Nonkulovski, Danilo
Preferred name
Nonkulovski, Danilo
Official Name
Nonkulovski, Danilo
Main Affiliation
Email
danilo.nonkulovski@medf.ukim.edu.mk
13 results
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Item type:Publication, PROCALCITONIN AS A PROMISING BIOCHEMICAL MARKER FOR EARLY DETECTION AND TREATMENT OF SEPSIS IN NEONATES AT INTENSIVE CARE UNIT AND ONCOLOGIC PATIENTS WITH FEBRILE NEUTROPENIA(Macedonian Association of Anatomists and Morphologists, 2020); ; Kimovska, Milica - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Semilobar Holoprosencephaly Caused by a Novel and De Novo ZIC2 Pathogenic Variant(Walter de Gruyter GmbH, 2023-05); ; ; Muaremoska-Kanzoska, LjeljaHoloprosencephaly (HPE) is the most common embryonic forebrain developmental anomaly. It involves incomplete or absent division of the prosencephalon into two distinct cerebral hemispheres during the early stages of organogenesis. HPE is etiologically heterogeneous, and its clinical presentation is very variable. We report a case of a 7 month old female infant, diagnosed with non-syndromic semilobar holoprosencephaly, caused by a novel, de novo pathogenic variant in ZIC2 - one of the most commonly mutated genes in non-syndromic HPE coding for the ZIC2 transcription factor. The patient presented with microcephaly, mild facial dysmorphic features, central hypotonia and spasticity on all four extremities. Ultrasound imaging demonstrated the absence of septum pellucidum, semilobar fusion of the hemispheres and mega cisterna magna and brain MRI with confirmed the diagnosis of HPE. Early diagnosis and management are important for the prevention and treatment of complications associated with this condition. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Late presenting congenital diaphragmatic hernia in a 4-year-old child(Macedonian Association of Anatomists, 2023); The majority of congenital diaphragmatic hernia (CDH) are diagnosed antenatally, immediately after birth or in the neonatal period. We report case of 4-year-old child who presented with recurrent wheezing and was diagnosed to have late presenting CDH. A 4-year-old girl was admitted to the hospital with a 5-days history of increasing shortness of breath and cough. The child had normal bird history and has enjoyed relatively good health till 3 years of age. Her medical history over the last year revealed that she had 4 episodes of wheezing variously treated with inhaled bronchodilators, steroids and antibiotics. On physical examination she was in mild respiratory distress with bilateral wheezing. The x-ray showed an unusual appearance of the chest with air-filled bowel loops. A barium X-ray examination of the gastrointestinal tract confirmed the diagnosis of CDH. The hernial contents were reduced back into the abdominal cavity and surgical repair of the diaphragmatic defect was done. Late presenting CDH can be misdiagnosed and lead to delayed treatment. It should be suspected in children presenting with recurrent respiratory symptoms. When the diagnosis is confirmed, the treatment of choice is surgical intervention. Clinical awareness, early diagnosis and operative treatment can lead to good outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EPILEPSY WITH HETEROZYGOUS ALDH7A1 AND SLC6A1 MUTATIONS(SHMSHM - AAMD, 2020); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DEFINITIVE TREATMENT OF PLANOCELLULAR OROPHARYNGEAL CARCINOMA WITH MODERATE ACCELERATION OF INTENSITY MODULATED RADIATION THERAPY WITH SIMULTANEOUS INTEGRATED BOOST(Macedonian Association of Anatomists and Physiologists, 2020); ; ; Stoleska, MarinaIntroduction: Intensity Modulated Radiation Therapy (IMRT) represents a new technique in the treatment of head and neck carcinomas. Oropharyngeal carcinomas are ideal target for this radiation technique, because of their anatomic localization close to critical healthy organs. Simultaneous Integrated Boost (SIB) in IMRT allows in at the same time at the same fraction delivering of different dose to different structures to irradiated volume with distribution on higher dose to the tumor and lower dose in elective irradiated regions. Moderate acceleration of IMRT-SIB allows in shorter time delivering of higher dose to planning target volume and achieving bigger tumor control. Objective: Aim of this study was to present planning technique IMRT – SIB with 95% dose coverage of volume of planning target volumes referring to primary oropharyngeal carcinoma, metastatic lymph nodes, elective region in head and neck which is irradiated and to critical organs near the tumor, achieving in the future better tumor control and fewer side effects on healthy tissues. Materials and methods: This retrospective study included 31 patients with advanced planocellular oropharyngeal cancer treated at University clinic of Radiotherapy and oncology- Skopje, with modulate acceleration of IMRT-SIB and weekly concurrent cisplatin. Results: With IMRT SIB we achieved high 95% dose coverage of the planned target volumes (PTV54 = 99,46 % and PTV66 = 98.74 %) and successfully spare the spinal cord as the most important organ at risk. Conclusion: IMRT- SIB fulfill the goal of better tumor coverage and moderate acceleration achieve dose reduction in critical healthy organs. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Procalcitonin-early biochemical marker for diagnosis, prognosis and treatment of sepsis in neonates and oncological patients with febile neutropenia(Macedonian Association of Anatomists, 2020); ; ; Kimovska Hristova, MicaPediatric sepsis is a life - threatening condition, in which the immune system, instead of controlling the infection,causes damage to tissues and organs. The aim of this study was to determine the role of procalcitonin (PCT)in the early diagnosis of sepsis in high - risk infants and Oncological patients with febrile neutropenia,its prognostic value,and the role of PCT in the cho ice of antibiotic. The study is designed as retrospective - prospective, it is being worked at the PHI UC for Children Diseases Skopje. I t includes 60 critical newborns and 40 O ncology patients.The examined group were divided into two subgroups:30 critical i nfants with bacterial sepsis in the intensive care unit and 20 O ncological patients with sepsis and febrile neutropenia. PCT was determined the first 24h,3 - 5 days and 6 - 14 days of hospitalization. The value of PCT during the first 24 hours of admission was increased in all 50 patients .Most of them had signs of severe sepsis and few od them had signs of septic shock . In all of them, double parenteral antibiotic therapy was started .Seven patients has died in the first five days. After 3 - 5 days of the start of antibiotic therapy, PC T values decreased . After the third measurement, PCT values continued to decrease and in majority of the patients the antibiotic therapy was discontinued. By measuring the values of PCT, an early diagnosis of sepsis can be made. This is important to start with antibiotics to prevent sepsis and septic shock . T he dynamic in the values of PCT determine the duration of antibiotic,its modification,the rational uses of antibiotics and the emergence of resistance to it. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, GENETIC TESTING ESSENTIAL IN EARLY DIAGNOSIS AND TREATMENT IN TUBEROUS SCLEROSIS COMPLEX(Macedonian Association of Anatomists and Physiologists, 2021); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, RADIATION-INDUCED MUCOSITIS IN PATIENTS WITH OROPHARINGEAL CANCER TREATED WITH MODERATE ACCELERATION OF INTENSITY-MODULATED RADIATION THERAPY AND SIMULTANEOUS INTEGRATED BOOST CONCOMITANT WITH WEEKLY CISPLATIN(Scientific foundation Spiroski, 2021); ; ; Stoleska MarinaRadiation-induced mucositis is one of the limiting factors during radiotherapy, disturbing the quality of life and in some cases leading to discontinuation of therapy. Intensity-modulated radiation therapy (IMRT) with simultaneous integrated boost (SIB) represents advanced form of radiotherapy technique in treatment of oropharyngeal carcinoma enabling precision cancer targeting with reducing dose to healthy normal tissues. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, GANGLIOMA ASSOCIATED WITH FOCAL EPILEPSY(Македонско лекарско друштво = Macedonian medical association, 2020); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CASE REPORT OF DOUBLE HETEROZYGOUS PATIENTC WITH SPINAL MUSCULAR ATROPHY(Macedonian Association of Anatomists, 2023); ; ;