Ivcheva, Ana

Preferred name

Ivcheva, Ana

Official Name

Ivcheva, Ana

Main Affiliation

ana.ivceva@medf.ukim.edu.mk

Now showing 1 - 10 of 18

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Unusual cause of death in a patient with Covid-19
(Springer, 2021-09)
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Dzengis, Jasar
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INFORMED CONSENT IN GENETIC REASEARCH
(Macedonian Association of Anatomists and Morphologists, 2023)
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Recognizing the ethical, legal, and social implications (ELSI) of genetic testing becomes crucial for physicians in the face of complex medical issues, as they are increasingly expected to counsel their patients regarding the medical, psychological, and social responses arising from genetic information. Genetic medicine, with its extreme complexity and the potential repercussions on an individual's life, raises important questions in the ethical, deontological, and legal realms of medicine, playing a primary role in personalized medicine. The aim of this paper is to underscore the significance of informed consent and to provide insights into the ethical procedures associated with genetic testing.
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TIME-DEPENDENT EXPRESSION OF IL-1β mRNA - A PRELIMINARY STUDY FOR POSSIBLE WOUND AGE MARKER
(Macedonian Association of Anatomists and Morphologists, 2023)
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Siamkouri, Rosica
Accurate estimation of wound age is a very important task in forensic medicine field, because it can helps in reconstruction of crime scene. IL-1β is proinflamatory cytokine and plays a major role in wound healing process. The aim of the study is to develop a method for the reliable estimation of dermal injury age. In this study the expression of IL-1β mRNA was evaluated by real-time PCR at skin human wounds with different post-injuried period. We collected 27 human skin wound samples from forensic autopsy cases at our Institute. In our study were include samples from lacerations, incised wounds and stab wounds, with a known time of injury and death. Wound samples were divided into five groups: control group (n=5); first group consisted of cases with immediate death (n=7); second group consisted of cases with survival from 1 hour to 6 hours (n=5); the third group comprised cases with survival from 6 hours to 72 hours (n=3); the fourth group comprised cases with survival from 72 hours to 168 hours (n=7). In this study we detected increased expression levels of IL-1 β mRNA in the second group with survival time from 1 to 6 hours.
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Age identification in children and youngsters
(Slovenska Sudnolekarska Spolovnost Slovenskej Lekarskej Spolocnosti, 2017-05)
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A new method to determine wound age in human skin injuries
(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023-06-16)
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Chakar, Ljupco
Wound age determination is a significant part of everyday practice in forensic medicine. Determining the wound age answers a large number of questions arising from a criminal-legal event. The RT-PCR technique enables qualitative and quantitative analysis of mRNA and can register minimal changes in gene expression, which makes it more sensitive and accurate compared to the immunohistochemical method. The study included 51 wound samples of autopsy cases. In this study we conducted comparative analyses for different methods of homogenization and isolation. An analysis was carried out for the selection of a suitable reference gene that will be used for normalization of the expression levels of the investigated target gene. Two reference genes, GAPDH and 18S, were analyzed in the study. A biphasic expression of IL-6 information RNA (mRNA IL-6) was determined in relation to the other groups, including the control group. 18S has better efficiency of amplification then GAPDH. RNA was isolated from all examined tissues with the TriXact kit on the MagCore Plus II instrument. It can also be concluded that mechanical maceration of the tissue was more effective than the other methods of homogenization. 18S is a more stable reference gene for the analysis of skin samples. IL-6 can could be used as a marker in wound age determination.
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Reconstruction of the traffic accidents by examining the body of the dead and the vehicle
(Institute of Criminological and Sociological Research, 2023)
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ETIOLOGY OF SUDDEN CARDIAC DEATH IN FORENSIC MEDICAL PRACTICE AND SELECTION OF CASES FOR POST-MORTEM GENETIC TESTING –5 YEAR RETROSPECTIVE STUDY
(Macedonian Association of Anatomists, 2023-05-10)
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Chakar, Ljupco
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Sudden cardiac death (SCD) is a term used to describe death in a person who has no previously diagnosed heart disease, or is not expected to die at that stage of the disease. SCD is considered a major health problem in the world, accounting for 15-20% of all deaths, and the mechanism of its occurrence includes the development of ventricular tachycardia, which progresses to ventricular fibrillation and finally asystole. SCD is generally seen in the older population; however, a significant mortality rate is also observed in young people with hereditary heart pathology. The use of substances that can have an effect on cardiac function is associated with many cases of SCD, so toxicological substances should always be considered by forensic doctors and screening tests should always be performed. The aim of this research is to analyze the causes of sudden cardiac death and to select cases in which post-mortem genetic testing is indicated. For this purpose, a review was made of the autopsies performed at the Institute of Forensic Medicine between 2018 and 2022, the biochemical and toxicological findings of the various causes of death were analyzed, and the cases where the exact cause of sudden cardiac death was not determined were also analyzed. In the analyzed period of 5 years, the cases with cardiomyopathy dominated, followed by coronary artery heart disease, and in 20 percent of the cases the exact cause of death was not determined. Men dominated with a percentage representation of 80%.
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Forensic perspective of sudden death due to pancreatitis: Case report
(Springer, 2018-09)
Belakaposka Srpanova, V
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Bituljanu, N
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Unusual Cause of Death in a Patient with COVID-19
(Bulgarian Academy of Sciences, "Prof. Marin Drinov" Publishing House, 2021)
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Jasar Dzengis
This is a case presentation of a patient with confirmed coronavirus disease (COVID-19) who ended his life with suicide by hanging. We are presenting the history of the disease, a clinical feature, the onset of the psychiatric symptoms and finally the pathological feature. Aims are: to perceive, in which phase of the disease occurred the psychiatric symptoms and eventually their connection with some morphological feature of the brain; to evaluate the changes of the primary disease to internal organs and finally, the ethical aspect i.e. how are these patients protected by the health care system. Results: patient committed suicide on the 12th day of the disease and around the 21st day after the infection, looking by its serum antibodies. On lungs dominated the picture of acute restrictive pulmonary disease and ARDS (acute respiratory distress syndrome) with strong inflammatory answer. A psychiatric disorder occurred with the epilog of double suicide attempt, of which the second one was successful.
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Форензичка епидемиолошка анализа на самоубиствата во Република Северна Македонија во периодот пред и за време на епидемијата со КОВИД 19 вирусот
(SHMSHM - AAMD, 2023)
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Ivcheva, Ana

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