Bojadjioska, Maja

Preferred name

Bojadjioska, Maja

Official Name

Bojadjioska, Maja

Main Affiliation

Now showing 1 - 10 of 29

Some of the metrics are blocked by your
consent settings
Severe Complicated secondary antiphospholipid syndrome conjointly with lupus erythematosus -case report
(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2025-01)
Vidinikj, Sonja
;
Antova, Dubravka
;
;
Guchev, Filip
;
Antiphospholipid syndrome (APS), is an autoimmune systemic disorder known to manifest with thrombosis in almost all vessels throughout the body, can also be accompanied by pregnancy morbidity, and is persistent with the presence of antiphospholipid antibodies, including lupus anticoagulant antibodies, or relatively high titers of anticardiolipin, or anti-β2Glycoprotein I antibodies. APS can occur alone or in association with other diseases, more commonly systemic lupus erythematous. In patients with both underlying diseases episodes of arthritis, skin changes in the form of livedo reticularis, thrombocytopenia and leucopenia were more common. Cardiac manifestations have also been reported. Here we present a complicated case of a young female patient with antiphospholipid syndrome and an underlying systemic lupus erythematosus.
Some of the metrics are blocked by your
consent settings
АSSESSMENT OF OSTEOPOROSIS AND OCCURRENCE OF VERTEBRAL FRACTURES IN POSTMENOPAUSAL PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH SMALL DOSES OF GLUCOCORTICOIDS
(Институт за јавното здравје на Република Македонија = Institute of public health of the Republic of Macedonia, 2020-12-11)
;
;
;
Nikolovska-Kotevska, Mimoza
;
Karadzova-Stojanoska, Andzelika
<jats:p>Osteoporosis (OP) is a serious extracorporeal manifestation that occurs in patients with rheumatoid arthritis (RA). One of the risk factors is long-term use of glucocorticoids (GC). Osteoporosis together with the increased risk of vertebral (VF) and non-vertebral fractures (non-VF) in particular has a negative impact on quality of life in patients with rheumatoid arthritis. The aim of the study was to detect the occurrence of OP and VF in postmenopausal patients with RA and their association with long-term use of small doses of glucocorticoids. Material and methods: A total of 46 patients were analyzed. All respondents underwent imaging for osteoporosis evaluation with a DXA scanner (Lunar iDXA, GE) and VF with incorporated Vertebral Fracture Assessment (VFA). Results: The values of bone mineral densities (BMD) were significantly smaller in the group that received glucocorticoids. According to VFA, 37,0% of patients were registered to have a fracture of middle degree, a mild fracture was registered in 19.6% of patients, and severe fractures were registered in 3 patients (6.5%). Conclusion: In postmenopausal patients with RA receiving GC therapy, a more common occurrence of osteoporosis and vertebral fractures was reported compared with the remaining group of RA patients. All patients with RA in menopause need to be screened for timely detection and treatment of osteoporosis and prevention of its complications.</jats:p>
Some of the metrics are blocked by your
consent settings
Satisfaction Level of Rheumatoid Arthritis Patients Enrolled in the Treatment with Subcutaneous Tocilizumab. Journal of Autoimmune Diseases and Rheumatology
(Karachi: Synergy Publishers, 2020)
Filip Guchev
;
;
D. Antova
;
B. Osmani
;
M. Nikolovska Kotevska
Background: The introduction of biological-Disease Modifying Agents (bDMARDs) has allowed serious improvement in the treatment of patients with rheumatoid arthritis (RA) by providing a better quality of life (QoL). Such improvements have been shown in patients using subcutaneous form of Tocilizumab SC (TCZ-SC), a humanized monoclonal antibody against IL-6 receptor. Objective: To assess the subcutaneous treatment satisfaction level and to evaluate the epidemiological profile of RA patients treated with TCZ-SC in North Macedonian Patients with RA. Methods: An observational study was conducted at the University Rheumatology Clinic in Skopje between October 1st and December 15th 2018, including 48 patients who have received TCZ-SC. In order to obtain patient’s satisfaction level and to evaluate the epidemiological characteristics of the patients, a standardized questionnaire was developed. Results: The mean age of the patient’s cohort was 50.9 years and 88.5% of the patients were females. More than half of the patients (58%) had high disease activity with mean disease duration of 5.35 years. Eighty three percent of the patients were entitled to receive subcutaneous TCZ because of the insufficient efficacy of previous treatment, All patients enrolled in the treatment with TCZ-SC, reported to be satisfied or very satisfied with the subcutaneous application of TCZ. They were also very satisfied with the previous education and the opportunity to receive the treatment at home. Conclusions: Tocilizumab as an efficient and well tolerated bDMARD is becoming a standard of care in the treatment of patients suffering from RA, offering unprecedented benefits for QoL improvement and satisfying the patients’ needs for modern and effective treatment.
Some of the metrics are blocked by your
consent settings
Карпал тунел синдром-дијагностичка и клиничка евалуација
(2013-10-02)
Е. Сандевска
;
;
Б. Османи
;
;
С. Павлова
Some of the metrics are blocked by your
consent settings
Rituximab in treatment of a patient with granulomatosis with polyangitis - a case report
(Македонско лекарско друштво = Macedonian medical association, 2023-01)
;
Guchev, Filip
;
Antova, Dubravka
;
Karadzova Stojanovska, Anzhelika
;
Vidinikj, Sonja
ANCA-associated vasculitis (AAV) is a necrotizing vasculitis with few or no immune deposits that can affect predominantly small vessels. It can affect vessels in every organ and tissue of the body; the clinical manifestations of the disease are extremely variable. B-cells are of major importance in the disease pathogenesis as precursors of ANCA-producing plasma cells and, possibly, also as antigen-presenting and cytokineproducing cells. Therefore, rituximab, a monoclonal antibody drug causing partial B-cell depletion, has emerged as a powerful option in the treatment of AAV such as granulomatosis with polyangiitis. We present the case of a 25-year-old female diagnosed with granulomatosis with polyangiitis and treated with rituximab and high-dose corticosteroids.
Some of the metrics are blocked by your
consent settings
Assessment of the risk of vertebral fractures and their incidence in postmenopausal patients with rheumatoid arthritis
(2025-04-10)
;
Guchev, Filip
;
Nikolovska Kotevska, M
;
;
Karadjova Stojanovska, Anzhelika
Objective The incidence of vertebral fractures and their association with the activity, duration of the disease, therapeutic modality, lifestyle, and functional impairments. Material and methods This is a cross-sectional analytical study that includes 150 patients with an established diagnosis of definitive RA according to the ACR (American College of Rheumatology) criteria from 1987, treated on an outpatient and inpatient basis at the University Clinic of Rheumatology in Skopje between 2019-2021. The subjects are females aged 50-80 years, postmenopausal women with a menopause duration of ≥ 2 years. We include patients who have not previously been treated with bisphosphonate therapy. All subjects with RA were treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and/or disease-modifying antirheumatic drugs (DMARDs) and corticosteroids (CS). Results The prevalence of vertebral fractures (VF) in postmenopausal patients with RA is 54.6%. Among 58 patients, VF with grade 2 reduction is 31.3%, mild fracture is 18.0%, and severe fracture is 5.3%. In patients due to CS therapy, there is an increased occurrence of VF, smoking is one of the significant risk factors (p>0.05), along with the duration and activity of the disease, while increased BMI reduces the risk of developing these fractures. In patients with vertebral fractures, osteopenia is registered in 51.2%, normal findings in 28.0%, and osteoporosis in 19.3%. There is a statistically significant association between osteopenia and normal findings versus vertebral fractures (Pearson Chi-square: 4.0793, df=1, p=.043412), as well as between osteoporosis and normal findings versus vertebral fractures (Pearson Chi-square: 4.7127, df=1, p=.029940) Conclusions RA represents a risk factor for the development of osteoporosis and increases the risk of vertebral and non-vertebral fractures in postmenopausal patients with RA. This risk is proportional to the reduction in weight, duration, and activity of the disease.
Some of the metrics are blocked by your
consent settings
PREVENTION OF BONE MINERAL LOSS IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES
(Македонско лекарско друштво = Macedonian Medical Association, 2020)
;
Filip Guchev
;
Mimoza Nicolovska-Kotevska
;
Dubravka Antova
;
Introduction. Corticosteroids are therapeutic support for many medical conditions including systemic inflammatory rheumatic diseases. Secondary osteoporosis is one of the major complications from this therapy. Bisphosphonates are indicated for prevention and treatment of corticosteroid-induced osteoporosis. Aim. In a retrospective cross-sectional study to assess the effect of the early use of bisphosphonates on bone mineral density in patients with inflammatory rheumatic diseases treated with corticosteroids. Methods. We compared bone mineral density in an examined group of 75 posmenopausal women with inflammatory rheumatic diseases on a corticosteroid therapy who were treated early with bisphosphonates, with a control group of 80 postmenopausal women with osteoarthritis who have never been treated with corticosteroids. Bone mineral density was measured at the lumbar spine and left femur using Dual X-Ray absorptimetry in both groups of subjects. Results. Patients with inflammatory rheumatic diseases had an average T-score at the lumbar spine of -2.19, and -1.41 at the left hip. The average T-score for the control group was -2.24 at the lumbar spine and -1.53 at the hip. Difference in T-score at the lumbar spine and the left hip between the two groups was 0.073 and 0.300 (P=0.639 and P=0.048), respectively. There was no statistically significant difference in the T-scores for both groups. Conclusion. Osteoporosis is more prevalent in patients with inlammatory rheumatic diseases, both at the hips and the spine. The early use of bisphosphonates in patients with inflammatory rheumatic diseases, especially in those who are on corticosteroids, can prevent the loss of bone mineral density
Some of the metrics are blocked by your
consent settings
A complicated case of granulomatosis with polyangiitis
(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2025-01)
Guchev, Filip
;
;
Vidinikj, Sonja
;
;
Granulomatosis with polyangiitis, formerly known as Wegener's granulomatosis, is a condition often presenting with granulomatous vasculitis of both the upper and lower respiratory tracts together with glomerulonephritis. Here we present a case of a 17-year-old female patient, who presented with symptoms of pansinusitis with other symptoms gradually following. She was treated with cyclophosphamide which was later switched to rituximab and is now in remission.
Some of the metrics are blocked by your
consent settings
Клиничко-епидемиолошки карактеристики на пациентите со псоријатичен артритис
(МАКЕДОНСКА РЕВМАТОЛОШКА АСОЦИЈАЦИЈА-МААР, 2009-09-30)
Stojanoska, A
;
;
Chalovski, J
;
Pavlova, S
;
Antova, D
Some of the metrics are blocked by your
consent settings
Gastrointestinal Lymphoma in Tertiary Gastroenterology Center: Epidemiological, Clinical and Endoscopic Features
(Македонско лекарско друштво /Macedonian Medical Association, 2017-06-01)
;
;
;
;
Introduction. Within the heterogeneous group of extra-nodal lymphoma, the gastrointestinal tract is the most frequently involved extranodal site accounting for 30-50% of all extranodal cases. Gastrointestinal involvement most oftenoccurs secondarily, while the primary gastrointestinal lymphomasare relatively rare accounting for 30%-45% of all extranodal lymphomas and 0.9% of all gastrointestinal tumors. Within the gastrointestinal tract, lymphoma can arise in any region but the stomach is the most commonly involved organ being affected in 50-70% of all the gastrointestinal lymphomas, followed by the small intestine and ileocecal region. The aim of the study was to analyze and present data regarding the endoscopic aspects and clinical presentation of patients with gastrointestinal lymphoma. Methods. We retrospectively reviewed the medical records of patients with primary or secondary gastrointestinal lymphoma diagnosed at our Clinic over a fifteen-year period (January 1, 1999 to December 31, 2013). We analyzed the demographic data, clinical presentation, anatomic distribution, endoscopic aspect of the lesion, extension of the neoplastic process and occurrence of different histological subtypes. Results. We discovered 18 patients with gastrointestinal lymphoma (7 males and 11 females). Fourteen patients (77.7%) were considered primary, while 4 patients (22.2%) were considered secondary gastrointestinal lymphoma. The stomach was affected in 14 cases (11 primary and 3 secondary), there were 2 duodenal lymphomas, 1 lymphoma of the terminal ileum and 1 peritoneal lymphoma. In most patients (10) massive and diffuse gastrointestinal infiltration was diagnosed, 5 patients had ulcerated lesions in the stomach and 3 patients presented with polyploid mass. Six patients presented with upper gastrointestinal bleeding, 1 patient with biliary tract obstruction, one patient with protein losing enteropathy, malabsorption and consecutive bowel perforation and one patient presented only with ascites and pleural effusion. All the malignant lymphomas were Non-Hodgkin type and among them we registered only one T-cell lymphoma. Being diagnosed in 6 patients (33.33%), diffuse large B-cell lymphoma was the most prevalent histological type. The lymphoma was limited to the gastrointestinal tract in 6 patients, 7 patients had regional nodal involvement, in 2 patients there was an intra-abdominal spread and in 3 patients there was an extra-abdominal dissemination. Most patients received chemotherapy and only 2 patients were treated surgically. Two patients had rapidly progressive clinical course and lethal outcome shortly after the diagnosis was established and before chemotherapy was administered. Conclusion. The gastrointestinal lymphoma has a variable clinical presentation and endoscopic aspect that often makes the diagnosis challenging. Substantial level of diagnostic awareness and comprehensive clinical approach are necessary in order to establish the correct diagnosis, provide appropriate treatment and prolong survival.

Bojadjioska, Maja

Filters

Settings

Sort By

Results per page