Poceva panovska, Ana
Preferred name
Poceva panovska, Ana
Official Name
Poceva panovska, Ana
Main Affiliation
Email
ana.poceva@ff.ukim.edu.mk
5 results
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Item type:Publication, Green RP-HPLC method for impurity profile of amlodipine in tablets(Centre for Evaluation in Education and Science (CEON/CEES), 2024); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PLS based quantitative determination of insulin aspart in solution using Raman spectroscopy(Centre for Evaluation in Education and Science (CEON/CEES), 2024); ; ; <jats:p>The complex structure of medicines containing polypeptide active substances requires the implementation of challenging analytical approaches, based on physicochemical methods, and, where necessary, biological assays for quality control, as well as for the detection of substandard and falsified products. Vibrational spectroscopic techniques, including Raman spectroscopy, are fast, powerful, and non-destructive techniques which, when combined with multivariate chemometric modelling, can provide specific identification, quantitative determination, and insight into the secondary structure of proteins and peptides. The aim of this study was to investigate the possibility of using Raman spectroscopy as a screening method for quantification of pharmaceutical products containing active substances with polypeptide structures. For that purpose, a model based on partial least square (PLS) analysis for quantitative determination of insulin aspart in solution was developed using Raman spectroscopy. The proposed model enables the establishment of a rapid approach for screening of the quality of formulations containing active substances with polypeptide structure, providing the selection of suspected samples that should be further analysed using routine techniques, which are time-consuming and costly.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, An experimental design approach in optimization of an extraction procedure for AAS determination of Ca, Mg, Zn, Cu and Fe in multimineral dietary supplements(2018-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Coumarin–Triazole–Isatin Hybrids as Selective Butyrylcholinesterase Inhibitors(MDPI AG, 2025-05-11); ; Mihajloska, Evgenija<jats:p>A series of 21 novel coumarin–triazole–isatin hybrids was synthesized and evaluated for their potential as multitarget agents in Alzheimer’s disease (AD). The compounds featured variations in alkyl linker length that connects coumarin and triazole and substitution at the 5-position of the isatin ring. Several derivatives showed potent butyrylcholinesterase (BChE) inhibition with selectivity over acetylcholinesterase (AChE). The lead compound, 6c1, exhibited strong BChE inhibition (IC50 = 1.74 μM), surpassing donepezil. Enzyme kinetics revealed a mixed-type mechanism, while molecular docking studies confirmed dual binding at catalytic and peripheral sites. Structure–activity relationship (SAR) analysis highlighted the influence of linker flexibility and steric/electronic effects of substituents. The observed BChE selectivity, combined with favorable in vitro profiles, identifies these hybrids as promising leads for AD drug development.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Green RP-HPLC method for impurity profile of amlodipine in tablets(Centre for Evaluation in Education and Science (CEON/CEES), 2024)