Stavrikj, Katarina
Preferred name
Stavrikj, Katarina
Official Name
Stavrikj, Katarina
Main Affiliation
Email
kstavric@hotmail.com
kstavric@medf.ukim.edu.mk
41 results
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Item type:Publication, Evidence Based Practice in Using Antibiotics for Acute Tonsillitis in Primary Care Practice(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Sciendo, 2017-09-01); ; The increased use of antibiotics for acute tonsillitis is a public health problem. 80% of the antibiotic prescriptions for acute tonsillitis are done in the Primary Care practice (PCP). The inappropriate use of the antibiotic causes bacterial resistance and treatment failure. Only patients with acute tonsillitis caused by Group A beta-hemolytic streptococcus (GAS) have benefit of the antibiotic treatment, which is a predict cause in 5-20%. In order to assess the antibiotic prescribing for acute tonsillitis by the doctors in the PCP in Macedonia we use the data from the national project about antibiotic prescribing for acute respiratory tract infections which was conducted in November 2014 during a period of 4 weeks as part of the E-quality program sponsored by the IPCRG. 86 general practitioners from Macedonia have participated. The group of 1768 patients, from 4 months to 88 years of age, with diagnosis of acute tonsillitis was analyzed. The antibiotic prescriptions according to the Centor score criteria were compared to the Cochran's guidelines which are translated and recommended as national guidelines. 88.8% of the patients with acute tonsillitis were treated with antibiotics, of which 52.9% with Centor score 0 to 2 were treated inappropriate. The diagnosis is mostly made based on the clinical picture and the symptoms. Only (23.6%) of the patients were treated with antibiotics (Penicillin V and cephalexin) according to the guidelines. We concluded that there is a low adherence to the national guidelines. The clinical assessment is not accurate in determining the etiology. Also, there is a high nonadherence in prescribing the first choice of antibiotics. We emphasize the need to change the general practitioners' prescription behavior according to the guidelines. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative Analysis of Family Medicine Education and Exams at Cathedras of Family Medicine of Universities in Southeastern Europe - Splitska inicijativa , Sarajevo, 2017(ScopeMed, 2017) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Adverse Reactions to Intravenous Immunoglobulins - Our Experience(ID-Design/Scientific foundation SPIROSKI, 2018-12-20); ; ; Arjeta Hasani - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Kawasaki disease misdiagnosed as acute pyelonephritis(Springer Science and Business Media LLC, 2003-08); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gene polymorphisms of 22 cytokines in Macedonian children with atopic dermatitis(2012-03); ; Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of T-helper 2 cells. The aim if this study was to determine whether cytokine gene polymorphisms might influence the development of AD. Single nucleotide polymorphisms in the genes for I-L1alpha, IL-1beta, IL-1R, IL-2, IL-4, IL-6, IL-10, IL-12, TGF beta, TNF and IFNgamma were investigated by PCR and sequence specific primers in Macedonian patients with AD (67 children, age of 6 months to 5 years) and 301 normal unrelated individuals. Susceptible cytokine polymorphisms for AD for eleven genotypes (IL-4 -33/T:T IL-4 -1098/G:G, TGFbeta cdn25C:G, IL-4 -1098/T:T, IL-1alpha -889/C:T, IL-2 +166/T:T, IL-1beta -511/C:T, IL-12 -1188/C:T, IL-10 -1082/A:G, IL-1beta +3962/C:T, IFNgamma +874/A:T), five diplotypes, six haplotypes, and for alleles were found. Protective cytokine polymorphisms for AD for seven cytokine genotypes (IL-4 -1098/G:T, TGFbeta cdn25/G:G, IL-4 -33/C:C, IL-1alpha -889/C:C, IFNgamma +874/A:A, IL-10 -1082/A:A, IL-1beta -511/C:C), one cytokine diplotypes, two cytokine haplotypes, and four cytokine alleles were also found. We concluded that several cytokine polymorphisms are protective, or susceptible associated with AD in population of Macedonians. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Values of lymphocyte subpopulations in healthy Macedonian children under the age of five(International Medical Association Bulgaria (IMAB) / Peytchinski Publishing Ltd., 2016-12); ; Background: The effects of demographic factors on a wide range of immunological variables demonstrate the importance of having normative data representative of particular patient population. There was no lymphocyte subpopulation data for Macedonian children and the purpose of this study was to establish such a data. Subject and methods: The study population consists of 87 healthy children. Subjects were grouped into four age categories as follows: group 1 age range 5d-10d (n=15); group 2 age range 1 mo-1 yr (n=18); group 3 age 1yr-2 yr(n=20) and group 4 age 2yr-5 yr(n=34 Monoclonal antibodies labeled with fluorochromes and immunofluorescent microscopy were used to detect cells bearing specific cell markers. Results: The mean lymphocyte cell count gradually fell with increasing age from 6,65x10^9/l in group 1, to 5,67x10^9/l in group 2, 4,55x10^9/l in group 3, and to 4,14x10^9/l in group 4. Absolute values of CD3, CD4 and CD20 positive cells decreased gradually with age. Significant differences in mean absolute values were observed for absolute lymphocyte counts between groups 1/2 and 1/4 (P<0,01) and groups 2/4(P<0,05); for CD3 positive lymphocytes between groups 1/3(P<0,05) and 1/4(P<0,01); for CD4 positive lymphocytes between groups 1/3 (P<0,05) and 1/4(P<0,01) and for CD20 positive lymphocytes between groups 1/3 and 3/4(P<0,05) and groups 1/4 (P<0,01). Significant difference for CD4/CD8 ratio and for percentage values of different lymphocyte subpopulations between the different age groups was not found. Conclusion: This data may serve as a reference range for studies of Macedonian pediatric subjects. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Преваленција и фактори на ризик асоцирани со астма, поленска треска и егзема кај школски деца во Република Македонија(Македонско лекарско друштво = Macedonian medical association, 2007); ; ; За утврдување и компарирање на преваленцијата на астма, поленска треска, егзема и ризик-фактори асоцирани со нив, анализирани се самореферираните податоци од 5507 школски деца од 8 градови во Р. Македонија добиени преку ISAAC фаза 3 прашалниците. Податоците се статистички анализирани со chi-квадрат тест. Генерално во Македонија, во Скопје, Велес, Тетово, Охрид, источна Македонија, е утврдена превеланција за wheezing во последните 12 мес. од 7,0%, 7,2%, 12,0%, 5,0%, 5,9%, 5,6% и за дијагностицирана астма од 1,8%, 2,1%, 1,5%, 2,1%, 2,1%, 1,1%; за риноконјуктивитис во последните 12 мес. од 9,4%, 9,5%, 11,6%, 9,5%, 7,6%, 8,9% и за дијагностицирана поленска треска од 6,3%, 4,4%, 4,9%, 7,4%, 8,2%, 6,4%; за исип со чешање во последните 12 мес. од 4,4%, 3,4, 6,4%, 4,2%, 4,7%, 3,6% и за дијагностицирана егзема од 3,4%, 2,6%, 0,7%, 3,1%, 7,6%, 3,0%. Највисоката преваленција на сите симптоми и тежината на астмата и егземата во Велес би можела да се должи на често конзумирање брза храна и парацетамол и на слаба физичка активност. При компарација на интернационално ниво, Македонија има умерено ниска преваленција на симптоми на астма и поленска треска и ниска преваленција на симптоми на егзема со можност за субдијагностицираност на овие болести. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dyspnea in Children as a Symptom of Acute Respiratory Tract Infections and Antibiotic Prescribing(Scientific Foundation SPIROSKI, 2018-03-15); Dyspnea is an unpleasant feeling of breathing difficulty, shortness of breath and inability to satisfy the hunger for air. The role of family physicians is to be prepared to recognise dyspnea as a symptom of acute respiratory infections (ARI), to perform triage and managing of children with acute dyspnea and make continuous education of parents. In the treatment of acute dyspnea more important is to treat dyspnea as a symptom than the prescribing of antibiotics (AB). Nowadays, even more often large amount of children, because of the noncompliance in the treatment and the pressure from the parents, unnecessary is hospitalised and frequently used antibiotics: According to the guidelines, a small percentage of children with ARI should be treated with AB. The rate of antibiotic prescription should be around 15-20% and lower. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Динамика на преваленцијата на астма кај млади адолесценти во 4-годишен временски интервал во Скопје(Македонско лекарско друштво = Macedonian medica association, 2008); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Antibiotic Consumption in Hospitalized Children at the University Clinic for Pediatric Diseases – Skopje(Scientific Foundation SPIROSKI, 2020-06-10); ; ; <jats:p>BACKGROUND: The misuse and overuse of antibiotics contribute to the development of antimicrobial residence. Official data in EU/ EEA in 2017 in the hospital sector suggested that the consumption is lowest in the Netherlands, with 1 DDD per 1,000 inhabitants/day in comparison with Finland, with 2.8 DDD/TID. AIM: The aim of this study was to analyze data on the scope and structure of the antibiotic prescription in pediatric patients at University Children’s Hospital for period of 3 months in 2018 and 2019. MATERIALS AND METHODS: The data for antibiotic consumption were obtained from a hospital pharmacy, which are ordinated to hospitalized patients. RESULTS: The total amount of utilized antibacterial drugs with ATC code J01 for first quarter in 2018 is 33.65 DDD/100BD in comparison to the first quarter of 2019 when it declined to 32.09 DDD/100BD. The most consummated antibiotics in the first trimester of both years were the group of cephalosporins, especially the 3rd- and 4th-generation parenteral cephalosporins with from 16.96 to 19.25 DDD/100BD in the evaluated period. Decrease of penicillin’s, carbapenems, macrolides and quinolones were confirmed in the analyzed period. The most commonly used drugs remain ceftriaxone – 13.49 DDD/100BD in 2018 and increased to 14.41 DDD/100BD in 2019, followed by amikacin 3.21 DDD/100BD in 2018 and increased to 3.50 DDD/100BD in 2019 but azithromycin consumption significantly declined from 1.97 DDD/100BD to 0.81 DDD/100BD administered orally. The third most commonly utilized antibiotic in first quarter of 2019 become meropenem, antimicrobial drug from the group of carbapenems with 2.71 DDD/100BD. CONCLUSION: The benefits of monitoring the antibiotic prescribed pattern are critical due to the fact that they provide adequate data on consumption of antibiotics and adherence to guidelines.</jats:p>