Tr/L-T and Tr/L-F DXA indexes cut-off point values of 1.6 and 1.8 best differentiated CS women from matched O women with high diagnostic accuracy. They confirmed abdominal, visceral obesity in CS with significantly higher values in CS compared to obese women and could be used as diagnostic indexes of abdominal obesity. Tr/L-T%f and Tr/L-F% indexes differeniated the two examined groups with lower diagnostic accuracy and are not useful in diagnosing abdominal obesity. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prospective study of needle fasciotomy for dupuytren’s contracture with three years follow-up(2018-10-10)