Canevska Taneska, Aleksandra
Preferred name
Canevska Taneska, Aleksandra
Official Name
Canevska Taneska, Aleksandra
Translated Name
Александра Цаневска Танеска
Alternative Name
A.Canevska
Aleksandra Canevska
Aleksandra C. Taneska
A.Canevska Taneska
Canevska-Tanevska A.
Canevska-Tanevska Aleksandra
Canevska-talevska Aleksandra
Main Affiliation
Email
aleksandracanevska@hotmail.com
18 results
Now showing 1 - 10 of 18
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Item type:Publication, USE OF EVODIAL DIALIZERS FOR HEMODIALYSIS IN PATIENTS WITH HIGH RISK FOR BLEEDING - SINGLE CENTRE EXPERIENCE(Macedonian Association of Anatomists, 2023); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, KIDNEY FUNCTION DECLINE AND MORTALITY IN DONORS WITH EXPANDED CRITERIA - FIVE YEARS FOLLOW UP STUDY(Macedonian Association of Anatomists and Morphologists, 2024); ; ; ; Kidney donors are considered healthy, but with a need for continued medical follow up and encouragement for continued healthy lifestyle, especially when expanded criteria for donation are applied. This study aims to analyse the five years follow up of kidney donors after explanation, encountering risks of kidney function decline and donors’ mortality. In a retrospective study we evaluated a donor cohort with 5 years of follow up. Demographic characteristics as age, gender and the presence comorbidities as diabetes, hypertension, hyperlipidemia and Body Mass Index (BMI) >30kg/m2 were analyzed. Estimated glomerular filtration rate (eGFR) by CKD EPI formula was notified prior donation, and annually afterwards. Consultations with nephrologist or other specialists were notified. In a multivariate regression analysis, the reduction ratio (RR) of eGFR was explored as dependent variable. Cox regression analysis exploited mortality; Kaplan Meier survival curve was applied in respect of BMI. Seventy-five donors with average age above 55 years were predominantly women (69%), nearly every nineth patient had diabetes or obesity (9%). Proportion of donors referred to nephrologist at the 12 months, declined up to 58% at the fifth year, ignoring medical checks showed ascending trend to 16% at the end of second and third year and 12% at the end of observational period. The univariate regression analysis found diabetes, hyperlipidemia and hypertension, the presence of multiple comorbidities, gender and age as insignificant predictors of eGFR 12 months reduction ratio. The nephrologist referral showed borderline significance (β = - 0.103, p=0.076). Only BMI over 30kg/m2 worsened the kidney function (β = 0.600, p=0.001). Five years mortality rate was 6.7%. The diseased donors were significantly older, more frequently had diabetes and obesity also they had significantly lower eGFR pre-donation, at the end of the first year but also and more step decline of it after 12 months. In the multivariate analysis BMI>30kg/m2 emerged as most powerful predictor of mortality (HR 40.02; CI: [4.11-389), p=0.0001). Survival of obese patients was significantly shorter when compared with patients with lower body weight (43.28 ± 7.51 vs. 59.33±0.65, Log rank p=0.000), respectively. Our study demonstrates that the mortality and declination of renal function after donation are associated with nephrologist referral and other potentially modifiable factors, especially obesity. Improved protocols for pre-donation information, education and adequate after-donation follow up is mandatory to achieve better longevity and kidney function survival in these frail and precious individuals. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Enterorrhagia Presented in Patient with Granulomatosis and Polyangitis - A Case Report(Macedonian Society of Nephrology, Dialysis, Transplantation and Artifical Organs, Department of Nephrology, 2022); ; ; Introduction. ANCA - associated vasculitis (AAV) as a term includes: microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). GPA is characterised by formation of granulomas and inflammation of small and medium-sized vessels leading to organ dysfunction, with a predilection for respiratory tract and kidneys. Gastrointestinal (GI) involvement happens rarely in GPA but when affected, has a poor prognosis. Case report. We report a case of 50-year-old male with GPA who presents with pulmonary and renal syndrome, along with enterorrhagia due to GI vasculitis. The patient was treated with: hemodialysis, pulse methylprednisolone, cyclophosphamide, and plasmapheresis. Our systematic review of the literature found only a few case reports where gastrointestinal symptoms were one of the first signs of GPA, however, this entity might be more frequent if physicians would think of this possibility more often. Conclusion. In cases of high clinical suspicion of GI involvement in GPA, an early aggressive immunosuppressive therapy and eventual surgical intervention remains the cornerstone of the management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Challenging Case of Multisystem Inflammatory Syndrome in a 19- Year Old Female: A Case Report(Macedonian Society of Nephrology, Dialysis, Transplantation and Artifical Organs, Department of Nephrology, 2022); ; Introduction. In comparison to older adults, SARSCoV-2, leads to a mild illness in children and young adults typically manifested with fever, cough and gastrointestinal symptoms. However, the multisystem inflammatory syndrome in children and young adults (MISC) emerged during the coronavirus disease in 2019 pandemic. Case report. We report a challenging case of a 19- year old female patient with signs and symptoms of multisystem inflammatory syndrome and SARS-CoV2 infection, most probably as a post infectious disease with onset between 2 to 4 weeks after the infection. Its clinical symptoms may have overlaped with classical Kawasaki disease (systemic vasculitis) or Kawasakilike syndrome (atypical) with fever, gastrointestinal symptoms, rash, conjunctival injection, hypotension, sore throat, mucosal changes with a relative lack of severe respiratory disease, myocarditis, hypoalbuminemia and elevated inflammatory markers. And indeed, the clinical presentation of COVID-19 in young adults resembles Kawasaki disease with gastrointestinal manifestations to severe inflammation with myocarditis. Conclusion. Timely diagnosis and proper treatment of the multisystem inflammatory syndrome and SARSCoV-2 infection are real challenge requiring multidisciplinary approach and tertiary resources. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Rhabdomyolysis and Acute Kidney Injury in a Patient with Severe Form of Covid-19 Pneumonia- A Case Report(Balkan Cities Association of Nephrology, Dialysis, Transplantation and Artificial Organs, 2020); ; ; Introduction. The ongoing pandemic with the novel Corona virus poses unprecented challenges for the me- dical professionals worldwide. Acute kidney injury is frequently seen in patients infected with corona virus and often associated with a poor patient outcome. Rhabdo- myolysis has been recognized as one of the possible contributing mechanisms. Case. A 68-year-old man was referred to the emergen- cy department complaining of a dry cough, myalgia, general weakness with devastated energy feeling, chest pain and difficulties in breathing, symptoms he expe- rienced in the past five days. He also noticed that his urine was dark and in reduced amount. Quick antigen test for SARS CoV2 was performed, and the patient found Covid-19 positive. He was admitted at the hos- pital ward in a covid-designated unit. Laboratory findings revealed elevation of the inflammatory markers and elec- trolyte disbalance. Metabolic degradation products were markedly increased, serum urea was 44mmol/L (RF=2.7- 7.8 mmol/L) and serum creatinine 689umol/L (RF=45- 109umol/L), when deterioration of the kidney function was diagnosed. Urgent intermittent hemodialysis treatment was initiated. Patient suffered from a severe form of covid-19 pneumonia and was continuously on high flow oxygen mask. Duration of the patient hospitalization was 30 days, and thereafter, he was transferred to the reha- bilitation center for 28 days. Complete restoration of the physical motion and activity was accomplished, oxygen support was no longer needed, since he main- tained blood oxygen saturation above 95%. Renal func- tion has also been recovered with degradation products maintained within normal ranges. Conclusion. Rhabdomyolysis in covid-19 patients should be always kept in mind. Sometimes it can be an initial clinical manifestation in covid-19 patients [15], but on the other hand it can be presented as a late complication sometimes caused by the therapy itself. Multidiscipli- nary and comprehensive approach in the diagnosis, treat- ment and follow up of the patients can only guarantee timely detection and wide range of therapeutical moda- lity, leading to a better prognosis and outcome. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, P1505COMORBIDITY AND AGE OF DIALYSIS PATIENTS OUTPERFORMS FRAILTY BURDEN AS A PREDICTOR FOR MORTALITY(Oxford University Press (OUP), 2020-06-01); ; <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Aims</jats:title> <jats:p>The life expectancy in dialysis patients depends on patients’ age and comorbidities. Frailty in elderly patients is a state of impaired homeostasis with loss of physiologic reserve and a consequent impaired responses to dialysis burden. In this study we assessed the impact of age, comorbidities and frailty on dialysis patients’ survival.</jats:p> </jats:sec> <jats:sec> <jats:title>Method</jats:title> <jats:p>The study enrolled 162 prevalent patients on chronic hemodialysis with mean dialysis vintage of 100 months, 55% were women and 21 % had diabetes. Patients were divided into three groups by the Khan Comorbidity index score, highest score was considered worse. Frailty was assessed by presence of 3 or more symptoms (unintentional weight loss, feeling exhausted, weak grip strength, slow walking speed and low physical activity) and expressed as absolute number. Estimates of five years life expectancy were assessed by Kaplan Meier survival log-rank test and Cox regression hazard model.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>There were 26 (16%) with lowest score, 85 (52%) with medium score and worst highest score in 51 (31%). During the 5 years of follow up 69(43%) patients died of all-cause mortality. There were no deaths in the group with lowest score and mortality rates in the intermediate and worse score group increased by double (0; 30%; 69%, respectively). Significantly higher mean life expectancy was found in lower Khan Score groups: 60mo; 48.40 ± 18.51; 32.44 ± 22.06, log-rank: p < 0.012. Patients that scored worse had four folds higher risk for death HR 4.2 (95% CI: 2.72 – 6.36), p=0.0001. In the multivariate model Khan Score was a more powerful predictor of mortality than frailty in elderly, with HR 3.2 (95% CI: 2.88 – 5.41), p=0.0001.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Comorbidities and age outperforms frailty burden as a predictor of mortality in dialysis patients.</jats:p> </jats:sec> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Excess Mortality in a Nephrology Clinic during First Months of Coronavirus Disease-19 Pandemic: A Pragmatic Approach(Scientific foundation Spiroski, 2020-12-20); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Focal Segmental Glomerulosclerosis and Collapsing Glomerulopathy after Covid 19 Infection(Macedonian Society of Nephrology, Dialysis, Transplantation and Artifical Organs, Department of Nephrology, 2021); ; ; ; Focal segmental glomerulosclerosis (FSGS) is defined as an increase in the mesangial matrix in some glomeruli with obliteration of capillary lumens, sclerosis, hyalinosis, foam cells, and adhesions to the Bowman’s capsule. Collapsing glomerulopathy is a morphologic variant of focal segmental glomerulosclerosis (FSGS) characterized by segmental and global collapse of the glomerular capillaries, marked hypertrophy and hyperplasia of podocytes, and severe tubulointerstitial disease. Actually secondary collapsing glomerulopathy is a heterogeneous group including numerous causes: viruses, toxins and drugs such as heroin and pamidronate - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study(Elsevier BV, 2022-10) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SUCCESSFUL TREATMENT OF ENDOCARDITIS WITH NONSPECIFIC PRESENTATION IN A KIDNEY TRANSPLANTPATIENT-CASE REPORT(Macedonian Association of Anatomists, 2023-11);