Zdravkovska, Maja
Preferred name
Zdravkovska, Maja
Official Name
Zdravkovska, Maja
Main Affiliation
Email
m.zdravkovska@medf.ukim.edu.mk
7 results
Now showing 1 - 7 of 7
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Insulin, insulin resistance and antropometric parameters in overweight and obese women(Macedonian Association of Anatomists and Morphologists, 2013); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Submental thyroid ectopy might cause subclinical hypothyroidism in early childhood(SAGE, 2016); ; ; ; Thyroid ectopy is a rare condition resulting from abnormal embryologic development and migration of the gland. Sublingual is the most common thyroid ectopy; all other ectopic thyroid locations occur very rare. There are no reports in the literature that describe the clinical course of patients with congenital hypothyroidism due to thyroid ectopy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Diagnostic re-evaluation of congenital hypothyroidism in Macedonia: predictors for transient or permanent hypothyroidism(2018-02); ; ; ; Diagnostic re-evaluation is important for all patients with congenital hypothyroidism (CH) for determining the etiology and identifying transient CH cases. Our study is a first thyroxine therapy withdrawal study conducted in Macedonian CH patients for a diagnostic re-evaluation. We aimed to evaluate the etiology of CH, the prevalence of transient CH and identify predictive factors for distinguishing between permanent (PCH) and transient CH (TCH). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, GENDER DIFFERENCES AND PREDICTORS OF INCRASED CORONARY CALCIUM SCORE AND MYOCARDIAL ISCHEMIA IN DIABETES TYPE 2 PATIENTS(Macedonian Association of Anatomists, 2021); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Diagnostic re-evaluation of congenital hypothyroidism in Macedonia: predictors for transient or permanent hypothyroidism(Bioscientifica, 2018); ; ; ; Background: Diagnostic re-evaluation is important for all patients with congenital hypothyroidism (CH) for determining the etiology and identifying transient CH cases. Our study is a first thyroxine therapy withdrawal study conducted in Macedonian CH patients for a diagnostic re-evaluation. We aimed to evaluate the etiology of CH, the prevalence of transient CH and identify predictive factors for distinguishing between permanent (PCH) and transient CH (TCH). Materials and methods: Patients with CH aged >3 years underwent a trial of treatment withdrawal for 4 weeks period. Thyroid function testing (TFT), ultrasound and Technetium-99m pertechnetate thyroid scan were performed thereafter. TCH was defined when TFT remained within normal limits for at least 6-month follow-up. PCH was diagnosed when TFT was abnormal and classified according the imaging findings. Results: 42 (55%) patients had PCH and 34 (45.0%) patients had TCH. Thyroid agenesia was the most prevalent form in the PCH group. Patients with TCH had lower initial thyroid-stimulating hormone (TSH) values (P < 0.0001); higher serum thyroxine levels (P = 0.0023) and lower mean doses of levothyroxine during treatment period (P < 0.0001) than patients with PCH. Initial TSH level <30.5 IU/mL and levothyroxine dose at 3 years of age <2.6 mg/kg/day were a significant predictive factors for TCH; sensitivity 92% and 100%, specificity 75.6% and 76%, respectively. Conclusion: TCH presents a significant portion of patients with CH. Initial TSH value and levothyroxine dose during treatment period has a predictive role in differentiating TCH from PCH. Earlier re-evaluation, between 2 and 3 years age might be considered in some patients requiring low doses of levothyroxine. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Biomarkers of oxidative stress in patients with acute coronary syndrome(2016-05-16); ; Purpose: To evaluate comparatively association between biomarkers of oxidative stress(OS) in patients with acute vs chronic coronary artery disease, and in comparison with healthy volunteers. Methods :Cross-sectional observational study was performed in patients admitted because of coronary artery disease (CAD). Pts were evaluated for their demographics, risk factors and co-morbidities, lipoprotein profile, HgbA1C and markers of oxidative stress: malondialdehyde (MDA) and hydroperoxids (HP), and antioxidant enzymes: superoxide dizmutaza (SOD), CATALASE and glutathione peroxidase (GPS). Pts were divided in 2 groups: pts with acute coronary syndrome (ACS) and chronic coronary artery disease (HCAD), and then subdivided, ACS pts in: STEMI, NSTEMI and APNS, HCAD in: asymptomatic CAD, revascularized and post MI patients. Statistical analysis: descriptive, t-test, ANOVA, Kruskall-Wallis ANOVA, correlation. Significance was determined at level of 0.05.Results :300 pts. 194 males and 106 females at mean age of 62.9±11,2 y were analyzed. 187 were with ACS and 113 with HCAD. 62,3% of pts. had HTA, 42,7% HLP, 28,3% DM, 57% smokers, 8% had anemia. There was no significant difference in the risk profile between the two groups. Mean values of the markers of OS (Table 1). Statistically significant differences didn’t existed between ACS and HCAD groups but inside the groups(Table 1), in lipid profile and HgbA1C in ACAD pts compared to HCAD.ACAD pts had higher HgbA1C, total, LDL and ApoB, but lower HDL-C and ApoA1. Correlation was found for HgbA1C and MDA (r=-,154**, p=0,008); age and total HP (r=-,143*, p=0,013); ApoA1 and total HP (r=-,157*, p=0,035);Conclusion: Markers of oxidative stress were significantly higher, and antioxidative activity was lower compared to healthy volunteers, but between ACAD and HCAD group significant differences were found only for HP from pro-oxidative, and SOD from anti-oxidative markers. Inside the groups, revascularized HCAD pts were with the highest pro-oxidative and lowest anti-oxidative activity, while in ACAD group, different markers of OS were the most pathological in different ACAD groups