Dimitrovska, Irena
Preferred name
Dimitrovska, Irena
Official Name
Dimitrovska, Irena
Translated Name
Димитровска, Ирена
Alternative Name
Ирена Димитровска
Irena Dimitrovska
Main Affiliation
8 results
Now showing 1 - 8 of 8
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Item type:Publication, Barriers and factors that facilitate the use of long-term oxygen therapy at home and the quality of life of patients with COPD(Association of Traditional Chinese Medicine and Acupuncture Tong Da Tang TCM, Skopje R.N. Macedonia, 2024) ;Suzana Arbutina; ; Aleksandra StefanovskaBackground: Long-Term Oxygen Therapy (LTOT) is a critical intervention for managing chronic obstructive pulmonary disease (COPD) in patients with severe hypoxemia. Despite its clinical benefits, the effective use of LTOT at home faces numerous barriers and facilitating factors that significantly influence the quality of life (QoL) of COPD patients. Objective: This study aims to explore the barriers and factors that influence the use of LTOT at home, as well as its impact on the quality of life of COPD patients Methods: Through a comprehensive review of the literature, we identify the challenges and facilitators associated with LTOT use, along with the factors that contribute to the quality of life of patients. A mixed-methods approach was utilized in this study, involving qualitative data from semi-structured interviews with patients, caregivers, and healthcare providers. The study included a cohort of COPD patients on LTOT, assessing their experiences and QoL over a specified period. Results: Key barriers to effective LTOT use at home included physical limitations, social stigma, equipment management issues, and insufficient patient education. Facilitating factors identified were robust social support, comprehensive education programs, and regular follow-up with healthcare providers. Conclusion: Understanding the barriers and facilitating factors in the use of LTOT at home is essential for enhancing adherence and improving the QoL of COPD patients. Tailored interventions that address these barriers and leverage facilitating factors can lead to more effective LTOT use and better patient outcomes. This study highlights the importance of a holistic approach in managing COPD, incorporating both medical treatment and supportive measures to optimize patient well-being. The findings provide valuable insights into enhancing the effectiveness of LTOT at home and improving the overall well-being of individuals living with COPD. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pulmonary embolism - Pulmonary thromboembolism in patient with rectal adenocarcinoma(Association of Traditional Chinese Medicine and Acupuncture Tong Da Tang TCM, Skopje R.N. Macedonia, 2024); ; ;Suzana Arbutina ;Gabrijela DimoskaAleksandra StefanovskaPulmonary thromboembolism (PTE) is potentially life-threatening disorder. The pathogenesis of pulmonary thromboembolism isn’t fully understood, but it is believed to involve imbalance between pro-coagulants and anticoagulants, as well as endothelial dysfunction and acute or chronic inflammation. Pulmonary embolism (PE) occurs when there is a disruption to the blood flow in the pulmonary artery or pulmonary branches by a thrombus that originated somewhere else. Risk factors for PE are deficiency of protein S,protein C deficiency, anti-thrombin III deficiency, LA-lupus anticoagulant, factor V Leiden deficiency, antiphospholipid syndrome (APLS), previous surgical treatment, chemotherapy, immunosuppressive drugs, immobility, overweight ,oral contraceptives, pregnancy ,history of vein thrombosis ,thrombophlebitis , varicose veins. There is a relationship between higher body mass index (BMI) and VTE, and patients with severe obesity (BMI ≥ 35) have higher risk of pulmonary thromboembolism compared with those of normal BMI. Patients with pulmonary thromboembolism may present with a spectrum of symptoms, including chest pain, shortness of breath, tachycardia, hemoptysis, asymmetric pitting edema on legs, prominent superficial collateral vessels, tenderness and pain to palpation of the leg, red or purple color, warmth on the affected leg. The diagnostic work-up of suspected pulmonary embolism includes D-dimer testing, ECG, ultrasonography of heart and CT angiography. Direct oral anticoagulants are first-line treatment options for venous thromboembolism because they are associated with a lower risk of bleeding disorders than vitamin K antagonists. Use of thrombolysis should be limited to pulmonary embolism associated with haemodynamic instability. Anticoagulants should be continued for at least 3 to 6 months to prevent early recurrences and relaps of PE. Haematological malignancies, lymphoma, lung cancers and colorectal cancers are the most common cause of PE - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A 75-year old woman with undiagnosed Behcet's disease presenting with recurrent thromboembolism and aortic disection:A multidisciplinary Perspective(Association of Traditional Chinese Medicine and Acupuncture Tong da Tang, 2024-11) ;Arbutina, Suzana; Behçet's disease (BD) is a systemic vasculitis characterized by recurrent oral and genital ulcers, uveitis, and skin lesions, often leading to severe vascular complications, including recurrent thromboembolism and aortic dissection. While its etiology remains uncertain, BD is thought to involve genetic predisposition and environmental triggers, with associations to HLA-B51 particularly prevalent among populations along the historical Silk Road. Diagnosing BD is challenging due to its diverse symptoms and lack of specific biomarkers, necessitating a holistic approach that considers a wide array of clinical, serological, and imaging findings. This report presents the case of a 47-year-old woman with previously undiagnosed BD who developed severe complications, including aortic dissection and pulmonary embolism. A multidisciplinary approach was critical in recognizing the systemic nature of her condition, eventually confirming BD through the combination of vascular involvement, mucocutaneous symptoms, and a positive HLA-B51 marker. Following diagnosis, targeted treatment involving immunosuppressive therapy and anticoagulation led to significant improvement. This case underscores the importance of a comprehensive, interdisciplinary perspective in managing BD, especially in complex cases where symptoms span multiple organ systems. Further research into BD’s underlying mechanisms and more effective, integrative treatment approaches is essential to improve patient outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Пулмонален синдром при инфекција со Ханта вирус(Residents' Doctor Association RDA, 2023-11); ;Suzana Arbutina; ;Aleksandra GeorgievaIle Kuzmanoski - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hipoventilacioni sindrom gojaznih (HSG) -Simptomi,dijagnoza i ljecenje(2024-06-06); ;Suzana Arbutina ;Lence ZdraveskaEleonora MilosheskaUvod. Hipoventilacioni sindrom gojaznih (HSG) predstavlja kombinaciju gojaznosti (BMI> 30), poremećaja disanja tokom spavanja i povišenih vrednosti parcijalnog pritiska ugljen dioksida (PCO2) u arterijskoj krvi tokom dana. Poznat je i pod nazivom Pikvikov sindrom (Sy Pickwick). HSG predstavlja kombinacija faktora: gojaznost, hipoventilacija, naruseno spavanje, apneja u toku spavanja, opstruktivna sleep apnea (OSA). Postoji globalna epidemija hipoventilacionog sindroma gojaznih koja obuhvata sve uzraste, uključujući decu, adolescente i odrasle; stoga se rasprostranjenost takođe povećava u ovim starosnim grupama. Trenutno 35 % stanovništva Sjedinjenih Ametickih Država pati od morbidne gojaznosti (BMI> 40 kg/m2). HSG je zastupljen sa oko 0.4% u opštoj populaciji i ukoliko se ne leči, udružen je sa visokim mortalitetom. Simptomi sindroma hipoventilacije se obično javljaju zbog hipoksemija. Ovi simptomi mogu da uključuju: nedostatak daha (dispeju), umor, nedostatak energije, dnevnu tromost, glavobolje, vrtoglavica, depresije. Tokom spavanja kod pacijenta se primecuje glasno hrkanje, gušenje ili dahtanje, pauze u disanju. Dijagnostika podrazumeva, pored anamneze i fizikalnog pregleda, određivanje BMI, merenje obima vrata. Potrebno je napraviti EKG, labaratorijske analize, pulsnu oksimetriju, spirometrijsko ispitivanje plućne funkcije, radiografiju grudnog koša, merenje gasnih analiza arterijske krvi i polisomnografsko ispitivanje. Spirometrijski nalaz može biti uredan ili se može naći restriktivan poremećaj. Ključnu ulogu u lečenju ima promena navika u ishrani, higieno-dijetetski rezim, povecana fizicka aktivnost, redukcija telesne i prekid pušenja. Primena neinvazivne CPAP-a ili BiPaP-a, mogla bi da bude od pomoci kod ovih pacijenata. Kod određenih pacijenata koji ispunjavaju kriterijume može se uraditi barijatrijska operacija. Paralelno sa primenom NIV-a potrebno je lečiti komorbiditete kao što su HTA, hiperlipidemija, dijabetes, hipofunkcija štitne žlezde, drugih endokrinioloskih i metabolnih poremecaja. Komplikacije bolesti su mogobrojne a u prvom redu podrazumevaju pojave DM2, HTA, srčane slabosti, hronično plućno srce, hronična respiratorna insuficijencija, sekundarna eritrocitoza i plućne tromboembolijske bolesti. Zaključak. Hipoventilacioni sindrom gojaznih je udružen sa visokim mortalitetom I prisustvom komorbiditeta kao HTA, DM2,srcane slabosti, hroničnog plućnog srca i hronične respiratorne insuficijencije. Vazna je dijagnostikovati bolest i leciti je na vreme. Pacijente kod koji postoji sumnja na HSG potreban je multidisciplinarni pristup. Ključne reči: Hipoventilacioni sindrom gojaznih, opstruktivna, sleep apnea, NIV, CPAP - Some of the metrics are blocked by yourconsent settings
Item type:Publication, STUDIJA PRESEKA – KVALITET ZIVOTA PACIJENATA SA HOBP-OM: UPOTREBA SGRQ I HADS(2024-01-06); ;Suzana Arbutina ;Aleksandra Stefanovska ;Verce JovanovskaValentina SmileskaHronična opstruktivna bolest pluća (HOBP) je dugotrajna, progresivna bolest pluća koja ometa normalan protok vazduha u plućima.Ova bolest obuhvata dva glavna stanja:hronični bronhitis i emfizem.Glavni uzroci HOBP-a su pušenje, dugotrajna izloženost drugim iritansima pluća, zagađenja vazduha ili hemikalija na radnom mestu. Simptomi HOBP-a uključuju kašalj, prisusvo sputuma, dispneju i umor. Lečenje HOBP-a obično uključuje promene u načinu života, kao što su prestanak pušenja, redovno vežbanje i ishrana, kao i lekove za olakšavanje simptoma i sprečavanje komplikacija. Teže slučajeve HOBP-a može zahtevati dodatne terapije poput kiseonika ili pulmološke rehabilitacije. Rano prepoznavanje i upravljanje HOBP-om ključni su za kontrolu simptoma i očuvanje kvaliteta života.Ova presečna studija imala je cilj da proceni kvalitet života pacijenata sa HOBP-om koji koristi respiratorni upitnik Svetog Đorđa (SGRQ) i bolničku skalu anksioznosti i depresije (HADS). Studija je obuhvatila 62 pacijenta koji su popunjavali upitnike na početku hospitalizacije i ponovo nakon otpuštanja iz bolnice. Rezultati studije su pokazali da je značajan deo pacijenata sa HOBP imao simptome anksioznosti i depresije. Utvrđeno je da su ovi simptomi mentalnog zdravlja snažno povezani sa negativnim ishodima kvaliteta života pacijenata. Studija je takođe otkrila da je anksioznost više zastupljena među pacijentima sa anksioznošću i depresijom u anamnezi, kao i među ženskom populacijom. Pored toga, utvrđeno je da komorbiditeti u HOBP-u doprinose nižem kvalitetu života u smislu simptoma mentalnog zdravlja. Korelacionom analizom otkrivena je jaka povezanost između SGRQ rezultata i prisustvo simptoma anksioznosti i depresije, naglašavajući međusobnu povezanost prirode fizičkog i mentalnog zdravlja kod pacijenata sa HOBP. Zaključak ovih nalaza naglašavaju važnost bavljenja i respiratornim i psihološkim aspektima HOBP u strategijama nege i lečenja pacijenata. Prepoznajući vezu između respiratornih simptoma i psihičkog stresa, zdravstveni radnici mogu da sprovedu ciljane intervencije za poboljšanje kvaliteta života pacijenata sa HOBP. Ova studija preseka pruža uvid u odnosu između respiratornih simptoma i psihološkog blagostanja kod ovih. Nalazi naglašavaju potrebu za integrisanim pristupom koja se bavi fizičkim i psihološkim aspektima HOBP - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pulmonary fibrosis - symptoms, causes and treatment(Македонско здружение за алергологија и клиничка имунологија - МЗАКИ, 2023-09) ;Suzana Arbutina - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HYPERTENSION IN PRIMARY HYPERPARATHYROIDISM: A CASE REPORT OF ECTOPIC PARATHYROID ADENOMA(Македонско лекарско друштво = Macedonian medical association, 2024); ;Vejseli, Ron; ;Arbutina, SuzanaTrajkovska, TinaPrimary hyperparathyroidism is a condition characteri- zed by excessive production of parathyroid hormone, often caused by an adenoma or hyperplasia of the parathyroid gland. One of the rare presentations of primary hyperparathyroidism is the development of an ectopic parathyroid adenoma, which can be challen- ging to diagnose and localize. Hypertension is observed seen in many cases of primary hyperparathyroidism (PHPT), although the exact mechanism is yet unclear. This paper aims to provide a comprehensive review of the current understanding of primary hyperparathy- roidism, with a focus on the presentation of ectopic adenomas and the relationship between primary hyper- parathyroidism and resistant hypertension. While most parathyroid adenomas are located in the normal ana- tomical position of the parathyroid glands, a small percentage (approximately 2-5%) can occur in ectopic locations, such as the thyroid gland, carotid sheath, or mediastinum. The atypical location of ectopic parathy- roid adenomas can make them more difficult to iden- tify and remove surgically, which can be difficult diag- nostic challenge. The prevalence of primary hyperpa- rathyroidism has been estimated to be around 0.1-0.4% in the general population, with a higher incidence in postmenopausal women. The imaging tests consist mainly of an initial 99mTc- sestamibi SPECT/CT. Sensitivity and specificity of sestamibi scans are between 73%-80%, respectively. Clinical sensitivity is increased to 96% when sestamibi scans are combined with ultrasound
