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Approaches to the Development of New Simple Rapid HPLC–Photodiode Array Method for the Simultaneous Determination of Levomenthol and Ibuprofen in Gel Pharmaceutical Formulation
(Wiley, 2025-05-19)
Piponski, Marjan
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Beneta, Antonija
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Stefkov, Gjose
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Karanfilova, Ivana Cvetkovikj
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Horyn, Mariana
ABSTRACT We have developed a new approach in creating a simple, fast analytical method for the simultaneous determination of ibuprofen and menthol in pharmaceutical dosage form by using an HPLC-photodiode array system with a selected reversed-phase column after numerous experiments with columns covering the full spectrum of polarities; C-18, C-8, phenyl, cyanopropyl, and silica-based liquid chromatography matrices. The main problem and challenge for the development method was using many liquid chromatography features to detect and measure the analyte molecule of menthol, which is almost UV-invisible, having a structure without any chromophore in its structure. The enormous UV-absorbing characteristics between ibuprofen and menthol complicate the creation of a simple, rapid, reproducible, rugged, and accurate simultaneous analytical method with high throughput character. Low injection volumes were used for conceptual purposes. The final analytical method has been developed with one simple sample preparation for the determination of two distinct analytes, always determined with two different techniques or one with more sophisticated detection systems and separate sample preparation. As we could check and compare, the proposed HPLC simultaneous quantification method for levomenthol and ibuprofen is one of the simplest and shortest analytical methods for mutual determination in pharmaceutical dosage forms.
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Development and validation of automated SPE‐LC‐MS/MS method for determination of indapamide in human whole blood and its application to real study samples
(Wiley, 2013-06-24)
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Mladenovska, K.
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Labacevski, N.
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Dimovski, A.
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Petkovska, R.
A fast and simple liquid chromatography–electrospray ionization tandem mass spectrometry method for determination of indapamide in human whole blood was developed and validated. The sample extraction of indapamide from human whole blood was achieved using automated solid-phase extraction. Chromatographic separation was performed on Kinetex C18 column (100 × 2.1 mm, 1.7 µm particle size) using acetonitrile and 2 mm ammonium formate in ratio 90:10 (v/v) as a mobile phase. The mass spectrometer was operated in the multiple reaction monitoring mode using positive electrospray ionization for indapamide and the internal standard (zolpidem tartarate). The total run time was 2.5 min. The present method was found to be linear in the concentration range of 1–50 ng/mL with the coefficient of determination 0.9987. The absolute recoveries of indapamide were 90.51–93.90%. The method was validated according the recommendations for validation of bioanalytical methods of European Medicines Agency guideline and was successfully used to analyze human whole blood samples for application in a pharmacokinetic study.
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Critical development by design of a rugged HPLC-MS/MS method for direct determination of ibuprofen enantiomers in human plasma
(Elsevier BV, 2015-06)
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Ugrinova, Liljana
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CHEMOMETRIC APPROACH FOR OPTIMIZATION OF HILIC METHOD FOR SIMULTANEOUS DETERMINATION OF IMIPENEM AND CILASTATIN SODIUM IN POWDER FOR INJECTION
(Informa UK Limited, 2013-12-11)
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High-Throughput HPLC-MS/MS Method for Quantification of Ibuprofen Enantiomers in Human Plasma: Focus on Investigation of Metabolite Interference
(Oxford University Press (OUP), 2016-10-12)
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Tonic-Ribarska, Jasmina
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Biochemical insights into cannabidiol–endocannabinoid system interactions in the regulation of metabolic pathways
(Society of Chemists and Technologists of Macedonia, 2025-12-26)
Xhemaili, Elona
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Rafailovska, Elena
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Unlocking the Antidiabetic Potential of CBD: In Vivo Preclinical Studies
(MDPI AG, 2025-03-21)
Rafailovska, Elena
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Xhemaili, Elona
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Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery
(Beilstein Institut, 2026-01-13)
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Zimmer, Andreas
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Geiss, Otmar
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Bacterial Nanocellulose Wound Dressings with Gentamicin-Loaded Chitosan Nanoparticles for Surgical Site Infection Management
(MDPI AG, 2026-02-19)
Livrinska Trpeska, Lina
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Petrushevska, Marija
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Djurdjic, Beti
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Comparative Modeling Approaches in the Development and Evaluation of Silica Nanoparticles as 5-Fluorouracil Carriers using PLS, DoE and GBR
(Springer Science and Business Media LLC, 2025-11-24)
Djurdjic, Beti
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Dimkovska, Teodora
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