Nancheva, Jasminka
Preferred name
Nancheva, Jasminka
Official Name
Nancheva, Jasminka
Main Affiliation
Email
jasminkananceva@yahoo.com
27 results
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Item type:Publication, General anesthesia: Is it safe for newborns, infants and young children?(Association of medical doctors "Sanamed" Novi Pazar, 2016); ; ; The exposure of neonates, infants and small children to general anesthesia is becoming a common occurrence. Accumulating preclinical data indicate that exposure to commonly used general anesthetic agents during key periods of brain development in this population(between late gestation and 3 to 4 years of age,) can lead to apoptotic neurodegeneration, synapse loss, and cognitive and neurobehavioral deficits that persist as the organism matures. New work suggests that infants and small children undergoing some types of surgery could have better recovery if they receive regional anesthesia rather than general anesthesia. In response to this concerns, the Food and drug administration (FDA) and the International Research Society in anesthesia (IARS) started an initiative called Smart Tots (Strategies for Mitigating Anesthesia- related neuro Toxicity in Tots) which examine the effects of anesthesia on brain development. Also another two major prospective studies are ongoing in children : PANDA (Pediatric Anesthesia Neurodevelopment assessment Study )project is a large, multi-center study based at the Morgan Stanley Childrens Hospital of New York at Columbia University, and another one is GAS study which is a multisite randomized controlled trial comparing neurodevelopment outcomes in infant receiving general anesthesia compared to spinal and other regional anesthetics to the stress response to surgery. The findings from these studies will help researches to design the safest anesthetic regimens and to develop the new and safer anesthetic drugs for use in pediatric medicine. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE EFFECT OF PLASMA PREPARATION RICH IN GROWTH FACTORS ON PATELLAR STABILITY AFTER MEDIAL PATELLOFEMORAL LIGAMENT REEFING(Association of medical doctors "Sanamed" Novi Pazar, 2016); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Opioid Free Anesthesia for Laparotomic Hemicolectomy: A Case Report(Macedonian Academy of Sciences and Arts /Walter de Gruyter GmbH, 2018-12-01); ; ; Opioid free anesthesia (OFA) is deffined as anaesthesiological technique where opioids are not used in the intraoperative period (systemic, neuroaxial or intracavitary). Anaphylaxis caused by opioids (fentanyl) is very rare, and the reaction is presented with hypotension and urticaria. When we have proven allergy to fentanyl, patients' refusal of placing epidural catheter and refusal of receiving bilateral ultrasound guided transversus abdominis plane block (USG TAPB), we must think of using multimodal nonopioide analgesia. The concept of multimodal balanced analgesia is consisted of giving different analgesic drugs in purpose to change the pathophysiological process which is included in nociception, in way to receive more effective intraoperative analgesia with less adverse effects. This is a case report of a 60-year-old male patient scheduled for laparotomic hemicolectomy, who previously had proven allergy to fentanyl. We have decided to give him an opioid free anaesthesia. Before the induction to anaesthesia, the patient would receive dexamethasone (dexasone) 0.1 mg/kg and paracetamol 1 gr intravenously. The patient was induced into general endotracheal anesthesia according to a standardized protocol, with midazolam 0.04 mg/kg, lidocaine hydrochloride 1 mg/kg, propofol 2 mg/kg and rocuronium bromide 0.6 mg/kg. Anaesthesia was maintained by using sevoflurane MAC 1 in order to maintain mean arterial pressure (MAP) with a value of +/- 20% of the original value. After tracheal intubation, the patient had received ketamine hydrochloride 0.5 mg/kg (or 50 mg ketamine) in bolus intravenously and a continuous intravenous infusion with lidocaine hydrochloride (lidocaine) 2 mg/kg/hr and magnesium sulfate (MgSO4) 1,5 gr/hr. At the end of surgery the continuous intravenous infusion with lidocaine and magnesium sulfate was stopped while the abdominal wall was closed and 2.5 g of metamizole (novalgetol) was given intravenously. VAS score 2 hours after surgery was 6/10 and 1 gr of paracetamol was given and the patient was transferred to the Department. Over the next 3 days, the patient had a VAS score of 4-6/10 and only received paracetamol 3x1g and novalgetol 3x1 gr daily, every four hours. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, VACCINATION, ANESTHESIA AND SURGERY(Medical faculty, Ss Cyril and Methodius University in Skopje, 2020); ; ; Baloski, M - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PEDIATRIC SURGICAL STRESS RESPONSE AND ANESTHESIA(MIT Univerzitet Skopje, 2021); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Does the Apolipoprotein E Genotype Increased the Risk of Postoperative Delirium in Adult Patients?(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2023-12); ; ; ; Toleska, MarijaBackground: The relationship between genetic predisposition and the development of postoperative delirium has not yet been established. The e4 allele of the apolipoprotein E gene has been reported as a genetic risk factor for delirium. Objective: This paper analyzed the relationship between the frequency of genotypes of the APOE rs7412/rs429358 polymorphism, which contains the minor allele e4, and the occurrence of postoperative delirium. Material and Methods: The study included patients aged 65 years and older without pre-existing cognitive impairment admitted to the University Clinic for Traumatology and Orthopedics for operative treatment of a fracture of the upper end of the thighbone. The Confusion Assessment Method (CAM) confirmed the delirium diagnosis. APOE rs7412/rs429358 polymorphism genotypes were determined by molecular genetic analysis using the quantitative real-time amplification method (qRT-PCR) on DNA samples extracted from venous blood leukocytes. Results: The presented results are from analyzed samples and data from 51 patients. Out of these, postoperative delirium was diagnosed in 12 patients, while in 39 patients weren’t registered, and they are the control group in the trial. Conclusion: This study results indicate the association of the studied polymorphism in the apolipoprotein E gene, which contains the minor allele e4, with the occurrence of postoperative delirium in this group of adult patients. A larger group is necessary to reach more valid conclusions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Myasthenia gravis and general anesthesia(Department of Anesthesia and reanimation, Faculty of Medicine, Ss.Cyril and Methodius University, Skopje, Macedonia, 2017-04); ; ; Myasthenia gravis patients undergoing general anesthesia are real challenge. Several contemporary issues of the disease, as well as the therapy and additional contributing factors interfere with the anesthetics on several levels. Up to day, literature has not proved which type of anesthesia or anesthetics are superior in such patients. The aim of this article is to elaborate and review some of the possible aspects of this disease and their interference with anesthesia that have direct influence on these patients outcome. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE OF MUSCULOSKELETAL DISORDERS IN PRIMARY SCHOOL CHILDREN(Faculty of Physical Education, Sport and Health, Skopje, Republic of Macedonia, 2020); ; ; ; Introduction: Early detection and understanding the musculoskelatal disordersof in children and young people is very important for understanding the etiology, development of musculoskeletal disorders and what is very important for creating nationally effective preventive strategies. The aim of this study is to evaluate the prevalence of skeletal disorders in all primary schools on the territory of the municipality Kisela voda, Skopje. Materials and Methods: The material for the investigation comprised 4609 school children. The data were collected through interview, questionnaire, observation, and examination. Data analyses was performed by SPSS version 22, using descriptive analytic statistics. The significance level was 95%. Results: The results showed that drooping shoulders (53%), scoliosis (25.3%) and kyphosis (7.4%) were the most common skeletal disorders. Conclusion: Prevention of the musculoskeletal system is very important to detect early-stage deformity. It is very important for the individual, the family and the whole society. With the help of prevention, there is an early cure, the possibility of treatment with less invasive methods or there is a possibility of reduction or complete non-surgical treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Choice of the most optimal surgical treatment of femoral neck fractures(Medical faculty, Ss Cyril and Methodius University in Skopje, 2019); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PRESENCE OF METATARSAL SYNDROME IN PATIENTS WITH HALLUX VALGUS DEFORMITY OPERATED BY KELLER'S METHOD(MIT Univerzitet Skopje, 2020); ; ; ; Metatarsalgia syndrome is a common pathological outcome in patients with hallux valgus deformity. However, the association between the occurrence of preoperative and the presence or absence of postoperative metatarsalgia in operated patients with this deformity has not been systematically investigated. The aim of this study was to investigate the presence of metatarsal syndrome preoperatively and postoperatively in patients with hallux valgus deformity operated by resection arthroplasty using the Keller method. Material and method: The material of the study included 35 patients with hallux valgus deformity, treated with the operative procedure according to the Keller method. The metatarsal pain was evaluated with the clinical method - accordion test. Clinical and radiographic examination of the subjects was done preoperatively and postoperatively. Results: Metatarsalgia was registered before surgery in 27 (77.1%) subjects, of which only 5 (18.5%) subjects had this symptom after surgery. All 8 (22.9%) subjects without metatarsalgia preoperatively, are without this symptom and postoperatively. Conclusion: Resection arthroplasty according to Keller method allows a drastic percentage reduction of metatarsal syndrome in the postoperative period.
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