Isjanovska, Rozalinda

Preferred name

Official Name

Isjanovska, Rozalinda

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rozalinda.isjanovska@medf.ukim.edu.mk

Now showing 1 - 10 of 29

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Incidence and prevalence of epilepsy in the Republic of North Macedonia: Data from nationwide integrated health care platform
(Elsevier BV, 2021-03-04)
Babunovska, Marija
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Boskovski, Bojan
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Kuzmanovski, I
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This study aimed to evaluate the incidence and period prevalence of epilepsy in the Republic of North Macedonia, an upper-middle-income country with universal access to healthcare, based on a nationwide healthcare platform (NHP).
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Myasthenia Gravis and Associated Diseases
(Scientific foundation SPIROSKI, 2018-03-05)
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Novotni, Gabriela
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Sazdova-Burneska, Slobodanka
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Kuzmanovski, I
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Boshkovski, Bojan
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease caused by the action of specific antibodies to the postsynaptic membrane of the neuromuscular junction, leading to impaired neuromuscular transmission. Patients with MG have an increased incidence of other autoimmune diseases. AIM: to determine the presence of other associated diseases in patients with MG.METHOD: A group of 127 patients with MG followed in 10 years period, in which the presence of other associated diseases has been analysed.RESULTS: The sex ratio is in favour of the female sex, the average age of the initial manifestation of the disease is less than 50 years, 65.4% of the patients with MG have another disease. 15.0% patients have associated another autoimmune disease. Thyroid disease is the most common associated with MG, rarely rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other autoimmune diseases. Other diseases include hypertension, heart disease, diabetes, respiratory diseases, dyslipidemia. 10.2% of the patients are diagnosed with extrathymic tumours of various origins. CONCLUSION: Associated diseases are common in patients with MG, drawing attention to the possible common basis for their coexistence, as well as their impact on the intensity and treatment of the disease.</jats:p>
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Impact of Size of the Tumour, Persistence of Estrogen Receptors, Progesterone Receptors, HER2Neu Receptors and Ki67 Values on Positivity of Axillary Lymph Nodes in Patients with Early Breast Cancer with Clinically Negative Axillary Examination
(2017-12-15)
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The study aimed to identify factors that influence the positivity of axillary lymph nodes in patients with early breast cancer and clinically negative axillary lymph nodes, who were subjected for modified radical mastectomy and axillary lymphadenectomy.
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Overweight hypothesis in asthma and eczema in young adolescents
(Elsevier BV, 2006)
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Stavric, Katerina
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Seckova, Lidija
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Kimovska, Milica
BACKGROUND: A positive association between body mass index (BMI) and allergic diseases has recently been suggested; however the sex-dependence of this association remains controversial. The aim of the present study was to explore the relationship between BMI and asthma and eczema, as well as its sex-dependence in young adolescents. METHODS: Self-reported data obtained through the standardized International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three written questionnaires of 2926 young adolescents aged 13-14 years old from randomly selected schools in Skopje (Republic of Macedonia) were used. The BMI for each individual was calculated and used-both unadjusted and adjusted for confounding factors-as a variable for analysis. The international cut-off points for BMI for overweight and obesity by sex and age were used. Because of the very low prevalence of obesity (1.5 %), obese respondents were included in the overweight group. The data were statistically analyzed by the chi-square test, the t-test for independent samples and odds ratios (OR, 95 % CI) in binary logistic regression. RESULTS: Being overweight was significantly associated with an increased risk of having a dry night cough without a cold or chest infection (adjusted OR: 1.54; 95 % CI: 1.09-2.16; p = 0.01) and with having had self-reported asthma at some time (adjusted OR: 2.36; 95 % CI: 1.02-5.44; p = 0.04) in boys only. A significant association between overweight and other symptoms of asthma or atopic eczema was not established. CONCLUSION: These findings suggest a male-specific positive association between overweight and a current dry night cough and having received a diagnosis of asthma at some time. No association was found with other asthma symptoms or atopic eczema in young adolescents.
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Prevalence of the metabolic syndrome in the Pech district
(Scientific Foundation SPIROSKI, 2018-11-12)
Kerveshi-Sulejmani, Ardita
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Selmanaj, Aferdita
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<jats:p>The metabolic syndrome (MS) is the main clinical and public health challenge in the world, in the wake of urbanization, excess energy intake, increased obesity, sedentary lifestyle and habits. MS leads to a 5-fold increase the risk of diabetes mellitus type 2 (T2DM) and 2 times the risk of cardiovascular disease (CVD) over the next 5 to 10 years. The aim of the research is to determine the prevalence of metabolic syndrome syndrome in the Pech District according to NCEP ATD III / 2001. Material and methods: Cross sectional study was carried out at the General Hospital in Pec, which represents a regional hospital for the Pec District. A total of 1667 patients from the Pech district were interviewed for a period of one year. Results: In the group, MS was present in 506 patients. In the majority of cases, we found the systolic blood pressure condition ≥ 130 mmHg -99.4%, followed by diastolic blood pressure ≥ 85 mmH-96.4%, elevated triglycerides ≥ 1.7 mmol / l- 94.7%, waist circumference> 88 cm in women-94.0% , increased glycemia ≥ 6.1mmol / L in 80.0%, waist circumference > 102cm in men-65.5%, HDL values <1.03mmol / L in men - 56.9% and HDL values <1.03mmol / L in females 51.5%. The mean value of systolic blood pressure in patients with MS is 151.1 ± 9.3 mmHg. The average value of diastolic blood pressure in patients with MS is 91.0 ± 4.7 mmHg. The average waist circumference of patients with MC was 103.6 ± 9.2 cm. The mean HDL of patients with MS is 1.1 ± 0.2 mmol / L. The average glycemic value in patients with MS is 6.5 ± 0.6 mmol / Average triglyceride value in patients with MS and is 2.5 ± 0.8 mmol / L. The most common in patients with MS is obesity / obesity - 70.8%, overweight is 27.8%, and 1.4% normal weight is registered. Conclusions: The prevalence of MS in the Pech district is 30.4% and was approximately as in Croatia 34% and Tetovo region with 28.25%, but it was dependent on the population and definitions used. The metabolic syndrome is one of the major public health problems, and a socioeconomic problem around the world and in Kosovo, too.</jats:p>
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Do household tobacco smoking habits influence asthma, rhinitis and eczema among 13-14 year-old adolescents?
(Elsevier BV, 2011)
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Stavric, Katerina
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Seckova, Lidija
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Kimovska, Milica
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BACKGROUND: Although the harmful impact of environmental tobacco smoke on respiratory health in early childhood is well known, its effect in adolescence is still ambiguous. This study aims to examine if parents' and household tobacco smoking habits influence asthma, rhinitis and eczema in early adolescence in The Republic of Macedonia, as a country with a very high rate of household tobacco smoke exposure despite the smoking cessation campaign, and low prevalence rates of asthma, rhinitis and eczema. METHODS: Children aged 13-14 years (n=3026) from randomly selected schools in Skopje, the capital of Macedonia, completed by themselves the standardised International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three written questionnaires on asthma, rhinitis, eczema and potential environmental risk factors. Maternal and paternal tobacco smoking habits and the number of smokers in households were separately correlated to current and ever-diagnosed asthma, rhinitis and eczema by odds ratios (OR, 95% CI) with and without adjustments for potential confounders using binary logistic regression. RESULTS: The maternal smoking habit was significantly positively associated only with current night dry cough apart from chest infection (aOR: 1.26; 1.03-1.54; p=0.026). No significant association was observed in relation to the other studied variables with either parental smoking habits or the number of smokers in the household. CONCLUSION: Household tobacco smoking habits were not found to have a significant influence on asthma, rhinitis and eczema in young adolescents. The established results point out the dominant influence of maternal smoking on cough as an unspecific asthma symptom.
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Depression and Anxiety in Adolescents and their Caregivers: A Cross-Sectional Study from North Macedonia
(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Walter de Gruyter GmbH/Walter de Gruyter GmbH, 2023-03-01)
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Kunovski, Ivo
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Bolinski, Felix
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Introduction: Mental health problems have increased internationally during the COVID-19 pandemic. Adolescents and their caregivers form a vulnerable group for the development of mental health problems. However, most data stems from high-income countries, and there is a clear lack of prevalence rates and potential risk factors from Balkan countries. No data is available on the impact of the COVID-19 pandemic on mental health in adolescents and their caregivers in North Macedonia. Materials and methods: A cross-sectional study was conducted on adolescents and their caregivers in a school setting in rural and urban areas of North Macedonia. Survey items assessed symptoms of depression, anxiety, and respondents' fear of COVID-19, as well as a number of risk factors, such as gender and living environment. Results: 506 adolescents and 492 caregivers completed the survey. Symptoms of depression and anxiety were mild to moderate in adolescents and their caregivers. Women and girls generally scored higher than men and boys, and adolescents in high school scored higher than those in elementary school. Prevalence rates for depression were 29.2% for adolescents and 10.4% for caregivers, while rates of anxiety were 23.7% for adolescents and 6.1% for caregivers. Conclusion: This study provides a first insight into the mental health of adolescents and their caregivers after the COVID-19 pandemic in North Macedonia. Further research is required to investigate the relatively low rates of caregivers' mental health problems compared to data from other countries.
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Преваленција и фактори на ризик асоцирани со астма, поленска треска и егзема кај школски деца во Република Македонија
(Македонско лекарско друштво = Macedonian medical association, 2007)
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Seckova, Lidija
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За утврдување и компарирање на преваленцијата на астма, поленска треска, егзема и ризик-фактори асоцирани со нив, анализирани се самореферираните податоци од 5507 школски деца од 8 градови во Р. Македонија добиени преку ISAAC фаза 3 прашалниците. Податоците се статистички анализирани со chi-квадрат тест. Генерално во Македонија, во Скопје, Велес, Тетово, Охрид, источна Македонија, е утврдена превеланција за wheezing во последните 12 мес. од 7,0%, 7,2%, 12,0%, 5,0%, 5,9%, 5,6% и за дијагностицирана астма од 1,8%, 2,1%, 1,5%, 2,1%, 2,1%, 1,1%; за риноконјуктивитис во последните 12 мес. од 9,4%, 9,5%, 11,6%, 9,5%, 7,6%, 8,9% и за дијагностицирана поленска треска од 6,3%, 4,4%, 4,9%, 7,4%, 8,2%, 6,4%; за исип со чешање во последните 12 мес. од 4,4%, 3,4, 6,4%, 4,2%, 4,7%, 3,6% и за дијагностицирана егзема од 3,4%, 2,6%, 0,7%, 3,1%, 7,6%, 3,0%. Највисоката преваленција на сите симптоми и тежината на астмата и егземата во Велес би можела да се должи на често конзумирање брза храна и парацетамол и на слаба физичка активност. При компарација на интернационално ниво, Македонија има умерено ниска преваленција на симптоми на астма и поленска треска и ниска преваленција на симптоми на егзема со можност за субдијагностицираност на овие болести.
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Динамика на преваленцијата на астма кај млади адолесценти во 4-годишен временски интервал во Скопје
(Македонско лекарско друштво = Macedonian medica association, 2008)
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Seckova, Lidija
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Kimovska, Mica
Вовед. Испитување на динамиката на преваленцијата на астма и симптомите на астма во 4-годишен временски интервал кај млади адолесценти од Скопје. Методи. Анализирани се самореферираните податоци од прашалникот за астма на Интернационалната студија за астма и алергии во детството-фаза 3, од 3026 испитаници во 2002 год. и 1088 испитаници во 2006 год. од Скопје. За споредување на преваленцијата на астма и симптомите на астма е користен тестот chi-квадрат. Резултати. Во 2006 год. наспроти 2002 год. е утврдена сигнификантно пониска преваленција за wheezing (W) кога и да било (15,3% наспроти 18,4%), W-асоциран со напор во последните 12 месеци (7,9% наспроти 14,2%), сува ноќна кашлица во отсуство на белодробна инфекција во последните 2 месеци (13,6% наспроти 16,5%) и несигнификантно пониска преваленција на W во последните 12 месеци. (7,2% наспроти 8,8%). Обратно, за тежок W во последните 12 месеци и дијагностицирана астма е добиена несигнификантно повисока преваленција во 2006 наспроти 2002 год. Преваленцијата на користење на инхалациски кортикостероиди во однос на дијагностицирана астма кога и да било беше сигнификантно повисока во испитувањето во 2006 год. (3,6% наспроти 2,1%). Само 25,6% од испитаниците кои користеле инхалациски кортикостероиди имале дијагноза на астма.
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Acetaminophen intake and risk of asthma, hay fever and eczema in early adolescence
(2007-09)
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Stavric, Katerina
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Seckova, Lidija
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Kimovska, Milica
A positive association between acetaminophen intake and allergic diseases has recently been reported in developed countries with impaired oxidant/antioxidant balance and promotion of atopy as proposed underlying mechanisms. The aim of the study was to explore the relationship between acetaminophen intake and asthma, hay fever, and eczema in The Republic of Macedonia as a country with acetaminophen intake not physician-controlled, high passive smoke exposure and dietary antioxidant intake, and moderately low prevalence of allergic diseases. Self-reported data obtained through the standardized International Study of Asthma and Allergies in Childhood Phase Three written questionnaires of 3026 adolescents aged 13/14 years from randomly selected schools in Skopje, the capital of Macedonia, were used. The frequency of current acetaminophen intake--both unadjusted and adjusted for confounding factors--was correlated to current and ever-diagnosed asthma, hay fever and eczema by odds ratios (OR, 95% CI) in binary logistic regression. Use of acetaminophen at least once monthly increased the risk of current wheeze (adjusted OR 2.04, 1.31-3.20 p = 0.002), asthma 'ever' (adjusted OR 2.77, 1.06-7.26 p=0.039), current allergic rhinoconjunctivitis (adjusted OR 2.95, 1.79-4.88 p=0.000) and hay fever 'ever' (adjusted OR 2.25, 1.36-3.70 p=0.002). A significant association between frequent acetaminophen intake and atopic eczema and also between infrequent acetaminophen intake and investigated allergic diseases was not established. The findings suggest an increased risk of asthma and hay fever, but not atopic eczema associated with frequent acetaminophen use in a developing country.

Isjanovska, Rozalinda

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