Popovska, Mirjana
Preferred name
Popovska, Mirjana
Official Name
Popovska, Mirjana
Main Affiliation
Email
mpopovska@stomfak.ukim.edu.mk
9 results
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Item type:Publication, Rational development of nanomedicines for molecular targeting in periodontal disease(Elsevier BV, 2018-09); ; Recent advances in understanding the etiology and pathogenesis of periodontal disease and polymicrobial synergy in the dysbiotic oral microbial community endorsed novel therapeutic targets and assured further improvement in periodontal disease treatment. Moreover, understanding of the events at the molecular level inspired the researchers to alleviate the stress from the disease by applying the bottom-up approach and delivering the drugs at the site of action, using nanoscale medicines. This review is focused on promising strategies for rational design of nanopaharmaceuticals for periodontal disease treatment based on novel therapeutic targets and the potential of advanced concepts for inflammation cascade targeting. Due to their size, nanomedicines are capable to interact with the elements of the immune system through cell receptor binding and to subsequently influence specific intracellular signaling pathways activation. They might also interfere with different signaling molecules continuously involved in the disease progression, in order to abolish cell activation and block the production of proinflammatory substances. Different biomacromolecules can be trafficked to the site of action using nanomedicines for gene targeting: i) decoy oligodeoxynucleotide (ODN) for suppression of NF-κB transcription activity, ii) DNA therapeutics for modulation of cell inflammatory response and iii) siRNA for cytokine production silencing. However, despite the potential of the nanotechnology for improvement of periodontal disease treatment, the translation of nano-drug delivery systems to clinical therapy is hindered by the lack of standard procedures for proper safety and efficacy profile evaluation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The impact of doxycycline use in periodontitis related periopatogens(International Dental Journal and Elsevier, 2024-10); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Oral Health Status in Diabetic and Non-Diabetic Patients on Maintenance Hemodialysis Treatment(Balkan Cities Association of Nephrology, Dialysis, Transplantation and Artificial Organs, 2022); Introduction. Uremic toxins and inflammation influence the oral health in patients on maintenance hemodialysis treatment. The presence of diabetes additionally aggravates the oral status. The aim of the study was to compare the oral health status in diabetic and non-diabetic patients on chronic hemodialysis program. Methods. Observational, cross-section, monocentric study was conducted in 72 hemodialysis (HD) patients divided into two groups regarding the presence of Diabetes mellitus (DM). Demographic characteristics as patients age, dialysis vintage, laboratory inflammatory markers as C-reactive protein (CRP), albumin and Interleukin 6 (IL-6) were measured at the start of the study. Also, uremic small and middle molecules as blood urea nitrogen (BUN), creatinine, β2-microglobilin (β2M), myoglobin, albumin, free light chains kappa (FLC-k), and free light chains lambda (FLC-λ) were analyzed. Patients were examined by a dentist specialist scoring the oral hygiene index (OHI) by Greene Vermillion as good, fair and poor. Presence of hyperkeratosis, periodontal disease, erosions, ulceration, erythema, pigmentations, tongue coating and uremic fetor were notified. Gingival hyperplasia (GH) was scored (1-3) with 3 for the worst score. Data was presented as mean and standard deviation for continuous and percentages for nominal values. X squared Fisher exact and Mann Whitney test were used for statistical analysis. P<0.05 was considered as significant. Results. The patients from group 1-with DM (N=26) didn’t differ from the non-diabetic group (N=46) in respect of gender, age but had significantly shorter dialysis vintage (48.68±37.45 vs. 88.13±63.29, p=0.02, respectively). From the inflammatory markers only Il6 was significantly higher in DM patients (p=0.03). All the analyzed uremic toxins-small and middle molecules also didn’t differ between the two groups. Diabetic patients were at 3 fold risk for manifestation of fissure, 4 fold risk for pigmentations and 7 fold risk for erythema (OR 3.58; CI:1.017-12.380, p= 0.003; OR 4.12; CI:0.684-22.870; p=0.02, OR 4.84; CI:1.343-17.498, p=0.000), (OR 7.25; CI:1.123-46.880, p=0.000), respectively. GH was more likely to be present in diabetic patients (35%, 54%, 11% vs 83%, 15, 0%, p=0.000, respectively). The presence of hyperkeratosis, periodontal disease, erosions, didn’t differ between the groups. Patients with DM were found with higher percentage of bad oral hygiene index (38% vs 20%), but the overall comparison of OHI showed no significant difference. Conclusion. Oral health is significantly deteriorated in dialysis patients, especially in those with inflammation. Diabetic patients are at higher risk of developing changes in the oral health status. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SKIN MANIFESTATIONS IN CHILDREN WITH COVID 19(Macedonian Association of Anatomists, 2022); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ASSOCIATION BETWEEN ANATOMICAL ANDMORPHOLOGICAL FEATURES OF THE DENTAL ROOT AND PERIODONTAL DISEASE: A COMPREHENSIVE REVIEW(Faculty of Dentistry, University „Ss. Cyril and Methodius“ in Skopje and Macedonian Dental Society, 2024); Introduction.Periodontal disease, as a chronic inflammatory condition affecting the tissues surrounding the teeth, is a major health concern. Various factors contribute to the development and progression of periodontal disease, including genetic component, environmental factors, and specific anatomical and morphological charac teristics of the dental root. Aim: To record therisk factors associated with periodontal disease focusing on the anatomical and morphological characteristics of dental roots. Material and method:A systematic search of databases including PubMed, Scopus and Google Scholar was conducted to identify relevant studies published up to March 2024. The keywords used in search term were “root morphology”, “root concavities”, “root grooves”, “root proximity”, “furcation anatomy” and “periodontal disease”.Selection criteria included English-language studies that provided quantitative or qualitative data on the impact of morphological variation on periodontal health. Results: By reviewing the current literature and numerous empirical studies, this paper elucidates how these anatomical factors contribute to the progression of peri odontal disease and discusses the implications in clinical practice, emphasizing the need for tailored preventive and therapeutic approaches based on individual anatomical conditions. Conclusion:The anatomical and morphological characteristics of the dental root are crucial inthe diagnosis and management of periodontal disease. These features not only affect how the disease starts and progresses, but impact the success of periodontal treatments as well. Dental professionals need to consider these factors in their clinical practice in order to personalize prevention and treatment plans effectively. This can lead to better periodontal health outcomes and help preserve patients’ teeth. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Probiotics and Oral Health(2017-06); ; ; ; Maja PandilovaThe aim of this study was to evaluate the effects of probiotic lozenges as an adjunct to scaling and root planing (SRP) in chronic periodontitis patients. Thirty chronic periodontitis patients divided in examined group (SRP+ probiotic, n=15) and control group (SRP, n=15), were monitored clinically (plaque index(PI), the gingival index(GI), the probing pocket depth(PD), clinical attachment level(CAL) and microbiological parameters were recorded on day 0, and 1 month after therapy. The Prolife lozenges containing: Bacillus coagulans (Lactobacillus sporogenes), Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus bulgaricus, Bifidobacterium bifidum (≥ 2,1 x 109), were used two times a day for 15 days. PI and GI were significantly reduced in both groups (p < 0.05) after the treatment. PD in examined group of 4,93 0,7mm decreased to 3,960,8 mm (p>0,05), versus mean PD of 5,2 0,7 mm in control group that was equally after the treatment (p>0,05). CAL gains of 4,21,3 mm to 3,861,3mm in the examined group versus 4,361,2 mm to 4,2 1,2 (p>0,05) in control group. Microbiological examination demonstrated decreased of quantum of above 100 bacterial colonies of anaerobes and facultative anaerobes, from 66,7% to 33,3% in the examined group, according to 53,3% to 46,7% in control group. Despite data indicate an effect of probiotics on the oral microbiota and a more limited effect on clinical periodontal outcome measures, it can be recommended as a useful adjunct to SRP in chronic periodontitis patients. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular detection of virus herpes simplex type 1 (HSV-1), virus herpes simplex type 2 (HSV-2), Cytomegalovirus (HCMV) and Epstein-barr virus (EBV) in supra-gingival dental plaque in patients with periodontal disease.(2018-12); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular detection of Herpes simplex virus type 1, Herpes simplex virus type 2, Cytomegalovirus and Epstein-barr virus in subgingival dental plaque in patients with periodontal disease(2019-04-17); ; ; Zendeli Bedjeti, Lindita - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Role of the Velopharyngeal Sphincter in the Speech of Patients with Cleft Palate or Cleft Lip and Palate Using Perceptual Methods(Scientific Foundation SPIROSKI, 2016-12-15);