Raleva, Marija
Preferred name
Raleva, Marija
Official Name
Raleva, Marija
Email
marijaraleva@gmail.com
5 results
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Item type:Publication, Depression and Resilience in Breast Cancer Patients(ID Design 2012/DOOEL Skopje, 2015-12-15); ; A significant number of breast cancer patients, during their life with the diagnosis, experience emotional distress in the form of depression and anxiety. Psychological resilience is the ability of a person to protect his/her mental health when faced with adverse circumstances such as the cancer diagnosis. This study aims to assess the resilience in breast cancer patients and to explore whether depression affects the resilience. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Association between adverse childhood experiences and health risk behaviours such as smoking, use of alcohol and substance abuse in adolescence(AU-CNS, 2016-08); Background. Adverse childhood experiences (ACEs) constitute a great proportion of the risk factors that predict poor health in later life. Aim. This study examined the association between ACEs and use of alcohol and illicit drugs, and recourse to smoking, as well as the role of gender in the association between ACEs and those health-harming behaviours. Methods. The study was retrospective and included 1,277 young adults that completed the survey on ACEs. Results. ACEs raised the likelihood of illicit drug use 2.2- to 4-fold, early initiation of smoking 2- to 3-fold, and smoking and alcohol use 1.5- to 2-fold. Compared with students without any ACEs, students with >3 ACEs showed a 2.2-fold probability of reporting illicit drug use, a 2-fold probability of starting to smoke early, and students with >4 ACEs were 60% more likely to be smokers. Almost the same percentage of female and male students smoked and used alcohol, male students smoked twice as much as female students and a significantly higher number of male students (11.3%) had drunk 6 drinks or more on a single occasion 3 or more times during the last month compared with 3.3% of female students. Significantly more male (7.6%) than female (3.6%) students had used illicit drugs in their lifetime and 3.5% of male versus 1.6% of female students had used illicit drugs more than 3 times in their life. Conclusions. ACEs increase the risks of smoking and substance use in students. Significantly more male students than female ones had used illicit drugs, and had smoked and drunk significantly greater quantities of cigarettes and alcohol. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Depression and Anxiety in Adolescents and their Caregivers: A Cross-Sectional Study from North Macedonia(Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Walter de Gruyter GmbH/Walter de Gruyter GmbH, 2023-03-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of Correlation Between the Pharmacogenetic Profiles of Risperidone Treated Psychiatry Patients with Plasma and Urine Concentration of Risperidone and its Active Moiety 9-OH Risperidone Determined with Optimized Bioanalytical LC Method(Walter de Gruyter GmbH, 2018-12-01); ; Atypical antipsychotic risperidone is widely used first-line monotherapy in schizophrenia and combined therapy in bipolar disorders. Therapeutic plasma concentrations of risperidone and its active moiety are directly influenced by genetic variations in metabolic CYP450 enzymes (CYP2D6 and CYP3A4/5) and transporter (ABCB1) protein and additional environmental factors. Since active metabolite 9-OH risperidone has a greater percentage of the pharmacologically active fraction and is equipotent to the parent drug risperidone, it is assumed that it contributes significantly to therapeutic and adverse effects. Unpredictable dose/concentration ratio, narrow therapeutic index, number of interactions, along with serious adverse reactions (ADR), raises the need for individualization of risperidone treatment and establishing of good therapeutic regime using TDM. A simple and reliable validated bioanalytical liquide-liquide extraction HPLC/UV method was applied for the simultaneous determination of risperidone and its active metabolite, 9-OH risperidone, in human plasma and urine of 52 hospitalized schizophrenia/bipolar disorder patients treated with risperidone as monotherapy and in polytherapy. All the patients were previously genotyped for CYP2D6 (EM=30, EM/IM=14, IM=4 IM/PM=1 and PM=3) and ABCB1 using Real-Time PCR methods with TaqMan SNP genotyping suitable assays according to the guidelines of the manufacturer (Life Technologies, USA).The influence of CYP2D6 phenotype on metabolic ratio MR (Ris/9-OHRis) in plasma (p=0.012) and in urine (p=0.048) was confirmed. Statistically significant correlation (R2=55.53%, Rho=0.844, p<0,0001) for MR in both plasma and urine indicates that urine may be utilized as appropriate media for initial CYP2D6 phenotype identification and selection of patients on risperidone treatment with high risk for ADR. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Social distance and stigma towards persons with serious mental illness among medical students in five European Central Asia countries(Elsevier BV, 2022-03)