Panovski, Nikola
Preferred name
Panovski, Nikola
Official Name
Panovski, Nikola
Main Affiliation
Email
nikola.panovski@medf.ukim.edu.mk
30 results
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Item type:Publication, COMPARISON OF THE SUSCEPTIBILITY OF ESBL-POSITIVE AND ESBL-NEGATIVE ISOLATES OF E. COLI AND KLEBSIELLA PNEUMONIAE TO ANTIMICROBIAL AGENTS(Macedonian Association of Anatomists and Morphologists (MAAM), 2014); ; ; The aim of this investigation was to compare the susceptibility between ESBL-positive and ESBL-negative isolates to different antimicrobial agents. Material and methods: A total of 1207 consecutive non-repeat isolates of E. coli and K. pneumoniae-Kp (E. coli-804, Kp-403) were obtained from different clinical specimens from patients hospitalized at the University Clinics in Skopje over a one year period. Conventional microbiological procedures for the isolation and detection of the strains were used. Susceptibility to beta-lactams and non-beta-lactams was determined by standard disk diffusion method and by automated method using Vitek (for determination of the MIC-minimal inhibitory concentration). A total of 251 isolates were selected (E. coli-126 and K. pneumoniae-125) using tests for phenotypic detection of the ESBL-production. A total of 233 randomly selected strains which were ESBL-negative by phenotypic tests (E.coli-130 and K.pneumoniae103) were used as a control strains for susceptibility testing. Results: Difference of the susceptibility to imipenem between ESBL-positive and ESBL-negative strains of E. coli and K. pneumoniae was not detected. Both groups of strains were 100% susceptible to imipenem. Considering the rest of the tested beta-lactams, as well as non-beta lactams and uroantiseptics, there was a difference in the susceptibility comparing both groups of strains of E. coli and K. pneumoniae. This was due to the fact that ESBL-negative strains were highly susceptible to all tested antimicrobial agents, unlike the ESBL-positive ones (except in cases of cotrimoxazole and nitrofurantoin, where the difference in susceptibility between ESBL-positive and ESBL-negative strains of E. coli was not statistically significant, because both groups of strains were susceptible to those antimicrobial agents).These data are important for recommending adequate treatment of infections with ESBL-producing bacteria. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease(Academy of Medical Sciences of Bosnia and Herzegovina, 2012); ; Chronic infections in CHD are due to one or both of the organisms Chlamydia pneumoniae and Helicobacter pylori. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of synbiotic soymilk on intestinal microbiota and lipid profile in adult spontaneously hypertensive rats(SHMSHM/AAMD, 2015); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of VITEK-2 yeast susceptibility test for antifungal susceptibility testing of Candida species to fluconazole(Македонско лекарско друштво = Macedonian Medical Association, 2011); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Етиологија на инфекциите на долните дишни патишта во детската возраст и значењето на директниот микроскопски препарат во нивната дијагностика(Македонско лекарско друштво = Macedonian Medical Association, 2003); ; ; ; Spasenovski, TrajceЦел на испитувањето е да е направи анализа на етиологијата на инфекции на долните дишни патишта (ДДП) кај деца според две различни микробиолошки испитувања: културелно и серолошко; да се компарираат микробиолошките наоди според етиолошкиот агенс (бактериски, вирусни, мешани) со наодите во директиот микроскопски препарат. Беа испитани трахеални аспирати (ТА) и крв од вкупно 118 деца со инфекции на ДДП од Клиниката за детски болести (ноември 2001-март 2002). ТА се испитуваа културелно и микроскопски (епителни клетки и леукоцити). Наодите беа групирани во 3 микроскопски категории: I (>25 ЛЕ, висока гнојност, <10 еп. кл. незначителна контаминација); II (>25 еп. кл. значителна контаминација; <10 ЛЕ ниска гнојност) и III (<10 ЛЕ, ниска гнојност, , <10 еп. кл. незначителна контаминација). Во серумот со Pneumo-slide тест се одредуваа ИгМ антитела на 4 атипични бактерии и 5 вируси. Со позитивен микробиолошки наод беа 109 деца. Докажани беа 243 микроорганизми (58 култивабилни бактерии, 29 атипични бактерии и 156 вируси) со најчеста застапеност на: S. pneumonia (29), M pneumonia (21), H influenzaе (17), C. burneti (7), ентеробактерии (8), Инфлуенца вирус Б (82) и Инфлуенца вирус А (74). Дваесет (18,3%) деца имаа бактериска инфекција, 38 (34,8%) вирусна а 51 (46,7%) мешана инфекција (бактериско/вирусна). Според директните микроскопски препарати, 46 (38,9%) ТА беа во I микроскопска категорија, 31 (26,2%) во II и 41 (34,7%) во III. Микроскопското испитување покажа дека бројот на децата со вирусни инфекции е поголем, 64 (58,7%) од оние со мешани 25 (23,0%). Бактериолошката (културелна+директен микроскопски препарат) и серолошката дијагностика е значајна за детекција на вистински етиолошки агенси на инфекции на ДДП (бактериски, вирусни), за одредување квалитет на примероците за обработка, за примена на соодветна антимикробна терапија. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Susceptibility profile of Candida parapsilosis in critically ill neonates determined with VITEK-2 antifungal susceptibility method(INSTITUTE OF PUBLIC HEALTH OF REPUBLIC OF NORTH MACEDONIA, 2011); ; ; ; Progressive increase in the incidence of serious fungal infections during the last decades has been registered. Although spectrum of fungi causing serious infections continues to expand, Candida species remains responsible for most of them. C.albicans is still the most frequent etiological agent, but shift towards non-albicans Candida species has been noticed. From recently, C.parapsilosis is an emerging pathogen that has increased in significance and prevalence. Premature born neonates and patients in intensive care units are at highest risk for severe infection. Due to emerging resistance in Candida species to antifungal agents, there is a need for determination of susceptibility profile of clinically significant yeasts. The aim of this study was to investigate the susceptibility profile of ten blood cultures’ isolates of C.parapsilosis from critically ill neonates to fluconazole, voriconazole and amphotericin B. Antifungal susceptibility testing of all isolates was performed with the automated VITEK-2 method. All isolates of C.parapsilosis were susceptible to the investigated antifungal agents. The emergence of C.parapsilosis as the leading non-albicans Candida species in the etiology of candidemia in critically ill patients poses a major threat for the future. The VITEK-2 system is the first automated approach to antifungal susceptibility testing and provides optimal susceptibility test standardization. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phenotypic and genetic relationship of Acinetobacter Baumannii isolates(Македонска академија на науките и уметностите, Одделение за биолошки и медицински науки = Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences, 2011); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CHRONIC WOUNDS - MICROBIOLOGY AND BIOFILM FORMATION(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024); ; ; ; Ahtarova, BiljanaIntroduction: Chronic wounds are wounds that do not heal for more than 4 weeks. Among the most important causes of wound chronicity are wound infection, biofilm formation with microbial agents that are resistant to antimicrobial agents. Aim: To investigate microbial agents in chronic wounds, their potential to form biofilm. Material and methods: This was a prospective study involving 24 patients from the University Clinic for in Skopje. Microbiological swabs were taken from patients with chronic wounds on the lower extremities,and were analyzed at the Institute of Microbiology and Parasitology, Faculty of Medicine in Skopje. The biofilm formation potential in isolates was determined using the tissue culture plate (TCP) biofilm detection method. Results: In 17 patients, at least one microorganism was isolated from 23 wounds, a total of 36, and in 7 patients there was no positive isolate from 7 wounds. Eighteen wounds (60%) had an isolate with the potential to form a biofilm. The following microorganisms from the wound samples were recorded: 17 (47%) isolates of the genus Staphylococcus, 4 (11%) isolates each from the genera Proteusand Pseudomonas, 3 (8%) isolates each from Enterococcusand Escherichia, 2 (6%) isolates from Streptococcus, 1 (3%) each isolate from the genera Acinetobacter, Enterobacterand Candida albicans. Conclusion: In 60% of the isolates, a biofilm formation with different degrees was confirmed. A statistically significant association was found between the degree of wound healing and isolates with low potential for biofilm formation, as well as the type of isolate. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of Multiplex PCR in diagnosis of invasive infections with Candida species(Medical Facilty, Ss Cyril and Methodius University, Skopje, R Macedonia, 2016); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phenotipic and genetic relationship of Acinetobacter baumannii isolates(Macedonian Academy of Sciences and Arts, 2011); ; ;
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