Popovska jovanovska, Kakja

Preferred name
Popovska jovanovska, Kakja
Official Name
Popovska jovanovska, Kakja
Main Affiliation
Email
kakja.popovska.jovanovska@medf.ukim.edu.mk

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Now showing 1 - 7 of 7
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    Detection of Biofilm Production and Antimicrobial Susceptibility in Clinical Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa
    (Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2022-08)
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    Todosovska Ristovska, Aneta
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    Lameski, Maja
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    Preshova, Ardian
    Acinetobacter baumannii and Pseudomonas aeruginosa are commensal which commonly colonize humans. As a result of their ubiquitous nature, reservoirs in hospital environment and resistance to many antimicrobial agents they are responsible for hospital – acquired infections. Additionally treatment of these infections is difficult because of the ability for biofilm formation. Aim of the paper was to determine the association between biofilm formation on medical devices and antibiotic resistance profile, compared to respiratory samples in clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa. Material and methods: The study comprised 50 clinical samples (36 from medical devices and 14 as а control group from respiratory secretions). Acinetobacter baumannii and Pseudomonas aeruginosa were identified by routine microbiological methods. Modification of the microtiter plate assay described by Stepanovic et al. was used to investigate the formation of biofilm. The antimicrobial susceptibility testing was performed according to EUCAST guidelines. Results: Of the 50 analyzed strains, 16 (32%) were non-biofilm producers, and 34 (68%) were producing biofilms. Out of these, 29 (58%) were from medical devices, and 5 (10%) from the control group. Acinetobacter baumannii showed biofilm formation in 19 (67.9%), of which 17 (60.7%) from medical devices, and 2 (7.1%) from control group. Pseudomonas aeruginosa produced biofilm in 15 (68.1%), of which 12 (54.5%) from medical devices, and 3 (13.6%) from the control group. Multidrug resistance was detected in 40 (80%). All strains of Acinetobacter baumannii were multidrug resistant (MDR). For Pseudomonas aeruginosa, 11 (73.3%) biofilm forming isolates were MDR, and 1 (14.2%) non-biofilm forming isolate was MDR. Conclusion: Biofilm production was higher in strains from medical devices. Eighty percent of isolates were MDR. This is a serious challenge for treatment of these hospital-acquired infections.
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    Susceptibility profile of Candida parapsilosis in critically ill neonates determined with VITEK-2 antifungal susceptibility method
    (INSTITUTE OF PUBLIC HEALTH OF REPUBLIC OF NORTH MACEDONIA, 2011)
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    Progressive increase in the incidence of serious fungal infections during the last decades has been registered. Although spectrum of fungi causing serious infections continues to expand, Candida species remains responsible for most of them. C.albicans is still the most frequent etiological agent, but shift towards non-albicans Candida species has been noticed. From recently, C.parapsilosis is an emerging pathogen that has increased in significance and prevalence. Premature born neonates and patients in intensive care units are at highest risk for severe infection. Due to emerging resistance in Candida species to antifungal agents, there is a need for determination of susceptibility profile of clinically significant yeasts. The aim of this study was to investigate the susceptibility profile of ten blood cultures’ isolates of C.parapsilosis from critically ill neonates to fluconazole, voriconazole and amphotericin B. Antifungal susceptibility testing of all isolates was performed with the automated VITEK-2 method. All isolates of C.parapsilosis were susceptible to the investigated antifungal agents. The emergence of C.parapsilosis as the leading non-albicans Candida species in the etiology of candidemia in critically ill patients poses a major threat for the future. The VITEK-2 system is the first automated approach to antifungal susceptibility testing and provides optimal susceptibility test standardization.
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    Evaluation of Multiplex PCR in diagnosis of invasive infections with Candida species
    (Medical Facilty, Ss Cyril and Methodius University, Skopje, R Macedonia, 2016)
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    Seasonality of Pseudomonas spp. In Surgical intensive Unit
    (DEPARTMENT OF ANAESTHESIA AND REANIMATION, FACULTY OF MEDICINE, “SS. CYRIL AND METHODIUS” UNIVERSITY, SKOPJE, MACEDONIA, 2021)
    Petrovska Basovska Branka
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    Toleska Marija
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    Pseudomonas strains are frequent microorganisms associated to healthcare-acquired infections. Pseudomonas aeruginosa is one of the leading intra-hospital pathogens in the intensive care units. Pseudomonas infections usually present wide antimicrobial resistance in treatment and they are important public health problem. Medical devices are the most often responsible for nosocomial infections in the intensive care centers. Pseudomonas colonization and its ability to form biofilm on medical devices highlights this organism as emergent pathogen at the Clinic for Anesthesiology, Resuscitation and Intensive Care in Skopje. Multidrug-resistant Pseudomonas aeruginosa is an endemic problem in the intensive care units. Also, Pseudomonas spp. strains demonstrate seasonality. This research will investigate its existence on respiratory medical devices (endotracheal tubes and nasal cannulas). The study will determine its seasonal variation and it will indicate preventive medical measures in critical seasons.
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    Isolation of Clostridium difficile and its toxin detection during two years period
    (Faculty of Medicine, Ss Cyril and Methodius University in Skopje, 2008)
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    Zdravkovska, M
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