Now showing 1 - 9 of 9
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    Item type:Publication,
    QT prolongation and cardiac toxicity of new tuberculosis drugs in Europe: a Tuberculosis Network European Trialsgroup (TBnet) study
    (European Respiratory Society (ERS), 2018)
    Guglielmetti, Lorenzo
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    Tiberi, Simon
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    Burman, Matthew
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    Kunst, Heinke
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    Wejse, Christian
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    Item type:Publication,
    Association of Inflammatory Markers with Disease Severity and Outcome in Covid-19 Patients
    (Macedonian Academy of Sciences and Arts, 2023-03-01)
    Gjuzelova Aleksoska, Aleksandra
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    Nakova Velkoska, Valentina
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    Metodieva, Marija
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    Stojkoska Jorganovic, Aleksandra
    Objectives: The coronavirus pandemic was associated with a high mortality rate in the Republic of North Macedonia. Finding early markers of the disease's severity may predict outcomes and guide the treatment of the disease. The aim of our study was to evaluate the role of inflammatory markers in predicting the outcome of COVID-19 in hospitalized patients. Methods: The study included 104 PCR-confirmed COVID-19 patients who underwent hospital treatment at the Institute of Lung Diseases and Tuberculosis in Skopje, North Macedonia, between November 2020 and May 2021. Inflammatory markers were assessed in all patients and correlated with the disease severity and outcome in terms of survival or death. Results: IL-6 and LDH at admission were significantly elevated in patients with a severe or critical form of the disease and among non-survivors. In addition, IL-6 showed 87.9% of sensitivity and 61.8% of specificity for distinguishing non-survivors from survivors with a cut-off value of 21.7 pg/ml in the receiver operator curve (ROC). Procalcitonin was significantly increased in non-survivors. Parallel to the increase of disease severity, the values of CRP and LDH increased significantly during hospitalization. Conclusion: The results of the study indicate that a significant association exists between the highly increased levels of CRP, LDH, IL-6 and procalcitonin and the severity of the disease and mortality in COVID-19 patients. Their measurements and follow-up during the course of the disease could be used as predictors for prognosis and outcome but also as a subject for targeted therapy.
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    Item type:Publication,
    Socio-demographic and clinical characteristics of patients with tuberculosis and diabetes in European countries. A TB-net study
    (European Respiratory Society, 2016-09)
    Sane Schepisi, Monica
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    Pontali, Emanuele
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    Manika, Katerina
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    Altet Gomez, M. Nieves
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    Rios Prego, Monica
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    Item type:Publication,
    National advisory services for multidrug-resistant tuberculosis (MDRTB) in Europe: an ERS-TBnet survey
    (European Respiratory Society, 2019-09-28)
    Bothamley, Graham H.
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    Andre, Emmanuel
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    Kuksa, Liga
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    Barkana, Linda
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    Keane, Joseph
    Introduction: Treatment of MDRTB is complex: regimens require microbiological data; adverse events are frequent; availability of drugs and authorization for new drugs varies. The aim of this study was to scope the available national resources. Method: A survey to determine whether practising physicians could access MDRTB advice was sent to TBnet members by email. The ERS Office also contacted national respiratory societies. Questions included the name and contact details for their national advisory service, whether it was national policy to use the service for each patient with MDRTB and whether advice was required to access bedaquiline and delaminid. Results: 65 replies were received (14 were uninformative). 26/31 EU/EEA and 10/19 other countries in the WHO European Region were represented. 7 countries referred all MDRTB to a tertiary centre; 12 countries had tertiary referral centres that also gave advice to physicians treating MDRTB. 11 countries had an electronic system for advice, 6 with multidisciplinary team meetings to review patients’ progress. Lead clinicians were identified for a further 8 countries, one of which had no national advisory service and the other 7 had not responded by the time of abstract submission. For 18 (58%) countries, discussion of MDRTB by a national /regional committee was national policy and most (15/18) required consultation to use bedaquiline or delamanid. Electronic platforms had a wide range of functionality but few retained anonymised data and audited patient outcomes. Conclusion: MDRTB management is often concentrated in tertiary centres. Clinical governance, regarding audit and outcome, are at an early stage in managing MDRTB.
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    Item type:Publication,
    Burden and Characteristics of the Comorbidity Tuberculosis-Diabetes in Europe: TBnet Prevalence Survey and Case-Control Study
    (Oxford University Press (OUP), 2019-01)
    Sane Schepisi, Monica
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    Navarra, Assunta
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    Altet Gomez, M Nieves
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    Dudnyk, Andrii
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    Dyrhol-Riise, Anne Margarita
    The growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment outcomes. We aimed to analyze the prevalence of DM among TB patients and to describe the characteristics and clinical presentation of TB-DM patients in Europe.
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    Key Issues in the Management of Multi-Drug Resistant Tuberculosis: A Case Report
    (ID-Design/Scientific foundation SPIROSKI, 2018-07-20)
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    Global tuberculosis (TB) epidemic is being driven to an increasing extent by the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis complex (MTBC). We present a case of primary multidrug-resistant tuberculosis (MDR-TB), highlighting Macedonian MDR-TB management issues.
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    ANTISYNTHETASE SYNDROME: A RARE AND CHALLENGING DIAGNOSIS – CASE REPORT AND LITERATURE REVIEW
    (Central Medical Library - Bulgaria, 2022-10)
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    Antisynthetase syndrome (ASS) is rare idiopathic inflammatory myopathy (IIM) characterized principally by myositis, generally symmetrical arthritis and interstitial lung disease (ILD) in association with serum autoantibodies to aminoacyl-transfer RNA synthetases. More variable features include arthralgia, Raynaud phenomenon, heliotrophic rash, distal esophageal dysmotility and mechanic's hands. In this case report we describe a 46-years old woman who initially presented with arthritis and subtle myositis which delayed the recognition of ASS and contributed for considering the condition as seronegative rheumatoid arthritis for several years. During the next few years, the patient was progressively worsening, with a disability to stand up from a sitting position, gradual onset of exertional dyspnea, difficult-to-control dry cough and thick, hyperkeratotic skin of both hands (mechanic’s hands). This constellation of symptoms was highly suspicious for ASS and additional serological and radiological examinations were done which confirmed the diagnosis. The need for further detailed investigation when an interstitial lung disease overlaps with a known rheumatoid condition is obligatory, as shown in this case. A multidisciplinary evaluation is highly recommended to evaluate the clinical, serological and radiological findings in each patient suspected for ASS in order to establish early diagnosis and timely management.
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    Scrofuloderma- a rare but serious diagnostic challenge
    (Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2024-04)
    Mitreski, Vladimir
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    Zejnel, Sead
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    Shurbevska, Biljana
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    Stojkovska J., Aleksandra