Miladinova, Daniela

Preferred name

Miladinova, Daniela

Official Name

Miladinova, Daniela

Main Affiliation

danielamiladinova@medf.ukim.edu.mk

Now showing 1 - 10 of 51

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Use of platelet rich plasma and split thickness skin graft in post-infection soft tissue defects, our initial experience
(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University Skopje, R.N.Macedonia, 2020-12)
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Trajkova A
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Georgieva G
Introduction. Necrotizing soft tissue infections (NSTI) are severe, potentially life-threatening medical emergencies that are accompanied with devastating and rapidly spreading destruction of soft tissue as a result of bacterial infection and systemic toxicity. Patients with NSTI who undergo split thickness skin graft (STSG) experience high rates of complications. Platelet-rich plasma (PRP) has shown to have positive effect on the healing of acute, chronic and diabetic wounds. The aim of this study was to analyze the outcome of skin grafting with PRP in post-infectious soft tissue defects. Materials and Methods. Fourteen patients were randomized in two groups: an experimental group – wound coverage with STSG and PRP, and control group – with STSG alone. PRP was applied to the donor site in the experimental group. Patients’ follow up was until complete healing of wounds. In both groups we analyzed the healing time, the need for regrafting, secondary infections, pain and adverse effects. Results. Patients in the PRP group have had significantly reduced healing time (32.5 days) versus control group (72.5 days). In the experimental group, the rate of skin graft success was 90.2% vs. 77.2% in the control group. The need for regrafting occurred in one patient in the control group. Pain at the donor site in experimental group was statistically significantly lower. No adverse effects were reported. Conclusion. The combination of STSG and PRP reduces healing time and lowers the complication rates. It is safe to use with no adverse effect. Further studies are needed with larger number of patients to further validate its efficacy
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Universal salt iodization potentially contributes to health equity: socio-economic status of children does not affect iodine status
(Walter de Gruyter GmbH, 2022-09-27)
Milevska-Kostova, Neda
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Ittermann, Till
Many studies have shown that socio-economic status (SES) contributes to health inequalities, with nutrition as one of the major risk factors. Iodine intake entirely depends on external sources, and deficiencies are known to be more prevalent in lower social groups, especially in countries with limited access to iodized salt. This study aimed to determine the influence of SES on iodine status and iodine availability from household salt in North Macedonia.
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Epidemiology of Thyroid Carcinomas in North Macedonia (1999-2015)
(SAGE Publications, 2021)
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Sentinel Lymph Node Detection in Colorectal Cancer - First Experience
(ID-Design/Scientific foundation SPIROSKI, 2017-10-15)
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Colorectal cancer (CRC) is the second commonest cancer in women, the third in men, being the fourth commonest cause of cancer death. The most important factor for prognosis and staging in CRC patients is the status of the regional lymph nodes (LN).
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Sentinel lymph node status versus tumor characteristics, neutrophil to lymphocyte ratio, C-reactive protein levels and C-reactive protein to albumin ratio-prognostic factors for primary cutaneus melanoma
(Springer Science and Business Media LLC, 2019-09-18)
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Aim/Introduction: The aim of this study was to identify tumor characteristics of primary malignant melanoma, neutrophil to lymphocyte ratio (NLR), C - reactive protein (CRP) levels and C - reactive protein to albumin ratio (CRP/Alb) predictive of sentinel lymph node (SLN) positive status and their impact on disease recurrence, melanoma specific survival (MSS), disease free survival (DFS) and overall survival (OS) period. Materials and Methods: 100 patients with primary malignant melanoma, clinically staged T1b/T2+ (1-4mm thick) N0, M0 underwent SLN detection procedure. Tumor characteristics, NLR, CRP levels and CRP/Alb ratio were analyzed in correlation with SLN status. The optimal cutoff values of NLR and CRP/Alb were determined by the receive operative characteristics (ROC) analysis. Univariate and multivariate Cox regression analyses, t - test for continuous or X2 test for categorical variables and Kaplan-Meier curve analyses were performed to assess factors predicting SLN positive status, regional recurrence rate, DFS, MSS and OS period. Results: We identified Breslow`s thickness (OR=1,51; 95% CI 1,02- 2,01; p=0,034), presence of ulceration (p=0,041), lymphocytic infiltration (OR=0,42; 95% CI 0,18-0,99; p=0,02), high mitotic rate (p=0,031), high Ki67 index (p<0,01), high NLR (HR=2,45; 95% CI 1,52-3,34; p<0,01), increased CRP levels (HR=1,53; 95% CI 1,33-1,75; p<0,001) and high CRP/Alb ratio (HR=2,01; 95% CI 1,15-3,52; p=0,016) as independent predictors of SLN positive status. SLN status was the strongest predictor (HR=0,241; 95% CI 0,45-1,01; p=0,04) of DFS, MSS and OS period. Conclusion: We confirmed Breslow’s thickness, presence of ulceration, lymphocytic infiltration extent, high mitotic rate, high Ki67 index, high NLR, increased CRP levels and high CRP/Alb ratio as factors predictive of SLN metastatic involvement. We also confirmed SLN status to be the most significant independent predictor of DFS, MSS, OS and risk of regional recurrence. Key words: neutrophil to lymphocyte ratio, c - reactive protein to albumin ratio, prognostic factors, melanoma, sentinel lymph node
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The Current State of Nuclear Nephrology in Modern Medicine
(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2023-12-01)
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Poposka, Daniela
Glomerular filtration rate (GFR) is the most reliable parameter of renal function. Regarding the complexity of the gold standard inulin clearance, different estimating equations have been developed with CKD-EPI creatinine equation recommended as the most reliable one. In some clinical situations where creatinine based equations might not be valid, alternative methods are needed. Nuclear medicine methods for measuring GFR with 51Cr EDTA and 99mTc DTPA have been widely used for decades. There are different methodologies for the measurement of kidney function with radiopharmaceuticals: urinary clearance, plasma clearance, multiple plasma sampling, slope intercept, single sample plasma equation, slope only, and the gamma camera-based method. Greater precision of measuring GFR is needed in certain clinical situations. The most common are diagnosis and follow up of chronic kidney disease and definition of the beginning of replacement therapy. The assessment of renal function is also important for potential kidney donors. In recent years, with the introduction of new chemotherapeutic drugs and targeted therapy, oncologic patients treated with nephrotoxic drugs have become more commonly referred for measuring GFR. The monitoring of renal function is important during treatment in order to detect the transformation from reversible acute kidney injury to irreversible chronic kidney disease as well as in the cases of renal insufficiency reduce the dosage and prevent accumulation of the drug and avoid dosage related toxic effects. Assessment of kidney function using measured mGFR will be an important milestone in the creation of more accurate and expanding personalized medicine principle in current onconephrology practice.
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Prognostic factors in thyroid carcinomas: a 17-year outcome study
(Archives of Endocrinology and Metabolism, 2019-09-30)
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The aim of our study was to evaluate the survival rate of all thyroid carcinomas (TCs) diagnosed in the 1999-2015 period in the Republic of North Macedonia and to analyze the prognostic influence of several characteristics on development of distant metastases, as well as to analyze the prognostic effect of seven clinical and constitutional features on mortality.
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Decoupling channel count from field of view and spatial resolution in single-sensor imaging systems for fluorescence image-guided surgery
(SPIE-Intl Soc Optical Eng, 2022-09-26)
Blair, Steven
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Garcia, Missael
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Zhu, Zhongmin
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Liang, Zuodong
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Lew, Benjamin
Near-infrared fluorescence image-guided surgery is often thought of as a spectral imaging problem where the channel count is the critical parameter, but it should also be thought of as a multiscale imaging problem where the field of view and spatial resolution are similarly important. Aim Conventional imaging systems based on division-of-focal-plane architectures suffer from a strict relationship between the channel count on one hand and the field of view and spatial resolution on the other, but bioinspired imaging systems that combine stacked photodiode image sensors and long-pass/short-pass filter arrays offer a weaker tradeoff. Approach In this paper, we explore how the relevant changes to the image sensor and associated image processing routines affect image fidelity during image-guided surgeries for tumor removal in an animal model of breast cancer and nodal mapping in women with breast cancer. Results We demonstrate that a transition from a conventional imaging system to a bioinspired one, along with optimization of the image processing routines, yields improvements in multiple measures of spectral and textural rendition relevant to surgical decision-making. Conclusions These results call for a critical examination of the devices and algorithms that underpin image-guided surgery to ensure that surgeons receive high-quality guidance and patients receive high-quality outcomes as these technologies enter clinical practice.
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Platlet-Rich Plasma - Review of Literature
(Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH, 2021-04-23)
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Trajkova, Andrijana
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Georgieva, Gordana
Wound healing is a dynamic and physiological process for restoring the normal architecture and functionality of damaged tissue. Platelet-rich plasma (PRP) is an autologous whole blood product that contains a large number of platelets in a small volume of plasma with complete set of coagulation factors, which are in physiological concentrations. PRP has haemostatic, adhesive properties and acts supraphysiologically in the process of wound healing and osteogenesis. Platelets play a very important role in the wound healing process by providing growth factors that enhance the rate and quality of wound healing by many different mechanisms. The aim of this review is to describe: the biology of platelets and their role in the wound healing process, the terminology of platelet rich products, PRP preparation, activation and concentration of PRP, as well as the use of PRP in plastic surgery.
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Comparative analysis of different nuclear medicine techniques in evaluation of renal function
(2023)
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Miladinova, Daniela

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