Mishevska Perchinkova, Snezhana

Preferred name
Mishevska Perchinkova, Snezhana
Official Name
Mishevska Perchinkova, Snezhana
Main Affiliation
Email
snezana.perchinkova@medf.ukim.edu.mk

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    Multicenter, Open-Label, Long-term Extension to Describe the Safety of Tocilizumab in Patients with Early, Moderate to Severe Rheumatoid Arthritis
    (Science Publishing Group, 2020)
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    Antova, Dubravka
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    Kotevska Nikolova, Mimoza
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    Stojanovska, Anzhelika
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    Myocardial perfusion in patients with systemic lupus erythematosus and low to intermediate risk for coronary artery disease, assessed with 99mtc mibi myocardial perfusion scintigraphy –case reports
    (2017-06)
    Sandevska, Emilija
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    Damjanovska Krstic, Ljubinka
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    Objective: Due to early and accelerated atherosclerosis, the patients with systemic lupus erythematosus (SLE), asymptomatic for coronary artery disease (CAD) are in particular risk of acute myocardial infarction (AMI). A diagnostic approach for their risk stratification is needed, followed with appropriate management and treatment. Material and Methods: We present three patents with SLE, from two patients cohorts (younger and older-age group), with SLE history for more than 7 years, with more active phase of disease (SLEDAI score 3-5) and atypical chest pain. With low to intermediate risk for CAD according to traditional risk factors for CAD, but with presence of SLE–related risk factors for atherosclerosis, they underwent 99mTc Myocardial perfusion scintigraphy (MPS) (at rest and stress, as one-day protocol) for evaluation of myocardial perfusion and left ventricular (LV) functional abnormalities. Visual and quantitative analysis of perfusion and functional tomoscintigrams detected the presence of one (in 2 patients) or two vessel’s stress-induced ischemia (in 1 patient), with mild to severe intensity and 10-27% extent of ischemic LV myocardial mass. Regions with the perfusion abnormalities were accompanied with wall motion abnormality during the stress study. The global LV functional parameters were normal in both studies (stress vs rest) with higher transient dilation parameter (TID) in one patient, indicating the presence of more profound perfusion abnormalities. Two patients were referred for angiography which in both cases showed no evidence of significant coronary artery stenosis of the major coronary arteries. Along with their higher levels of serum concentrations of endothelin (ET-1) and C-reactive protein (CRP) the myocardial perfusion abnormalities resemble microvascular functional affection. Conclusion: We emphasize the importance of identification of asymptomatic high CAD risk patients with SLE and CAD evaluation in this patients' cohort in order to prevent premature cardiac death. Determination of the clinical pretest probability for CAD and assessment of myocardial perfusion with non-invasive imaging technique such as 99mTc SPECT MIBI MPS may help in detecting the patients that should be subjected to coronary angiography. Even in the case of microvascular dysfunction, without significant obstruction of coronary vassels, prevention and/or treatment of CAD traditional risk factors and better control of the SLE disease can prevent or postpone the accelerated development of atherosclerosis and the decrease the risk of cardiovascular events.
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    Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians
    (Springer, 2009-11-28)
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    Karadzova-Stojanoska, Anzelika
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    Strezova, Ana
    To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against RA in Macedonians. In this study, 301 healthy unrelated individuals and 85 patients with RA were studied. Cytokinegenotyping was performed by PCR with sequence-specific priming (PCR–SSP) (Heidelberg kit). Results showed a susceptible association for four cytokine alleles, six cytokine genotypes, one haplotype, and four combinations of haplotypes, while protective associations were found for four cytokine alleles, three cytokine genotypes, three haplotypes, and only one combination of haplotypes. These results suggest that L-4−1098, IL-4−590, IL-10−1082, IL-10−819, IL-2−330, IL-6−174, and TNF-α−238cytokine gene polymorphisms might be significantly associated and affect host susceptibility and/or resistance to RA in Macedonians.
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    Satisfaction Level of Rheumatoid Arthritis Patients Enrolled in the Treatment with Subcutaneous Tocilizumab. Journal of Autoimmune Diseases and Rheumatology
    (Karachi: Synergy Publishers, 2020)
    Filip Guchev
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    D. Antova
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    B. Osmani
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    M. Nikolovska Kotevska
    Background: The introduction of biological-Disease Modifying Agents (bDMARDs) has allowed serious improvement in the treatment of patients with rheumatoid arthritis (RA) by providing a better quality of life (QoL). Such improvements have been shown in patients using subcutaneous form of Tocilizumab SC (TCZ-SC), a humanized monoclonal antibody against IL-6 receptor. Objective: To assess the subcutaneous treatment satisfaction level and to evaluate the epidemiological profile of RA patients treated with TCZ-SC in North Macedonian Patients with RA. Methods: An observational study was conducted at the University Rheumatology Clinic in Skopje between October 1st and December 15th 2018, including 48 patients who have received TCZ-SC. In order to obtain patient’s satisfaction level and to evaluate the epidemiological characteristics of the patients, a standardized questionnaire was developed. Results: The mean age of the patient’s cohort was 50.9 years and 88.5% of the patients were females. More than half of the patients (58%) had high disease activity with mean disease duration of 5.35 years. Eighty three percent of the patients were entitled to receive subcutaneous TCZ because of the insufficient efficacy of previous treatment, All patients enrolled in the treatment with TCZ-SC, reported to be satisfied or very satisfied with the subcutaneous application of TCZ. They were also very satisfied with the previous education and the opportunity to receive the treatment at home. Conclusions: Tocilizumab as an efficient and well tolerated bDMARD is becoming a standard of care in the treatment of patients suffering from RA, offering unprecedented benefits for QoL improvement and satisfying the patients’ needs for modern and effective treatment.
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    Overlap syndrome in refractory case
    (Macedonian Association of Anatomists, 2022)
    Filip Gucхev
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    This is a report of the case of a 23 years-old girl with refractory dermatomyositis, complications in her treatment and the unfortunate fatal end. Dermatomyositis can be a notoriously difficult disease to treat, and remission is often elusive or short-lived despite aggressive therapy. In the years after the diagnosis, many aggressive modalities of treatment were tried, including rituximab. The patient had frequent exacerbations of the myositis, needed aggressive therapy and developed many side effects associated with the treatment. Most common of these were infections. After suffering severe stress, she developed fever, was diagnosed with sepsis and despite exhaustive treatment at the intensive care unit she passed away.
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    Клиничко-епидемиолошки карактеристики на пациентите со псоријатичен артритис
    (МАКЕДОНСКА РЕВМАТОЛОШКА АСОЦИЈАЦИЈА-МААР, 2009-09-30)
    Stojanoska, A
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    Chalovski, J
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    Pavlova, S
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    Antova, D
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