Jankulovska, Anamarija
Preferred name
Jankulovska, Anamarija
Official Name
Jankulovska, Anamarija
Translated Name
Јанкуловска, Анамарија
Alternative Name
Jankulovska, A
Jovanovska, Anamarija
Jovanovska, AM
Jovanovska, A
Anamarija Jankulovska
Anamarija Jovanovska
Анамарија Јанкуловска
Анамарија Јовановска
Main Affiliation
Email
anamarija.jovanovska@medf.ukim.edu.mk
a.jankulovska@medf.ukim.edu.mk
25 results
Now showing 1 - 10 of 25
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Coexistence of Paget disease and lung cancer - importance of patient management(Discover STM Publishing Ltd., 2022); ; ; Background: The coexistence of metabolic bone disease, such as Paget disease (PD) and malignant tumor is frequently described in patients with breast, prostate, lung, lymphoproliferative, colorectal, and renal neoplasms. Indeed, when evaluating cancer patients, there may be diagnostic dilemma of interpreting some changes in bone involvement, whether they are malignant or metabolic changes, since some radiological features of metabolic bone disease can mimic those of bone metastases. Case Presentation: We report a case of 55-year-old male patient, with diagnosed lung adenocarcinoma, referred to the Nuclear Medicine Department for a bone scintigraphy (BS), for evaluation of presented bone metastasis. The Single photon emission computed tomography (SPECT)/computer tomography (CT) scan revealed intensive metabolic accumulation of the radiotracer in cervical vertebra C7, and thoracic vertebra Th1, Th6, Th11, Th12, as well as lumbar vertebra L4, L5, left sacroiliac joint, both iliac and pubic bones and left proximal femur. The FDG PET/CT showed diffuse, but mildly increased uptake in Тh6, Тh11, L4, L5 and pelvic bones (SUV max = 3.3). The CT revealed destruction of Th11 body with compression fracture. Diagnosis of PD was made based on the findings of BS and PET/CT and further confirmed on bone biopsy and the patient was started with bisphosphonate therapy. Conclusion: BS and SPECT/CT are of great importance in accurate detection of incidental PD in patients with lung cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Nuclear medicine hybrid imaging (SPECT/CT) in distinguishing the presence of a hepatic hemangioma: Single center study(Centre for Evaluation in Education and Science (CEON/CEES), 2023); ; ; <jats:p>Objective. Hepatic hemangioma (HH) is the most common benign liver tumor, and the second most frequent tumor in the liver after hepatic metastasis. The SPECT/CT hybrid technique will be beneficial for the investigation of this type of HH since it can precisely identify the hepatic lesions. The aim of this study was to reevaluate the sensitivity and specificity of the nuclear medicine method for confirmation or exclusion of benign hemangioma of the liver based on a series of cases at our department and briefly review the literature. Methods. We retrospectively analyzed 107 patients, 62 females (57.94%) and 45 males (42.05%) with mean age 50.05±11.92 years, referred to the Nuclear Medicine Department for 99mTc-RBC scintigraphy of the liver to conclude or exclude the presence of HH, in the period 2019 to 2020. Results. Hepatic scintigraphy located the hemangiomas mostly in the right hepatic lobe. The size of the lesion varied from to 6-140 mm (46.04 ± 27.1); 13 hemangiomas were described as giant. SPECT-CT confirmed HH in 1 patient that was negative on ultrasound, besides 30/87 (34.48%) patients who were described as positive on US and turned out to be negative on the scintigraphic method. In 53 (60.92%) patients, positive matching of the US images and hybrid SPECT/CT imaging for HH was found. Most of the patients had benign referral diagnosis, while 12 of them had confirmed malignant diagnosis in whom eight (n=8, 66.67%) were confirmed free of hepatic metastasis and SPECT-CT detected HH, while in 4 patients who were described as positive for HH on the CT scan, the scintigraphic method excluded HH and further evaluation of the hepatic lesion was needed. Conclusion. Hepatic hemangiomas require a careful diagnosis to differentiate from other focal hepatic lesions, cooccurring diagnoses are also possible. Differentiating between HH and hepatic metastatic disease is a typical clinical difficulty when the problem is present in staging or monitoring patients with oncological disease.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Unusual scintigraphic finding in a patient with amiodarone - induced thyrotoxicosis : a case report(Macedonian Association of Anatomists, 2021); Amiodarone, an antiarrhythmic drug with 37% iodine of its weight, is often used for treatment of severe cardiac arrhythmias. Enormous iodine content and structural similarity to thyroxine leads to thyroid dysfunction in 14 - 18% of patients. A 64 - year - old man presented at our department with signs of thyrotoxicosis for further work up. He reported taking amiodarone for treatment of atrial fibrillation for two years. The patient deni ed any thyroid dysfunctions in the past. Full thyroid examination revealed elevated FT4 and suppressed TSH, with undetectable level of thyroid antibodies, increased iodine urinary concentration and normal thyroid ultrasound features. Although the above men tioned was indicative for amiodarone - induced thyrotoxicosis (AIT) type 2, 99mTc - pertechnetate scan showed normal thyroid uptake, highly unusual for iodine contamination and destructive thyroiditis. We presumed that this was a mixed form of AIT. Amiodarone administration was stopped and the patient was put on antithyroid drug therapy with thiamazole. During the follow up period he became clinically and biochemically euthyroid and thiamazole was discontinued. Thyroid screening should be performed in all patie nts undergoing amiodarone treatment. The presented case highlights the challenge of differentiation and management of a form of AIT with mixed features of both types. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Evaluation of Sentinel Lymph Node Biopsy Using Radiocolloid in First Stage Endometrial Cancer(Galenos Yayinevi, 2023-06-20); ; ; Detection of a sentinel lymph node (SLN) in patients with endometrial cancer (EC) reduces the rate of unnecessary systemic lymph dissection. The aim of this study was to assess the SLN detection rate, accuracy of the method using Tc-99m-SENTI-SCINT and the rate of metastatic nodal involvement in patients with preoperative first stage EC. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Thyroid cancer detection rate and associated risk factors in patients with thyroid nodules classified as Bethesda category III(Walter de Gruyter GmbH, 2018); ; ; ; Background Ultrasound guided fine-needle aspiration (FNA) is a standard procedure for thyroid nodules management and selecting patients for surgical treatment. Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS), as stated by The Bethesda System for Reporting Thyroid Cytopathology, is a diagnostic category with an implied malignancy risk of 5-15%. The aim of our study was to review cytology and histopathology reports, as well as clinical and ultrasound data, for thyroid nodules reported as AUS/FLUS, in order to evaluate the malignancy rate and to assess factors associated with malignant outcome. Patients and methods A total of 112 AUS/FLUS thyroid nodules in 105 patients were evaluated, of which 85 (75.9%) were referred to surgery, 21 (18.8%) were followed-up by repeat FNA and 6 nodules (5.3%) were clinically observed. Each was categorized in two final diagnostic groups - benign or malignant, which were further compared to clinical data of patients and ultrasonographic features of the nodules. Results Final diagnosis of malignancy was reached in 35 cases (31.2%) and 77 (68.8%) had benign lesions. The most frequent type of cancer was papillary thyroid carcinoma (PTC) - 58.1% PTC and 25.8% had follicular variant of PTC. Patients' younger age, smaller nodule size, hypoechoic nodule and presence of calcifications were shown to be statistically significant risk factors for malignancy. Conclusions The rate of malignancy for the AUS/FLUS diagnostic category in our study was higher than estimated by the Bethesda System. Clinical and ultrasound factors should be considered when decision for patient treatment is being made. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HYPERPARATHYROIDISM DUE TO INTRATHYROIDAL PARATHYROID ADENOMA(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-07-18); ; ; The intrathyroidal parathyroid adenoma (IPA) represents a rare anatomical variant where parathyroid tissue is located within the thyroid gland instead of its usual extrathyroidal position. This condition arises due to aberrant embryologic migration of the parathyroid glands and is identified in approximately 1.3% to 6.7% of all parathyroid lesions. Case report: We present the case of a 56-year-old female diagnosed with a thyroid nodule, incidentally found on neck ultrasound. Fine-needle aspiration biopsy reported only microfollicular and macrofollicular arrangement of benign thyrocytes and lymphocytes. Due to continuous fatigue, loss of appetite, pain in bones, osteoporotic changes and constipation, hyperparathyroidism was suspected and laboratory revealed hyperparathyroidism with increased parathormone (1587 pg/mL), ionized calcium (2.25 mmol/L) and low phosphates. 99mTc-MIBI scintigraphy revealed a focal accumulation in the lower quadrant of the right thyroid lobe, indicative of intrathyroidal parathyroid adenoma, which was confirmed by histopathology report. After surgery, continuous decrease in PTH levels were reported, and after 7 months PTH levels were 66.73 pg/mL, ionized calcium 1.12 mmol/L and inorganic phosphate 1.15 (0.8-1.4 mmol/L). Follow-up of the patient revealed variations in the PTH levels, above the upper reference limit, along with hypoechogenic nodule in the posterior parts of the contralateral thyroid lobe. Further close follow-up is recommended due to the possibility of recurrence. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Absent 99mTc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism(ID Design 2012/DOOEL Skopje, 2018-05-20); ; ; ; Thyroid uptake of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) during parathyroid scintigraphy can be affected by various conditions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, FALSE POSITIVE RADIOIODINE POST-ABLATION SCAN IN SCALP REGION IN A WOMAN WHO USED HAIR COLORING REVEALED BY SPECT/CT(2019); ; ; Radioiodine ablation with iodine-131 is a standard therapeutic procedure for patients diagnosed with differentiated thyroid carcinoma (DTC). We present a contamination artifact on whole-body scan (WBS), after radioiodine ablation due to papillary thyroid carcinoma. The hybrid imaging resolved the question of metastasis versus contamination. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Identification of Sentinel Lymph Node in Breast Cancer with three Tracers (Radiocolloid, Methylene blue, and Indocyanine Green). (Case Report)(Scientific foundation SPIROSKI, 2020-09-10); ; ; BACKGROUND: Sentinel lymph node (SNL) biopsy in breast cancer for the determination of axillary status is standard procedures in surgical treatment of early-stage breast cancer. The identification of the SNL is usually performed by radiocolloid injection or/and injection of methylene blue due. The use of indocyanine green (ICG) dye, which is fluorescent dye, which movement in breast and axillar pit, can be followed with special cameras which detect near infrared specatar of light. CASE REPORT: In this paper, we present case report of patient with breast cancer, where we perform SNL detection with three methods: Use of radiocolloid which we trace with static gamma camera, and intraoperatively with hand held gamma probe, methylene blue dye which movement we followed by eye contact and using indocyanine green which movement was followed by specially constructed multispectral camera, which can detect near-infrared fluorescence that is emitted by ICG and methyline blue, respectively. CONCLUSION: Fluorescent imaging with ICG is a sensitive, valuable, and safe method for SNL biopsy. Finding new agents that would identify the SNL, especially if they are not radioactive would be an important step in wider application of this method. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Radiation exposure dose of medical workers during radioguided sentinel lymph node biopsy(Tehran University of Medical Sciences, 2022-04); ; ; ; Introduction: Radiation monitoring of professionally exposed workers is obligatory in nuclear medicine departments. The purpose of our study was to evaluate the radiation exposure dose received by medical workers during radioguided sentinel lymph node biopsy in breast cancer and endometrial cancer patients. Methods: Radiation exposure dose of medical staff was prospectively recorded during 35 radioguided sentinel lymph node biopsy procedures in a 6-month period. All patients received 4 mCi [99mTc]Tc-SENTI-SCINT on the day of surgery. Thermoluminescent dosimeters in the shape of a bracelet, ring and badge were used for recordings and data was compared to dose limits imposed by the regulations. Results: Mean time interval between activity administration and surgery was 223.63 min and mean duration of surgery was 142.5 min. The recorded 6-month cumulative dose was 0.33 mSv for the senior surgeon, 0.25 mSv for the surgeon's first assistant, 0.24 mSv for the anesthesiologist and 0.54 for both nuclear medicine physician and resident. The approximately equivalent dose for the surgical staff in each procedure was 9.7 µSv, 7.3 µSv and 7.05 µSv respectively, which means that the senior surgeon could perform 106 and 2127 sentinel lymph node biopsy procedures per year in order to reach the annual dose limit for a public member and a radiation worker. Conclusion: Occupational radiation exposure dose of medical staff during radioguided sentinel lymph node biopsy is low and under annual dose limits, requiring no routinely personal dosimetry for surgical staff performing the procedure.
- «
- 1 (current)
- 2
- 3
- »