Faculty of Pharmacy

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Start date: 2008End date: 2009

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    Chitosan coated Ca-alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa
    (Elsevier BV, 2008-03)
    Simonoska Crcarevska, Maja
    ;
    Glavas Dodov, Marija
    ;
    Goracinova, Katerina
    Using a novel one-step spray-drying process uncoated and Eudragit S 100 coated chitosan-Ca-alginate microparticles efficiently loaded with budesonide (BDS), with bioadhesive and controlled release properties in GIT, were prepared. Microparticles were spherical with mean particle size of 4.05-5.36 microm, narrow unimodal distribution and positive surface charge. A greater extent of calcium chloride limited the swelling ratio of beads, while swelling behaviour of coated beads was mainly determined by properties of enteric coating. Comparing the release profiles of formulations, under different pH conditions, influence of polymer properties and concentration of cross-linker on the rate and extent of drug release was evident. Coating has successfully sustained release of BDS in buffers at pH 2.0 and 6.8, while providing potential for efficient release of BDS at pH 7.4. Release data kinetics indicated influence of erosion and biodegradation of polymer matrix on drug release from microparticles. Prepared formulations were stable for 12 months period at controlled ambient conditions. In conclusion coated microparticles prepared by one-step spray-drying procedure could be suitable candidates for oral delivery of BDS with controlled release properties for local treatment of inflammatory bowel diseases.
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    Bioefficacy of budesonide loaded crosslinked polyelectrolyte microparticles in rat model of induced colitis
    (Informa UK Limited, 2009-12)
    Crcarevska, M Simonoska
    ;
    Dodov, M Glavas
    ;
    Petrusevska, G
    ;
    Gjorgoski, I
    ;
    Goracinova, K
    A targeted delivery system for inflammatory bowel diseases, chitosan-Ca-alginate microparticles efficiently loaded with budesonide (BDS), were designed using one-step spray-drying process. They were eudragit-coated and examined for in vivo efficacy. Experimental colitis was induced by rectal instillation of 2,4,6-trinitrobenzene sulphonic acid (TNBS) into male Wistar rats. Drugs were administered by oral gavage daily for 5 days. Colon/body weight ratio, gross morphological and histological evaluation, and clinical activity score were determined as inflammatory indices. Individual clinical and histological evaluation showed that colitis severity was suppressed the most greatly in order BDS < BDS/C-Ca-A < E-BDS/C-Ca-A. Clinical activity score decreased in the same order. Statistical analyses of total score points indicate that the incorporation of BDS in microparticles had significant differences in favor of efficacy of designed delivery system with mucoadhesive and controlled release properties (one-way ANOVA, P < 0.05). The results established the prediction by previous in vitro studies.
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    Development and Validation of an SEC-HPLC Method for the Analysis of Lenogratsim (rHuG-CSF) in Pharmaceutical Formulations
    (Informa UK Limited, 2009-10-05)
    Tonic-Ribarska, Jasmina
    ;
    ;
    Trajkovic-Jolevska, Suzana