Faculty of Pharmacy

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Skopje

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Bootstrap analysis for dissolution similarity factor f2 - bringing confidence for borderline results – a case study
(Macedonian Pharmaceutical Association in cooperation with Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy., 2022)
Tina Achkoska
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Marijana Bozhinovska
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Angela Arnaudova
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Packa Antovska
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In vitro dissolution testing is one of the most important tools for characterizing the performance of oral solid dosage forms. In order to demonstrate similarity between test and reference product, comparative dissolution profiles are performed. Selection of a suitable method for comparison of the dissolution profile of the reference product and the test product is of great importance especially in the case of biowaivers when similarity assessment is based on the in vitro data only. Various approaches have been developed for the comparison of dissolution profiles, however the usage of the f2 similarity factor is widely accepted due to its simplicity. When the conditions for using f2 similarity factor are not fulfilled due to high variable dissolution profiles, f2 bootstrap method is then recommended. The focus of this study is to see whether it is benefitial f2 bootstrap analysis to replace the usage of simple f2 for comparison of dissolution profiles that fulfill the prerequisites for using the f2 method in cases when borderline f2 results are obtained.
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Topical gel with ethyl cellulose based microsponges loaded with clindamycin hydrochloride for acne treatment
(Springer Science and Business Media LLC, 2020-06-10)
Dimitrovska, Ivana
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Olumceva, Tanja
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Markova, Elena
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Kostoska, Monika
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Taneska, Lea
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Concentration of heavy metals in spring waters of Kochani and their impact on human health
(Macedonian Pharmaceutical Association, 2022)
Serafimova Mijalova, Emilija
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Tortevska Danilov, Elena
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Pendevski, Vasil
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Zhivikj, Zoran
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<jats:p>The concentration of lead (Pb), cadmium (Cd), aluminium (Al), manganese (Mn), and iron (Fe) in spring waters in the vicinity of Kochani was investigated to ascertain the health risk exposure. Heavy metal water contamination is possible mostly due to wrongful human activities either industrially or residentially and exposure to toxic doses of heavy metals can cause acute and chronic diseases. To examine heavy metal contamination of spring waters as well as possible seasonal variations, water samples in two seasons, autumn 2021 and spring 2022 were collected. For this aim, ten locations within the area of Kochani were selected. The spring water samples were collected directly from the source or from the catchment that was made. The samples were collected in appropriate bottles, previously washed with detergent and rinsed with distilled water. The examination of heavy metals was carried out immediately after sampling using UV spectrophotometric method, with an absorption spectrum of 190-1100 nm. The results have revealed no major deviations from the maximum concentrations allowed for Pb, Cd, Al, Mn, and Fe defined within the Official Guidelines in the Republic of North Macedonia, except moderately increased levels of lead in two samples during autumn season and manganese in four samples in the spring season 2022. Key words: heavy metal levels, spring water, UV spectrophotometry, human health</jats:p>
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Root causes for presence of nitrosamine impurities in active pharmaceutical substances and finished pharmaceutical products
(Macedonian Pharmaceutical Association, 2022-12-31)
Prculovska, Milena
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Poceva Panovska, Ana
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Dimtirovska, Aneta
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Development and validation of a bioanalytical LC-UV method with solid-phase extraction for determination of valproic acid in saliva.
(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2012-06)
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Haxhiu, Arlinda
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A bioanalytical HPLC method with UV detection for the determination of the antiepileptic drug valproic acid in human saliva has been developed and validated. Saliva represents an alternative matrix for therapeutic monitoring of antiepileptic drugs due to the increasing interest in free drug concentration. The proposed method involved solid-phase extraction for sample preparation and yielded very good mean recoveries of 99.4 % and 97.9 % for valproic acid and IS, respectively. The calibration function for valproic acid was linear over the concentration range of 1.0-50.0 μg mL⁻¹ (R² = 0.9989). Within-run and between-run precision and accuracy were studied at four concentrations and RSDs were less than 7.3 and 2.2 %, while accuracy values were higher than 96.8 and 97.5 %, respectively. The described method provides sensitivity, linearity, precision, accuracy and is suitable for analyses of valproic acid in saliva samples.
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Selection of appropriate manufacturing technology for development of Oxycodone prolonged release film-coated tablets using QbD approach
(Macedonian pharmaceutical association, 2022)
Memed, Oja
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Hadzieva-Gigovska, Maja
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AML-327: Plasmacytoid Dendritic Cell Proliferation Associated with Acute Myeloid Leukemia: A Case Report
(Elsevier BV, 2021-09)
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Ridova, Nevenka
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Stojanovska, Simona
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Trajkova, Sanja
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Insight in the Current Progress in the Largest Clinical Trials for Covid-19 Drug Management (As of January 2021)
(Macedonian Academy of Sciences and Arts/Sciendo, 2021-04-23)
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Ridova Nevenka
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Stojanoska, Tatjana
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Abstract The outbreak of the COVID-19 pandemic has generated the largest global health crisis of the 21st century, evolving into accelerating socioeconomic disruption. In spite of all rapidly and widely emerging scientific data on epidemiology, diagnosis, prevention and treatment of the COVID-19 disease, severe acute respiratory coronavirus 2 (SARS-CoV-2) is continuing to propagate in lack of definitive and specific therapeutic agents. Current therapeutic strategies are mainly focused on viral inhibition by antiviral drugs and hampering the exuberant immune response of the host by immunomodulatory drugs. In this review, we have studied the reports of the largest clinical trials intended to COVID-19 treatment published during the first year of the pandemics. In general, these results concentrate on seven therapeutic options: remdesivir, chloroguine/hydroxychloroquine, lopinavir-ritonavir combination, corticosteroids, tocilizumab, convalescent plasma and monoclonal antibodies. In line with the reviewed data, as of January 2021, most of the evidence support the use of remdesivir in hospitalized patients with moderate and severe forms of the disease and provide reliable data on the substantial beneficial effect of corticosteroids in patients requiring supplemental oxygen. Moreover, preliminary RECOVERY trial results have demonstrated the efficacy of tociluzumab in the treatment of critically ill patients. The reports presenting the outcomes of the other immune-based therapies under investigation are enthusiastically awaited.
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Anti-inflammatory properties of L. casei loaded whey protein-alginate microparticles in animal model of colitis
(2014)
Smilkov, K.
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Dodov, M.G.
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Hadzieva, J.
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Pavlova, M.J.
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Ivanoska, T.P.
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Consumer perception of risk-benefit of weight loss supplements and building safety
(Macedonian Pharmaceutical Association, 2020-10-29)
Zhivikj, Zoran
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Lonchar Velkova, Marijana

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