Sofijanova, Aspazija
Preferred name
Sofijanova, Aspazija
Official Name
Sofijanova, Aspazija
Main Affiliation
Email
aspazija.sofijanova@medf.ukim.edu.mk
34 results
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Item type:Publication, TROPONIN – OUR EXPERIENCE IN DETERMINATION OF MYOCARDIAL ISCHEMIC DAMAGE IN POSTOPERATIVE PERIOD OF CARDIAC SURGERY IN PEDIATRIC POPULATION(2017); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PROCALCITONIN AS A PROMISING BIOCHEMICAL MARKER FOR EARLY DETECTION AND TREATMENT OF SEPSIS IN NEONATES AT INTENSIVE CARE UNIT AND ONCOLOGIC PATIENTS WITH FEBRILE NEUTROPENIA(Macedonian Association of Anatomists and Morphologists, 2020); ; Kimovska, Milica - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EVALUATION OF PROCALCITONIN AND SERUM ALBUIN LEVELS AS EARLY INFLAMMATORY BIOMARKERS IN NEONATAL SEPSIS(Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2020); ; ; ; Kimovska MPrematurity is the leading cause of death globally, and the second largest contributor to all deaths under the age of 5. The aim of this study was to evaluate serum albumin levels and procalcitonin levels for the diagnosis and prognosis of preterm newborns with neonatal sepsis. In this study, we included 100 hospital admitted preterm newborns with the first 24 hours of life, hospitalized at the Intensive Care Unit at the University Children's Hospital-Skopje, for the time period between November 2018 until 30 April 2020. The preterm newborns have been divided into three groups according to albumin levels (>30, 25-30, or <25 g/l). There was a highly significant difference between the discharge diagnosis groups, regarding their serum albumin levels and Procalcitonin (PCT) levels, and there was a significant correlation between serum albumin level and PCT levels in preterm newborns, as well. Lower serum albumin levels might be associated with a poorer prognosis in neonatal sepsis. Serum albumin and procalcitoni levels have been proposed to be an early marker for the diagnosis of neonatal sepsis and a valuable follow-up tool. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, OSTEOMYELITIS OF FEMUR IN A DRUG ADDICTED CHILD(Macedonian Association of Anatomists, 2021); ; ; ; One of the serious complicationsrelated to intravenous drug use is osteomyelitis. We report a13-year-old male child with a history of intravenous heroin abuse, who was admitted to the hospital complaining of abdominal pain and pain in the left leg. Anteroposterior roentgenogram and CT scan of the left thigh and femur,confirmed the diagnosis of osteomyelitis. Pus culture was positive for Staphylococcus aureus. Despite extensive antibiotic and anticoagulant therapy,the patient’sclinical status improved very slowly. Surgical procedure was not undertaken. Femoral osteomyelitis due to injection drug use in childhood is an extremely rare and uncommoncondition. Intravenous drug abuse, late-onset treatment, and secondary bacterial infection can lead to complications which occurred in the case presented.Itis an extremely difficult condition to treat and is a real challenge for physicians. The rapid response and participation of a multidisciplinary team of physiciansis of particularimportance - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HYDROCEPHALUS WITH VENTRICULOPERITONEAL SHUNT IN INFANTS: OUR EXPERIENCES AND CLINICAL OUTCOMES(Macedonian Association of Anatomists, 2022-12); ; ; Mica Kimovska-HristovAbstractHydrocephalus is a condition resulting from disorder in absorption and circulation of the cerebrospinal fluid (CSF). It leads toaprogressive ventricular dilatation and need of ventriculoperitoneal shunt (VP)placement. The aim of our study wasto present our experience withinfantswith hydrocephalus,ventriculoperitoneal shunt placement, and earlypostoperative follow-up.A retrospective study was conducted comprising infantswith hydrocephalus born between January 2019-January 2022with ventriculoperitoneal shunt placement performedatthe University Clinic for Neurosurgery in Skopje,Macedonia. Demographic and clinical characteristics, complications and the need for ventriculoperitoneal shunt were documented.Of twenty-three infantswith hydrocephalus,14 (60.8%) were preterm infants (median birth weight 2120g; mean gestational age 33.1weeks), 9(39.1%) were term infants(mean birth weight 3600g; mean gestational age 38.4 weeks). The etiology of hydrocephalus was:congenital hydrocephalusin 5infants(21.7%),prematurityin 6 infants(26.08%), spina bifida in 2 infants(8.7%),systemic infection in 4 infants(17.3%), and intraventricular hemorrhage in 6 infants(26.08%).Ventriculoperitoneal shunt was placed inall 23infants, at the mean age of 33.5(30-43) days.Postoperative complicationsas a result of ventriculoperitoneal shuntplacement were:ventriculitismanifested in3 preterm (13%) infants,of which 2(8.6%) died;fiveterm infants(21.7%) had postoperativeseizures, of which2 infants(8.6%) died. Nineteeninfants(82.6%) were discharged and transferredto the neonatology department. Ventriculoperitoneal shunt placementis atreatment of choice for infantswith hydrocephalus, although postoperative complications in preterm infantsincrease the percentageof morbidity and mortality. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Semilobar Holoprosencephaly Caused by a Novel and De Novo ZIC2 Pathogenic Variant(Walter de Gruyter GmbH, 2023-05); ; ; Muaremoska-Kanzoska, LjeljaHoloprosencephaly (HPE) is the most common embryonic forebrain developmental anomaly. It involves incomplete or absent division of the prosencephalon into two distinct cerebral hemispheres during the early stages of organogenesis. HPE is etiologically heterogeneous, and its clinical presentation is very variable. We report a case of a 7 month old female infant, diagnosed with non-syndromic semilobar holoprosencephaly, caused by a novel, de novo pathogenic variant in ZIC2 - one of the most commonly mutated genes in non-syndromic HPE coding for the ZIC2 transcription factor. The patient presented with microcephaly, mild facial dysmorphic features, central hypotonia and spasticity on all four extremities. Ultrasound imaging demonstrated the absence of septum pellucidum, semilobar fusion of the hemispheres and mega cisterna magna and brain MRI with confirmed the diagnosis of HPE. Early diagnosis and management are important for the prevention and treatment of complications associated with this condition. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Neonatal lupus erythematosus-a rare syndrome of transient autoimmunity(Wiley, 2022-06); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, NEONATAL ACUTE KIDNEY INJURY IN INTENSIVE CARE UNIT(2017); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DIAGNOSTIC VALUES OF BIOCHEMICAL MARKERSIN ASPHYXED NEWBORNS WITH PROVEN SEPSIS(Macedonian Association of Anatomists, 2020); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ACUTE KIDNEY INJURY IN NEONATES AND NEUTOPHILIC GELATINOUS ASSOCIATED LIPOCALIN AS EARLY BIOMARKER(Macedonian Association of Anatomists, 2019); ;