GJeorgjieva janev, Olivera
Preferred name
GJeorgjieva janev, Olivera
Official Name
GJeorgjieva janev, Olivera
7 results
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Item type:Publication, Case report on a switch from hypothyroidism to hyperthyroidism(The Endocrine Society, 2023-01-18); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Emphysematous pyelonephritis and sepsis in a diabetic female patient caused by extended-spectrum beta-lactamase-producing Escherichia coli – case report(Slovenian Medical Association, 2023-07-13); ; ; ; <jats:p>Emphysematous pyelonephritis (EPN) is a rare, severe, spontaneous gas-forming infection of renal parenchyma and its surrounding areas. EPN was detected in diabetic patients. A 49-year-old female with type I diabetes mellitus presented with severe thrombocytopenia, acute kidney injury (AKI) and was in need of haemodialysis treatment. She had impaired liver function tests, with active urine sediment, indicating severe upper urinary tract infection with suspected sepsis. The contrast enhanced CT scan of the abdomen showed multiple areas of air density in renal parenchyma and perirenal regions, suggestive of left-side EPN. The blood and urine cultures reported growth of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli. The final diagnosis of emphysematous pyelonephritis complicated with severe sepsis and AKI was established. The patient was managed conservatively with wide-spectrum antibiotics, fluid resuscitation, consistent blood sugar control, and haemodialysis treatment. Percutaneous drainage techniques (PCD) and nephrectomy were postponed because of the initial clinical response to the antibiotics treatment. However, the patient experienced sudden clinical deterioration and died only a few hours after the established diagnosis. An autopsy was not performed upon the patient’s family’s request. EPN should be highly suspected in poorly controlled diabetic patients with urinary tract infection and should be promptly recognized and aggressively treated. The patients with multiple risk factors had high mortality, even with timely diagnosis and combined (conservative and surgical) treatment.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Late onset of SLE in males: A misdiagnosed disease(Macedonian Association of Anatomists and Morphologists, 2022); ; Systemic lupus erythematosus (SLE) is an autoimmune disease characterisedby the production of antibodies to components of the cell nucleus in association with a diverse array of clinical manifestations. When the immune system attacks its own tissues, it causes widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy.Late-onset SLE represents a specific subgroup of SLE and is often initially missed leading to a significant delay in diagnosis. Elderly patients frequently present to hospital with nonspecific symptoms such as fatigue, recurrent fever of an unknown cause, weight loss, serositis (pleural and/or pericardial effusions), and acute kidney injury.We are describing a case of late onset SLE in a male patient that has been previously only syptomaticaly treated for the complications of the disease itself, whilst it took a longer period for physicians to thinkof SLE and make further investigations about it, because of the age and sex of the patient. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANTISYNTHETASE SYNDROME: A RARE AND CHALLENGING DIAGNOSIS – CASE REPORT AND LITERATURE REVIEW(Central Medical Library - Bulgaria, 2022-10); ; ; Antisynthetase syndrome (ASS) is rare idiopathic inflammatory myopathy (IIM) characterized principally by myositis, generally symmetrical arthritis and interstitial lung disease (ILD) in association with serum autoantibodies to aminoacyl-transfer RNA synthetases. More variable features include arthralgia, Raynaud phenomenon, heliotrophic rash, distal esophageal dysmotility and mechanic's hands. In this case report we describe a 46-years old woman who initially presented with arthritis and subtle myositis which delayed the recognition of ASS and contributed for considering the condition as seronegative rheumatoid arthritis for several years. During the next few years, the patient was progressively worsening, with a disability to stand up from a sitting position, gradual onset of exertional dyspnea, difficult-to-control dry cough and thick, hyperkeratotic skin of both hands (mechanic’s hands). This constellation of symptoms was highly suspicious for ASS and additional serological and radiological examinations were done which confirmed the diagnosis. The need for further detailed investigation when an interstitial lung disease overlaps with a known rheumatoid condition is obligatory, as shown in this case. A multidisciplinary evaluation is highly recommended to evaluate the clinical, serological and radiological findings in each patient suspected for ASS in order to establish early diagnosis and timely management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus, a diagnostic and a management challenge(Bulgarian Rheumatology Society, 2023-08-31); Thrombotic thrombocytopenic purpura (TTP) is a rare, potentially fatal blood disorder that can be challenging for clinicians to identify in the setting of autoimmune diseases such as systemic lupus erythematosus (SLE). SLE can present with thrombotic microangiopathy (TMA) and differentiation between the two diseases can be quite difficult. In this case report we present a 62-year-old female with a history of SLE who was hospitalized with thrombocytopenia, dysarthria, dizziness, paresthesia and altered mental status. The laboratory results revealed direct Coombs negative hemolytic anemia, severe thrombocytopenia, significant elevation of lactate dehydrogenase, leukocytosis and presence of few schistocytes in the peripheral film. In addition, we also present evidence for circulating anti-ADAMTS13 antibody/ADAMTS13 antigen. Based on clinical, hematological, and biochemical findings, we concluded that it was a case of TTP-like microangiopathy associated with SLE and indicated treatment with methylprednisolone pulses and plasmapheresis. Later on, she developed psychosis and made plasmapheresis difficult to perform. We continued corticosteroids (dose 1mg/kg), RhoGAM, Chloroquine and Azathioprine, obtaining a satisfactory response after one week of treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Excellent Response to Alectinib in ALK Positive NSLC Adenocarcinoma, Case Report and Literature Review(Macedonian Association of Anatomists and Morphologists, 2023); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BULL’S EYE: IS THIS PHENOMENON GIVEN ENOUGH ATTENTION(Macedonian Association of Anatomists and Morphologists, 2024);