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    How to prevent skin damage from air pollution. Part 1: Exposure assessment
    (Wiley, 2020)
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    Boev, Blazho
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    Mirakovski, Dejan
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    Petrov, Andrej
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    Darlenski, Razvigor
    Both epidemiological and experimental studies have demonstrated the crucial connection between air pollution exposure and skin disorders. The exact mechanisms by which air pollutants mediate skin damage remain largely unknown. Therefore, it is very necessary to investigate the mechanism of air pollution-induced skin damage and explore some potential protective and therapeutic methods. In this review, we focus on the qualitative and quantitative skin exposure assessment methodologies-a relatively new field of interdisciplinary research.
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    Scleredema of Buschke associated with lichen sclerosus: Three cases
    (Imaging Science Today, 2020)
    Venturi, Michela
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    Ferreli, Caterina
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    Pinna, Anna Luisa
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    Atzori, Laura
    Scleredema adultorum of Buschke is a rare fibromucinous, scleroderma-like connective tissue disease most commonly found in a post-infectious setting or linked to hematological disorders or diabetes. Lichen sclerosus et atrophicus is an autoimmune condition only in 2.5% of cases localized exclusively at an extragenital site, occurring in up to 34% of patients in association with other autoimmune diseases such as vitiligo, thyroid disorders, alopecia areata, lichen planus, morphea, pernicious anemia and systemic lupus erythematosus. In particular, a stronger link with an autoimmune background in lichen sclerosus et atrophicus has been observed in women who showed higher prevalence for autoimmune conditions and circulating autoantibodies. Literature reveals a genetic susceptibility linked to specific HLA types. We report three patients who developed lichen sclerosus et atrophicus superimposed on skin involved by scleredema adultorum of Buschke. Although the association of lichen sclerosus et atrophicus with scleredema adultorum of Buschke could be coincidental, both diseases could be considered part of the spectrum of sclerodermoid disorders with common underlying pathogenetic mechanisms; which could explain the sequential or simultaneous occurrence of both lesions in our patients.
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    Hydroxyurea Associated Cutaneous Lesions: A Case Report
    (Scientific Foundation SPIROSKI, 2018-08-20)
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    Hydroxyurea (HU) is an antimetabolite agent that interferes with the S-phase of cellular replication and inhibits DNA synthesis, with little or no effect on RNA or protein synthesis. It is used in the treatment of many myeloproliferative disorders (MD) and is particularly a first line treatment drug for intermediate to high-risk essential thrombocythemia. Although safe and very well tolerated by the patients suffering from MD, there have been numerous reports of a broad palette of cutaneous side effects associated with prolonged intake of the medication. These may include classical symptoms such as xerosis, diffuse hyperpigmentation, brown-nail discolouration, stomatitis and scaling of the face, hands, and feet or more serious side effects such as actinic keratosis lesions, leg ulcers and multiple skin carcinomas.
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    Unsuccessful treatment of progressive macular hypomelanosis with oral isotretinoin
    (Wiley Online Library, 2017)
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    Lence Neloska
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    ПРИКАЗ НА СЛУЧАЈ (MYCOSIS FUNGOIDES),ХИПО-ХИПЕР ПИГМЕНТИРАН ТИП
    (Association of the Albanian Doctors from Macedonia, 2019)
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    Mycosis fungoides е најчеста варијанта на кутаните Т-клеточни лимфоми и е типичен кај повозрасната популација. Во повеќето случаи е индолентен со спора еволуција од макулозна кон плакарна, на крајот со туморски промени на кожата. Во подоцнежните стадиуми со зафаќање на лимфните јазли и висцерализација. Даваме приказ на случај со ретка форма на хипо – хиперпигментиран Mycosis fungoides кај млада пациентка на 26 годишна возраст. Хистопатолошки верифициран, направени две биопсии, дијагнозата е потврдена и со имунохистохемија. Спрема ревидираната класификација за стејџинг (ISCLE/EORTC 2007) пациентката е во IB стадиум. Применета терапија кај пациентката PUVA (Psoralen +UVA) 35 сесии. На последната контрола во септември 2015 без знаци за прогресија на болеста.
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    Comorbidities as Risk Factors for Acute and Recurrent Erysipelas
    (ID-Design/Scientific foundation SPIROSKI, 2019-03-30)
    Vesna Brishkoska-Boshkovski
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    Andrej Petrov
    Erysipelas is a common infectious skin disease. A typical feature of erysipelas, especially on the lower limbs, is the tendency to reoccur and the study aimed to define the comorbidities associated with it.
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    How to prevent skin damage from air pollution part 2: Current treatment options
    (Hindawi Limited, 2021-11)
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    Darlenski, Razvigor
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    Damevska, Stefana
    In the first part of this review, we have summarized the methods used to examine skin exposure to air pollution and the fundamental concept of skin-exposome interactions. Part 2 of this review focuses on dermatoses, whose aggravation or initiation by air pollution has been confirmed in evidence based medicine manner. Based on the model of photodermatology and photodermatoses, we propose a new concept of "polludermatoses." A key feature of this concept is identifying patients at risk, which will reveal the noxious effects of air pollutants on skin health. Identifying clinical signs of pollution-damaged skin could be beneficial in categorizing conditions caused or exacerbated by exposure to air pollution. Finally, we discuss the current treatment options and the pathogenetic processes targeted by these therapeutics or the development of novel treatment modalities.
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    Dermatologische Erkrankungen bei Palliativpatienten: eine prospektive Studie an 271 Patienten
    (Wiley Online Library, 2017-06)
    Lenche Neloska
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    Andjelka Kuzmanova
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    Lidija Pavleska
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    Adult-onset Still's disease as a cutaneous marker of systemic disease
    (Elsevier BV, 2019)
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    Katlein França
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    Filip Gucev
    Adult-onset Still's disease (AOSD) is a rare, systemic, inflammatory disorder characterized by spiking fevers, an evanescent eruption, arthritis, and multiorgan involvement. The disease has been recently classified as a polygenic autoinflammatory disorder at the "crossroads" of autoinflammatory and autoimmune diseases. The highly characteristic salmon-colored eruption is a cutaneous manifestation of a generalized inflammatory reaction and an important diagnostic criterion. In addition to the evanescent eruption, there are atypical persistent papules and plaques in many patients with AOSD. Emerging data suggest that AOSD with this typical evanescent eruption has a different clinicopathologic presentation and clinical course than AODS with atypical cutaneous manifestations. It appears that there are two subtypes of AOSD with different immunologic profiles, including (1) a systemic disease with high fever, organ involvement, and elevated levels of ferritin, and (2) a chronic disease course with arthritis as the predominant finding. These observations provide novel insight into the disease pathogenesis, suggesting that the underlying mechanisms might differ between these two forms, partially explaining the reported differences in drug response. Recent advances in the understanding of AOSD are summarized with a focus on the spectrum of cutaneous manifestations and its relationship to systemic inflammation.