Faculty of Pharmacy
OrgUnit's Researchers publications
(Dept/Workgroup Publication)
Subject
- 1 insulin analogues, capillary electrophoresis, chemometrics
- 1 intellectual property rights, counterfeiting, medicines, drug packaging
- 1 International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR) | February 2022 | Volume 12 | Issue 1 | Page 7-16 LIljana Anastasova, Application of Experimental Design Approach in Optimization of Quality Parameters of Calcium- and Magnesium-Enriched Milk ISSN (Online) 2249-6084 (Print) 2250-1029 www.eijppr.com Application of Experimental Design Approach in Optimization of Quality Parameters of Calcium- and Magnesium-Enriched Milk LIljana Anastasova1*, Tanja Petreska Ivanovska2, Andrijana Ancevska2, Rumenka Petkovska1, LIdija Petrushevska-Tozi2 1Institute of Applied Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, University of Ss. Cyril and Methodius, Skopje, Republic of North Macedonia 2Institute of Applied Biochemistry, Faculty of Pharmacy, University of Ss. Cyril and Methodius, Skopje, Republic of North Macedonia. ABSTRACT Full factorial (23) design was applied to evaluate the effects of addition of calcium chloride, magnesium chloride, and time of magnetic stirring on quality parameters of milk in the preparation process of calcium- and magnesium-enriched milk. The quality of the mineral enriched milk was evaluated in terms of relative density, dry matter, titratable acidity, the content of proteins, lipids, and carbohydrates as well as the content of calcium, magnesium, and phosphorus, and calcium: phosphorus ratio. In parallel, sensorial properties were analyzed to select the most preferable sample for consumers. The results from the experimental design and the sensorial analysis indicated that the application of medium levels of calcium and magnesium salts for milk enrichment provides acceptable quality and sensory characteristics similar to commercial milk. The determined content of calcium and magnesium in these samples was sufficient to give an additional 9.0% of the recommended daily allowance (RDA) for calcium (700 mg/day) and 2.6% of the RDA for magnesium (300 mg/day). Enrichment with calcium more than 0.3 g/100 g was inadequate in respect to certain quality parameters, and also off-flavors were developed during the first five days of the cold storage. The PCA was efficient in identifying and measuring the attributes of functional milk important for consumer acceptability. This study constitutes a step forward in developing strategies for the preparation of functional milk with increased nutritional value and favorable sensory profile that can be used as a vehicle for delivering more minerals to the human body. Key Words: Mineral-enriched milk, Optimization, Design of experiments, Sensory acceptability
- 1 intoxication
- 1 JAK2V617 mutation
- 1 Juniperus communis
- 1 Juniperus oxycedrus
- 1 Ki-67
- 1 Lactobacillus casei 01
- 1 Lavandula angustifolia; essential oil; liposome; nanoemulsion; DU145; cancer cell line
- < previous next >
Date issued
- 171 2020 - 2025
- 121 2010 - 2019
- 8 2000 - 2009
Type
- 185 Article
- 26 Journal Article
- 23 Proceeding article
- 15 Proceedings
- 8 Book
- 2 Book chapter
- 1 Other
- 1 Presentation
Fulltext
- 191 No Fulltext
- 108 With Fulltext
Results 1-20 of 300 (Search time: 0.242 seconds).
| Preview | Title | Author(s) | Issue Date | Type | |
|---|---|---|---|---|---|
| 1 | [(3-Chlorobenzamido)methyl]triethylammonium Chloride | Breznica-Selmani, Pranvera; Mladenovska, Kristina ; Kavrakovski, Zoran ; Mikhova, Bozhana; Draeger, Gerald; Popovski, Emil | 1-Apr-2015 | ||
| 2 | 3D printed extended-release hydrochlorothiazide tablets | Tasevska, Teodora; Adamov, Ivana; Geškovski, Nikola ; Ibrić, Svetlana; Gorachinova, Katerina ; Simonoska crcarevska, Maja | 1-Mar-2025 | Journal Article | |
| 3 | AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers - a pilot study in healthy volunteers | Kapedanovska Nestorovska, Aleksandra ; Jakjovski, Krume ; Naumovska, Zorica ; Sterjev, Zoran ; Geskovska, Nadica Matevska; Mladenovska, Kristina ; Suturkova, Ljubica; Dimovski, Aleksandar | 1-Sep-2019 | Article | |
| 4 | Alcohol involvement in fatal traffic accidents | Bujaroska, Marija ; Anastasova, Liljana; Zhivikj, Zoran ; Bozhinoska, Zorica; Pavlovski, Goran ; Bitoljanu, Natasha ; Belakaposka, Viktorija ; Petrushevska Tozi, Lidija | 2022 | Article | |
| 5 | Allele frequency and genotype distribution of aldo keto reductase 1D1 (AKR1D1) rs1872930 genetic variant in a Macedonian population | Kapedanovska Nestorovska, Aleksandra ; Naumovska, Zorica ; Jakjovski, Krume ; Sterjev, Zoran ; Matevska Geskovska, Nadica; Dimovski, Aleksandar ; Shuturkova, LJubica | 2018 | Article | |
| 6 | AML-327: Plasmacytoid Dendritic Cell Proliferation Associated with Acute Myeloid Leukemia: A Case Report | Panovska Stavridis, Irina ; Ridova, Nevenka; Stojanovska, Simona; Trajkova, Sanja; Pivkova Veljanovska, Aleksandra ; Popova-Labachevska, Marija; Ivanovski, Martin; Cadievski, Lazar; Cevreska, Lidija; Petrushevska, Gordana ; Dimovski, Aleksandar | Sep-2021 | Proceeding article | |
| 7 | Analysis of ergosterol as a potential contaminant in two herbal raw materials | Varsamovska, Kristina; Zhivikj, Zoran ; Topkoska, Marina; Kadifkova panovska, Tatjana ; Petrushevska tozi, Lidija ; Petreska ivanovska, Tanja | 29-Oct-2020 | Article | |
| 8 | Analysis of total aflatoxins in commercially available cereal products in the Republic of North Macedonia | Dimovska, Elena; Zhivikj, Zoran; Gavazova, Elizabeta; Petreska ivanovska, Tanja ; Petrushevska tozi, Lidija | Jan-2023 | Article | |
| 9 | Analytical Techniques for Phytocannabinoid Profiling of Cannabis and Cannabis-Based Products-A Comprehensive Review | Stefkov, Gjoshe; Cvetkovikj Karanfilova, Ivana; Stoilkovska Gjorgievska, Veronika; Trajkovska, Ana; Geskovski, Nikola; Karapandzova, Marija ; Kulevanova, Svetlana | 1-Feb-2022 | Article | |
| 10 | Analytical Techniques for Phytocannabinoid Profiling of Cannabis and Cannabis-Based Products-A Comprehensive Review | Stefkov, Gjoshe; Cvetkovikj Karanfilova, Ivana; Stoilkovska Gjorgievska, Veronika; Trajkovska, Ana; Geskovski, Nikola; Karapandzova, Marija ; Kulevanova, Svetlana | 1-Feb-2022 | ||
| 11 | Anti-inflammatory and immunomodulatory effects of rosuvastatin in patients with low-to-moderate cardiovascular risk | Ana Vavlukis; Marija Vavlukis ; Aleksandar Dimovski ; Gordana Petrushevska ; Aleksandar Eftimov ; Sashka Domazetovska; Kristina Mladenovska | 30-Dec-2021 | Article | |
| 12 |  | Anti-inflammatory properties of L. casei loaded whey protein-alginate microparticles in animal model of colitis | Smilkov, K.; Dodov, M.G.; Hadzieva, J.; Pavlova, M.J.; Ivanoska, T.P.; Ristoski, Trpe ; Gjurovski, I; Tozi, L.P.; Mladenovska, Kristina | 2014 | |
| 13 |  | Anti-inflammatory properties of synbiotic loaded chitosan-Ca-alginate microparticles in animal model of colitis | Petreska Ivanovska, T.; Zhivikj, Z.; Pavlova, M. J.; Glavas Dodov, M.; Ristoski, T.; Gjurovski, I.; Petrushevska-Tozi, L.; Mladenovska, Kristina | 2015 | |
| 14 |  | Anti-inflammatory properties of synbiotic loaded chitosanCa-alginate microparticles in animal model of colitis | Petreska ivanovska, T ; Zhivikj Z; Jurhar Pavlova, M ; Glavas Dodov, M ; Ristoski, T; Gjurovski, I; Petrushevska Tozi, L ; Mladenovska, K | 2015 | Article |
| 15 | Antibiotic consumption and management at Kocani General Hospital – Annual report | Ilieva, Nada; Nikolova, Milena; Pankov, Donka; Simonoska Crcarevska, Maja; Mladenovska, Kristina ; Shalabalija, Dushko; Mihailova, Ljubica; Gigopulu, Olga; Glavas Dodov, Marija | 2019 | Article | |
| 16 | Antibiotic Consumption in Hospitalized Children at the University Clinic for Pediatric Diseases – Skopje | Pechijareva-Sadikarijo, Iskra; Naumovska, Zorica ; Petrovski, Ognen ; Stavrikj, Katarina ; Balkanov, Trajan | 10-Jun-2020 | Article | |
| 17 | Antibiotic dispensing and over the counter drug sale: case study in “Villa” community pharmacy in Montenegro 2019-2021 | Djurdjic, Beti; Milosevic, Kristina; Mudresa, Jelena; Maric, Savo; Naumovska, Zorica ; Kapedanovska Nestorovska, Aleksandra ; Simonoska Crcarevska, Maja | 2022 | Article | |
| 18 | Antimicrobial activity of needle essential oil of Pinus peuce Griseb. (Pinaceae) from Macedonian flora | Marija Karapandzova ; Gjose Stefkov; Elena Trajkovska Dokic ; Ana Kaftandzieva ; Svetlana Kulevanova | Mar-2012 | Article | |
| 19 | Antioxidant activity of PEGylated liposomes loaded with rosemary dry extract for treatment of Alzheimer’s disease | Cambuleva, Ljubica; Shalabalija, Dushko; Cvetkovikj, Ivana ; Simonoska Crcarevska, Maja ; Glavas Dodov, Marija | 19-Mar-2018 | Proceeding article | |
| 20 | Antioxidative Effects of Rosuvastatin in Low-to-Moderate Cardiovascular Risk Subjects | Vavlukis, Ana; Vavlukis, Marija ; Mladenovska, Kristina ; Dimovski, Aleksandar ; Muñoz-García, Natàlia; de Santisteban Villaplana, Victoria; Padro, Teresa; Badimon, Lina | 22-Apr-2022 | Article |
Organization name
Faculty of Pharmacy
Parent OrgUnit
City
Skopje
Country
Macedonia, the Former Yugoslav Republic of