Petreska, Biljana

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Petreska, Biljana
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Petreska, Biljana
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    ASSOCIATED RISK FACTORS AND PREVALENCE OF METABOLIC SYNDROME IN PEOPLE WHO ARE LIVING WITH HIV AND ARE ON ANTIRETYROVIRAL TREATMENT
    (Macedonian Association of Anatomists, 2025-05-02)
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    Saveski, Velimir
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    The extended life expectancy of people living with HIV infection increases the risk of metabolic syndrome (MS). To assess the prevalence of MS, the association of triple regimen antiretroviral therapy (ART) and the role of the chronic inflammatory process caused by the HIV virus with the onset of MS. A prospective cross-sectional study was conducted on 141 HIV infected adult patients with confirmed HIV infection who regularly receive ART at the University Clinic for infectious diseases and febrile conditions in Skopje. In all patients, the presence of MS was determined according to the criteria of the National Cholesterol Education Program Adult Treatment Panel ATP III (NCEP ATPIII) 2005. The statistical software SPSS (ver. 23.0; IBM, SPSS, USA) was used for statistical analysis. The prevalence of MS in persons with HIV infection in RNM was 17.96%. The group of patients with MS were significantly older and had significantly higher Body Mass Index and greater waist circumference (28.82 ± 4.6 kg/m2 vs 23.91 ± 3.6 kg/m2 p<0.0001) and (101.04 ± 12.4 vs 87.19 ± 9.8cm,p<0.0001), respectively. Treatment of patients with ART did not show a significant difference in the group with and without MS. There is a significant difference regarding the frequency of IL 6 (p=0.012). Aging and increasing Body Mass Index are significant risk factors in the developing of MS in persons with HIV infection who are on ART treatment.
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    ASSOCIATION OF SPECIFIC GENETIC MARKERS OF THE HOST WITH THE RESPONSE TO ANTIRETROVIVAL THERAPY IN HIV POSITIVE PATIENTS
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023)
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    V. Saveski
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    B. Toshevski
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    METABOLIC SYNDROME IN ANTIRETROVIRAL THERAPY TREATMENT EXPERIENCED BY PEOPLE LIVING WITH HIV
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024)
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    Saveski, Velimir
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    Introduction: Metabolic syndrome (MS) constitutes a group of risk factors that significantly affect the quality of life and life expectancy of people living with HIV. Aim: To estimate the prevalence of MS among people living with HIV who receive antiretroviral therapy (ART) in the Republic of North Macedonia (RNM). Material and methods: A study was conducted on 53 adult patients with confirmed HIV infection at the University Clinic for Infectious Diseases and Febrile Conditions, who are receiving ART. In all patients, the presence of MS was determined according to the criteria of the National Cholesterol Education Program Adult Treatment Panel ATP III (NCEP ATP III), defined by at least three of five risk factors including: low values of HDL - high density lipoprotein cholesterol, elevated waist circumference, hypertriglyceridemia, increased values of fasting glucose and hypertension. The statistical analysis was made by utilizing the statistical program SPSS 23.0. Results: The average age of patients was 35.7 ± 8.3, with a male predominance of 90.57%. All patients had undetectable values of HIV RNA viral load in serum and 79.25% had achieved immune reconstitution with a CD4 count above 350 cells/ml. The prevalence of MS among people living with HIV in RNM was 7.55%, or out of 53 respondents 4 had MS. Conclusion: People with HIV infection in RNM who regularly receive ART have a low prevalence of metabolic syndrome.
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    Life -Threating laryngeal Kaposi Sarkoa in patient with late HIV diagnosis
    (Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2019-12)
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    Duganova M
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    Marinkovic S
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    THE BEGINNING OF THE NEW ERA IN THE TREATMENT OF HCV INFECTION
    (Macedonian Medical Association, Macedonian Infectious Diseases Society, 2016-10)
    Gasheva, Magdalena
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    Evtimovska, Cvetanka
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    Toshevski, Boban
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    Characteristics of an Outpatient Cohort with HBeAg-Negative Chronic Hepatitis B
    (Scientific foundation Spiroski, 2019-07-14)
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    Gaseva, Magdalena
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    Toshevki, Boban
    Background: Patients with hepatitis Be antigen-negative chronic hepatitis B (HBeAg-negative CHB), and patients' inactive carriers (IC) have similar laboratory and serologic characteristics and are not always easy to distinguish. Aim: To characterise hepatitis Be antigen (HBeAg) negative chronic hepatitis B cohort based on their laboratory and virology evaluations at one point of time. Methods: A prospective non-randomized study was conducted on 109 patients with HBeAg negative chronic hepatitis B treated as outpatients at the Clinic for Infectious Diseases and Febrile Conditions. All patients underwent laboratory and serology testing, quantification of HBV DNA and HBs antigen (qHBsAg). Results: A group of 56 patients were inactive carriers (IC), and 53 patients had HBeAg-negative CHB (AH). The mean values of ALT, HBV DNA and qHBsAg in IC were 29.13 U/L; 727.95 IU/ml and 2753.73 IU/ml respectively. In the AH group, the mean values of ALT, HBV DNA and quantitative HBsAg were 50.45 U/L; 7237363.98 IU/ml and 12556.06 IU/ml respectively. The serum value of ALT was more influenced by qHBsAg than HBV DNA in both IC and AH groups (R = 0.22 vs R = 0.15) (p > 0.05). Conclusion: patients with inactive and active HBeAg-negative CHB have similar laboratory and serology profile. It is necessary to combine analysis of ALT, HBV DNA and qHBsAg for better discrimination between patient's IC and patient with HBeAg-negative CHB. Keywords: ALT; Chronic hepatitis B; HBV DNA; HBeAg; Inactive carriers; Quantitative HBsAg.
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    De Ritis сооднос кај пациентис со хроничен хепатитис Б
    (Macedonian Infectious Diseases Society, 2023-11)
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    Mateska, Sofija
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    Gasheva, Magdalena
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    Toshevski, Boban
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    Евалуација на фиборза на црн дроб со транзиентна еластрографија и ФИБ-4 индекс кај пациенти со Хроничен хепатитис Ц
    (Macedonian Medical Association, Macedonian Infectious Diseases Society, 2016-10)
    Toshevski, Boban
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    Gasheva, Magdalena
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    Nastevska, Cvetanka
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