Cvetanovska, Marija
Preferred name
Cvetanovska, Marija
Official Name
Cvetanovska, Marija
Translated Name
Цветановска Марија
Alternative Name
М Цветановска
M Cvetanovska
Cvetanovska M
Цветановска М
Марија Цветановска
Marija Cvetanovska
Cvetanovska Marija
Цветановска Марија
Main Affiliation
Email
marija.cvetanovska@medf.ukim.edu.mk
67 results
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Item type:Publication, SAPS 2 score valid parameter for outcome in severe influenza(Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, R Macedonia, 2021); ; ; ; Cvetanovski, Vlatko - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ARTERIALIZATION OF GREAT SAPHENOUS VEIN IN SITU FOR LIMB SALVATION: OUR CLINICAL EXPERIENCES(Македонско лекарско друштво = Macedonian Medical Association, 2021) ;V Cvetanovski ;A Arsovski ;L Brajevikj ;A MitevskiIntroduction. Critical lower limb ischemia in the ab-sence of distal arterial circulation presents an urgent situation, which must be treated immediately if we want to save the foot or limb from amputation. Approximately 14%-20% of patients with critical lower limb ischemia are unsuited for distal arterial reconstruc-tion and face major distal amputation [1]. Arterializa-tion of great saphenous vein is a unique procedure in which the venous bed is used as an alternative conduit for perfusion of peripheral tissues of lower limb. Methods. We present our clinical experience in 6 patients who underwent in situ arterialization of great saphenous vein for treatment of critical below- and above-knee ischemia. Maintaining the great saphenous vein in situ allows the arterialization with one anastomosis without removing the vein of its original bed. All patients were diagnosed with color Doppler ultrasound and with CT angiography. Results. In all 6 patients we managed to safe the limb or foot from amputation in the first 6 months after the procedure. Postoperative color Doppler ultrasound was performed to assess arterial inflow and arterialized flow in the graft, the anastomosis and venous run-off. In all patients with significant intraoperative reverse flow in upper and below the knee part of great saphe-nous vein the procedures were initially successful. Conclusion. Distal revascularization of the limb with critical ischemia, by creating a reverse flow with in situ saphenous vein arterialization must be seriously considered as an attempt for salvage of the foot or below-knee without distal arterial run-off. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Procalcitonin values as prognostic marker in patients with sepsis and septic shock.(Македонско лекарско друштво = Macedonian Medical Association, 2018); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Seasonal influenza-factors associated with a severe clinical form of the illness.(Македонско лекарско друштво = Macedonian Medical Association, 2016); ; ; ; Kirova Urosevic V - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Osteoarticular Involvement in Childhood Brucellosis(Wolters Kluwer/Lippincott, 2013-08); ;Kirova-Urosevic, Valerija; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute bacterial meningitis – challenges and conclusions(IMAB Peytchinski Publishing Ltd., 2024-10); ; ;Cana, Fadil; Acute bacterial meningitis is an urgent condition characterized by significant morbidity and mortality. In the last decades, epidemiology of the most common etiologic agents as well as the age limit has changed significantly, with dominant involvement of the adult population and population at risk. Streptococcus pneumoniae remains the most common bacteria causing bacterial meningitis. The aim of this study is to observe the changes in the prevalence of etiologic agents and their dominance, the most commonly affected age groups, as well as comorbidities and complications in patients with acute bacterial meningitis treated at the University Clinic for Infectious Diseases in Skopje, R.N. Macedonia. In the last seven-year period, 194 patients with acute bacterial meningitis were treated. The etiologic agent in cerebrospinal fluid was confirmed in 94 (48.45%) patients, with the predominance of S. pneumoniae in 74 (78.72%). L. monocytogenes with 10 (10.63%) and N. meningitides with 6 (6.38%) were less represented. Male sex is dominant with 111 (57.21%) and older age groups as well. More than half of the patients, from the study, belonged to the at risk population with the highest percentage of them presenting with more than two comorbidities, as well as complications. In our study group, 41 (21.13%) of the patients died. Because of the substantial mortality and morbidity, it remains an urgent need to optimally deploy existing vaccines worldwide and develop new prevention strategies and treatment options. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pneumonia impact on the flow and the outcome at patients with seasonal influenza(European Respiratory Society, 2020-09); ; ; ; Abstract Seasonal influenza complications are the cause of development of severe clinical picture as well as death. The most common are the respiratory ones, and the leading one that stands out is the secondary bacterial pneumonia. The aim of this study is determining the pneumonia impact on the severity of the clinical picture as well as the outcome for the patients with influenza. The research is prospectively compared in groups, carried out at University Clinic for Infectious Diseases during a 3-year period. 122 adult patients with clinical and laboratory confirmed influenza have been analyzed. Based on the severity of the clinical picture, patients were divided into two groups, a severe (n=87) and a mild (n=35) form of the disease. During the study demographic, general data, clinical symptoms and signs as well as complications have been recorded. Out of 122 patients with influenza, there were registered complications at 108 (88.52%), with significant appearance in the group with severe influenza 93.1% vs 77.14% (p=0.012). The most common one in percentage is pneumonia 98(80.33%) which also significantly influenced the severity of the disease (p=0.002). Complications such as ABI 8(6.56%), ARDS 7(5.74%), sepsis 5(4.1%), DIC 4(3.28%), and otitis 2(1.64%) have been registered only in the group with severe influenza. At 5(4.1%) patients acute meningoencephalitis has been registered, gastroenterocolitis at 3(2.46%), an hepatic damage at 14(11.47%) of the patients. Pneumonia as the most common complication for patients with severe influenza has significant impact on the clinical flow ant the outcome of the disease. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, FEMOROPOPLITEAL BYPASS VS PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY AND STENTING IN TREATMENT OF PERIPHERAL ARTERY DISEASES OF INFRAINQUINAL SEGMENT – SHORT-TERM RESULTS(Macedonian Academy of Sciences and Arts, 2009-06) ;Cvetanovski V.; ; ;Blazevski B.A b s t r a c t: Critical limb ischaemia is a result of occlusive arterial disease in the infrainquinal segment and is a major indication for arterial revascularization, which implies a femoropopliteal bypass procedure or an interventional procedure – stent grafting of the occluded segment. Although indications for both techniques are clearly defined, there are still controversies. Thus, the aim of this study was to determine shortterm results in patients treated with these two treatment modalities. In the period between 2002 and 2008 a total of 70 patients with occlusive arterial diseases of the low extremity were analysed. In 50 out of 70 patients a femoropopliteal bypass was made. Of these, in 30 (60%) patients PTFE material was used and in 20 (40%) patients an autologous saphenous vein graft was used. The other group comprised 20 patients who underwent stenting. In patients treated with surgical revascularization, the major indication for surgery was occlusive arterial disease in: stage II – in 10 patients (20%), stage III – in 5 patients (10%), stage IV – in 25 patients (50%) and the remaining 10 patients (20%) had subacute ischaemia. Arteriography showed three crural patent tributaries in 18% of the patients, two patent crural tributaries in 40% of the patients and one crural patent tributary in 32% of the patients. There were no significant differences concerning indications and arteriographic findings between the two subgroups. The follow-up period lasted for 6 months and the patency rate was 85% (17) for venous bypass, 11 (64.6%) – short-segment lesions (< 4 cm) and 6 (35.3%) longer segment lesions (> 4 cm) versus 76.5% (23) for PTFE graft (p < 0.05), of which 13 (56.5%) were short-segment (<4 cm) and 10 (43.5%) longer segment lesions (> 4 cm). 106 Cvetanovski M. V., Jovev S. et al. Contributions, Sec. Biol. Med. Sci., XXX/1 (2009), 105–118 The following results were obtained for the second group of patients: initially successful stents in 85%; failure in 15% or 2 patients; technical failure in 1 patient or 5%. After 6 months the patency rate was 75% (15), of which 11 patients (73.2%) had short-segment occlusions (< 4 cm) whereas 4 patients (26,8%) had lesions > 4 cm. The baseline value of the lower limb index (ABI – ankle-brachial index) was significantly increased in both groups, from 0.41 to 0.91 in the group with surgical revascularization and from 0.47 to 0.88 in the second group treated with stenting. The same trend was observed after six months. This study demonstrated a small but significant difference (85% vs 75%, p < 0.05) in favour of the autologous saphenous vein, which should be a preferred graft material in all cases for reconstruction of the femoropopliteal segment. When compared to the overall patency rate of PTFE grafts after 6 months there was no significant difference in patency in the group treated with stent grafting (76.5% vs 75%). However, stenting is a method of choice in the treatment of short-segment occlusions – smaller than 4 cm with good early run off (73.2% vs 64.6%, p > 0.05 p = ns). It is obvious that the results are identical to those in treatment with an autologous great saphenous vein, but in comparison with PTFE the results imply stent usage (73.2% vs 56.5%, p < 0.005). Prosthesis (PTFE) is a graft material of choice when the great saphenous vein is used, damaged or calcified and when the occlusion is longer than 4 cm and is not suitable for stent grafting (43.5% vs 26.6%, p < 0.001). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Developments in surgical treatment of pleural empiema(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University in Skopje, R.N.Macedonia, 2023-12); ;Cholanceski R; ; Thoracic empyema is the accumulation of pus within the pleural cavity. The most frequent cause is direct contiguous spread of infection, the most frequent from lung infection. Current management of empyema is based on local empirical practice as there is no consensus on an optimal regimen. It is estimated that 40% (7-57%) of pneumonia, results with parapneumonic effusion, out of which 10% develop empyema of pleural space. Treatment covers antibiotics, pleural drainage, pleural drainage and use of fibrinolytics, VATS early debridement, VATS decortication, open decortication, open pleural window and thoracoplasty. The choice of adequate treatment is according to stage of empyema: I (exudative stage) - thoracic drainage, II (fibrinopurulent stage) - thoracic drainage with fibrinolytics and VATS debridement or VATS early decortication and for III (empyema in organization stage) - VATS or open decortication or later thoracoplasty. Early VATS debridement effectively manages simple parapneumonic effusions. VATS decortication has efficacy for managing early-stage empyema. In the past (2011-15) period 234 patients with empyema were treated, out of which 124 (52.99%) of empyema were treated with pleural drainage, 105 (44.87%) were treated with open decortication and 5 (2.14%) with thoracoplasty. In the last 6 months of 2023, 21 patients were treated, 19 (90.5%) male and 2 (9.5%) female. Unfortunately, in the last 6 months only 5 (23.8%) of the patients were treated only with pleural drainage, 4 (19%) patients were treated with VATS debridement or early decortication and 12 (57.14%) patients were treated with pleural drainage that finished with open decortication. This situation suggests that, unfortunately, empyema was detected in advanced stage that needed aggressive surgical treatment. Early detection of parapneumonic effusion and treatment in this stage will prevent development of empyema and need of aggressive treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Epidemiology of Community-Acquired Sepsis in Adult Patients: A Six Year Observational Study(Macedonian Academy of Sciences and Arts/Sciendo, 2018-07-01); ; ; ; Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection and it is a major cause of morbidity and mortality worldwide. The aim of this study is to describe epidemiology of community-acquired sepsis in the Intensive care unit (ICU) of the Macedonian tertiary care University Clinic for Infectious Diseases. A prospective observational study was conducted over a 6-year period from January, 2011 to December, 2016. All consecutive adults with community-acquired sepsis or septic shock were included in the study. Variables measured were incidence of sepsis, age, gender, comorbidities, season, source of infection, complications, interventions, severity indexes, length of stay, laboratory findings, blood cultures, 28-day and in hospital mortality. Of 1348 admissions, 277 (20.5%) had sepsis and septic shock. The most common chronic condition was heart failure (26.4%), and the most frequent site of infection was the respiratory tract (57.4%). Median Simplified Acute Physiology Score (SAPS II) was 50.0, and median Sequential Organ Failure Assessment (SOFA) score was 8.0. Blood cultures were positive in 22% of the cases. Gram-positive bacteria were isolated in 13% and Gram-negatives in 9.7% of patients with sepsis. The overall 28-day and in hospital mortality was 50.5% and 56.3% respectively. The presence of chronic heart failure, occurrence of ARDS, septic shock and the winter period may influence an unfavorable outcome. Mortality compared to previous years is unchanged but patients that we have been treating these last 6 years have had more severe illnesses. Better adherence to the Surviving Sepsis guidelines will reduce mortality in this group of severely ill patients.
