Kafedjiska, Irena

Preferred name

Kafedjiska, Irena

Official Name

Kafedjiska, Irena

Translated Name

Кафеџиска, Ирена

Alternative Name

Kafedziska, Irena

Kafedziska, I

Kafedjiska, I

I Kafedjiska

I Kafedziska

Кафеџиска, Ирена

Кафеџиска, И

Ирена Кафеџиска

И Кафеџиска

Irena Kafedjiska

Irena Kafedziska

Main Affiliation

irena.kafedziska@medf.ukim.edu.mk

irenakafedziska@yahoo.com

Now showing 1 - 10 of 27

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Multicenter, Open-Label, Long-term Extension to Describe the Safety of Tocilizumab in Patients with Early, Moderate to Severe Rheumatoid Arthritis
(Science Publishing Group, 2020)
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Antova, Dubravka
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Kotevska Nikolova, Mimoza
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Stojanovska, Anzhelika
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Myocardial perfusion in patients with systemic lupus erythematosus and low to intermediate risk for coronary artery disease, assessed with 99mtc mibi myocardial perfusion scintigraphy –case reports
(2017-06)
Sandevska, Emilija
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Damjanovska Krstic, Ljubinka
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Objective: Due to early and accelerated atherosclerosis, the patients with systemic lupus erythematosus (SLE), asymptomatic for coronary artery disease (CAD) are in particular risk of acute myocardial infarction (AMI). A diagnostic approach for their risk stratification is needed, followed with appropriate management and treatment. Material and Methods: We present three patents with SLE, from two patients cohorts (younger and older-age group), with SLE history for more than 7 years, with more active phase of disease (SLEDAI score 3-5) and atypical chest pain. With low to intermediate risk for CAD according to traditional risk factors for CAD, but with presence of SLE–related risk factors for atherosclerosis, they underwent 99mTc Myocardial perfusion scintigraphy (MPS) (at rest and stress, as one-day protocol) for evaluation of myocardial perfusion and left ventricular (LV) functional abnormalities. Visual and quantitative analysis of perfusion and functional tomoscintigrams detected the presence of one (in 2 patients) or two vessel’s stress-induced ischemia (in 1 patient), with mild to severe intensity and 10-27% extent of ischemic LV myocardial mass. Regions with the perfusion abnormalities were accompanied with wall motion abnormality during the stress study. The global LV functional parameters were normal in both studies (stress vs rest) with higher transient dilation parameter (TID) in one patient, indicating the presence of more profound perfusion abnormalities. Two patients were referred for angiography which in both cases showed no evidence of significant coronary artery stenosis of the major coronary arteries. Along with their higher levels of serum concentrations of endothelin (ET-1) and C-reactive protein (CRP) the myocardial perfusion abnormalities resemble microvascular functional affection. Conclusion: We emphasize the importance of identification of asymptomatic high CAD risk patients with SLE and CAD evaluation in this patients' cohort in order to prevent premature cardiac death. Determination of the clinical pretest probability for CAD and assessment of myocardial perfusion with non-invasive imaging technique such as 99mTc SPECT MIBI MPS may help in detecting the patients that should be subjected to coronary angiography. Even in the case of microvascular dysfunction, without significant obstruction of coronary vassels, prevention and/or treatment of CAD traditional risk factors and better control of the SLE disease can prevent or postpone the accelerated development of atherosclerosis and the decrease the risk of cardiovascular events.
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99mTc-MIBI GATED-SPECT Myocardial Perfusion Scintigraphy in Asimptomatic patients with Systemic Lupus Erythematosus.
(Medical Facilty, Ss Cyril and Methodius University, Skopje, R. Macedonia, 2018)
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Tanevska, B
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Sandevski, A
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Myocardial Perfusion Abnormalities in Young and Premenopausal Women with Systemic Lupus Erythematosus, Detected with 99MTC MIBI Myocardial Perfusion Scintigraphy - Prevalence and Correlation with Proatherogenic Factors
(Walter de Gruyter GmbH/Macedonian Academy of Sciences and Arts, 2018-12-01)
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Pop-Gjorcheva, Daniela
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Sandevski, Aleksandar
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Atherosclerosis in young and premenopausal women with systemic lupus erythematosus (SLE) is frequent, premature and progressive. Although asymptomatic or with atypical clinical presentation, the patients are at high risk of cardiac events. Aim of this study is to estimate the risk profile for atherogenesis and the prevalence of myocardial perfusion abnormalities with 99mTc myocardial perfusion scintigraphy (MPS) in young and premenopausal women.
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Epidemiological Analysis and Geographical Distribution of Patients Suffering from Rheumatoid Arthritis, Eligible for First-Line Therapy/Monotherapy Treatment with Subcutaneous Formulation of Tocilizumab in the Republic of Macedonia
(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2018-12-01)
Gucev, Filip
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Perchinkova-Mishevska, Snezana
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Bozinovski, Georgi
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Antova, Dubravka
Rheumatoid arthritis is an inflammatory arthritis characterized by synovial tissue inflammation that leads to structural damage and disability. There are several treatment options available, which include glucocorticoids, DMARDs and biologics given alone as monotherapy or in a variety of combinations. Recent evidence has shown that early treatment is important in reducing the rate of progression of erosions and decreasing disability. The lack of adequate statistical data on number of patients that are eligible for first-line therapy/monotherapy of rheumatoid arthritis in Macedonia, triggered this epidemiological analyse describing eligible patients for first-line treatment/monotherapy distributed by gender, age and geographical allocation. The study was conducted by fulfilling a tailored questionnaire every two months in a period of six months (September 2017-February 2018) by including summarized data not related to personal data of patients nor specific drug information. The results have shown that a total of 115 patients in Macedonia are eligible for first-line therapy, whereby 54 (46%) patients were eligible for monotherapy of rheumatoid arthritis. Precise determination of these data provides patients' determination by geographical allocation and proper selection of the best treatment option and optimized therapy for each patient, furthermore when subcutaneous formulation of tocilizumab is available as an effective clinically proven treatment option for RA.
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АSSESSMENT OF OSTEOPOROSIS AND OCCURRENCE OF VERTEBRAL FRACTURES IN POSTMENOPAUSAL PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH SMALL DOSES OF GLUCOCORTICOIDS
(Институт за јавното здравје на Република Македонија = Institute of public health of the Republic of Macedonia, 2020-12-11)
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Nikolovska-Kotevska, Mimoza
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Karadzova-Stojanoska, Andzelika
<jats:p>Osteoporosis (OP) is a serious extracorporeal manifestation that occurs in patients with rheumatoid arthritis (RA). One of the risk factors is long-term use of glucocorticoids (GC). Osteoporosis together with the increased risk of vertebral (VF) and non-vertebral fractures (non-VF) in particular has a negative impact on quality of life in patients with rheumatoid arthritis. The aim of the study was to detect the occurrence of OP and VF in postmenopausal patients with RA and their association with long-term use of small doses of glucocorticoids. Material and methods: A total of 46 patients were analyzed. All respondents underwent imaging for osteoporosis evaluation with a DXA scanner (Lunar iDXA, GE) and VF with incorporated Vertebral Fracture Assessment (VFA). Results: The values of bone mineral densities (BMD) were significantly smaller in the group that received glucocorticoids. According to VFA, 37,0% of patients were registered to have a fracture of middle degree, a mild fracture was registered in 19.6% of patients, and severe fractures were registered in 3 patients (6.5%). Conclusion: In postmenopausal patients with RA receiving GC therapy, a more common occurrence of osteoporosis and vertebral fractures was reported compared with the remaining group of RA patients. All patients with RA in menopause need to be screened for timely detection and treatment of osteoporosis and prevention of its complications.</jats:p>
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Satisfaction Level of Rheumatoid Arthritis Patients Enrolled in the Treatment with Subcutaneous Tocilizumab. Journal of Autoimmune Diseases and Rheumatology
(Karachi: Synergy Publishers, 2020)
Filip Guchev
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D. Antova
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B. Osmani
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M. Nikolovska Kotevska
Background: The introduction of biological-Disease Modifying Agents (bDMARDs) has allowed serious improvement in the treatment of patients with rheumatoid arthritis (RA) by providing a better quality of life (QoL). Such improvements have been shown in patients using subcutaneous form of Tocilizumab SC (TCZ-SC), a humanized monoclonal antibody against IL-6 receptor. Objective: To assess the subcutaneous treatment satisfaction level and to evaluate the epidemiological profile of RA patients treated with TCZ-SC in North Macedonian Patients with RA. Methods: An observational study was conducted at the University Rheumatology Clinic in Skopje between October 1st and December 15th 2018, including 48 patients who have received TCZ-SC. In order to obtain patient’s satisfaction level and to evaluate the epidemiological characteristics of the patients, a standardized questionnaire was developed. Results: The mean age of the patient’s cohort was 50.9 years and 88.5% of the patients were females. More than half of the patients (58%) had high disease activity with mean disease duration of 5.35 years. Eighty three percent of the patients were entitled to receive subcutaneous TCZ because of the insufficient efficacy of previous treatment, All patients enrolled in the treatment with TCZ-SC, reported to be satisfied or very satisfied with the subcutaneous application of TCZ. They were also very satisfied with the previous education and the opportunity to receive the treatment at home. Conclusions: Tocilizumab as an efficient and well tolerated bDMARD is becoming a standard of care in the treatment of patients suffering from RA, offering unprecedented benefits for QoL improvement and satisfying the patients’ needs for modern and effective treatment.
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Асоцијација помеѓу N-Acetyl-B-D-Glukosaminidaza и крвниот притисок кај ревматоиден артритис третиран со кетопрофен и метотрексат
(2009-09-30)
Ј. Чаловски
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Н. Марина
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М. Грличков
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Карпал тунел синдром-дијагностичка и клиничка евалуација
(2013-10-02)
Е. Сандевска
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Б. Османи
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С. Павлова
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PREVENTION OF BONE MINERAL LOSS IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES
(Македонско лекарско друштво = Macedonian Medical Association, 2020)
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Filip Guchev
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Mimoza Nicolovska-Kotevska
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Dubravka Antova
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Introduction. Corticosteroids are therapeutic support for many medical conditions including systemic inflammatory rheumatic diseases. Secondary osteoporosis is one of the major complications from this therapy. Bisphosphonates are indicated for prevention and treatment of corticosteroid-induced osteoporosis. Aim. In a retrospective cross-sectional study to assess the effect of the early use of bisphosphonates on bone mineral density in patients with inflammatory rheumatic diseases treated with corticosteroids. Methods. We compared bone mineral density in an examined group of 75 posmenopausal women with inflammatory rheumatic diseases on a corticosteroid therapy who were treated early with bisphosphonates, with a control group of 80 postmenopausal women with osteoarthritis who have never been treated with corticosteroids. Bone mineral density was measured at the lumbar spine and left femur using Dual X-Ray absorptimetry in both groups of subjects. Results. Patients with inflammatory rheumatic diseases had an average T-score at the lumbar spine of -2.19, and -1.41 at the left hip. The average T-score for the control group was -2.24 at the lumbar spine and -1.53 at the hip. Difference in T-score at the lumbar spine and the left hip between the two groups was 0.073 and 0.300 (P=0.639 and P=0.048), respectively. There was no statistically significant difference in the T-scores for both groups. Conclusion. Osteoporosis is more prevalent in patients with inlammatory rheumatic diseases, both at the hips and the spine. The early use of bisphosphonates in patients with inflammatory rheumatic diseases, especially in those who are on corticosteroids, can prevent the loss of bone mineral density

Kafedjiska, Irena

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