Belakaposka, Viktorija
Preferred name
Belakaposka, Viktorija
Official Name
Belakaposka, Viktorija
Main Affiliation
Email
viktorija.belakaposka@medf.ukim.edu.mk
24 results
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Item type:Publication, INFORMED CONSENT IN GENETIC REASEARCH(Macedonian Association of Anatomists and Morphologists, 2023); ; ; ; Recognizing the ethical, legal, and social implications (ELSI) of genetic testing becomes crucial for physicians in the face of complex medical issues, as they are increasingly expected to counsel their patients regarding the medical, psychological, and social responses arising from genetic information. Genetic medicine, with its extreme complexity and the potential repercussions on an individual's life, raises important questions in the ethical, deontological, and legal realms of medicine, playing a primary role in personalized medicine. The aim of this paper is to underscore the significance of informed consent and to provide insights into the ethical procedures associated with genetic testing. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, TIME-DEPENDENT EXPRESSION OF IL-1β mRNA - A PRELIMINARY STUDY FOR POSSIBLE WOUND AGE MARKER(Macedonian Association of Anatomists and Morphologists, 2023); ; ; ; Siamkouri, RosicaAccurate estimation of wound age is a very important task in forensic medicine field, because it can helps in reconstruction of crime scene. IL-1β is proinflamatory cytokine and plays a major role in wound healing process. The aim of the study is to develop a method for the reliable estimation of dermal injury age. In this study the expression of IL-1β mRNA was evaluated by real-time PCR at skin human wounds with different post-injuried period. We collected 27 human skin wound samples from forensic autopsy cases at our Institute. In our study were include samples from lacerations, incised wounds and stab wounds, with a known time of injury and death. Wound samples were divided into five groups: control group (n=5); first group consisted of cases with immediate death (n=7); second group consisted of cases with survival from 1 hour to 6 hours (n=5); the third group comprised cases with survival from 6 hours to 72 hours (n=3); the fourth group comprised cases with survival from 72 hours to 168 hours (n=7). In this study we detected increased expression levels of IL-1 β mRNA in the second group with survival time from 1 to 6 hours. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Drug-related deaths linked with concomitant use of methadone and benzodiazepines in the period between 2011 and 2015 in the Republic of Macedonia(Macedonian Pharmaceutical Association, 2016); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Age identification in children and youngsters(Slovenska Sudnolekarska Spolovnost Slovenskej Lekarskej Spolocnosti, 2017-05); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Morphology of microglia in cerebral contusions(Macedonian Association of Anatomists and Morphologists, 2015); ; ; ; - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Importance of quality control in sample preparation workflow of forensic degraded samples for massively parallel sequencing (MPS)(IAR Publishing, 2023); ; ; ; Molecular genetic analyses occupy a significant part of laboratory tests in forensic practice. Pre-prepared commercial kits used for DNA extraction are an excellent choice for samples provided by living people, but in forensic practice, most of the samples that undergo molecular processing are often degraded and may pose a challenge in the laboratory. A special challenge is to provide quality genetic material from post-mortem samples that would be suitable for further analysis with massively parallel sequencing. The aim of this paper is to evaluate the applicability of two silica-based DNA extraction methods for post-mortem blood samples with varying storage time and degrees of degradation, and also, to establish proper quality control in sample preparation workflow for Massively Parallel Sequencing using Ion Torrent GeneStudio™ S5 platform. The study was performed on 48 blood samples with different storage time. Silica-based DNA extraction protocols was applied and quantification was made using Qubit 3.0 fluorimeter, followed by Real-Time PCR quantification. The results indicate high variability between the obtained DNA quantities from post-mortem blood samples with different storage time. Correlation was determined between storage time and sample quantity and quality. The Qiagen Mini Kit & Micro Kit are applicable for DNA extraction from blood samples with various storage periods and degradation levels, which can be used for further NGS analyses after careful quality control and optimization of library preparation conditions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Alcohol involvement in fatal traffic accidents(Macedonian Pharmaceutical Association, 2022); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Siderophages as parametar determing age of cerebral contusions(Medical Faculty, Ss Cyril and Methodius University in Skopje, 2015); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The power of forensic DNA data bases in solving crime cases(Elsevier Ireland Ltd., 2017-09-18); ; ; ; Forensic DNA databases constitute an important investigative resource in contemporary criminal justice systems. The centralized and computerized storage of DNA profiles in a database enables the systematic comparison and automated matching of crime scene samples and individual profiles. Many countries operate forensic DNA-databases to identify owners of crime related stains. Using DNA to trace people who are suspected of committing a crime has been a major advance in policing. When DNA profiling is used wisely it can help to convict people who have committed serious crimes or exonerate people who are innocent. DNA database is a computer database containing records of DNA profiles. Usually there are two different sources of these DNA profiles: crime scene DNA samples and individuals’ DNA samples. The use of DNA databases in criminal investigations requires an individual’s identity to be revealed only if there is a match between their DNA profile and a crime scene DNA profile. We present two homicide cases where killers where identified by comparing the unknown STR’s profile found on ropes, which were used to tie the victims, and exhibit from the crime scene with the Macedonian forensic DNA database stored in Forensic department of MIA. Statistical analyses were performed using DNA View software.
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